• International Journal of Computer Science & Network Security
• /
• 제21권7호
• /
• pp.284-296
• /
• 2021

Quality Models are important element of the software industry to develop and implement the best quality product in the market. This type of model provides aid in describing quality measures, which directly enhance the user satisfaction and software quality. In software development, the inheritance technique is an important mechanism used in object-oriented programming that allows the developers to define new classes having all the properties of super class. This technique supports the hierarchy design for classes and makes an "is-a" association among the super and subclasses. This paper describes a standard procedure for validating the inheritance metric in Quality Model for Object-Oriented Design (QMOOD) by using a set of nine properties established by Weyuker. These properties commonly using for investigating the effectiveness of the metric. The integration of two measuring methods (i.e. QMOOD and Weyuker) will provide new way for evaluating the software quality based on the inheritance context. The output of this research shows the extent of satisfaction of the inheritance metric in QMOOD against Weyuker nine properties. Further results proved that Weyker's property number nine could not fulfilled by any inheritance metrics. This research introduces a way for measuring software that developed using object-oriented approach. The theoretical validation of the inheritance metric presented in this paper is a small step taken towards producing quality software and in providing assistance to the software industry.

• Nuclear Engineering and Technology
• /
• 제54권4호
• /
• pp.1439-1448
• /
• 2022

Background: We investigated the feasibility of in vitro radiosensitivity prediction with gene expression using deep learning. Methods: A microarray gene expression of the National Cancer Institute-60 (NCI-60) panel was acquired from the Gene Expression Omnibus. The clonogenic surviving fractions at an absorbed dose of 2 Gy (SF2) from previous publications were used to measure in vitro radiosensitivity. The radiosensitivity prediction model was based on the convolutional neural network. The 6-fold cross-validation (CV) was applied to train and validate the model. Then, the leave-one-out cross-validation (LOOCV) was applied by using the large-errored samples as a validation set, to determine whether the error was from the high bias of the folded CV. The criteria for correct prediction were defined as an absolute error<0.01 or a relative error<10%. Results: Of the 174 triplicated samples of NCI-60, 171 samples were correctly predicted with the folded CV. Through an additional LOOCV, one more sample was correctly predicted, representing a prediction accuracy of 98.85% (172 out of 174 samples). The average relative error and absolute errors of 172 correctly predicted samples were 1.351±1.875% and 0.00596±0.00638, respectively. Conclusion: We demonstrated the feasibility of a deep learning-based in vitro radiosensitivity prediction using gene expression.

• 대한화학회지
• /
• 제46권4호
• /
• pp.309-317
• /
• 2002

형광분광법에 의하여 주성분 회귀분석(principal component regression, PCR)과 부분 최소자승법(Partial least squares, PLS)을 이용하여 아미노산(Tryptophan and Tyrosine)을 동시에 정량하는 방법에 대하여 연구하였다. 아미노산 혼합물의 형광 스펙트럼은 들뜸파장을257nm로 고정하여 측정하였다. 두 가지 아미노산이 서로 다른 농도로 혼합되어 있는 32개의 시료용액을 280nm∼500nm 범위에서 스펙트럼들을 얻었고 이를 이용하여 PCR과 PLS회귀모델을 얻었다. 두 가지 아미노산이 서로 다른 농도로 포함된 6개의 외부검정용 시료들의 스펙트럼들을 이용해서 회귀모델의 적합성을 검정하기 위하여 외부검정용 시료의 농도를 계산하였다. 계산된 농도를 이용하여 relative standard error of prediction($RSEP_a$)를 얻었고 같은 방법으로 overall relative standard error of prediction($RSEP_m$) 도 구하였다

• Asia pacific journal of information systems
• /
• 제9권4호
• /
• pp.23-40
• /
• 1999

This paper proposes a hybrid intelligent system that predicts the failure of firms based on the past financial performance data, combining neural network and rough set approach, We can get reduced information table, which implies that the number of evaluation criteria such as financial ratios and qualitative variables and objects (i.e., firms) is reduced with no information loss through rough set approach. And then, this reduced information is used to develop classification rules and train neural network to infer appropriate parameters. Through the reduction of information table, it is expected that the performance of the neural network improve. The rules developed by rough sets show the best prediction accuracy if a case does match any of the rules. The rationale of our hybrid system is using rules developed by rough sets for an object that matches any of the rules and neural network for one that does not match any of them. The effectiveness of our methodology was verified by experiments comparing traditional discriminant analysis and neural network approach with our hybrid approach. For the experiment, the financial data of 2,400 Korean firms during the period 1994-1996 were selected, and for the validation, k-fold validation was used.

• 한국식품과학회지
• /
• 제28권1호
• /
• pp.40-43
• /
• 1996

비파괴적이고 신속분석이 가능한 근적외 분광분석법으로 마요네즈의 식염분석을 시도하였다. 식염은 근적외선영역에서 주성분 피크가 존재하지 않음으로 식염 함량을 다양한 통계처리 기법중에 PLS회귀법을 사용하여 100시료로 검량식을 작성하였다. $1{\sim}15$개 요인변수를 사용하여 작성된 검량식 중에서 최소값의 SECV, SE를 갖는 3개의 검량식(요인변수 : 10, 11, 12)을 선택하였다. 이 검량식들을 독립된 40시료의 검정용 시료에 적용시켜 검정한 결과, 요인변수 11의 검량식이 R 0.946, SEP 0.0166%로 가장 우수하게 평가되었다. 이 결과로부터 마요네즈의 식염분석이 근적외 분광분석법으로 측정 가능함을 확인할 수 있었다.

• Steel and Composite Structures
• /
• 제51권1호
• /
• pp.25-41
• /
• 2024

The measurement of pile bearing capacity is crucial for the design of pile foundations, where in-situ tests could be costly and time needed. The primary objective of this research was to investigate the potential use of fuzzy-based techniques to anticipate the maximum weight that concrete driven piles might bear. Despite the existence of several suggested designs, there is a scarcity of specialized studies on the exploration of adaptive neuro-fuzzy inference systems (ANFIS) for the estimation of pile bearing capacity. This paper presents the introduction and validation of a novel technique that integrates the fire hawk optimizer (FHO) and equilibrium optimizer (EO) with the ANFIS, referred to as ANFIS_FHO and ANFIS_EO, respectively. A comprehensive compilation of 472 static load test results for driven piles was located within the database. The recommended framework was built, validated, and tested using the training set (70%), validation set (15%), and testing set (15%) of the dataset, accordingly. Moreover, the sensitivity analysis is performed in order to determine the impact of each input on the output. The results show that ANFIS_FHO and ANFIS_EO both have amazing potential for precisely calculating pile bearing capacity. The R² values obtained for ANFIS_FHO were 0.9817, 0.9753, and 0.9823 for the training, validating, and testing phases. The findings of the examination of uncertainty showed that the ANFIS_FHO system had less uncertainty than the ANFIS_EO model. The research found that the ANFIS_FHO model provides a more satisfactory estimation of the bearing capacity of concrete driven piles when considering various performance evaluations and comparing it with existing literature.

• Korean Journal of Radiology
• /
• 제21권6호
• /
• pp.660-669
• /
• 2020

Objective: To evaluate the accuracy of a deep learning-based automated segmentation of the left ventricle (LV) myocardium using cardiac CT. Materials and Methods: To develop a fully automated algorithm, 100 subjects with coronary artery disease were randomly selected as a development set (50 training / 20 validation / 30 internal test). An experienced cardiac radiologist generated the manual segmentation of the development set. The trained model was evaluated using 1000 validation set generated by an experienced technician. Visual assessment was performed to compare the manual and automatic segmentations. In a quantitative analysis, sensitivity and specificity were calculated according to the number of pixels where two three-dimensional masks of the manual and deep learning segmentations overlapped. Similarity indices, such as the Dice similarity coefficient (DSC), were used to evaluate the margin of each segmented masks. Results: The sensitivity and specificity of automated segmentation for each segment (1-16 segments) were high (85.5-100.0%). The DSC was 88.3 ± 6.2%. Among randomly selected 100 cases, all manual segmentation and deep learning masks for visual analysis were classified as very accurate to mostly accurate and there were no inaccurate cases (manual vs. deep learning: very accurate, 31 vs. 53; accurate, 64 vs. 39; mostly accurate, 15 vs. 8). The number of very accurate cases for deep learning masks was greater than that for manually segmented masks. Conclusion: We present deep learning-based automatic segmentation of the LV myocardium and the results are comparable to manual segmentation data with high sensitivity, specificity, and high similarity scores.

• 한국간담췌외과학회지
• /
• 제27권2호
• /
• pp.195-200
• /
• 2023

Backgrounds/Aims: We aimed to build a machine learning tool to help predict low-grade intraductal papillary mucinous neoplasms (IPMNs) in order to avoid unnecessary surgical resection. IPMNs are precursors to pancreatic cancer. Surgical resection remains the only recognized treatment for IPMNs yet carries some risks of morbidity and potential mortality. Existing clinical guidelines are imperfect in distinguishing low-risk cysts from high-risk cysts that warrant resection. Methods: We built a linear support vector machine (SVM) learning model using a prospectively maintained surgical database of patients with resected IPMNs. Input variables included 18 demographic, clinical, and imaging characteristics. The outcome variable was the presence of low-grade or high-grade IPMN based on post-operative pathology results. Data were divided into a training/validation set and a testing set at a ratio of 4:1. Receiver operating characteristics analysis was used to assess classification performance. Results: A total of 575 patients with resected IPMNs were identified. Of them, 53.4% had low-grade disease on final pathology. After classifier training and testing, a linear SVM-based model (IPMN-LEARN) was applied on the validation set. It achieved an accuracy of 77.4%, with a positive predictive value of 83%, a specificity of 72%, and a sensitivity of 83% in predicting low-grade disease in patients with IPMN. The model predicted low-grade lesions with an area under the curve of 0.82. Conclusions: A linear SVM learning model can identify low-grade IPMNs with good sensitivity and specificity. It may be used as a complement to existing guidelines to identify patients who could avoid unnecessary surgical resection.

• Psychiatry investigation
• /
• 제15권11호
• /
• pp.1030-1036
• /
• 2018

Objective In this study, we aimed to develop a model predicting individuals with suicide ideation within a general population using a machine learning algorithm. Methods Among 35,116 individuals aged over 19 years from the Korea National Health & Nutrition Examination Survey, we selected 11,628 individuals via random down-sampling. This included 5,814 suicide ideators and the same number of non-suicide ideators. We randomly assigned the subjects to a training set (n=10,466) and a test set (n=1,162). In the training set, a random forest model was trained with 15 features selected with recursive feature elimination via 10-fold cross validation. Subsequently, the fitted model was used to predict suicide ideators in the test set and among the total of 35,116 subjects. All analyses were conducted in R. Results The prediction model achieved a good performance [area under receiver operating characteristic curve (AUC)=0.85] in the test set and predicted suicide ideators among the total samples with an accuracy of 0.821, sensitivity of 0.836, and specificity of 0.807. Conclusion This study shows the possibility that a machine learning approach can enable screening for suicide risk in the general population. Further work is warranted to increase the accuracy of prediction.

• Toxicological Research
• /
• 제17권
• /
• pp.313-317
• /
• 2001

The Ministry of Health and Welfare of Japan has set up six research groups concerning the endocrine disrupting chemicals. One of these projects was "A study on development of testing methodology for health effects due to exposure of environmental endocrine disruptors". In this paper, three topics are described. In OECD collaboration for pre-validation of uterotrophic assay, the most sensitive response to ethnyl estradiol was noted in the ovarectomized rats treated subcutaneously for 7 days. Secondly, it was suggested that changes of the serum $\alpha_{2u}$-globulin level may be a sensitive parameter for detecting the estrogenic activities of chemicals. Finally, development of the sexually dimorphic nucleus of preoptic area in the brain oj male rats was inhibited by the treatment with estrogenic chemicals, and their masculine behaviors and reproductive abilities were impaired after sexual maturation. In conclusion, these parameters are considered to be sensitive endpoints for testing estrogenic chemicals.chemicals.