• Title/Summary/Keyword: VD

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Effect of Vitamin D on YKL-40: Rat Hypercholesterolemia Model

  • Rahim Kocabas
    • Korean Circulation Journal
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    • v.53 no.2
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    • pp.92-102
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    • 2023
  • Background and Objectives: YKL-40 is considered to be associated with cardiovascular disease (CVD). In this study, the effect of serum 25(OH) vitamin D [25(OH)VitD] differences between groups on YKL-40 was evaluated on a hypercholesterolemia rat model. Methods: Thirty-two male rats (wistar albino) were equally divided into 4 groups. The first group was the control group; the second group was high-cholesterol (H-CH) adequate vitamin D (VitD) group (H-AdeVD). The third group was the H-CH deficient VitD group (H-DefVD), and the last group was designed with the H-CH supplement VitD (H-SupVD). The feeding process consisted of 2 stages. At the first stage (5 months), the H-DefVD group was fed on VitD deficient chow, while the other groups (control, H-AdeVD, H-SupVD) were fed on standard chow. At the second stage (3 months), the H-AdeVD and the H-SupVD groups were fed on the H-CH chow, whereas the H-DefVD group was fed on the H-CH-VitD deficient chow. Moreover, the H-SupVD group was given 100 IU/kg/day VitD along with the H-CH chow. Results: Compared with the control group, interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and YKL-40 values in the H-DefVD groups increased significantly (p<0.001, p<0.001, p=0.009, p=0.005; sequentially). Conclusion: It can be concluded that VitD can suppress the YKL-40, thus, it will prevent CVD development in rat. Therefore, further clinical studies related with human will reveal the effect of VitD and YKL-40 on CVD development.

Mechanical Properties and Ionic Conductivities of Plasticized Gel Polymer Electrolyte Based on P(VdF-co-HFP) (가소화된 P(VdF-co-HFP)계 고분자 전해질의 기계적 성질 및 이온전도도)

  • 최종국;김성훈
    • Polymer(Korea)
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    • v.24 no.2
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    • pp.259-267
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    • 2000
  • Gel polymer electrolytes were prepared from poly(vinylidene fluoride-co-hexafluoro propylene)[P(VdF-co-HFP)] that had higher mechanical properties as well as higher dielectric constant ($\varepsilon$=8~13) than other polymeric matrix. Mechanical properties and ionic conductivities have been investigated as a function of blend ratio of electrolyte solution and polymer matrix. Ethylene carbonate (EC)/${\gamma}$-butyrolactone (${\gamma}$-BL) and lithium triflate (LiCF$_3$SO$_3$) were used as solvent and salt, respectively. The mechanical properties such as tensile strength, tensile modulus, compression modulus, and dynamic shear modulus were evaluated. The highest ionic conductivity was 1.09$\times$10$^{-3}$ S/cm for PVH40 containing 28.6 wt% of P(VdF-co-HFP) at $25^{\circ}C$. Tensile strength, tensile modulus and compression modulus were increased with P(VdF-co-HFP) content and abruptly changed between PVH70 and PVH80. Dynamic shear moduli showed a typical gel behavior and changed with shear strain.

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An enhanced VS/VD switching algorithm to support fairly ABR service in ATM (ATM 망에서 공정한 ABR 서비스를 제공하는 확장된 VS/VD 스위칭 알고리즘)

  • 양해권;전광탁
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.4 no.2
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    • pp.313-322
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    • 2000
  • The ATM Forum has been focusing on flow control mechanism for ABR traffic management. The goal of this activity is to efficiently manage the leftover network bandwidth and fairly distribute it among contending ABR VC so that communication links can be optimally utilized. ABR traffic is difficult to predict traffic shape because it has bursts and variable behavior. Also it's sensitive to lose but not to delay. This behavior makes difficult to UPC function in network and cause of congestion in switch, thus performance is degraded. To resolve this problem, various flow control mechanism has been worked in the ATM Forum. Especially, the rate-based flow control mechanism for ABR traffic has been standardized in the ATM Forum, Sept. 1994. Thus, various flow control mechanism has been working which likes EFCI, ER, VS/VD. VS/VD control is superior than existed ER control because it isolate different networks from each other. In this paper, we propose an expanded VS/VD flow control algorithm and compare with existed VS/VD flow control algorithm. Simulation result shows that this algorithm improve a problem in aspect of delay and fairness.

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Effect of Feeding Aflatoxin $B_1$ and Vitamin $D_3$ on Metatarsus Bone Minerals of Broiler Chicks (Aflatoxin $B_1$과 Vitamin $D_3$ 결여가 Broiler병아리의 중족골 무기물함량에 미치는 영향)

  • 장윤환;여영수
    • Korean Journal of Poultry Science
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    • v.17 no.4
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    • pp.296-302
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    • 1990
  • This study was conducted to investigate the interaction of aflatoxin B$_1$($AFB_1$) and vitamin D$_3$($VD_3$) in broiler chicks. The 336 broiler chicks(Hubbard line) of equally mixed sex were allocated to triplicate 8(2$\times$4 factorial) treatment groups. The 0 or 1ppm of AFB$_1$and 0, 500, 1,000 or 1,500IU/kg of VD$_3$ were supplemented to the basal diet Fourteen broilers of equally mixed sex were allocated to each replica and 24 groups were arranged in a randomized block design After 3 weeks of feeding the metatarsus were collected from the right and left legs of 4 chicks (2 for each sex) per group. The bone ash and minerals were measured. 1. In respect to the fresh weight of metatarsus bone no significant difference was found between 0 and 1ppm $AFB_1$ treatments, however, decreasing trend was recognized when fed increasing level of $VD_3$(P<.01). 2. The ash content in non-fat dry metatarsus bone decreased when fed 1ppm $AFB_1$(P<.01). However, that increased according to the increasing amount of $VD_3$(P<.01). Although there was no interaction between $AFB_1$ and $VD_3$ it was shown that the 1500IU/kg of $VD_3$ was neccessary to cover the decrease in ash content of metatarsus. when fed 1ppm of $AFB_1$. 3. The Ca contents in metatarsus were not influenced by feeding $AFB_1$ but an increasing trend was verified by feeding increasing levels of $VD_3$(P<.05). 4. The P content decreased as $AFB_1$ was fed(P<.01), while no response was found when fed'different levels of $VD_3$ 5. The Cu content decreased when fed $AFB_1$(P<.05). 6. The Na, Mg, K, Zn, Fe and Mn contents were not affected by feeding $AFB_1$ and /or $VD_3$.

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Incidence of Coleus blumei viroid 1 in Seeds of Commercial Coleus in Korea

  • Chung, Bong-Nam;Choi, Gug-Sun
    • The Plant Pathology Journal
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    • v.24 no.3
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    • pp.305-308
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    • 2008
  • A viroid was detected from symptomless Coleus blumei cultivar 'Kong Scarlet'. It consisted of 249 nucleotides(GenBank accession no. EU410620), which was 100% identical to a Coleus blumei viroid 1(CbVd 1) reported from China(GenBank accession no. DQI78399), indicating that the viroid was an isolate of CbVd1. Attempts were made to determine if commercial Coleus seeds were infected with CbVd. Infection rates in seedlings of the 14 commercial cultivars of Coleus ranged from 0 to 100%. CbVd1 caused discoloration and growth retardation in some cultivars, but is symptomless in others. These results indicated that Coleus in commercial markets in Korea is highly infected with CbVd.

A Study on the Development of Digital CT/VD for GIS (가스절연개폐장치(GIS)용 디지털 CT/VD 개발에 관한 연구)

  • Kim, M.S.;Kim, J.B.;Song, W.P.;Kim, D.S.
    • Proceedings of the KIEE Conference
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    • 2002.11a
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    • pp.22-24
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    • 2002
  • 지금까지 변전소나 개폐소에서 전류, 전압을 계측하는 수단으로서 주로 철심과 권선으로 구성되어진 변류기(CT), 계기용 변압기(PT, PD)가 사용되어져 왔다. 최근, 2차측의 계측기나 보호 Relay의 Digital화가 진전되어, 또한 이것을 Digital Network으로 총합한 Intelligent 변전소의 구축이 검토되어짐에 따라, Digital Network에 대응한 신형 CT, VD가 요구되어지고 있다. 상기와 같은 요구로 인해 당사에서는 CT는 검출부에 Rogowski Coil을 적용하며 그 후단에 적분기를 설치하였으며, VD는 검출부에 중간 전극을 이용해서 분압하는 방식인 Capacitive Voltage Divider를 사용하고 증폭기를 삽입하여, 각각 요구되는 전압 신호를 얻었다. 이러한 신형 CT/VD의 적용으로 종래의 CT/PT가 차지하는 공간이 필요 없게 되어 컴팩트한 GIS의 구조가 가능하게 되어 있다.

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Total Phenolic Contents and Antioxidant Activities of Undaria pinnatifida and Capsosiphon fulvescens (미역과 매생이의 총 페놀함량 및 항산화성)

  • Kim, Yoo-Kyeong
    • Korean journal of food and cookery science
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    • v.26 no.5
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    • pp.499-502
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    • 2010
  • This study compared the total phenolic contents and antioxidant activities of two seaweed cultivars, Undaria pinnatifida (UP) and Capsosiphon fulvescens (CF), subjected to different drying methods. UP and CF were dried under two different conditions: vacuum drying (VD) at $20^{\circ}C$ and hot-air drying (HD) at $60^{\circ}C$. After drying, the total phenolic content, DPPH, and nitrite scavenging activities of the water extracts were determined. Total phenolic contents were 101.94 mg/100 g for UP and 171.35 mg/100 g for CF upon VD-20, and these values were significantly decreased to 67.59 mg/100 g for UP and 141.48 mg/100 g for CF upon HD-60. UP upon VD-20 and HD-60 had 46.17% and 35.20% DPPH radical scavenging activity, whereas CF upon VD-20 and HD-60 scavenged 57.73% and 35.22%, respectively. UP upon VD-20 and HD-60 had 40.36% and 40.01% nitrite scavenging activity at pH 1.2, whereas CF upon VD-20 and HD-60 scavenged 72.35% and 55.24%, respectively. Nitrite scavenging activities of UP and CF were reduced at pH 3.0.

Comparison of Cosmetical Activities of Curcuma longa L. Leaf Extracts Using Different Extraction Methods (추출 방법에 따른 강황 잎 추출물의 향장 활성 비교)

  • Kim, Nam Young;Lim, Hye Won;Lee, Hyeon Yong
    • Korean Journal of Medicinal Crop Science
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    • v.22 no.4
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    • pp.255-261
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    • 2014
  • Cosmetic activities of the leaves of Curcuma longa L. were compared according to different drying methods, to expand the use of the by-products of Curcuma longa L. The highest extraction yield of 29.4% was obtained from vacuum drying process (VD), whose value was very close to 29.2% from freeze drying process (FD). Relatively lower extraction yield were observed as 24.5% and 25.3% from the raw leaf (RL) as control and hot air drying process (HD). The cytotoxicity was observed lower FD and VD than RL and HD. It shows that cytotoxicity was closely related to cosmetic activities such as tyrosinase and melanin inhibition activities by showing much better cosmetic activities of the extracts from both FD and VD than those from the RL and HD. It was interesting that was differences of the cosmetic activities and cytotoxicity between FD and VD, which implies that VD method should be a more efficient process than FD method in terms of drying time and operation costs: 6 hours vs 24 hours and 3-5 times higher extraction costs in drying. It was observed that VD is more excellent dry method than others. This result could be utilized to effectively dry other soft plant biomass.

Echocardiographic Assessment of Papillary Muscle Size and Function in Normal Beagle Dogs

  • Kim, Mijin;Choi, Sooyoung;Choi, Hojung;Lee, Youngwon;Lee, Kija
    • Journal of Veterinary Clinics
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    • v.36 no.3
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    • pp.155-158
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    • 2019
  • Morphologic changes or functional impairments of the papillary muscle (PM) can influence mitral valve competence. The purpose of this study was to investigate PM size and contractile function using two-dimensional and color tissue Doppler echocardiography in normal dogs. 35 unsedated Beagle dogs without cardiovascular disease were examined. The vertical (VD) and horizontal diameter (HD) of the posterior and anterior PM was measured at end-diastole, and compared with the thickness of the left ventricular posterior wall (LVPWd). Longitudinal systolic movement of the PM was quantified as myocardial velocity and strain using tissue Doppler. The VD, HD, and ratios (VD/LVPWd, HD/LVPWd, VD/HD) were significantly greater in the posterior than anterior PM (P < 0.001). The VD and HD of posterior PM and the HD of anterior PM were significantly correlated with LVPWd (r = 0.47, 0.44, and 0.42, respectively). Body weight was significantly correlated with VD of posterior PM (r = 0.37). The peak systolic tissue velocity of the PM was $4.93{\pm}1.25cm/sec$ and peak strain was $-30.83{\pm}11.92%$. PM size and systolic function can be quantitatively assessed using two-dimensional and tissue Doppler. The establishment of these objective PM measurements may be useful to evaluate morphological and functional abnormalities of the canine PM.

Evaluation of Pharmacotherapy for the Patients with Depression in Alzheimer's Disease, Parkinson's Disease or Vascular Dementia (알츠하이머병, 파킨슨병 및 혈관성치매 환자들의 우울증에 대한 약물 치료 평가)

  • Lee, Hyo Jin;Lee, Ok Sang;Jung, Sun Hoi;Park, Mi Sook;Lim, Sung Cil
    • Korean Journal of Clinical Pharmacy
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    • v.23 no.1
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    • pp.33-41
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    • 2013
  • Background: Prevalence of depression comorbid with neurologic disorders such as Alzheimer' disease (AD), Parkinson's disease (PD) and vascular dementia (VD) is higher than that of primary depression. Antidepressant medications, suggested by many researches for depression comorbid with neurologic disorders such as AD, PD and VD, are mainly selective serotonin reuptake inhibitors (SSRI). Objective: The primary objective of this study is the evaluation of antidepressant drug therapy for AD, PD and VD. Method: This study was a retrospective study based on medical records, carried out for 3 years and 6 months (Jan. 2007~Jul. 2010). Patients, diagnosed as comorbid depression through Beck Depression Inventory (BDI), Cornell Depression Scale (CDS), Geriatric Depression Scale (GDS) among neurologic out-patients of Chungnam National University Hospital because of AD, PD and VD, were selected. The results were evaluated by efficacy and safety of antidepressant drug therapy. Results: In result, the prescribing rates of antidepressants were 30%, 55% and 40% for each AD, PD and VD. Depression cure rates of patients receiving antidepressants vs patients not receiving antidepressants were 40% vs 39%, 33% vs 23% and 38% vs 30% for AD, PD and VD. The frequencies of prescriptoin of SSRI were 21%, 11% and 27% for each AD, PD and VD. The frequencies of prescriptoin of benzodiazepine (BZD) was 61%, 82% and 61% for each AD, PD and VD. The ratio of single BZD prescription was more than that of combination prescription of antidepressants. Tricyclic antidepressants (TCA) were rarely prescribed. The rate of patients with BZD-related side effects was 54%. The most frequent side effects of BZD were dizziness (30%), drowsiness (21%) and headache (16%). Side effects of SSRI were rare. Conclusion: In conclusion, the frequencies of prescription of antidepressants were not common for AD, PD and VD. There was little difference in depression cure rate between patient receiving antidepressants and not receiving. Even though SSRI has to be the highest priority of usage, the frequencies of prescription of SSRI were lower than those of BZD. Additional researches and efforts are required to improve antidepressant drug therapy for neurologic disorders such as AD, PD and VD.