• 한국약용작물학회:학술대회논문집
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• 한국약용작물학회 2011년도 추계학술발표회
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• pp.196-197
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• 2011

• 한국약용작물학회지
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• 제14권2호
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• pp.101-106
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• 2006

We established a practical method for rapid and large-scale production of Valeriana fauriei var. dasycarpa Hara roots by bioreactor culture and confirmed valerenic acids and valepotriates production. We also compared valerenic acids and valepotriates production patterns according to various media conditions. Among the media tested, B5 medium gave the maximum biomass production of 101 g fresh weight, which was a 5.03-fold multiplication rate obtained 4 weeks after inoculation of 20 g of fresh weight. The best production of total valerenic acids $(7.86\;mg/l)$ and valepotriates $(8.96\;mg/l)$ was B5 medium.

• Natural Product Sciences
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• 제28권4호
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• pp.181-186
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• 2022

A germacrane-type sesquiterpenoid was isolated and purified from a methanol extract of the roots of Valeriana fauriei (RVF) through open column chromatography using silica gel. This compound was verified to be heishuixiecaoline A by spectroscopic analysis. This compound was isolated for the first time from RVF. Quantitative analysis of heishuixiecaoline A from RVF cultivated from three different regions (Eumseong, Jinbu, and Jinan regions) was performed by combining high-performance liquid chromatography with a photodiode array detector. The extract of RVF cultivated in the Jinbu region showed the highest content (9.23 mg/g). In addition, a significant amount of the compound was detected in all RVF samples, which could be expected since it is a characteristic compound of RVF. The sesquiterpenoid group heishuixiecaoline A was isolated from RVF, a resource for various pharmacological substances, and quantitative analysis of RVF cultivated from three different regions was performed. As a result of these experiments, basic data on RVF that can be used in the development and application of pharmaceuticals and health functional foods in the future were obtained.

• 한국연초학회지
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• 제25권1호
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• pp.80-86
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• 2003

The contents of valepotriates, valerenic acid and their derivatives as mild sedative and antispamodic principles in two Korean valerian roots (Valeriana officinalis var. latifolia Miq. and V. fauriei var. dasycarpa Hara) were investigated and were compared with those in European valerian roots(Valeriana officinalis L.) by BPLC method. Among valepotriate compounds, valtrate was detected as a small amount in two Korean valerian roots, and iso-valtrate and dihydrovaltrate were detected as a trace amount. Among valerenic acid and their derivatives, valerenic acid were contained from 0.9∼3.46 mg/g base on dry weight. Over the vegetation periods investigated, the content of valepotriates remained more or less constant, hut the content of valerenic acid reached its maximum in 3-year old age. The compound isolated from Korean V. officinalis var. latifolia was elucidated as valerenic acid by spectroscopic data such as GC-MS, $^1$H-NMR and $^{13}$ C-NMR, and comparison of GC retention time with that of authentic compound.

• 한국약용작물학회지
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• 제3권2호
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• pp.77-80
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• 1995

한국산 광릉쥐오줌풀에 대한 광합성 및 호흡특성과 아울러 광합성의 일중(日中)변화와 이와 관련된 특성 및 생육상황에 미치는 온도의 영향을 조사하였던 그 결과는 다음과 같다. 1. 온도와 쥐오줌풀 잎의 광합성간에는 고도로 유의한 2차곡선회귀가 인정되었으며, 이 회귀식에 의해 산출한 최대광합성을 위한 은도는 $17.7^{\circ}C$이었다. 2. 쥐오줌풀 잎의 기공수는 잎의 표면에서 약 $25/mm^2$, 이면에서 $85mm^2$이었으며 기공의 크기는 $21{\sim}30/{\mu}m$로 나타났다. 3. 온도와 쥐오줌풀의 엽폭 및 근중간에는 각각 고도로 유의한 2차곡선회귀가 인정되었으며 이 회귀식에 의해 산출한 근생장(根生長)의 최적온도는 약 $20.3^{\circ}C$이었다.

• 한국약용작물학회지
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• 제15권4호
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• pp.241-245
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• 2007

쥐오줌풀 부정근으로부터 valepotriates와 valerenic acids 함량을 증진시키고자 다양한 elicitor를 처리하였다. 쥐오줌풀 부정근의 생장은 YE 처리구를 제외한 모든 처리구에서 대조구에 비해 감소하였다. 그러나 valepotriates와 valerenic acids 생산은 모든 처리구에서 대조구에 비해 증가하였으며 특히, valepotriates는 $100\;{\mu}M$ MeJA 처리구에서 $12.56\;{\pm}\;0.78\;mg/{\ell}$, valerenic acids는 1 $g/{\ell}$ YE 처리구에서 $10.63\;{\pm}\;1.1\;mg/{\ell}$ 로 가장 높았으며, 이는 대조구에 비해 1.6배와 1.8배의 생산성증가를 가져왔다.

• Journal of Applied Biological Chemistry
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• 제61권1호
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• pp.47-50
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• 2018

최근 문제 해충인 갈색날개매미충에 대하여 수증기 증류, 용매 및 초임계 추출법에 의하여 추출된 길초근 정유성분을 가지고 생물활성을 검정하여 방제 가능성을 확인하였다. 길초근의 수증기 증류, 용매 및 초임계 추출 정유성분의 살충활성 결과, 수증기 증류 추출물은 갈색날개매미충 성충에 대해 $1,040{\mu}L/mL$ 로 가장 뛰어한 활성을 나타냈고, 약충에 대하여 $2,370{\mu}L/mL$ 의 살충 활성을 나타내었다. 추출방법별 수율은 0.67%로 다른 방법에 비하여 다소 낮았지만 추출 시간과 비용대비 효과를 감안하였을 때 길초근의 수증기 증류 추출물이 가장 방제 효율이 높다고 여겨진다. 이번의 연구결과는 길초근의 정유성분의 갈색 날개매미충에 대한 방제 가능성을 보여준다.

• 생약학회지
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• 제8권3호
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• pp.95-101
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• 1977

Substance A, white prismatic crystal, mp $134{\sim}135,\;C_{29}H_{50}O$, substance B, white needle crystal, mp $131{\sim}132^{\circ},\;C_{17}H_{28}O_4$ and substance C colorless oils, bp $84{\sim}85,\;C_{15}H_{24}O$ were isolated from the underground portion of Valeriana fauriei var. dasycarpa $H_{ARA}$(Valerianaceae) according to Thies method. Substance A was confirmed as known sterol, ${\beta}-sitosterol$ by chemical and spectral discussions. Substance B was estimated as hitherto unknown sesquiterpenoid, 11-acetoxylhydroxyvaleranone by chemical and spectral discussions. Substance C was proposed as hitherto unknown sesquiterpenoid 1, 4-dimethyl-7-isopropenyl 4, 5, 6, 8, 9, 10-hexahydroazulene-1-ol by chemical and spectral discussions, and the general biogenetic considerations.

• 한국연초학회지
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• 제14권1호
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• pp.66-78
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• 1992

The essential oil of Korean valerian root ( Valeriana fauriei roar. dasycarpa Hara) was isolated by simultaneous distillation Sl extraction. The oil content of fresh root was 0.7% (wb) and that of dried root was 2.1 5 (db) and sensory analysis of the oil indicated sweet-balsamic, woody and floral characteristic aroma notes. The oil was fractionated into one hydrocarbon fraction and three oxygenated hydrocarbon fractions by using silica gel column chromatograpy. Each fraction was analyzed by capillary GC and GC-MS. Out of 81 characterized compounds, the major compounds were a-pinene, camphene, $\beta$-pinene, bornyl acetate, borneol , bornyl iso-valerate and sesquiphellandrene and the characteristic floral and woody aroma of neutral fraction of Korean valerian root could be due to be the presence of oxygenated compounds such as borneol, bornyl acetate, bornyl iso-valerate, p-ionone ana $\beta$-ionone epoxide. Comparing the yield of Korean valerian root with those from other origins reported, oil content of Korean valerian root was higher than those of European and Indian origins.

• 한국식물생명공학회:학술대회논문집
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• 한국식물생명공학회 2005년도 춘계학술대회 및 국제심포지움 초록집
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• pp.186-186
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• 2005