Toxicological Research
- Volume 17
- /
- Pages.313-317
- /
- 2001
- /
- 1976-8257(pISSN)
- /
- 2234-2753(eISSN)
Hormone-Mimic Chemicals and Their Possible Endocrine Disruption - Development of Testing Methods -
Abstract
The Ministry of Health and Welfare of Japan has set up six research groups concerning the endocrine disrupting chemicals. One of these projects was "A study on development of testing methodology for health effects due to exposure of environmental endocrine disruptors". In this paper, three topics are described. In OECD collaboration for pre-validation of uterotrophic assay, the most sensitive response to ethnyl estradiol was noted in the ovarectomized rats treated subcutaneously for 7 days. Secondly, it was suggested that changes of the serum
Keywords
- Endocrine disruptors;
- OECD pre-validation test;
- Uterotrophic assay;
- Serum $\alpha_{2u}$-globulin;
- SDN-POA