• 대한한방내과학회지
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• 제29권1호
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• pp.1-11
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• 2008

Objectives : Essential hyperhidrosis is a socially and occupationally disabling disorder. There are many suggestions that hyperhidrosis is associated with the autonomic nervous system. This study was designed to investigate the autonomic nerve system the patients with hyperhidrosis. Methods : 348 palmar and plantar hyperhidrosis patients and 20 systemic hyperhidrosis patients in the ambulatory care were investigated. All patients were inspected at the first medical examination, using the PSA of HRV. HRV was measured for 5 minutes after 5 minutes' bed rest. We checked the frequency domain analysis of HRV (i.e. TP, VLF, LF, HF and LF/HF) which were transformed into natural logarithm of patients against the standard measures of the HRV components. Then, we compared the means of patients with means and highest values of in the normal range of Koreans 1) between the patients with palmar and plantar hyperhidrosis and the healthy controls and 2) between the patients with the systemic hyperhidrosis and healthy controls, by the frequency domain analysis of heart rate variability (HRV), respectively. We then compared the results between 1) and 2). Results : The values of natural logarithmic measures of LF/HF ratio in the patients with palmar and plantar hyperhidrosis we examined were significantly higher than the values of healthy controls, but those in the patients with systemic hyperhidrosis were not higher. Conclusion : This study suggests that the autonomic nervous function did not simply increase but that the balance between sympathetic and parasympathetic nervous function did matter in patients with palmar and plantar hyperhidrosis. This balance included that the sympathetic nervous function aggravated comparatively with parasympathetic nervous function. On the other hand, we couldn't find any significance of the patients with the systemic hyperhidrosis as for the autonomic nervous function.

• 대한한의학회지
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• 제28권1호통권69호
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• pp.105-116
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• 2007

Objectives : Mahuang (Ephedra sinica), well known as an herbal medicine in the East and West, contains a relatively high percentage of ephedrine known as sympathomimetic alkaloid. We investigated the effects of Mahuang on sympathetic nervous system with heart rate variety (HRV). Time and frequency domain analysis of HRV is a noninvasive technique capable of providing information on autonomic modulation of the sinus node. Methods : We investigated 57 healthy volunteers consisting of 37 subjects in the Mahuang group and 20 subjects in the placebo group. Study form was a randomized, placebo-controlled, double-blind clinical trial. The 37 subjects in the Mahuang group took 3 Mahuang capsules (1 capsule equivalent to 2g herb Mahuang) twice a day at 10 a.m. and 2 p.,., while the 20 subjects in the placebo group took 3 placebo-capsules filled with glutinous rice powder at the same times. Mahuang medicine and placebo medicine were made into opaque capsules. We measured HRV at 3 p.m. 1 or 2 days before medication and at 3 p.m. after medication. Results : Mean-RR and SDNN of the Mahuang group significantly decreased compared with that of the placebo group, but the heart rate of the Mahuang group significantly increased compared with the placebo. HRV-Index, RMSSD and SDSD of the Mahuang group significantly decreased compared with that of the placebo group, but PNN50 of the Mahuang group significantly increased compared with placebo. Ln(TP), Ln(VLF), Ln(LF) and Ln(HF) of the Mahuang group significantly decreased compared with those of the placebo group. There were no significant differences in normalized LF, normalized HF and LF/HF ratio between the Mahuang and placebo groups. Conclusion : The results suggest that Mahuang in healthy adults tends to reduce the autonomic nervous system within the normal range.

• 동의신경정신과학회지
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• 제19권1호
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• pp.107-124
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• 2008

We investigated the effects of distilled Astragali Radix Herbal Acupuncture on autonomic nervous system with the Heart Rate Variability(HRV) in adult man. as well as we tried to observe how distilled Astragali Radix Herbal Acupuncture on the balance of the autonomic nervous system. Methods : We investigated on 61 healthy volunteers consisted of 31 subjects in experiment(distilled Astragali Radix Herbal Acupuncture) group and 30 subjects in control(Normal Saline) group. Study form was a randomized, placebo-controlled, double-blind clinical trial. 31 subjects in experiment group were injected distilled Astragali Radix Herbal Acupuncture at GB21(Kyonjong) and 30 subjects in control group were injected Normal Saline at GB21(Kyonjong). except of 2 subjects(in control group) who can't be measured and 10 subjects(6 in experiment group and 4 in control group) who move or make unforceable error during measuring. Finally 25 subject in experiment group and 24 subject in control group are studied. We measured HRV by PolyG-I on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 10.0 for windows was used to analyze the data and the paired t test(in group) and Student t test(between two groups) were used to verify the result. Results : I. After distilled Astragali Radix Herbal Acupuncture injection, SDNN is significantly high from 5 minute to 10 minute and from 15 minute to 30 minute, Complexity is significantly low from 20 minute to 30minute. HRV index is significantly mgb for first 20 minute and from 25 minute to 30 minute, RMSSD is significantly high only from 15 minute to 20 minute. 2. HRV index of distilled Astragali Radix Herbal Acupuncture Group significantly increased from 25 minute to 30 minute, pNN50 of distilled Astragali Radix Herbal Acupuncture Group significantly decreased from 25 minute to 30 minute and RMSSD of distilled Astragali Radix Herbal Acupuncture Group significantly increased from 25 minute to 30 minute compared with those of Normal Saline group. 3. After distilled Astragali Radix Herbal Acupuncture injection, Ln(TP) is significantly high from 5 minute to 10 minute and from 15 minute to 30 minute. Ln(VLF) is significantly high after 5 minute, Ln(LF) is significantly high after 15 minute and Ln(HF) is significantly high from 5 minute to 10 minute and 25 minute to 30 minute, but significantly low for first 5 minute and from 10 minute to 20 minute. Normalized LF is significantly high after 20 minute and Normalized LF is significantly low after 20 minute. Conclusions : The results suggest that distilled Astragali Radix Herbal Acupuncture in healthy adult man tend to activate the autonomic nervous system within normal range. This result is derived from that parasympathetic nervous system was continuously activated and sympathetic nervous system was activated a little later.

• 대한한방내과학회지
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• 제40권4호
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• pp.582-596
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• 2019

Objective: The aims of this study were to analyze the deficiency-excess pattern identification (虛實辨證) and compare it to the sputum cytokines of asthma patients. Method: 50 asthma patients who met the inclusion and exclusion criteria were included in this study. They were divided into two groups: deficiency and excess syndrome groups. Sputum examinations were performed including $TNF-{\alpha}$, Interleukin (IL)-4, IL-5, IL-10, and IL-13. The Quality of Life Questionnaire for Adult Korean Asthmatics (QLQAKA), the Visual Analog Scale(VAS), and heart rate variability (HRV) were also measured. We also conducted laboratory tests, including the hematological indexes. Results: Based on the pattern identification, 50 asthma patients can be divided into two categories of groups: the deficiency syndrome group (N=24) and the excess syndrome group (N=26). In the analysis of sputum cytokines, although the $TNF-{\alpha}$, IL-4 and IL-13 were at a higher level in the deficient pattern group than in the excess pattern group, it was insignificantly different. There was a negative correlation in the analysis of QLQAKA and VAS. In the analysis of HRV, although the mean value of VLF, LF, and HF in the deficiency syndrome group was higher than in the excess syndrome group, it was insignificantly different. There was no significant difference in the hematological tests between the deficiency and the excess syndrome group. The mean value of the IgE in the blood tests was five times greater than the reference value. Conclusion: The cytokines of sputum including $TNF-{\alpha}$, IL-4, IL-5, IL-10, and IL-13 were indifferent statistically. Reinforcing the healthy and eliminating the pathogenic factors should be considered.

• 정신신체의학
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• 제14권2호
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• pp.94-101
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• 2006

연구목적 : 본 연구는 불안장애 환자들과 정상대조군을 대상으로, 심박변이도(heart rate variability, HRV)를 이용해서 자율신경계의 심장조절기능을 비교하고 그 생리학적 의미를 살펴보고자 한 것이다. 또한 불안장애 환자들에게 세로토닌재흡수억제제 (selective serotonin reuptake inhibitor, SSRI)를 투여한 뒤 투여전과 투여후를 비교해보고 치료효과를 판정하여 임상적 적용가능성을 고찰해보고자 하였다. 방법: DSM-IV의 진단기준에 의하여 불안장애로 진단받은 환자 30명과 정상대조군 30명을 대상으로 연구를 수행하였다. 불안증상의 심각도를 평가하기 위하여 Hamilton Anxiety Scale을 사용하였으며 정상대조군은 학생과 의사, 간호사 그리고 병원에 근무하는 직원들이었다. 검사는 불안장애 환자군과 정상대조군의 HRV를 측정한 후 시영역과 주파수 영역별로 분석하였다. 그리고 불안장애 환자들을 대상으로 SSRI 투여전과 투여 뒤 4주후 HRV를 측정하였다. SSRI 약물로는 fluoxetine, paroxetine, citalopram, sertraline을 사용하였다. 통계적 검증은 SPSS-Windows (version 10.0)을 이용하여 independent t-test, chi-square test, 그리고 paired t-test를 사용하였다. 결과: 불안장애 환자군과 정상대조군의 연령, 성별의 유의한 통계적 차이는 없었으며, 치료 후의 Hamilton Anxiety Scale 점수는 치료전과 비교하여 유의하게 감소되었다.(p<0.05). 정상대조군과 치료전 불안장애군을 비교하였을 경우, 치료전 불안장애군이 시간영역변수들인 RMSSD, SDNN에서 유의한 감소를 나타내었다. 또 주파수 영역 변수들을 살펴보면, 치료 전 불안장애 환자군이 정상대조군에 비해 TP, VLF, LF, HF에서 유의한 감소를 나타내었으며 LF/HF는 유의한 차이가 없었다. 그리고 불안장애 환자군에서 SSRI 치료 전과 치료 후의 HRV 변인들은 통계적으로 유의한 차이가 없었다. 결론: 치료전 불안장애군이 정상대조군에 비하여 감소된 HRV를 나타내었고, 불안장애 환자군을 대상으로 한 SSRI 치료전후 비교에서는 두 군간에 유의한 차이가 없었다. SSRI제제들이 자율신경의 활성을 반영하는 HRV의 인자에 영향을 미치지 않는 것으로 결과가 나타난 것이지만, 향후 더 많은 환자를 대상으로 한 연구가 진행되어야 할 것이다.

• Journal of Acupuncture Research
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• 제22권3호
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• pp.137-144
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• 2005

본 저자는 2004년 3월 9일부터 2004년 5월15일까지 경희의료원 침구과 외래를 내원한 특발성 파킨슨병 환자를 대상으로 하여 파킨슨병 증상의 호전도를 판단하는 임상척도인 H-Y stage에 따른 HRV를 관찰한 결과 다음과 같은 결론을 얻었다. 1. 시간영역분석에서 H-Y stage I, II, III 그룹의 SDNN은 $28.21{\pm}10.10$, $22.25{\pm}11.26$, $14.57{\pm}5.31$으로 그룹 I과 그룹III 간에는 유의한 차이가 있었다(P<0.05). RMS-SD는 $19.23{\pm}13.27$, $14.63{\pm}6.44$, $6.44{\pm}2.32$ 으로 역시 그룹 I과 그룹III 간에는 유의한 차이가 있었 다(p<0.05). 2. 주파수영역분석에서 TP는 H-Y stage Ⅰ, II, III 그룹에서 각각 $499.86{\pm}345.45$, $243.72{\pm}212.22$, $99.44{\pm}51.01$로 ANOYA 검정결과 p-value가 0.007로 매우 유의 있었으며, 사후 검정에서는 그룹 I과 II, 그룹 II와 III에서는 유의한 차이가 없었으나 그룹 I과 III에서는 매우 유의한 차이가 있었다(p<0.01). LF는 H-Y stage I과 III 그룹에서 유의한 차이가 있었으나(p<0.05) VLF, HF, LF norm HF nonm LF norm, LF/HF ratio에서는 각 그룹 간 유의한 차이가 없었다. 3. SDNN, RMS-SD, TP가 UPDRS 총점이 증가함에 따라 유의성 있게 감소하는 경향 (p<0.05)을 보이는 것으로 보아 파킨슨병이 진행함에 따라 자율신경계의 활동성이 저하될 것으로 보인다.