• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 제38회 하계학술대회
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• pp.473-474
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• 2007

The Jeju power grid experienced several major power disturbances over the last decade. The postmortem studies of the incidents indicated that some of the generating units did not respond as predicted by system analysis & studies. Consequently, the Korean Power Exchange (KPX) mandated that all units (generators, excitation, governor and turbine systems) in the Korean network greater than or equal to 20MVA be tested to verify the generator reactive power limits as well as the dynamic model data being used for system studies. This paper presents field experiences of the authors in testing and modeling of steam turbines and their associated governors during the generator and model validation.

• International Journal of Aeronautical and Space Sciences
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• 제14권2호
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• pp.122-132
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• 2013

In this research the development of unstructured grid discretization solution techniques is presented. The purpose is to describe such a conservative discretization scheme applied for experimental validation work. The objective of this paper is to better establish the effects of mesh generation techniques on velocity fields and particle deposition patterns to determine the optimal aerodynamic characteristics. In order to achieve the objective, the mesh surface discretization approaches used the VLA prototype manufacturing tolerance zone of the outer surface. There were 3 schemes for this discretization study implementation. They are solver validation, grid convergence study and surface tolerance study. A solver validation work was implemented for the simple 2D and 3D model to get the optimum solver for the VLA model. A grid convergence study was also conducted with a different growth factor and cell spacing, the amount of mesh can be controlled. With several amount of mesh we can get the converged amount of mesh compared to experimental data. The density around surface model can be calculated by controlling the number of element in every important and sensitive surface area of the model. The solver validation work result provided the optimum solver to employ in the VLA model analysis calculation. The convergence study approach result indicated that the aerodynamic trend characteristic was captured smooth enough compared with the experimental data. During the surface tolerance scheme, it could catch the aerodynamics data of the experiment data. The discretization studies made the validation work more efficient way to achieve the purpose of this paper.

• 대한의용생체공학회:의공학회지
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• 제38권3호
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• pp.111-115
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• 2017

Blood pressure is one of the important vital signs for monitoring the medical condition of a patient. Automated NIBP(non-invasive blood pressure) monitoring devices calculate systolic and diastolic blood pressures from the oscillation in cuff pressure caused by a pulsation of an artery. To validate the NIBP devices, we developed a simulator to supply the oscillometric waveforms obtained from human subjects. The simulator provided pressure pulses to device-under-test and device readings were compared to the auscultatory references. Fully automated simulation system including OCR(optical character recognition) were developed and used for NIBP monitoring devices. The validation results using the simulator agreed well with previous clinical validation. More validation studies using the standardized oscillometric waveforms would be required for the replacement of clinical trials to validate a new automated NIBP monitoring device.

• Journal of Pharmaceutical Investigation
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• 제39권4호
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• pp.263-267
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• 2009

The purpose of this study is to evaluate the efficacy of stipulated cleaning process, and the prohibition of cross-contamination and microbiological contamination, which inadequate cleaning in multi-production could occur, through cleaning validation of multi-purpose facility used to produce five biopharmaceutical products as sterile injection. After production of five biopharmaceutical products such as hGH, rhGCSF, rhEPO, rhFSH and rhIFN using vial filling machine, the cleaning validation such as residual analysis of active ingredients or human serum albumin, measurement of total organic carbon (TOC), residual analysis of detergent and microbiological contamination were carried out. In the case of rhGH and rhGCSF clean validations, drug residues were not detected. Furthermore, in the case of rhEPO, rhFSH and rhIFN clean validations, human serum albumin residues were not detected. At TOC (total organic carbon) analysis, all clean validations gave the TOC of about average 137.93%, not more than 150% of acceptance criteria. At sodium analysis for the checking of residues of cleaning agent, sodium residues were not detected. In sterility test, they showed no microbiological contamination of bacteria and fungi. Thus, this cleaning validation was determined as successful in protection of cross-contamination and induction of safety in multi-purpose facility.

• 국제학술발표논문집
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• The 2th International Conference on Construction Engineering and Project Management
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• pp.820-829
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• 2007

This paper presents an evaluation of feasibility studies conducted to justify investments in infrastructure projects. An analysis of a previous feasibility study for a highway construction project is presented in this paper with an emphasis on the estimates and forecasts presented in that study in order to weigh expected benefits from the project against expected costs. The forecasted numbers are compared with actual data collected during the operation phase about the usage of the facility. The comparison reveals a huge difference between estimated numbers and actual numbers. Based on the lessons learned from the analyzed case study, recommendations are presented to improve feasibility studies for infrastructure projects including: peer review of feasibility studies; before-and-after feasibility studies; and defined scope and methodology for feasibility studies. Decision makers are advised to take outcomes of feasibility studies for infrastructure projects with extreme caution as some studies may provide erroneous and misleading input to their decisions regarding investment in infrastructure projects.

• 한국지리정보학회지
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• 제21권1호
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• pp.83-95
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• 2018

최근 조선 산업의 기술이 발전함에 따라 선박의 크기 및 성능이 향상되었다. 이에 따라 한 번의 선박 간 충돌로 인한 좌초 등의 사고가 대형 해난사고를 초래할 수 있게 되었다. 이러한 심각성을 고려하여 국제 사회에서는 해사안전 향상을 위해 지속적으로 전자해도 기준을 업데이트하고 있다. 국제수로기구(IHO)에서 관리하는 기존의 전자해도 관련 표준은 S-57로, S-57 안에는 기존 이진(Binary) 형태의 전자해도 데이터를 제작하기 위한 기준이 담겨있다. 그러나 S-57은 2000년 12월 3.1 버전이 발표된 이후 업데이트가 중단되어 지속적으로 성장하고 있는 해양공간정보의 기술 경향을 반영하지 못하고 있다. IHO에서는 이러한 흐름에 대처하기 위해 차세대 전자해도 제작기준 표준인 S-100을 제정하였으며, 기존 S-57과 다른 데이터의 교환 형식을 사용하였다. 기존 전자해도의 경우에는 이진 형태로 구성되었으나 차세대 전자해도 표준을 기반으로 한 S-10X 전자해도 데이터의 경우에는 피처 카탈로그(Feature Catalogue), 포트리얼 카탈로그(Portrayal Catalogue), GML로 구성되어 있다. 이러한 점을 고려할 때 전자해도의 유효성 검증 표준인 S-58의 업데이트 또는 새로운 유효성 검증 표준의 제정이 필요하다. 본 연구에서는 이에 변화된 데이터의 유효성 검증 시험을 위해 자체 소프트웨어를 개발하였고 테스트 결과에 따른 개선점을 도출하였다.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2001년도 제2회 생물정보학 국제심포지엄
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• pp.103-127
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• 2001

Gene expression studies require statistical experimental designs and validation before laboratory confirmation. Various clustering approaches, such as hierarchical, Kmeans, SOM are commonly used for unsupervised learning in gene expression data. Several classification methods, such as gene voting, SVM, or discriminant analysis are used for supervised lerning, where well-defined response classification is possible. Estimating gene-condition interaction effects require advanced, computationally-intensive statistical approaches.

• Journal of Microbiology and Biotechnology
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• 제16권5호
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• pp.651-660
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• 2006

Natural products are a rich source of biologically active small molecules and a fertile area for lead discovery of new drugs [10, 52]. For instance, 5% of the 1,031 new chemical entities approved as drugs by the US Food and Drug Administration (FDA) were natural products between 1981 and 2002, and another 23% were natural product-derived molecules [53]. These molecules have evolved through millions of years of natural selection to interact with biomolecules in the cells or organisms and offer unrivaled chemical and structural diversity [14, 37]. Nonetheless, a large percentage of nature remains unexplored, in particular, in the marine and microbial environments. Therefore, natural products are still major valuable sources of innovative therapeutic agents for human diseases. However, even when a natural product is found to exhibit biological activity, the cellular target and mode of action of the compound are mostly mysterious. This is also true of many natural products that are currently under clinical trials or have already been approved as clinical drugs [11]. The lack of information on a definitive cellular target for a biologically active natural product prevents the rational design and development of more potent therapeutics. Therefore, there is a great need for new techniques to expedite the rapid identification and validation of cellular targets for biologically active natural products. Chemical genomics is a new integrated research engine toward functional studies of genome and drug discovery [40, 69]. The identification and validation of cellular receptors of biologically active small molecules is one of the key goals of the discipline. This eventually facilitates subsequent rational drug design, and provides valuable information on the receptors in cellular processes. Indeed, several biologically crucial proteins have already been identified as targets for natural products using chemical genomics approach (Table 1). Herein, the representative case studies of chemical genomics using natural products derived from microbes, marine sources, and plants will be introduced.

• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.565-570
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• 2013

Objectives: To describe the development and validation of a cancer awareness questionnaire (CAQ) based on a literature review of previous studies, focusing on cancer awareness and prevention. Materials and Methods: A total of 388 Chinese undergraduate students in a private university in Kuala Lumpur, Malaysia, were recruited to evaluate the developed self-administered questionnaire. The CAQ consisted of four sections: awareness of cancer warning signs and screening tests; knowledge of cancer risk factors; barriers in seeking medical advice; and attitudes towards cancer and cancer prevention. The questionnaire was evaluated for construct validity using principal component analysis and internal consistency using Cronbach's alpha (${\alpha}$) coefficient. Test-retest reliability was assessed with a 10-14 days interval and measured using Pearson product-moment correlation. Results: The initial 77-item CAQ was reduced to 63 items, with satisfactory construct validity, and a high total internal consistency (Cronbach's ${\alpha}$=0.77). A total of 143 students completed the questionnaire for the test-retest reliability obtaining a correlation of 0.72 (p<0.001) overall. Conclusions: The CAQ could provide a reliable and valid measure that can be used to assess cancer awareness among local Chinese undergraduate students. However, further studies among students from different backgrounds (e.g. ethnicity) are required in order to facilitate the use of the cancer awareness questionnaire among all university students.

• 한국연초학회지
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• 제36권1호
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• pp.20-25
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• 2014

As part of a balanced testing battery, subchronic inhalation studies on rats are performed to ensure that proposed cigarette modifications do not increase the toxicity of smoke and to demonstrate any instances where a modification may actually contribute to harm reduction. For subchronic inhalation studies with aerosols, the OECD suggests an exposure regimen of 6 hours/day (OECD Guideline 413, 1981), but alternative regimens have also been published: 1 hour/day and $2{\times}1$ hour/day. The aim of this study was to validate a rodent nose-only exposure system for the assessment of inhalation toxicity of cigarette smoke. In this study, cigarette smoke exposure system is consisted of cigarette smoke generator, smoke concentration adjusting system, and 20-port nose-only exposure system. Male SD rats were exposed for 35 days ($2{\times}1$ hour/day) to 3R4F Reference cigarette smoke and analysed major monitoring items of OECD Gudeline 413. WTPM, was measured in the test atmosphere, respiratory function (Buxco Biosystems) during exposure, postexposure urinary exposure biomarkers and alveolar neutrophiles in BAL fluid (Day 35) were evaluated. Validation demonstrated steady WTPM ($257{\pm}20ug/L$, $502{\pm}27ug/L$) and spatial uniformity (<10%). Nose port temperature ($22{\sim}26^{\circ}C$ and RH (45~75%) were acceptable over 35 days. Reductions in respiratory rate and minute volume and increase in the neutrophiles in BALF and the urinary exposure biomarkers were observed cigarette smoke dose dependently. This validation and 35-day inhalation study has shown that the rodent nose-only exposure system may be useful in the inhalation toxicity assessment of cigarette smoke.