The Relationship between Carotid Intima-Media Thickness and 24-hour Ambulatory ECG in Ischemic Stroke Patients

뇌경색 환자의 경동맥 초음파 검사와 24시간 홀터 검사와의 연관성 연구

  • Kang, Ji-Suck (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Park, Sung-Hwan (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Song, Moon-Koo (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Ahn, Young-Min (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Ahn, Se-Young (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University) ;
  • Lee, Byung-Cheol (Dept. of Internal medicine, College of Oriental Medicine, Kyung-hee University)
  • 강지석 (경희대학교 한의과대학 신계내과학교실) ;
  • 박성환 (경희대학교 한의과대학 신계내과학교실) ;
  • 송문구 (경희대학교 한의과대학 신계내과학교실) ;
  • 안영민 (경희대학교 한의과대학 신계내과학교실) ;
  • 안세영 (경희대학교 한의과대학 신계내과학교실) ;
  • 이병철 (경희대학교 한의과대학 신계내과학교실)
  • Published : 2009.06.30

Abstract

Background : Stroke is the second leading cause of death in Korea, following cancer. Stroke consists of ischemic and hemorrhagic stroke, and ischemic stroke can be largely classified as atherothrombotic stroke or embolic stroke. Carotid intima-media thickness (IMT) is an indicator of atherosclerosis used commonly as a screening test for abnormalities of the coronary artery. 24-hour ambulatory ECG is widely used to screen for underlying diseases that causes syncope, palpitation, arrhythmia, etc. Objectives : Since both carotid IMT and 24-hour ambulatory ECG are used to screen for cardiac problems, we endeavored to explore the correlation between carotid IMT and 24-hour ambulatory ECG of stroke patients. Methods : The records of ischemic stroke patients who were admitted to Kyunghee Medical Center Oriental Hospital ward from March 2006 to May 2009 were reviewed. 28 patients who had both carotid Doppler US and 24-hour ambulatory ECG test undertaken during their admission were analyzed. The relationship of abnormal ambulatory results and common carotid artery(CCA) IMT were statistically analyzed using Fisher's exact test and t-test. Results : The mean age of the abnormal ambulatory group was older than the normal group (74${\pm}$ 8.0 vs. 61${\pm}$12.1, p=0.0098). Although insignificant, the abnormal ambulatory group showed much thicker CCA-IMT than normal ambulatory group (2.l7${\pm}$ 1.16 vs. 1.51${\pm}$0.97. p=0.l389). Conclusion: No significant correlation was observed between abnormal ambulatory results and CCA-IMT. However, the difference in CCA-IMT between the two groups was too big to be ignored and further investigation with larger and better controlled trials are warranted.

Keywords

References

  1. 대한민국 통계청. 사망원인통계(전국편, 2007년). 2007.
  2. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and meta-analysis. Circulation. 2007;115(4): 459-67. https://doi.org/10.1161/CIRCULATIONAHA.106.628875
  3. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK,Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and Stroke in older adults. cardiovascular health study collaborative research group. N Engl J Med. 1999;340(1):14-22. https://doi.org/10.1056/NEJM199901073400103
  4. Johnsen SH, Mathiesen EB. Carotid plaque compared with intima-media thickness as a predictor of coronary and cerebrovascular disease. Curr Cardiol Rep. 2009;11(1):21-7. https://doi.org/10.1007/s11886-009-0004-1
  5. Adams HP,Jr, del Zoppo G, Alberts MJ, Bhatt DL, Brass L, Furlan A et al. Guidelines for the early management of adults with ischemic Stroke: A guideline from the american heart Association/ American Stroke association Stroke council, clinical cardiology council, cardiovascular radiology and intervention council, and the atherosclerotic peripheral vascular disease and quality of care outcomes in research interdisciplinary working groups: The american academy of neurology affirms the value of this guideline as an educational tool for neurologists. Stroke. 2007;38(5):1655-711. https://doi.org/10.1161/STROKEAHA.107.181486
  6. European Stroke Organisation (ESO) Executive Committee, ESO Writing Committee. Guidelines for management of ischaemic Stroke and transient ischaemic attack 2008. Cerebrovasc Dis. 2008; 25(5):457-507. https://doi.org/10.1159/000131083
  7. 윤현주, 강원유, 이민구, 김계훈, 김주한, 안영근 et al. 노인 허혈성 뇌졸중 환자에서 경동맥반과 좌심실 이완기 기능의 관련성. J Korean Geriatr Soc. 2009;13(1):16-22. https://doi.org/10.4235/jkgs.2009.13.1.16
  8. Salonen R, Salonen JT. Determinants of carotid intima-media thickness: A population-based ultrasonography study in eastern finnish men J Intern Med. 1991;229(3):225-31. https://doi.org/10.1111/j.1365-2796.1991.tb00336.x
  9. Johnsen SH, Mathiesen EB, Joakimsen O, Stensland E, Wilsgaard T, Lochen ML et al. Carotid atherosclerosis is a stronger predictor of myocardial infarction in women than in men: A 6-year follow-up study of 6226 persons: The tromso study Stroke. 2007;38(11):2873-80. https://doi.org/10.1161/STROKEAHA.107.487264
  10. Bots ML, Hoes AW, Koudstaal PJ, Hofman A, Grobbee DE. Common carotid intima-media thickness and risk of stroke and myocardial infarction: The rotterdam study Circulation. 1997;96(5):1432-7. https://doi.org/10.1161/01.CIR.96.5.1432
  11. 고호연, 김중길, 강병갑, 김보영, 고미미, 강경원 et al. 한국형 중풍변증 표준안-II에 대한 보고. 동의생리병리학회지. 2006;20(6):1789-92.
  12. Aronow WS, Ahn C, Gutstein H. Prevalence of atrial fibrillation and association of atrial fibrillation with prior and new thromboembolic stroke in older patients. J Am Geriatr Soc. 1996;44(5): 521-3.
  13. Allan PL, Mowbray PI, Lee AJ, Fowkes FG. Relationship between carotid intima-media thickness and symptomatic and asymptomatic peripheral arterial disease. the edinburgh artery study. Stroke. 1997;28(2):348-53. https://doi.org/10.1161/01.STR.28.2.348
  14. Crawford MH, Bernstein SJ, Deedwania PC, DiMarco JP, Ferrick KJ, Garson A,Jr et al. ACC/ AHA guidelines for ambulatory electrocardiography: Executive summary and recommendations. A report of the american college of Cardiology/American heart association task force on practice guidelines(committee to revise the guidelines for ambulatory electrocardiography). Circulation. 1999;100(8):886-93. https://doi.org/10.1161/01.CIR.100.8.886
  15. Antman Elliott M, Selwyn Andrew P, Braunwald Eugene, Loscalzo Joseph. Harrison's principles of internal medicine. 17th ed: McGraw Hill; 2008, p.1514-27.
  16. Schaer B, Sticherling C, Lyrer P, Osswald S. Cardiological diagnostic work-up in Stroke patients-a comprehensive study of test results and therapeutic implications. Eur J Neurol. 2009;16(2):268-73. https://doi.org/10.1111/j.1468-1331.2008.02413.x
  17. Schaer BA, Zellweger MJ, Cron TA, Kaiser CA, Osswald S. Value of routine holter monitoring for the detection of paroxysmal atrial fibrillation in patients with cerebral ischemic events. Stroke. 2004;35(3):e68-70. https://doi.org/10.1161/01.STR.0000117568.07678.4B
  18. Jabaudon D, Sztajzel J, Sievert K, Landis T, Sztajzel R. Usefulness of ambulatory 7-day ECG monitoring for the detection of atrial fibrillation and flutter after acute Stroke and transient ischemic attack. Stroke. 2004;35(7):1647-51. https://doi.org/10.1161/01.STR.0000131269.69502.d9
  19. Vemmos KN, Tsivgoulis G, Spengos K, Papamichael CM, Zakopoulos N, Daffertshofer M et al. Common carotid artery intima-media thickness in patients with brain infarction and intracerebral haemorrhage. Cerebrovasc Dis. 2004;17(4):280-6. https://doi.org/10.1159/000077338
  20. Howard G, Sharrett AR, Heiss G, Evans GW, Chambless LE, Riley WA et al. Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC investigators. Stroke. 1993;24(9):1297-304. https://doi.org/10.1161/01.STR.24.9.1297
  21. 이준희, 김상혁, 이의주, 송일병, 고병희. 사상체질과 대사증후군 및 경동맥 내중막두께와의 상관관계 연구. 사상체질의학회지. 2007;19(1):148-59.