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http://dx.doi.org/10.5483/BMBRep.2014.47.9.265

Propranolol, a β-adrenergic antagonist, attenuates the decrease in trabecular bone mass in high calorie diet fed growing mice  

Baek, Kyunghwa (Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University)
Hwang, Hyo Rin (Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University)
Park, Hyun-Jung (Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University)
Kwon, Arang (Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University)
Qadir, Abdul S. (Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University)
Baek, Jeong-Hwa (Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University)
Publication Information
BMB Reports / v.47, no.9, 2014 , pp. 506-511 More about this Journal
Abstract
We investigated the effects of high calorie and low calorie diets on skeletal integrity, and whether ${\beta}$-adrenergic blockade (BB) attenuates bone loss induced by dietary calorie alteration. Male 6-week-old C57BL/6 mice were assigned to either an ad-lib fed control diet (CON), a high calorie diet (HIGH), or a low calorie diet (LOW) group. In each diet group, mice were treated with either vehicle (VEH) or propranolol, a ${\beta}$-adrenergic antagonist. Over 12-weeks, ${\beta}$-blockade mitigated body weight and fat mass increases induced by the high calorie diet. Femoral trabecular bone mineral density and the expression levels of osteogenic marker genes in bone marrow cells were reduced in HIGHVEH and LOWVEH mice, and BB significantly attenuated this decline only in HIGH mice. In summary, the magnitude of bone loss induced by low calorie diet was greater than that caused by high calorie diet in growing mice, and ${\beta}$-blockade mitigated high calorie diet-induced bone loss.
Keywords
Beta-adrenergic receptor; Bone mineral density; High calorie diet; Low calorie diet; Propranolol;
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