• 대한산업공학회지
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• 제37권2호
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• pp.153-162
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• 2011

The demands of complicated data communications have issued a new challenge to port logistics systems. Customers expect ports to handle their generated administrative data while a vessel is docked in a port. One port logistics system, known as the Vessel Clearance Process (VCP), manages large numbers of documents related to port of entry. In the VCP, information flows through many organizations such as the port authority, shipping agents, marine offices, immigration offices, and others. Therefore, for effective management of the Business Process (BP) of the VCP, a standardized method of BP modeling is essential, especially in heterogeneous system environments. In a port, according to port policy, terms and data are sued that are similar to but different from those of other logistics partners, which hinders standardized modeling of the BP. In order to avoid tedious and time-consuming document customization work, more convenient modeling of BP for VCP is essential. This paper proposes an ontology-based process similarity measurement to assist designer for process modeling in port domain, especially VCP. We expect that this methodology will use convenient and quick modeling of port business processes.

• 한국정밀공학회지
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• 제22권12호
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• pp.93-99
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• 2005

In this work, computer-aided process design is carried out to develop an optimal preform of a pressure vessel. Knowledge-based rules are employed to design the preform, and they are formulated using the handbooks of plasticity theories. In the FE-analysis, a commercial finite element code, ABAQUS was employed. Axisymmetric deep drawing of a hemisphere-bottomed cup has been analyzed fur various combinations of die design parameters. The length of the land of die, the clearance between punch and die and the clearance between the blank holder and die are optimized to minimize the forming load. The results of the simulations are verified with the experiments which are scaled down to one tenth of the actual size.

• Biomolecules & Therapeutics
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• 제20권3호
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• pp.245-255
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• 2012

Amyloid-${\beta}$ peptide ($A{\beta}$) is still best known as a molecule to cause Alzheimer's disease (AD) through accumulation and deposition within the frontal cortex and hippocampus in the brain. Thus, strategies on developing AD drugs have been focused on the reduction of $A{\beta}$ in the brain. Since accumulation of $A{\beta}$ depends on the rate of its synthesis and clearance, the metabolic pathway of $A{\beta}$ in the brain and the whole body should be carefully explored for AD research. Although the synthetic pathway of $A{\beta}$ is equally important, we summarize primarily the clearance pathway in this paper because the former has been extensively reviewed in previous studies. The clearance of $A{\beta}$ from the brain is accomplished by several mechanisms which include non-enzymatic and enzymatic pathways. Nonenzymatic pathway includes interstitial fluid drainage, uptake by microglial phagocytosis, and transport across the blood vessel walls into the circulation. Multiple $A{\beta}$-degrading enzymes (ADE) implicated in the clearance process have been identified, which include neprilysin, insulin-degrading enzyme, matrix metalloproteinase-9, glutamate carboxypeptidase II and others. A series of studies on $A{\beta}$ clearance mechanism provide new insight into the pathogenesis of AD at the molecular level and suggest a new target for the development of novel therapeutics.

• 방사성폐기물학회지
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• 제17권4호
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• pp.437-445
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• 2019

고리1호기의 영구정지 이후 해체공정에 대해 관심이 집중되고 있다. 방사선관리구역 내부 방사화구조물의 해체는 2026년 이후 본격적으로 진행될 예정이다. 원자로와 내부구조물은 원자력발전소의 구조물 중 가장 높은 수준의 방사능을 갖고 있으며 1차측의 대표적인 중량물로, 절단해체 과정에서 방사선학적 측면과 산업안전 측면에서 주의가 요구된다. 효율적인 해체 폐기물 관리를 달성하기 위해 원자로와 내부구조물의 절단해체공정에 대한 연구가 수행되었다. 방사화 평가결과 내부구조물의 노심 측면부와 상/하부의 일부는 중준위 폐기물로 평가되었고 이외의 구성품은 저준위로 평가되었다. 상대적으로 방사화가 많이 되고 복잡한 형상을 갖는 내부구조물의 경우 작업자의 피폭을 저감하기 위해 수중에서 다양한 절단방법을 통해 원격절단하는 방안이 제안되었고, 절단물은 약 19개의 극저준위/저준위 포장용기와 9개의 중준위 포장용기에 적재될 것으로 예상되었다. 방사화 평가결과 원자로의 노심 측면부는 저준위 폐기물로 평가되었고 이외의 부분은 극저준위 또는 자체처분수준의 폐기물로 확인되었다. 상대적으로 방사화가 적게 된 원자로의 경우 열적절단 방법을 사용해 현재위치에서 인양하며 공기중에서 원격절단하는 방안이 제안되었고, 절단물은 약 42개의 극저준위/저준위 포장용기에 적재될 것으로 예상되었다.