• Archives of Pharmacal Research
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• v.7 no.2
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• pp.121-126
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• 1984

From the roots of Patrinia scabiosaefolia Valerianaceae), scopoletin (1), esculetin (2), oleanonic acid (3), 3-O-.alpha.-L-rhamnopyranosyl (1.rarw.2)-.alpha.-l-arabinopyranosyl oleanolic acid (4) and 3-O-.alpha.-L- rhamnopyranosyl (1 .rarw. 2)-.alpha.-L-arabinopyranosyl header agenin (5) were isolated and characterized by spectral data.

• Korean Journal of Pharmacognosy
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• v.16 no.1
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• pp.1-6
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• 1985

Effect of various fractions from the roots of Patrinia scabiosaefolia (Valerianaceae) and whole plants of Melandryum firmum (Caryophyllaceae) on enzyme activities in mice was investigated. The butanol fractions from both plants caused a significant elevation of serum transaminase activities when administered intraperitoneally, but did not, orally. Prolonged exposure by oral administration of both plants elevated hepatic cytochrome p-450 content, indicating the induction of drug metabolizing enzymes in liver.

• Archives of Pharmacal Research
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• v.24 no.5
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• pp.416-417
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• 2001

A new triterpene lactose named patrinolide A (7) has been isolated from the roots of Patrinia scabiosaefolia (Valerianaceae). Its structure was determined to be 11$\beta$,21$\beta$-dihydroxy-3-oxooleanan-28,13$\beta$-olide on the basis of spectral analysis, including 2D-NMR techniques.

• Korean Journal of Pharmacognosy
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• v.37 no.4 s.147
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• pp.302-306
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• 2006

'Pae Jang (敗醬)' is one of Chinese crude drugs used mainly as a edema, abdominal pain and hemoptysis, etc. With regard to the botanical origin of 'Pae Jang', it has been considered to be Patrinia scabiosaefolia of Valerianaceae, but there has never been studied pharmacognostically. To clarify the botanical origin of the 'Pae Jang', we studied on the anatomical characteristics of the roots of three species growing in Korea. Through our studies, the botanical origin of 'Pae Jang' from Korea was proved to be the under ground portions of Patrinia scabiosaefolia and Patrinia villosa.

• Korean Journal of Pharmacognosy
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• v.16 no.4
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• pp.248-252
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• 1985

During the biological screening of Chinese drugs, it was found that alcoholic extract of the roots of Patrinia scabiosaefolia (Valerianaceae) caused a significant prolongation of hexobarbital-induced sleeping time and elevation of serum transaminase activities accompanied by severe histopathological changes in the hepatic tissues in mice on three day pretreatments. The systematic fractionation of the methanol extract monitoring by bioassay led to isolation of toxic saponins such as $3-O-{\alpha}-{_L}-arabinopyranosyl$ hederagenin $28-O-{\beta}-{_D}-glucopyranosyl\;(1{\rightarrow}6)-{\beta}-{_D}-glucopyranoside$ and its 2'-acetate and $3-O-{\beta}-{_D}-glucopyranosyl\;(1{\rightarrow}3)-{\alpha}-{_L}-rhamnopyranosyl\;(1{\rightarrow}2)-{\alpha}-{_L}-arabinopyranosyl$ oleanolic acid and its $28-O-{\beta}-{_D}-glucopyranosyl\;(1{\rightarrow}6)-{\beta}-{_D}-glucopyranoside$.

• Natural Product Sciences
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• v.19 no.2
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• pp.77-119
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• 2013

The genus Patrinia, belonging to the Valerianaceae family, includes ca. 20 species of herbaceous plants with yellow or white flowers, distributed in Korea, China, Siberia, and Japan. Among them, P. scabiosaefolia (yellow Patrinia), P. saniculaefolia, P. villosa (white Patrinia), and P. rupestris are found in Korea. Several members of this genus have long been used in folk medicine for the treatment of inflammation, wound healing, ascetics, and abdominal pain after childbirth. Thus far, ca. 217 constituents, namely flavonoids, iridoids, triterpenes, saponins, and others have been identified in this genus. Crude extract and isolated compounds have been found to exhibit anticancer, anti-inflammatory, antioxidant, antifungal, antibacterial, cytotoxic activities, lending support to the rationale behind several of its traditional uses. The present review compiles information concerning the phytochemistry and biological activities of Patrinia, with particular emphasis on P. villosa, as studied by our research group.

• Korean Journal of Pharmacognosy
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• v.26 no.2
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• pp.175-178
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• 1995

The study was conducted to investigate the effect of cultivation area with different sea levels on essential oil in the root of Valeriana fauriei var. dasycarpa Hara (Valerianaceae). The total content of the essential oil was not different in various cultivation area, however, its composition varied. The major components were bornyl acetate and sesquiterpene alcohol in three cultivation areas. Among the valepotrate components known as major active components in Europe and Nepal valerian, valtrate was detected in a small amount, but the quantity was not changed.

• Korean Journal of Plant Taxonomy
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• v.38 no.2
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• pp.163-177
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• 2008

Pollen grains of 17 taxa (14 species with two additional subspecies and one variety) of genera Patrinia Juss. and Nardostachys DC. in tribe Patrinieae (Valerianaceae) were studied using light microscope, scanning electron microscope, and transmission electron microscope. Pollen grains are medium ($37.41{\times}43.60{\mu}m$ - $45.65{\times}48.50{\mu}m$) to large ($54.88{\times}59.41{\mu}m$ - $61.70{\times}71.00{\mu}m$) in size, tricolpate (rarely tetracolpate) with the characteristic halo surrounding the aperture. In equatorial view, the pollen is oblate to subprolate, and in polar view, it is mostly circular or rarely 3-lobed. Two major pollen types are recognized on the basis of exine sculpturing patterns; Type I: Exine is composed of echinae together with sparse or dense microechinae, and verrucae shallow or rarely absent (Nardostachys and sections Paleopatrinia, and Monanadropatrinia of Patirinia). - Type II: Exine is composed of massive echinae together with dense microechinae, and prominent verrucae (section Centrotrinia of Patrinia). In TEM sections, columellae are extended from the footlayer into verrucae, and exine thickness is uniform at the pole and equator. Additionally, the infrageneric classification systems of the Patrinieae were evaluated on the basis of the present data.

• Korean Journal of Pharmacognosy
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• v.28 no.2
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• pp.93-98
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• 1997

Rutin, ${\alpha}-hederin$ and kalopanax saponin B and a mixture of hederagenin and 23-hydroxyursolic acid were isolated from the aerial parts of Patrinia scabiosaefolia Fisch.

• Natural Product Sciences
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• v.14 no.4
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• pp.249-253
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• 2008

Two oleanane-type triterpenes (1, 2) and their glycosides (4-6), and one ursane-type triterpene (3) have been isolated from a methanolic extract of Patrinia saniculaefolia Hemsley (Valerianaceae) through repeated silica gel and reversed-phase C-18 column chromatography. Their chemical structures were determined as oleanolic acid (1), oleanonic acid (2), 23-hydroxyursolic acid (3), 3-O-${\alpha}$-L-arabinopyranosyl-oleanolic acid (4), 3-O-${\beta}$-D-glucopyranosyl-oleanolic acid (5), and oleanolic acid 3-O-[${\alpha}$-D-xylopyranosyl-($1{\rightarrow}3$)-${\beta}$-D-glucuronopyranoside-6-O-butyl-ester] (6) on the basis of their MS, $^1H$-, and $^{13}C$-NMR spectral data. All compounds were isolated from the whole plant of the P. saniculaefolia for the first time. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Among them, compounds 1 - 3 exhibited anti-complement activity with $IC_{50}$ values of 470.1, 212.2, and 121.0 ${\mu}M$, respectively, whereas compounds 4 - 6 were inactive. These results suggest that the carbonyl or hydroxy group at C-3 in the oleananeand/or ursane-triterpenes are important for the anti-complement activity against the classical pathway.