• International Journal of Air-Conditioning and Refrigeration
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• 제13권1호
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• pp.31-43
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• 2005

The new HVAC system is developed to lower the conveyance energy and building height using IAV(Increasing Air Volume) technique. IAV units which are equipped in each zone carry out air-conditioning and supply fresh air by induction of outdoor air in main duct. The design program which decides size of OAHU and IAV unit according to air conditioning load and fresh air demand of each zone is presented. The control system is developed to operate efficiently HVAC system and IAV unit, so that individual zone operation and well-deal with partial load and IAQ problem are possible. The new system is investigated in model building and makes more profit in conveyance energy. size of air conditioning facilities room and building height than VAV system. But in construction cost it is worse by about 15 percentage.

• 설비공학논문집
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• 제1권3호
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• pp.210-218
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• 1989

The ASHRAE Simplified Energy Analysis Procedure using the Modified Bin Method(SEAP) is compared with the hourly calculation program, HASP/ACLD. The HASP/ACLD model office building with VAV system in Seoul is used as the basis for comparison. And the parameters considered are glass to wall area ratio and internal heat gains. The results show that SEAP predictions of annual energy use agree with HASP/ACLD predictions within 5% deviation. But there is a large difference in cooling and heating energy as glass to wall area ratio is varied. The SEAP cooling energy is 65-85% and the heating energy is 104-160% of the HASP/ACLD results. This is probably due to the solar heat gain data. the data related to the SEAP must be developed prior to use it.

• Molecular & Cellular Toxicology
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• 제3권4호
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• pp.231-237
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• 2007

Exposure to DNA-damaging agents can elicit a variety of stress-related responses that may alter the expression of genes associated with numerous biological pathways. We used 19 k whole human genome chip to detect gene expression profiles and potential signature genes in human normal hepatocytes (THLE-3) by treatment of five direct acting mutagens, furylfuramide (AF-2), N-nitroso-N-methylurea (MNU), methylmethanesulfonate (MMS), 4-nitroquinoline-N-oxide (4-NQO) and 2-nitrofluorene (2NF) of the $IC_{20}$ concentration for 3 h. Fifty one up-regulated common genes and 45 down-regulated common genes above 1.5-fold by five direct-acting mutagens were identified by clustering analysis. Many of these changed genes have some association with apoptosis, control of cell cycle, regulation of transcription and signal transduction. Genes related to these functions, as TP73L, E2F5, MST016, SOX5, MAFB, LIF, SII3, TFIIS, EMR1, CYTL1, CX3CR1 and RHOH are up-regulated. Down-regulated genes are ALOX15B, xs155, IFITM1, BATF, VAV2, CD79A, DCDC2, TNFSF8 and KOX8. We suggest that gene expression profiling on mutagens by toxicogenomic analysis affords promising opportunities to reveal potential new mechanistic markers of genotoxicity.

• International Journal of Aeronautical and Space Sciences
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• 제10권1호
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• pp.30-36
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• 2009

Many formation guidance laws have been proposed for VAV formation flight. Since most autonomous formation flight methods require various active communication links between the vehicles to know motion information of other vehicles, damage to the receiver or the transmitter and communication delay are critical problem to achieve a given formation flight mission. Therefore, in this point of view, the method that does not need an inter-vehicle communication is preferred in the autonomous formation flight. In this paper, we first summarize the formation guidance law without an inter-vehicle communication using feedback linearization and sliding mode control proposed in previous study. We also propose the modified formation guidance law with robust disturbance observer, which can provide significantly better performance than previously mentioned guidance law in case that other vehicles maneuver with large accelerations. The robust disturbance observer can estimate uncertainties generated by acceleration of leader vehicle. By eliminating the uncertainties using the estimated uncertainties, VAVs are able to achieve the tight formation flight. The performance of the proposed approach is validated by numerical simulations.

• Molecules and Cells
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• 제37권8호
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• pp.628-635
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• 2014

2-(Trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate [(R)-TEMOSPho], a derivative of an organic chemical identified from a natural product library, promotes highly efficient megakaryopoiesis. Here, we show that (R)-TEMOSPho blocks osteoclast maturation from progenitor cells of hematopoietic origin, as well as blocking the resorptive function of mature osteoclasts. The inhibitory effect of (R)-TEMOSPho on osteoclasts was due to a disruption of the actin cytoskeleton, resulting from impaired downstream signaling of c-Fms, a receptor for macrophage-colony stimulating factor linked to c-Cbl, phosphoinositol-3-kinase (PI3K), Vav3, and Rac1. In addition, (R)-TEMOSPho blocked inflammation-induced bone destruction by reducing the numbers of osteoclasts produced in mice. Thus, (R)-TEMOSPho may represent a promising new class of antiresorptive drugs for the treatment of bone loss associated with increased osteoclast maturation and activity.

• 전기전자학회논문지
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• 제26권3호
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• pp.333-340
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• 2022

고전압용 정전기 보호소자인 DDDNMOS(double diffused drain N-type MOSFET) 소자의 더블 스냅백 방지를 위한 최적의 이온주입 조건을 결정하기 위해 공정 및 소자 시뮬레이션이 수행되었다. HP-Well, N^- 드리프트 및 N⁺ 드레인 이온주입량의 변화가 더블 스냅백 및 애발란치 브레이크다운 전압에 미치는 영향을 고찰함으로써 더블 스냅백을 방지하여 정전기 보호 성능 개선할 수 있었다. HP-Well 영역보다는 N^- 드리프트 영역의 이온주입 농도를 최적으로 설계할 경우, 1차 on 상태에서 2차 on 상태로 전이하는 것을 막아주므로 비교적 양호한 정전기 보호 성능을 얻을 수 있었다. 또한 드리프트 이온주입 농도는 누설전류 및 애발란치 브레이크다운 전압에도 영향을 미치므로 동작전압이 30V보다 큰 공정기술에서는 DPS와 같은 새로운 구조를 적용하거나, 대안으로 여러 공정 변수들을 종합(colligation)하여 적용할 경우 향상된 정전기 보호 성능을 실현할 수 있을 것이다.