• 대한한방내과학회지
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• 제28권3호
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• pp.421-433
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• 2007

Objectives : This study was performed to evaluate the relationships among blood-stasis. cardio-ankle vascular index(CAVI) and cardiovascular risk. Methods : We obtained general characteristics. blood-stasis score and CAVI from 150 stroke patients. Blood-stasis score was evaluated by blood-stasis criteria. Cardiovascular risk (the following. Stuart's risk score) was evaluated by Stuart's risk scoring scale. We divided subjects into a blood-stasis group and a non blood-stasis group by blood-stasis scores. high CAVI and normal CAVI groupsby CAVI. We compared the general characteristics. CAVI (excluded from comparison between high CAVI group and normal CAVI group), Stuart's risk score and blood-stasis score (excluded from comparison between blood-stasis group and non blood-stasis group) between each pair of groups. Pearson correlation analysis was applied to examine the relationship between blood stasis score and CAVI, blood stasis score and Stuart's risk score. CAVI and Stuart's risk score. Results : The blood-stasis group had significantly higher CAVI and Stuart's risk scores than the non blood stasis group. The high CAVI group had significantly higher blood-stasis score and Stuart's risk score than the normalCAVI group. In correlation analysis. there were significant positive relationship between blood stasis score and Stuart's risk score, CAVI and Stuart's risk score. and blood stasis score and CAVI. Conclusions : This study suggeststhat there is a significant relationship among blood stasis,CAVI and cardiovascular risk.

• 대한한의학회지
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• 제31권2호
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• pp.48-63
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• 2010

Objectives: Yonnyuniksoogobon-dan (Yan Nian Yi Shou Gu Ben Dan 延年益壽固本丹) is composed of 11 herbs (Polygoni Mutiflori Radix, Lycii Radicis Cortex, Polia, Rehmanniae Radix, Rehmanniae Radix Preparat, Asparagi Radix, Liriopis Tuber, Lycii Fructus, Acori Graminei Rhizoma, Angelicae Acutiloba Radix, and Pini Folium) based on Yonryunggobon-dan (Yan Ling Gu Ben Dan 延齡固本丹) and Yonnyuniksoobulrho-dan (Yan Nian Yi Shou Bu Lao Dan 延年益壽不老丹). This study evaluated hair growth promoting effect of Yonnyuniksoogobon-dan on the shaved C57BL/6 mice. Methods: Yonnyuniksoogobon-dan was treated by oral administration (Sample I) and oral administration plus skin application (Sample II) once a day for 12 days. Hair regrowth was photographically and histologically determined during the experimental period. Hair growth cycle related factors (EGF, TGF-${\beta}1$) and vascular factors (VEGF, iNOS) were also determined with immunohistochemistry. Results: 1. On gross observation of hair regrowth, Sample I and Sample II groups demonstrated acceleration of hair regrowth. 2. The hair regrowth index of the Sample I group increased significantly from 7 days (P<0.05) to 12 days (P<0.01) after the shave while that of the Sample II group significantly increased at 12 days (P<0.05). 3. On histological observation, both Sample I and Sample II groups demonstrated histological improvement and increases of number and diameter of the hair follicles. 4. EGF expressions on the root sheath of hair follicles were up-regulated in both Sample I and Sample II groups. 5. TGF-${\beta}1$ expressions on the root sheath of hair follicles were not regulated in Sample I or Sample II groups. 6. VEGF expressions in the surrounding tissues of hair follicles were up-regulated in both Sample I and Sample II groups. 7. iNOS expressions in the surrounding tissues of hair follicles were down-regulated in both Sample I and Sample II groups. Conclusions: These results suggest that Yonnyuniksoogobon-dan has hair growth-promoting activity and these effects relate to up-regulations of EGF and VEFG expressions and down-regulations of TGF-${\beta}1$ and iNOS expressions on hair roots.

• 대한한의학회지
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• 제29권5호
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• pp.77-89
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• 2008

Objectives : This study evaluates the hair growth promoting effect of Yonnyuniksoogobon-dan on shaved C57BL6 mice. Methods : Yonnyuniksoogobon-dan was administered orally (Group I) and both orally and by skin application (Group II) once a day for 12 days. The experimental groups were compared to Control, which was orally administered physiological saline solution. Hair regrowth was photographically and histologically determined during the experimental period. The levels of hair growth cycle related factors (EGF, TGF-${\beta}$1) and vascular factors (VEGF, iNOS) were also determined by immunohistochemistry. On gross observation of hair growth, both Group I and Group II shaved C57BL6 mice showed accelerated hair regrowth. Results : The hair regrowth index of Group I increased significantly from 7 days (P<0.05) to 12 days (P<0.01) after shaving and that of Group II was significantly higher at 12 days (P<0.05). On histological observation, both Group I and Group II demonstrated histological improvement and increases in the number and diameter of the hair follicles. EGF expression on the root sheath of hair follicles was up-regulated in both Group I and II. TGF-${\beta}$1 expression on the root sheath of hair follicles was unchanged in both Group I and II. VEGF expression in the tissues surrounding hair follicles was up-regulated in both groups. iNOS expression in the tissues surrounding hair follicles was down-regulated in both groups. Conclusions : These results suggest that Yonnyuniksoogobon-dan promotes hair growth and this effect is related to up-regulation of EGF and VEFG expression and down-regulation of TGF-${\beta}$1 and iNOS expression on hair roots.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
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• pp.322-326
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• 1998

In order to evaluate menopausal syndrome objectively, examinations were performed as follows: 1) Simplified Menopausal Index (SMI Koyama) and QOL questionnaire (Nagata) were examined subjectively. 2) Urine 17-KS-5 (S Nishikaze), 17-OHCS (OH) were examined objectively. 3) A mobile telemedical device with EKG and KSG was lent to Patients. The subjects were 48 menopausal patients who visited our university hospital as outpatients. According to the results of 5, OH, the subjects were divided into 4 Groups; Group I is high S & high OH, Group ll low S & low OH, Group 111 is low S & high OH, Group tl is high S & low OH. Group IH was the largest (64.6%), Group of was none. The subjects showed significantly lower QOL condition and higher score of SMI. In the QOL, questionnaire items of fixation to physical status (psychogenic reaction), sleep (insomnia), pain(chronic pain) were in common. In SMI, functional vascular symptoms were the largest number. On treatment, Group I was considered to have no need for supplementary agents, but anti-Oketsu agents was prescribed. For Group ll and in some supplementary agents such as red ginseng were prescribed, because they showed low 5. In conclusion, all the groups showed a sign- nificant improvement of QOL and SMI. Group I showed a decrease of OH, Group ll showed an increase of 5, Group In showed an increase of S and SIOH and a decrease of OH. These phenomena were considered prohomeostatic. In QOL, the items of chronic pain, insomnia and appetite were improved. In SMI, chillness, dyspnea, palpitation, pain and fatigability were improved. In mobile tole-medical device, abnormal findings were found in 88.2% of patients. General sdaptation syndrome (Selye, H.) is considered to adjust human life. Menopause is the transit period to exhausted stage in it. So its symptoms vary from person to person. In conclusion, 5 and OH are useful both for classification of menopausal syndrome and for determining treatments according to the classification

• The Korean Journal of Ecology
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• 제28권1호
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• pp.15-23
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• 2005

아까시나무 우점림의 식생유형에 대한 분류와 분포양식 그리고 생태식물상적 특성을 규명하였다. 전통적인 식물사회학적 방법과 식생조사자료 및 식생유형간의 유사성 분석을 위하여 주좌표분석법(Principal Coordinates Analysis)과 상관 계수(correlation coefficient)가 이용되었다. 생태식물상의 분석에는 출현 식물종들의 특질(넌출형, 일이년생 생명환, 삼림식생요소, 체감도시화지수)이 이용되었다. 이러한 분석은 출현종의 상대기여도를 바탕으로 하는 입지-식생조사구 매트릭스의 식물군락표 및 군락합성표를 토대로 이루어졌다. 아까시나무 우점림은 총 77과 193속 323종으로 이루어져 있었으며, 아까시나무-닭의장풀군집(전형아군집, 떡갈나무아군집, 자귀나무아군집, 소나무아군집, 굴참나무아군집, 가중나무아군집), 아까시나무-갈대군락(전형하위군락, 띠하위군락)으로 분류되었으며, 크게 네 가지 식생형(도시형, 농촌형, 하천형, 복합형)으로 구분되었다. 아까시나무-닭의장풀군집은 졸참나무-작살나무아군단의 냉온대 남부 저산지대의 아까시나무 조림식생을 대표하는 식생단위이며, 아까시나무-갈대군락은 하천(정수역)형으로 기재되었다. 가중나무아군집은 높은 체감도시화지수에 의하여 도시형 아까시나무림으로 규정되었다. 하천형을 제외한 우리나라의 아까시나무 우점림은 지속군락으로 고려되었다.

• 한국자원식물학회지
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• 제18권2호
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• pp.315-324
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• 2005

본 연구는 미선나무 자생지 주변의 식물상과 초본군락을 체계적이고 객관적으로 분석함으로써 자생지 복원 및 보전대책에 대한 기초자료 제공을 위해 수행되었다. 식물상 조사결과, 가장 많은 분류군을 보인 지역은 괴산군 율지리(III)로 48과 91속 99종 15변종 등 총 114분류군이 조사되었으며, 가장 적은 지역은 진천군 용정리(V)로 28과 49속 47종 7변종 등 총 54분류군이 출현하였다. 초본군락의 우점종은 환삼덩굴과 쑥(괴산군 추점리 I), 주름조개풀(괴산군 송덕리 II와 영동읍 매천리 IV), 대사초${\cdot}$칡${\cdot}$쑥(괴산군 율지리 III), 덩굴닭의장풀(진천군 용정리 V), 조릿대(부안군 중계리 VI)로 확인되었다. 상관관계분석 결과, 쑥과 대사초, 조릿대와 김의털, 조릿대와 청미래덩굴, 김의털과 청미래덩굴이 매우 높은 상관성을 보였다. 유사도지수 분석결과, 유사도지수가 가장 높은 것은 III과 VI지역으로 $27.27\%$를 보였다. 환경요인과 식물종수간의 회귀분석 결과, 해발고도와 식물종수의 설명력은 약 $70.0\%$였다.

• 한국습지학회지
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• 제17권4호
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• pp.339-347
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• 2015

저수지의 이용목적에 따라서 수력발전용, 농업용수용, 생활 공업용수용 및 홍수조절용으로 구분한 우리나라 35개 저수지의 호안에서 출현하는 관속식물 종류와 지형, 수문, 물 및 토양 환경을 조사하여 이용목적에 따른 호안 환경과 식물상 특성의 차이를 규명하고자 하였다. 호안의 식물상은 저수지의 용도에 따라서 종수, 종류 및 식물종 특성에서 차이를 나타내었다. 단계별 변수선택법 결과에 의하면 저수지 호안의 출현종수는 중앙수위에서 범람빈도가 높고 호안의 연평균노출기간이 길수록 증가하였다. 주좌표분석과 집괴분석의 결과에서 저수지 호안의 식물상은 이용목적에 따라서 크게 3가지 유형, 홍수조절용과 생활 공업용수용, 농업용 및 발전용 저수지로 구분이 되었다. 식물상의 특성에 영향을 미치는 주요한 환경 요인은 연간 수위변동폭, 중앙수위 연범람빈도, LQI 지수 및 연평균노출기간이었다. 수위가 안정적으로 유지되고 수질이 중영양으로 유지되는 발전용 저수지에서는 종풍부도가 높고 침수식물종을 비롯한 수생식물종이 풍부한 연안대가 발달하였다. 수위변동이 심하고 수질이 빈영양 혹은 중영양인 홍수조절용과 생활 공업용수용 저수지 식물상은 수위변동역에서 단명의 교란지식물이 분포하였다. 수위변동이 중간 정도이고 중영양 또는 부영양인 농업용 저수지에서는 부엽식물과 부유식물과 같은 수면을 덮는 식물종이 특징적으로 분포하였다. 결론적으로 저수지 호안의 식물상 특성은 이용목적에 따라서 수위변동, 수질 등의 환경요인이 차이가 나타나고 이에 따라서 식물상의 구조와 종풍부도가 다르게 나타났다.

• Journal of Genetic Medicine
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• 제14권1호
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• pp.8-17
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• 2017

Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<$5{\times}10^{-8}$) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<$5{\times}10^{-8}$) with baPWV. The 5 SNPs (P<$5{\times}10^{-8}$) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

• Archives of Hand and Microsurgery
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• 제23권4호
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• pp.301-305
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• 2018

혈관종은 내피세포로부터 기원한 양성종양의 일종으로, 수부에서는 드물게 발생하는 것으로 알려져 있다. 62세 여자환자로 우측 2수지 요골측의 통증을 주소로 내원하였으며, 시행한 자기공명영상에서 수지신경을 압박하는 것으로 보이는 혈관종이 의심되었다. 수술을 시행하여 요골측 수지신경 및 수지혈관을 압박하고 있는 혈관종을 확인하였으며, 수지신경 및 혈관을 가능한 보존하기 위하여 미세수술을 통해 혈관종을 제거하였다. 공간점유성 병변에 의한 압박성 신경병증은 드문 일로, 정확한 진단에 어려움이 있으나, 본 증례와 같이 자기공명영상을 통한 술 전 평가와 및 미세수술을 이용한 병변 제거 및 신경 보존을 통하여 신경병성 통증을 성공적으로 호전시킬 수 있을 것으로 생각한다.

• 한국응용과학기술학회지
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• 제35권4호
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• pp.1096-1107
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• 2018

본 연구는 만 70~85세의 고령여성을 대상으로 주 1회 아쿠아로빅과 주 2회 맨손근력운동을 실시하는 복합운동프로그램을 12주간 적용하여 혈중 염증인자, DHEA-s 및 동맥경직도에 미치는 영향을 구명하기 위하여 운동군 21명, 대조군 21명으로 구분하여 실시하였다. 1회 운동지속시간은 60분으로 4주 간격으로 운동강도를 점진적으로 증가시켜 실시하였다. 복합운동 전과 후에 측정된 자료의 상호작용 효과 검증을 위해 이원반복측정 분산분석을 실시하였고, T검정을 사용하여 사후분석을 하였으며, 유의수준은 .05로 설정하여 분석하였다. 그 결과 12주간의 복합운동은 고령여성의 염증반응을 감소 시켰으며, DHEA-s가 증가함에 따라 노화호르몬에도 긍정적인 영향을 미치는 것으로 나타났다. 동맥경직도는 중심동맥혈압(수축기, 이완기)이 감소하였고, 맥압 및 파형증가지수의 증가를 완화하였으며, 맥파전파속도를 감소시키는 것으로 나타났다. 이상의 결과 고령여성의 건강한 노화와 장수를 위해서 항염증, 노화호르몬의 개선 및 혈관건강의 역할로 규칙적이고 지속적인 복합운동이 권장 될 수 있을 것으로 사료된다.