• Korean Journal of Radiology
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• 제24권4호
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• pp.349-361
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• 2023

Objective: To quantitatively assess the pulmonary vasculature using non-contrast computed tomography (CT) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) pre- and post-treatment and correlate CT-based parameters with right heart catheterization (RHC) hemodynamic and clinical parameters. Materials and Methods: A total of 30 patients with CTEPH (mean age, 57.9 years; 53% female) who received multimodal treatment, including riociguat for ≥ 16 weeks with or without balloon pulmonary angioplasty and underwent both non-contrast CT for pulmonary vasculature analysis and RHC pre- and post-treatment were included. The radiographic analysis included subpleural perfusion parameters, including blood volume in small vessels with a cross-sectional area ≤ 5 mm² (BV5) and total blood vessel volume (TBV) in the lungs. The RHC parameters included mean pulmonary artery pressure (mPAP), pulmonary vascular resistance (PVR), and cardiac index (CI). Clinical parameters included the World Health Organization (WHO) functional class and 6-minute walking distance (6MWD). Results: The number, area, and density of the subpleural small vessels increased after treatment by 35.7% (P < 0.001), 13.3% (P = 0.028), and 39.3% (P < 0.001), respectively. The blood volume shifted from larger to smaller vessels, as indicated by an 11.3% increase in the BV5/TBV ratio (P = 0.042). The BV5/TBV ratio was negatively correlated with PVR (r = -0.26; P = 0.035) and positively correlated with CI (r = 0.33; P = 0.009). The percent change across treatment in the BV5/TBV ratio correlated with the percent change in mPAP (r = -0.56; P = 0.001), PVR (r = -0.64; P < 0.001), and CI (r = 0.28; P = 0.049). Furthermore, the BV5/TBV ratio was inversely associated with the WHO functional classes I-IV (P = 0.004) and positively associated with 6MWD (P = 0.013). Conclusion: Non-contrast CT measures could quantitatively assess changes in the pulmonary vasculature in response to treatment and were correlated with hemodynamic and clinical parameters.

• Tuberculosis and Respiratory Diseases
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• 제62권5호
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• pp.359-364
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• 2007

• 대한약리학회:학술대회논문집
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• 대한약리학회 2006년도 The 6th Congress of the Federation of Asian and Oceanian Physiological Societies
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• pp.111.2-111.2
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• 2006

• 대한수의학회지
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• 제36권4호
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• pp.915-918
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• 1996

This study was performed to investigate the normal ocular fundus in 30 Korean native goats. The shape of two peaks of a mountain was shown in the tapetal fundus which was mostly greenish-blue color. The nontapetal fundus which was differentiated from the tapetal fundus, was generally a uniform shade with dark blue. The optic disc was nearly round and varied in color : orange, gray, tan and various combinations. It was mostly located at the junctional area of the nontapetal and the tapetal fundus. In the retinal vasculature, three or four major arterioles and two or three major venules emerged from the optic disc and the arterioles could be distinguished from the venules. The superior arteriole and venule in the tapetal fundus did not twist each other.

• International Journal of Contents
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• 제2권3호
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• pp.27-32
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• 2006

We present an effective algorithm for automatic tracing of retinal vessel structure and vascular landmark extraction of bifurcations and ending points. In this paper we deal with vascular patterns from RGB images for personal identification. Vessel tracing algorithms are of interest in a variety of biometric and medical application such as personal identification, biometrics, and ophthalmic disorders like vessel change detection. However eye surface vasculature tracing in RGB images has many problems which are subject to improper illumination, glare, fade-out, shadow and artifacts arising from reflection, refraction, and dispersion. The proposed algorithm on vascular tracing employs multi-stage processing of ten-layers as followings: Image Acquisition, Image Enhancement by gray scale retinal image enhancement, reducing background artifact and illuminations and removing interlacing minute characteristics of vessels, Vascular Structure Extraction by connecting broken vessels, extracting vascular structure using eight directional information, and extracting retinal vascular structure, and Vascular Landmark Extraction by extracting bifurcations and ending points. The results of automatic retinal vessel extraction using jive different thresholds applied 34 eye images are presented. The results of vasculature tracing algorithm shows that the suggested algorithm can obtain not only robust and accurate vessel tracing but also vascular landmarks according to thresholds.

• BMB Reports
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• 제54권6호
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• pp.285-294
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• 2021

The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development.

• 한국임상수의학회지
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• 제20권2호
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• pp.145-149
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• 2003

개의 정상안혈관저항지수와 그 재현성을 측정하고자 컬러도플러 초음파를 이용하여 본 실험을 수행하였다. 내측 긴 후모양체 동맥, 모양체 동맥, 안동맥의 혈관저항지수의 정상범주를 측정하기 위하여 58두의 개에서 컬러도플러 초음파를 실시하였다. 정상견에서 내측 긴 후모양체동맥, 모양체동맥, 안동맥의 저항지수(%)를 측정한 결과, 그 수치는 각각 0.67$\pm$0.07, 0.70$\pm$0.06, 그리고 0.08$\pm$0.04이었으며, 모든 혈관의 저항지수는 좌우안구간에 차이가 없었으며, 성별이나 두개골 형태가 미치는 영향도 없는 것으로 판명되었다. 안혈관 저항지수의 반복측정에 따른 오차를 평가하기 위해서 4회 반복 측정한 결과, 안동맥저항지수의 반복측정변이계수가 4.1%로 가장 낮았으며 긴 후모양체동맥과 모양체동맥의 저항지수의 반복측정변이계수는 각각 12.9%와 7.8%로 모든 동맥에서 높은 재현성을 보였다. 이상의 결과로 보아, 컬러도플러 초음파가 개의 안구 및 안와의 혈순환에 대한 객관적인 측정자료를 제시하는데 매우 유용한 지표인 것으로 판단된다.

• 대한한의학회지
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• 제26권3호
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• pp.13-26
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• 2005

Objectives : Applying herbal-acupuncture using Ursi Fet into Zusanli (UZ) on to the atopic dermatitis (AD) in mice to study changes in external dermal formation, change of leukocytes in vasculature, change of lipid formation in stratum corneum and distribution of ceramide. This study was done through forcing an injury to the mice's back skin which damages the lipid protection formation in the stratum corneum. Methods : The AD which was caused intentionally using the external application on the mice's back skin was treated with VB; the change of leukocytes in the vasculature was identified through optima 5.2 and Student's t-test and the results were made into a dermal formation graph. Results : After dispensing UZ into the AD, the dermal injury decreased. The recovery of the lipid protection formation which includes lipid and ceramide in the stratum comeum (for suppressing acute inflammation due to factors such as PKC, $TNF-\alpha,\;IL-1\beta$, which controlled the secretion of the relating inflammatory cytokine) also went on to show a decrease of both angiogenesis and degranulated mast cells. In addition, the decrease of epithelial injury also caused the growth of cells to decrease in the stratum basale and cytoclasis. In the vasculature, the leukocytes were also decreased na this could relate to a decrease in AD. Conclusions : UZ has an effect on AD by suppressing dermal injury through the recovery of the lipid protection formation in the stratum corneum.

• 대한한의학회지
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• 제25권3호
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• pp.137-148
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• 2004

Objectives : To study change of external dermal formation, change of leukocytes in vasculature, change of lipid formation in stratum corneum and distribution of ceramide through administering Sihocheonggan-san (SC) extract on to the control (CON). This study was done through forcing injury to mice's back skin which have lipid protection formation in stratum corneum. Materials and Methods : The CON to which damage was caused intentionally using the external application on the mice's back skin used the SC. The change of leukocytes in vasculature were identified through optima 5.2 and Student's t-test and the results were made into a dermal formation graph. Results : After dispensing SC extract into the CON, dermal injury was decreased. Especially, recover of lipid protection formation, which includes lipid and ceramide in stratum corneum suppressing acute inflammation that some factors are PKC, TNF-α, IL-12B which controlled the secretion of relating inflammatory cytokine, also went onto decrease of angiogenesis, and a decrease of degranulated mast cells was noted. In addition, the decrease of epithelial injury also caused the growth of cells to decrease in stratum basale and cytoclasis. In the vasculature, the leukocytes were also decreased and it could relate to decrease in CON. Conclusions : SC has effect on CON suppressing the dermal injury through recovering of lipid protection formation in stratum corneum.

• Fisheries and Aquatic Sciences
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• 제20권9호
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• pp.21.1-21.10
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• 2017

The aim of this study was to assess visible implant fluorescent elastomer (VIE) tagging and stress response in marine medaka, Oryzias dancena. The experimental fish were anesthetized individually and marked with red, yellow, or green elastomer at each of the following three body locations: (1) the abdomen, (2) the back, and (3) the caudal vasculature. During 12 months, the accumulated survival rates of fish in the experimental treatments were not different among red, yellow, and green elastomers. The experimental fish retained > 85% of the tags injected in the back, > 70% of the tags injected in the caudal vasculature, and > 60% of the tags injected in the abdomen (P < 0.05). An important observation was that the abdomen site was associated with poor tag retention. For all injected sites, the red and green tags were able to be detected more easily than the yellow tags when observed under both visible and UV lights. Tag readability was lower for the abdomen site than for the other sites (back and caudal vasculature). Thus, VIE tags were easy to apply to marine medaka (< 1 min per fish) and were readily visible when viewed under UV light.