• 한국인터넷방송통신학회논문지
• /
• 제20권6호
• /
• pp.27-32
• /
• 2020

본 논문에서는 오차 신호의 비선형 함수를 이용하는 VS-CCA (Varying Step-Compact Constellation Algorithm)에서 적응을 위한 step 변화 속도값에 따른 적응 등화의 성능을 비교하였다. VS-CCA 알고리즘은 16-QAM과 같은 nonconstant modulus 신호를 4개의 4-QAM constant modulus 신호군으로 compact화한 후, 송신 신호의 통계치인 고정 modulus를 이용하여 오차 신호를 발생하여 이의 비선형 함수를 이용하는 varying step으로 최소비용 함수를 얻도록 적응 등화기의 탭 계수를 갱신한다. 이때 비선형 함수의 step 변화 속도값에 따라 순시 적응 step값이 결정되며, 이의 값에 따라 상이한 적응 등화 성능을 얻을 수 있음을 컴퓨터 시뮬레이션을 통해 확인하였다. step 변화 속도값에 따른 등화 성능 비교 지수로는 등화기 내부 지수와 외부 잡음에 대한 강인성을 나타내는 등화기 외부 지수를 사용하였다. 컴퓨터 시뮬레이션 결과 정상 상태에서 변화 속도를 1.0보다 적게 할수록 모든 성능 지수에서 1.0보다 큰 경우 보다 우월해짐을 알 수 있었다.

• Journal of Yeungnam Medical Science
• /
• 제40권1호
• /
• pp.65-77
• /
• 2023

Background: This study aimed to compare clinical outcomes between surveillance and adjuvant therapy (AT) groups after R0 resection for cholangiocarcinoma (CCA). Methods: A total of 154 patients who underwent R0 resection for CCA at the Daegu Catholic University Medical Center between January 2010 and December 2019 were included. Overall survival (OS) and progression-free survival (PFS) were analyzed. Results: The median follow-up duration was 899 days. There were 109 patients in the AT group and 45 patients in the surveillance group. The patients in the AT group were younger (67 years vs. 74 years, p<0.001) and included more males (64.2% vs. 46.7%, p=0.044). The proportion of patients with stage III CCA was larger in the AT group than in the surveillance group (13.8% vs. 2.2%, p=0.005). In addition, AT did not improve OS (5-year OS rate, 69.3% in the AT group vs. 64.2% in the surveillance group, p=0.806) or PFS (5-year PFS rate, 42.6% in the AT group vs. 48.9% in the surveillance group, p=0.113). In multivariate analysis using the Cox proportional hazards model, stage III CCA (hazard ratio [HR], 10.81; 95% confidence interval [CI], 2.92-40.00; p<0.001) was a significant predictor of OS. American Society of Anesthesiologists classification II (HR, 0.50; 95% CI, 0.31-0.81; p=0.005), and American Joint Committee on Cancer stages II (HR, 3.14; 95% CI, 1.25-7.89; p=0.015) and III (HR, 8.08; 95% CI, 2.80-23.32; p<0.001) were independent predictors of PFS. Conclusion: AT after R0 resection for CCA did not improve OS or PFS.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권13호
• /
• pp.5443-5447
• /
• 2014

The cholangiocarcinoma (CCA) is a relatively rare cancer worldwide but it is highly prevalent in Thailand where the liver fluke, Opisthorchis viverrini is endemic. There are reports that interleukin 6 (IL-6) may play an important role in the pathogenesis of opisthorchiasis associated CCA. Functionally, IL-6 can act on target cells through its receptor, IL-6R, and IL-6R polymorphisms may affect the functional activity of IL-6 leading to susceptibility to cholangiocarcinogenesis. Therefore, we assessed the association of the 48892 A/C (Asp358Ala) polymorphism in exon 9 of the IL-6R gene in 79 CCA cases compared to 80 healthy controls using the PCR-RFLP technique. The results showed significant differences between CCA cases and controls in overall genotype (p=0.001) and allele frequencies (p=0.0002). Chi-square for trend test revealed a significant association between genotype and CCA susceptibility (p=0.0002). The odds ratios (ORs) for genotype were 0.283 (95% CI=0.131-0.605, AC vs. AA; p=0.0003) and 0.206 (95% CI=0.196-1.245, CC vs. AA; p=0.0416), the OR for alleles was 0.347 (95% CI=0.187-0.633, allele C vs. allele A; p=0.0002) and that for the carrier C variant was 0.272 (95% CI=0.130-0.564; p=0.0001). This study demonstrated a close association between an IL-6R polymorphism, specifically higher A allele, and cholangiocarcinoma.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제16권12호
• /
• pp.3960-3975
• /
• 2022

To analyze and compare the most influencing factors on cloud computing adoption (CCA) in the healthcare organization, a systematic review and meta-analyses of studies was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and Cochrane collaboration recommendations. A search of PubMed, ScienceDirect, Springer, Wiley Online, and Taylor & Francis Online digital libraries (From inception to January 19, 2022) was performed. A total of 17 studies met the defined studies' inclusion and exclusion criteria. Statistical significance difference favoring most influencing factors on CCA were (MD 0.76, 95% CI -1.48 - 3.01, p <0.00001, I² = 90%), (MD 1.40, 95% CI -4.76 - 7.55, p < 0.00007, I² = 97%) (MD 0.17, 95% CI -2.69 - 3.03, p<0.00001, I² = 96%) for technology vs. organizational, technology vs. environmental and business vs. human factors, respectively. Organizational and environmental factors had greater impacts on CCA compared with technological factors. Moreover, business factors were more influential than the human factors.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권10호
• /
• pp.4217-4224
• /
• 2014

Cholangiocarcinoma (CCA), a slow growing but highly metastatic tumor, is highly prevalent in Northeast Thailand. Specific tests that predict prognosis of CCA remain elusive. The present study was designed to investigate whether peripheral blood leukocyte (PBL) transcriptional profiles might be of use as a prognostic test in CCA patients. Gene expression profiles of PBLs from 9 CCA and 8 healthy subjects were conducted using the Affymetrix HG_U133 Plus 2.0 GeneChip. We indentified informative PBLs gene expression profiles that could reliably distinguish CCA patients from healthy subjects. Of these CCA specific genes, 117 genes were up regulated and 60 were down regulated. The molecular and cellular functions predicted for these CCA specific genes according to the Gene Ontology database indicated differential PBL expression of host immune response and tumor progression genes (EREG, TGF ${\beta}1$, CXCL2, CXCL3, IL-8, and VEGFA). The expression levels of 9 differentially expressed genes were verified in 36 CCA vs 20 healthy subjects. A set of three tumor invasion related genes (PLAU, CTSL and SERPINB2) computed as "prognostic index" was found to be an independent and statistically significant predictor for CCA patient survival. The present study shows that CCA PBLs may serve as disease predictive clinically accessible surrogates for indentifying expressed genes reflective of CCA disease severity.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권9호
• /
• pp.4597-4606
• /
• 2012

Cholangiocarcinoma (CCA) is an uncommon adenocarcinoma which arises from the epithelial cells of the bile ducts. The aim of the study was to investigate the cytotoxicity, toxicity, and anticancer activity of a crude ethanolic extract of ginger (Zingiber officinale Roscoe) against CCA. Cytotoxic activity against a CCA cell line (CL-6) was assessed by calcein-AM and Hoechst 33342 assays and anti-oxidant activity was evaluated using the DPPH assay. Investigation of apoptotic activity was performed by DNA fragmentation assay and induction of genes that may be involved in the resistance of CCA to anticancer drugs (MDR1, MRP1, MRP2, and MRP3) was examined by real-time PCR. To investigate anti-CCA activity in vivo, a total of 80 OV and nitrosamine (OV/DMN)-induced CCA hamsters were fed with the ginger extract at doses of 1000, 3000, and 5000 mg/kg body weight daily or every alternate day for 30 days. Control groups consisting of 10 hamsters for each group were fed with 5-fluorouracil (positive control) or distilled water (untreated control). Median $IC_{50}$ (concentration that inhibits cell growth by 50%) values for cytotoxicity and anti-oxidant activities of the crude ethanolic extract of ginger were 10.95, 53.15, and $27.86{\mu}g/ml$, respectively. More than ten DNA fragments were visualized and up to 7-9 fold up-regulation of MDR1 and MRP3 genes was observed following exposure to the ethanolic extract of ginger. Acute and subacute toxicity tests indicated absence of any significant toxicity at the maximum dose of 5,000 mg/kg body weight given by intragastric gavage. The survival time and survival rate of the CCA-bearing hamsters were significantly prolonged compared to the control group (median of 54 vs 17 weeks). Results from these in vitro and in vivo studies thus indicate promising anticancer activity of the crude ethanolic extract of ginger against CCA with the absence of any significant toxicity. Moreover, MDR1 and MRP3 may be involved in conferring resistance of CCA to the ginger extract.

• Korean Journal of Radiology
• /
• 제24권10호
• /
• pp.983-995
• /
• 2023

Objective: To compare the diagnostic performance and interobserver agreement between contrast-enhanced computed tomography (CECT) and contrast-enhanced magnetic resonance imaging (CE-MRI) with magnetic resonance cholangiopancreatography (MRCP) for evaluating the resectability in patients with extrahepatic cholangiocarcinoma (eCCA). Materials and Methods: This retrospective study included treatment-naïve patients with pathologically confirmed eCCA, who underwent both CECT and CE-MRI with MRCP using extracellular contrast media between January 2015 and December 2020. Among the 214 patients (146 males; mean age ± standard deviation, 68 ± 9 years) included, 121 (56.5%) had perihilar cholangiocarcinoma. R0 resection was achieved in 108 of the 153 (70.6%) patients who underwent curative-intent surgery. Four fellowship-trained radiologists independently reviewed the findings of both CECT and CE-MRI with MRCP to assess the local tumor extent and distant metastasis for determining resectability. The pooled area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of CECT and CE-MRI with MRCP were compared using clinical, surgical, and pathological findings as reference standards. The interobserver agreement of resectability was evaluated using Fleiss kappa (κ). Results: No significant differences were observed between CECT and CE-MRI with MRCP in the pooled AUC (0.753 vs. 0.767), sensitivity (84.7% [366/432] vs. 90.3% [390/432]), and specificity (52.6% [223/424] vs. 51.4% [218/424]) (P > 0.05 for all). The AUC for determining resectability was higher when CECT and CE-MRI with MRCP were reviewed together than when CECT was reviewed alone in patients with discrepancies between the imaging modalities or with indeterminate resectability (0.798 [0.754-0.841] vs. 0.753 [0.697-0.808], P = 0.014). The interobserver agreement for overall resectability was fair for both CECT (κ = 0.323) and CE-MRI with MRCP (κ = 0.320), without a significant difference (P = 0.884). Conclusion: CECT and CE-MRI with MRCP showed no significant differences in the diagnostic performance and interobserver agreement in determining the resectability in patients with eCCA.

• 대한한방내과학회지
• /
• 제30권2호
• /
• pp.422-430
• /
• 2009

Background : Stroke is the second leading cause of death in Korea, following cancer. Stroke consists of ischemic and hemorrhagic stroke, and ischemic stroke can be largely classified as atherothrombotic stroke or embolic stroke. Carotid intima-media thickness (IMT) is an indicator of atherosclerosis used commonly as a screening test for abnormalities of the coronary artery. 24-hour ambulatory ECG is widely used to screen for underlying diseases that causes syncope, palpitation, arrhythmia, etc. Objectives : Since both carotid IMT and 24-hour ambulatory ECG are used to screen for cardiac problems, we endeavored to explore the correlation between carotid IMT and 24-hour ambulatory ECG of stroke patients. Methods : The records of ischemic stroke patients who were admitted to Kyunghee Medical Center Oriental Hospital ward from March 2006 to May 2009 were reviewed. 28 patients who had both carotid Doppler US and 24-hour ambulatory ECG test undertaken during their admission were analyzed. The relationship of abnormal ambulatory results and common carotid artery(CCA) IMT were statistically analyzed using Fisher's exact test and t-test. Results : The mean age of the abnormal ambulatory group was older than the normal group (74${\pm}$ 8.0 vs. 61${\pm}$12.1, p=0.0098). Although insignificant, the abnormal ambulatory group showed much thicker CCA-IMT than normal ambulatory group (2.l7${\pm}$ 1.16 vs. 1.51${\pm}$0.97. p=0.l389). Conclusion: No significant correlation was observed between abnormal ambulatory results and CCA-IMT. However, the difference in CCA-IMT between the two groups was too big to be ignored and further investigation with larger and better controlled trials are warranted.

• 대한환경공학회지
• /
• 제30권11호
• /
• pp.1102-1110
• /
• 2008

본 연구는 폐목재 발생원별 삼성분, 발열량, 그리고 중금속 및 Cl 함량을 분석하여 폐목재 특성을 평가함으로써 향후 폐목재 등급화를 위한 품질근거 기준을 마련하는데 필요한 기초자료를 제시하고자 하였다. 임목부산물, 생활계폐목재, 건설폐목재, 그리고 사업장폐목재의 4가지로 분류한 폐목재에서 수분함량은 대부분 5$\sim$10%를 나타내었으며, 이를 수분함량을 제외한 건조기준으로 환산하였을 때 가연분함량은 95% 이상이었고, 회분함량은 5% 이하를 나타내었다. 폐목재는 수분함량이 55%로 높았던 버섯재배폐목을 제외하고는 '건설폐기물의재활용촉진에관한법률'의 고형연료제품의 품질기준 중 발열량 기준(저위발열량 $\geq$ 3,500 kcal/kg)을 만족하였다. CCA (Cr, Cu, As)로 처리된 벤치목, 폐선박, 철도침목 등 방부목에서 CCA가 매우 높게 나타나 방부목의 사용과 관리, 폐기처분에 대한 엄격한 관리가 필요한 것으로 나타났다. Cl 함량은 목재 어(魚)상자에서만 약 1.3%로 가장 높게 나타났고 나머지 폐목재 및 재활용제품에서는 0.2% 이하의 낮은 값을 보였으나 고형연료제품의 염소함량 품질기준 (건조기준 2wt.%)을 모두 만족시켰다. 발생원별 폐목재를 유해물질 함유량을 기준으로 3등급화할 경우 대부분의 폐목재가 1등급에 해당하였으며, 합판류, MDF (medium density fiber), 표면도색된 전선드럼은 2등급에 해당하였다. 3등급에 해당하는 폐목재는 벤치목, 재활용공장목재분진, 폐선박과 철도침목으로 나타났다.

• 미생물학회지
• /
• 제50권2호
• /
• pp.137-151
• /
• 2014

댐의 존재가 하천 생태계에 미치는 영향을 연구하기 위해 다양한 연구가 지금까지 수행되어 왔지만, 댐이 하류의 탈질화에 미치는 영향은 잘 알려져 있지 않다. 대한민국 낙동강의 댐 원류에서 탈질화 효소 활성도(잠재 탈질율)와 탈질균 분포(nirS, nirK, nosZ 유전자를 표지유전자로 사용)를 조사하였다. 자갈 혹은 모래로 채워진 하천의, 갈대가 우거진 하변지역과 강바닥의 침전물을 채취하여 조사하였다. 이 실험의 가설은 다음과 같다. (i) 하천 침전물의 N과 C의 사용유효량이 높을수록 대조군에 비해 미생물 군집의 탈질화 작용이 더욱 증진한다, (ii) 하천생태계마다 상이하게 나타나는 잠재 탈질율 간의 차이는 탈질 미생물의 양에 비례한다. 30여 년간 댐에 의해 수문학적으로 큰 차이가 있었고 또한 댐 하류의 저서에 무기질소와 용존유기탄소 농도가 대조군에 비해 매우 높았음에도 불구하고, 탈질균 군집의 양과 잠재 탈질율은 하천 간에 큰 차이가 없었다. 하지만 nirS 유전자와 nosZ 유전자의 양과 잠재 탈질율은 댐 하류에 존재하는 자갈이 많은 하변과 모래가 많은 하천 바닥에서 홍수빈도와 계절별 온도변동에 관련하여 크게 증가함을 알 수 있었다. nirK 유전자는 모든 시료에서 발견되지 않았다. Canonical correspondence analysis (CCA) 분석결과는 탈질균 군집 양과 영양염류 가용도와 잠재 탈질율 사이에는 약한 상관관계가 있음을 보여주었다.