• 한국임상약학회지
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• 제23권3호
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• pp.223-231
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• 2013

Objective: This study aimed to identify the status and risk factors of rituximab infusion-related adverse events (ADE) in rituximab-na$\ddot{i}$ve patients with cancer diseases. Method: A retrospective analysis using electronic medical records review was conducted. Inclusions were patients with a diagnosis of cancer disease with the initiation of rituximab-included treatment who were na$\ddot{i}$ve to rituximab during January 2011 to March 2013 at National Cancer Center (NCC) in Korea. Result: Total 110 patients, 582 cases of rituximab administrations, were reported in the study. About 57.2% of patients were 51-70 years old and evenly distributed between two genders and 72.7% were BMI less than $25kg/m^2$. All of study patients were diagnosed with non-Hodgkin lymphoma. Fifty patients (45.4%) and 54 cases (9.3%) were experienced rituximab infusion-related AEs even with conservative administration protocol at NCC. The most frequently occurring AEs were shivering followed by rash and itching. In single variant analysis, we found that the early stage of NHL, low exposure to rituximab administrations, high white blood cell counts, high lymphocyte counts, high absolute neutrophil count and low lactate dehydrogenase were associated with infusion-related AEs (p<0.05). The early stage of disease, high lymphocyte counts, low exposure to rituximab administrations were also related significantly with AEs in multiple variants analysis (p<0.05). Conclusion: Rituximab infusion-related AEs for patients who were na$\ddot{i}$ve to rituximab were still a concern with conservative administration protocol. The adverse drug reactions were significantly associated with early stage of NHL, higher lymphocyte counts and low exposure to rituximab administrations. The factors need to be considered with close monitoring to prevent rituximab infusion-related AE.

• 한국지역지리학회지
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• 제15권6호
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• pp.736-751
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• 2009

중국은 개혁 개방과 함께 사회주의 계획경제제도에서 자본주의 시장경제제도로 이행중이며 이러한 과정에서 주택의 상품화와 함께 빈곤의 문제가 수면위로 등장하게 되었다. 본 연구에서는 장소적 빈곤의 개념을 기반으로 하여, 국내외 문헌을 통해 중국의 사회보장제도와 주택의 상품화 과정을 분석하고 파악된 내용을 중심으로 중국의 주택상품화의 특징 및 문제점을 지적했다. 아울러, 중국을 8개 권역으로 구분하여 지역의 특성을 인구 사회적 지표, 경제적 지표, 주택지표로 고찰했다. 분석결과, 주택상품화 과정은 주거빈곤에 영향을 미치고 이었으며 권역별로 상이한 특징을 보였다. 본 연구에서는 중국의 지역별 상황이 매우 다양하므로 주거정책에서 일원적 방법이 아닌 다원적 방법으로 접근해야함을 제시한다.

• 벤처창업연구
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• 제9권4호
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• pp.155-161
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• 2014

본 연구에서는 신제품개발의 실시에 있어서 가장 중요한 기능분석의 단계를 제품의 설계 단계에서부터 소비자의 만족도를 조사하여 반영하였다. 품질기능전개를 이용하여 전개함으로서 원가절감과 품질개선의 합리적인 기능분석을 실시하고자 하는데 그 목적이 있다. 가치공학과 품질기능전개(QFD: Quality Function Deployment) 의 상호연계에 대한 필요성과 적합성을 분석하였다. 사례연구에서는 이러한 이론적인 배경 하에 품질기능전개를 이용하여 VE 기능 분석을 의료기기 제품에 적용하였다. 본 연구결과 소비자의 만족도와 품질기능전개를 이용하여 나타난 제품의 가치가 연구결과와 일치하고 있음을 파악하였다.

• 한국BIM학회 논문집
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• 제6권4호
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• pp.9-17
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• 2016

Currently whole-house refurbishment for substantial energy efficiency improvement of existing housing stock is needed to achieve the targeted 80% CO2 emission reduction. As whole-house refurbishment requires a larger capital investment for lower CO2 emission, the simultaneous use of Life Cycle Costing (LCC) and Life Cycle Assessment (LCA) methodologies are recommended to generate affordable refurbishment solutions. However, two methodologies are difficult to use due to a lack of proper LCC and LCA datasets. As a response to the current problems, many researchers explore potentials in Building Information Modelling (BIM) to improve current construction practice. As a result, a BIM tool - IES IMPACT (Integrated Material Profile And Costing Tool) - has been introduced to the UK construction industry for simultaneous calculation of LCC and LCA. Thus, this research aims at examining the capability and limitation of the IES VE/IMPACT as a BIM tool for whole-house refurbishment. This research reveals that the IES VE/IMPACT is feasible for whole-house refurbishment by providing LCC and LCA information simultaneously for informed decision on refurbishment solution selection. This research shed lights on the current problems lying on the data exchange between two different BIM tools. It is revealed that additional efforts from construction professionals and industry are required to make reliable BIM objects library with LCC and LCA datasets.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 학술대회 논문집 정보 및 제어부문
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• pp.298-299
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• 2008

The materials are measured and analyzed by the UTM combined with a contact type extensometer so as to analyze the characteristics such as strain-stress curve. However, the JIG and Fixture utilized in the UTM according to the standard [ASTM] can not only scratch the specimens but also have a serious distort on test result by the weight of the ZIG itself. In this paper we propose a moncular vision based visual extensometer [VE] securing the measuring accuracy using a new cross correlation in detecting the two feature points previously marked on the specimen from two successive images, and verify the usefulness of this VE through a real experiment on the UTM.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2005년도 지반공학 공동 학술발표회
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• pp.429-436
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• 2005

In this study, we have compared with the differences between the extent of sampling disturbance and consolidation characteristics by experiments, which are consolidation test and have been performed with Kwang-Yang clay samples. The effects on sampling disturbance to consolidation characteristics of soft clay have been inverstigated by using soil samples obtained from large block sampling and piston sampling methods. Through a few experiments, we've got important results which are that the consoilidation parameter of large block sample(Pc, Cc, Cv) is much larger than the value of parameter of piston sample. We've also found the fact that the large block sample using the large size sampler is much better than piston sample in the quality of goods to lessen the effects on disturbance of sampling. When compared to the parameter of consolidation along with the methods of experiment, we found that the result performed by large size consolidation test is the greatest one and CRS is much better than standard consolidation test to seek for proper parameter.

• 한국조리학회지
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• 제9권2호
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• pp.44-63
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• 2003

This study is about internet marketing of family restaurant through marketing mix and we found out the way which can make to activate by means of analysis of family restaurant's homepage. This study was done as following precedure. First, we've compared between characteristic was based on contents distinctive quality of family restaurant's homepage through the marketing mix. And in the next step, we've compared and ana lysed homepage of family restaurant which was chosed by the internet surfing. In the last, we evaluate strategy of marketing mix which is going well in the each field of business and then research of the way can improve internet-marketing. We draw the findings which is seperated by goods, price, promotion, distribution, other service according to marketing constituents. As a result of study, it is found that each company has given much more weight on some part in internet marketing's field of activity. In general, they put an emphasis on activity of goods and promotion. On the other hands they don't consider prices and delivery to be important compared with other parts. One of the most important things about internet-marketing is that fast and exact feedback and community makes each firm to be able to help to communicate with customer. It's like off-line-restaurant make use of free-coupon and an anniversary service.

• Journal of Advanced Marine Engineering and Technology
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• 제20권5호
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• pp.82-92
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• 1996

A computer simulation with predict the fuel injection rates and the fuel injection pressure behaviors in diesel engine fuel injection systems would by very useful in designing or improving fuel injection systems. In this paper we developed computer program in order to predict the behaviors of the fuel injection rate and the injection pressure for Electronic Hydraulic Ultra-High Pressure Fuel Injection System. We've applied the continuity and momentum equations for the hydraulic phenomena and the dynamics of individual components of the Electronic Hydraulic Fuel Injection System. To solve all the equations numerically we've applied the Runge-kutta IV method. Water hammer equations were applied for the hydraulic pipe solution, and the method of characteristics was employed in our calculations. The simulation results were compared with the experimental results for: Accumulator pressure, Injection pressure and unjection rate. As a result, The simulation results agree very well with our experimental results. We found that a large accumulator and the high speed solenoid valve were required, and the compression volume of the fuel had to be as small as possible in order to acheive ultra-high pressure fuel injection.

• The Journal of Korean Physical Therapy
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• 제12권3호
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• pp.379-386
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• 2000

This study is aimed to determine the cardiovascular function response to maximal exercise of chronic low back pain patients(N=13) and normal group(N=13). by using BRUCE PROTOCOL, subjects underwent tredmill exercise test. Their cardiovascular function responses during rest and after maximal exercise were compared The responses were analyzed using t-test for SPSS 7.0 program. The Cardiovascular function variables employed at rest time(Vo2, HR. Vo2/kg, VE, Vco2.) and all out time(Vo2peak. HRpeak, Vo2peak/kg, VEpeak. Vco2peak). Result show that : 1 There was no significant difference in Vo2 between chronic low back pain patients and normal group at rest time. However significant difference in Volpeak was observed after maximal exercise( p<.05). 2. There was no significant difference in HR between chronic low back pain patients and normal group at rest time. No significant difference in HRpeak likewise observed. 3. There was no significant difference in Vo2/kg between chronic low back pain patients and normal group at rest time. However significant difference in Vo2peak/kg was observed after maximal exercise load(p<.05). 4. There was no significance in VE between chronic low bark pain patients and normal group at rest time. However significant difference in VEpeak observed after maximal exercise load(p<.05).

• 한국태양에너지학회 논문집
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• 제26권1호
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• pp.99-104
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• 2006

This paper presents an analysis of heating energy for apartment houses in apartment building, paying special attention on the effect of pilotis which is increasing recently. A four-zone model composed of one conditioned and three unconditioned space is developed in this study. IES VE is adopted to estimate heating energy. Especially, we used Apache module for a heating energy calculated. The predicted result shows fairly good agreements with the available measured data and simulation data. Heating energy needed for an apartment located on the pilotis floors is far greater compared with the case of intermediate floors. Insulation thickness of walls, floors and underground structure appears to be a dominant factor affecting heating energy, which leads to needs of revision of the related regulation. It is finally concluded that the location dependent, severe imbalance in heating energy should be improved and reflected in the policy making process and the design standards.