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http://dx.doi.org/10.20307/nps.2022.28.4.181

Structure Determination of Heishuixiecaoline A from Valeriana fauriei and Its Content from Different Cultivated Regions by HPLC/PDA Analysis  

Hyejin Cho (Department of Plant Science and Technology, Chung-Ang University)
Ki Hyun Kim (School of Pharmacy, Sungkyunkwan University)
Sin Hee Han (Department of Herbal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration)
Hak-Jae Kim (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University)
Ik-Hyun Cho (Department of Convergence Medical Science, College of Korean Medicine, Kyung Hee University)
Sanghyun Lee (Department of Plant Science and Technology, Chung-Ang University)
Publication Information
Natural Product Sciences / v.28, no.4, 2022 , pp. 181-186 More about this Journal
Abstract
A germacrane-type sesquiterpenoid was isolated and purified from a methanol extract of the roots of Valeriana fauriei (RVF) through open column chromatography using silica gel. This compound was verified to be heishuixiecaoline A by spectroscopic analysis. This compound was isolated for the first time from RVF. Quantitative analysis of heishuixiecaoline A from RVF cultivated from three different regions (Eumseong, Jinbu, and Jinan regions) was performed by combining high-performance liquid chromatography with a photodiode array detector. The extract of RVF cultivated in the Jinbu region showed the highest content (9.23 mg/g). In addition, a significant amount of the compound was detected in all RVF samples, which could be expected since it is a characteristic compound of RVF. The sesquiterpenoid group heishuixiecaoline A was isolated from RVF, a resource for various pharmacological substances, and quantitative analysis of RVF cultivated from three different regions was performed. As a result of these experiments, basic data on RVF that can be used in the development and application of pharmaceuticals and health functional foods in the future were obtained.
Keywords
Valeriana fauriei; heishuixiecaoline A; cultivation; HPLC;
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