• 한국항공우주학회지
• /
• 제46권7호
• /
• pp.602-609
• /
• 2018

본 논문은 LTE 통신망 환경에서 군집 UAV의 비디오 영상 데이터를 고속으로 암호화하기 위한 하이브리드 암호시스템을 제안한다. 이 암호시스템은 ECC 공개키 알고리즘과 LEA 대칭키 알고리즘으로 구성된다. ECC는 RSA보다 빠르면서 동일한 보안성을 가지며, LEA는 동일한 키로 AES보다 빠른 국내 표준 알고리즘이다. 본 논문은 OpenSSL과 OpenCV를 활용하여 Socket 프로그램으로 8개의 군집 UAV 환경에서 하이브리드 암호시스템을 구성하여 구현하였다. 실험을 통하여 본 하이브리드 암호시스템이 실시간 환경에서 효율적으로 적용이 가능함을 보인다.

• BMB Reports
• /
• 제47권9호
• /
• pp.506-511
• /
• 2014

We investigated the effects of high calorie and low calorie diets on skeletal integrity, and whether ${\beta}$-adrenergic blockade (BB) attenuates bone loss induced by dietary calorie alteration. Male 6-week-old C57BL/6 mice were assigned to either an ad-lib fed control diet (CON), a high calorie diet (HIGH), or a low calorie diet (LOW) group. In each diet group, mice were treated with either vehicle (VEH) or propranolol, a ${\beta}$-adrenergic antagonist. Over 12-weeks, ${\beta}$-blockade mitigated body weight and fat mass increases induced by the high calorie diet. Femoral trabecular bone mineral density and the expression levels of osteogenic marker genes in bone marrow cells were reduced in HIGHVEH and LOWVEH mice, and BB significantly attenuated this decline only in HIGH mice. In summary, the magnitude of bone loss induced by low calorie diet was greater than that caused by high calorie diet in growing mice, and ${\beta}$-blockade mitigated high calorie diet-induced bone loss.

• 생약학회지
• /
• 제40권4호
• /
• pp.339-344
• /
• 2009

Diabetic cataract is a major complication of diabetes mellitus. Excess accumulation of sorbitol plays an important role in the pathogenesis of diabetic complications such as cataract formation. In this study, we investigated the inhibitory effect of the extract of the aerial parts of Aster koraiensis (AK) on diabetic cataractogenesis. To examine this further, we evaluated sorbitol accumulation during cataract development using streptozotocin-induced diabetic rat, an animal model of type 1 diabetes. Diabetic rats were treated orally with AK (100 mg/kg and 200 mg/kg body weight) once a day orally for 9 weeks. In vehicle-treated diabetic rats, lens opacity was increased, and lens fiber swelling and membrane rupture were observed. In addition, sorbitol accumulation in diabetic lens was markedly enhanced. However, AK treatment delayed the progression of diabetic cataract through the inhibition of sorbitol accumulation, and prevented lens fiber degeneration in a dose-dependent manner. These observations suggest that AK treatment can delay the progression of lens opacification in the diabetic rats during the early diabetic cataractogenesis.

• Toxicological Research
• /
• 제16권4호
• /
• pp.269-274
• /
• 2000

Epoxidised soya bean oil (ESBO, 1000, 2000 or 4000 mg/kg) was orally administered to BALB/c mice daily for 28 consecutive days, and the control mice were exposed to vehicle (corn oil). Mice were immunized and challenged with sheep red blood cells (SRBC) or bovine serum albumin (BSA). In groups exposed to ESBO, the body weight gains and the relative lymphoid organ weights were not significantly changed as compared with control group. Secondary IgG antibody response to BSA was not significantly changed by ESBO, but plaque-forming cell (PFC) response to SRBC was significantly suppressed in mice treated with 4000 mg ESBO/kg/day. The mitogenic response of splenic B cells induced by LPS was not effected by ESBO in any of the groups. These results indicate that ESBO did not induce significant humoral immune response at a dose less than 2000 mg/kg/day in mice.

• Toxicological Research
• /
• 제27권3호
• /
• pp.153-160
• /
• 2011

To evaluate the whitening effect of black tea water extract (BT), BT was topically applied to artificially hyperpigmented spots on the back skins of brown guinea-pigs (weight: 450~500 g) induced by 1,500 mJ/$cm^2$ of ultraviolet B (UVB) irradiation. The test compounds of 30 ${\mu}l$ were applied twice a day, six days a week, for four weeks. The artificially hyperpigmented spots were divided into 5 groups: control (UVB + saline, C), vehicle control [UVB + propylene glycol: ethanol: water (5 : 3 : 2), VC], positive control (UVB + 2% hydroquinone, PC), experimental 1 (UVB + 1% BT), experimental 2 (UVB + 2% BT). After 4-week application, the spots were removed by biopsy punch under anesthetic condition and used as specimens for the histological examination. The total polyphenol and flavonoid contents of BT were 104 and 91 mg/g, respectively. The electron-donating ability of BT revealed a dose-dependent response, showing the excellent capacities of 86% at 800 ${\mu}g$/ml. The artificially hyperpigmented spots treated with the PC and BT were obviously lightened compared to the C and VC groups. At the fourth week, the melanin indices for the PC and BT groups were significantly lower (p < 0.001) than those of the C and VC groups. In histological examination, PC and BT groups were significantly reduced in the melanin pigmentation, the proliferation of melanocytes and the synthesis of melanosomes compared to the C and VC groups. It is found that BT inhibits the proliferation of melanocytes and synthesis of melanosomes in vivo using brown guinea pigs, thereby showing a definite skin whitening effect.

• Toxicological Research
• /
• 제34권2호
• /
• pp.85-95
• /
• 2018

The term Butterfly tea refers to decoction of Mariposa christia vespertilionis leaves which is widely consumed by cancer patients throughout Malaysia and has gained a huge popularity among Malaysians, not only cancer patients but also researchers to discover the real potential of this plant. Herein, the study is aimed at evaluating the possible toxicity in 28-day subacute oral toxicity of ethanolic extract M. christia vespertilionis in male Sprague Dawley rats. The 28-day subacute toxicity study was conducted to detect the no-observed adverse effect level (NOAEL). In this study, a total of 30 rats were divided into the control, 5% DMSO (vehicle), low dose (75 mg/kg), medium dose (125 mg/kg) and high dose (250 mg/kg) groups. The extract was administered daily from day 1 until day 28. At the end of the study, the animals were humanely sacrificed and assessed for the effect extract of Mariposa christia vespertilionis leaves on body weight and relative organ weights and haematological, biochemical and histopathological parameters. The haematological and serum biochemical parameters for the assessment of kidney and liver injuries were carried out. Results of haematological and serum biochemistry results showed no changes in the control and treated groups. In the histopathology, evaluation of kidney tissues in all treated groups showed no significant (p > 0.05) lesions. In contrast to kidney, liver tissues showed significant differences (p < 0.05) in lesions observed in low dose (430 mg), medium dose (700 mg) and high dose (1480 mg) groups with very mild, mild and mild to moderate lesion of hepatic necrosis, in the respective groups, and very mild hepatic degeneration and hepatitis were scored in all three groups.

• 대한임상검사과학회지
• /
• 제43권4호
• /
• pp.179-187
• /
• 2011

Animal models are important tools in thrombosis research and preclinical drug development. In recent studies, ferric chloride ($FeCl_3$) has been widely used to induce arterial thrombosis in a variety of species. The purpose of this study was to find an optimal concentration of $FeCl_3$ and validate this model suited better for thrombosis research. A small piece of filter paper, soaked in $FeCl_3$ solution (10, 20 or 35%, v/v, in distilled water) was topically applied on the carotid artery of SD rats to measure the time to occlusion (TTO) and thrombus weight (TW) to ascertain 35%, as an optimal $FeCl_3$ concentration ($8.63{\pm}0.92min$; p =0.000, $0.79{\pm}0.03mg/mm$; p =0.000, respectively). To validate this experimental model, Ginkgo biloba special extract EGb761 (5, 10 or 30 mg/kg) as a reference agent administered by peritoneal route for 1h prior to the induction of thrombosis, showed significantly delayed TTO in a dose dependent manner ($18.50{\pm}2.17$, $29.17{\pm}1.83$, and $38.00{\pm}1.79min$, respectively) and significantly reduced TW and repaired collagen fibre in the injured vessel compare to vehicle group. Our results provide a simple, reproducible and well controlled in vivo screening system to induce thrombosis in rats by the topical application of 35% $FeCl_3$ to assess the efficacy of the new anti-thrombotic agents.

• 한국정보전자통신기술학회논문지
• /
• 제10권5호
• /
• pp.364-371
• /
• 2017

본 TPMS는 타이어의 공기압을 측정하여 운전자에게 현재 타이어의 상태를 알려주는 차량용 전장 시스템이다. TPMS 센서는 소형화, 경량화, 저가격성, 저전력을 위해서 단방향 통신을 사용한다. TPMS 센서 정보의 전송 주기는 운전자에게 제공하는 서비스의 질을 나타내는데, 최적의 전송 주기를 결정하기 위해서 프레임 충돌 확률과 생존 시간(Life time)에 대해서 분석하여야 한다. 본 논문에서는 정상모드와 경고모드가 존재하는 저전력 운영 TPMS에서 벤 다이어그램을 이용한 충돌 확률 모델을 설계하였고, 정상모드 전송 주기 대 경고모드 전송 주기에 대한 비율(n)에 따라 생존 시간과 충돌 확률을 분석하였다. 타이어 교체 시기를 5년, 7년으로 가정하고, 생존시간과 충동 확률을 이용하여 최적화하였을 때, 5년에서 $T_{nP}=31$ 초, $T_{wP}$는 2.4초이고, 7년에서 $T_{nP}=71$초, $T_{wP}$는 2.5초가 된다.

• 대한물리치료과학회지
• /
• 제16권3호
• /
• pp.55-66
• /
• 2009

Background: The purpose of this research was to investigate the factors affecting the low back pain of workers in hospital. 214 subjects waking at two general hospitals in Yosu city participated in this survey. Subjects consisted of doctors, nurses, medical engineers, officers and general laborers. The survey data were collected by a written questionnaire which made out by themselves for 25 days, from fourth August to 29th August, 2008. Methods: The questionnaire consisted of four categories, general, occupational, working habitual and the daily living characteristics. The collected data were analyzed by Chi-square test based on the present or absent of low back pain. Results: 1. In the general characteristics, low back pain had no significant relationship to all factors, sex, ago, body mass index, weight and height. 2. In the occupational characteristics, the phase of distribution of low back pain had statistical significant differences in the working hours a week, satisfaction of pay, satisfaction of occupation(p<0.05). However low back pain did not significantly related to the kind of occupation, period of work and degree of stress. 3. In the habitual characteristics, low back pain was significantly influenced by working posture, frequency of using lumbar and heavy material lifting, monotonous repetition of working operation and noise(p<0.05). No significant difference was shown in the factor of convenience of chair. 4. In the daily living characteristics, low back pain shown the significant differences in walking time a day, status of health and smoking pattern(p<0.05). there were, however, no significant differences in the aspect of the kind of house and bed, sleeping attitude, driving, riding time on the vehicle, exercising, frequency of cultural life and drinking alcohol. Conclusion: when I see above resultants totally, it appears a higher incidence caused by working environment rather than living habit and then consequently compared to hospital workers, they also have high incidence like others. In order to reduce incidence of low back pain and enjoy the our life we need to educate ourselves preventing program for low back pain and try to effort for preventing of low back pain on each department and individual.

• 전력전자학회논문지
• /
• 제9권6호
• /
• pp.635-642
• /
• 2004

본 논문에서는 최대 견인력 제어를 위해서 부하토크외란관측기와 속도센서리스 백터제어를 이용하여 점착력 계수를 추정하고 추정한 점착력 계수의 미분치를 PI 토크 제어하는 Anti-slip제어를 제안한다. 점착력 계수를 추정하기 위해서는 전압, 전류값 뿐만 아니라 자속이나 속도정보가 필요하다. 따라서 전동기의 회전속도를 정확하게 검출 할 수 있는 속도센서가 필요하게 된다. 그러나 속도검출을 위해 속도센서를 부착하는 것은 여러 가지 면에서 단점을 가지고 있다. 이러한 문제점을 해결하기 위하여 속도센서 없는 센서리스 구동방식에 의한 부하토크외란관측기를 설계하여, 점착력 계수를 추정한다. 이와같은 제어 알고리즘을 구현하기 위하여 1C1M 철도모의장치를 이용하여 제안된 알고리즘을 실험을 통하여 확인하였다.