• International Journal of Oral Biology
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• 제34권4호
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• pp.191-197
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• 2009

Somatostatin (SST) is a known neuromodulator of the central nervous system. The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) receives many thinmyelinated $A{\delta}$-fiber and unmyelinated C primary afferent fibers and is involved in nociceptive processing. Many studies have demonstrated that SST plays a pivotal role in pain modulation in the spinal cord. However, little is yet known about the direct effects of SST on the SG neurons of the Vc in adult mice. In our present study, we investigated the direct membrane effects of SST and a type 2 SST receptor agonist, seglitide (SEG), on the SG neurons of the Vc using a gramicidin-perforated current clamp in adult mice. The majority (53%, n = 27/51) of the adult SG neurons were hyperpolarized by SST (300 nM) but no differences were found in the hyperpolarization response rate between males and females. When SST was applied successively, the second response was smaller ($76{\pm}9.5%$, n=19), suggesting that SST receptors are desensitized by repeated application. SST-induced hyperpolarization was also maintained under conditions where presynaptic events were blocked ($75{\pm}1.0%$, n=5), suggesting that this neuromodulator exerts direct effects upon postsynaptic SG neurons. SEG was further found to induce membrane hyperpolarization of the SG neurons of the Vc. These results collectively demonstrate that SST inhibits the SG neuronal activities of the Vc in adult mice with no gender bias, and that these effects are mediated via a type 2 SST receptor, suggesting that this is a potential target for orofacial pain modulation.

• 대한산업공학회지
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• 제20권1호
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• pp.87-98
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• 1994

This paper describes a method of constructing VC2 Chord-length spline surface from semi-evenly spaced 3D point array. The suface uses Hermite interpolant as Ferguson surface, and it is an extention of chord-length spline curve to surface The proposed surface may be widely used in interpolating smoothly 3D point data obtaind by measurement or engineering design.

• Toxicological Research
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• 제27권3호
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• pp.153-160
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• 2011

To evaluate the whitening effect of black tea water extract (BT), BT was topically applied to artificially hyperpigmented spots on the back skins of brown guinea-pigs (weight: 450~500 g) induced by 1,500 mJ/$cm^2$ of ultraviolet B (UVB) irradiation. The test compounds of 30 ${\mu}l$ were applied twice a day, six days a week, for four weeks. The artificially hyperpigmented spots were divided into 5 groups: control (UVB + saline, C), vehicle control [UVB + propylene glycol: ethanol: water (5 : 3 : 2), VC], positive control (UVB + 2% hydroquinone, PC), experimental 1 (UVB + 1% BT), experimental 2 (UVB + 2% BT). After 4-week application, the spots were removed by biopsy punch under anesthetic condition and used as specimens for the histological examination. The total polyphenol and flavonoid contents of BT were 104 and 91 mg/g, respectively. The electron-donating ability of BT revealed a dose-dependent response, showing the excellent capacities of 86% at 800 ${\mu}g$/ml. The artificially hyperpigmented spots treated with the PC and BT were obviously lightened compared to the C and VC groups. At the fourth week, the melanin indices for the PC and BT groups were significantly lower (p < 0.001) than those of the C and VC groups. In histological examination, PC and BT groups were significantly reduced in the melanin pigmentation, the proliferation of melanocytes and the synthesis of melanosomes compared to the C and VC groups. It is found that BT inhibits the proliferation of melanocytes and synthesis of melanosomes in vivo using brown guinea pigs, thereby showing a definite skin whitening effect.

• 한국지반공학회지:지반
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• 제14권1호
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• pp.37-48
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• 1998

압밀응력비, 과압밀비 및 반복재하를 포함하는 압밀응력이력이 점성토의 비배수전단강도에 미치는 영향에 관해서 연구하였다. $(S_u/\sigma'_{vc})ckou/(S_U/\sigma_{vc})cuv$의 강도비는 과압밀비가 증가함에 따라 증가됨이 관찰되었다. Mayne(1980)이 과압밀점토의 비배수전단강도를 추정하기 위해 제안한 식(1)과 Yasuhara(1994)가 반복재하로 인해 발생된 간극수압이 소산된 후의 비 배수전단강도를 구하기 위해 제안한 식(4)는 Ko압밀상태에서도 비교적 잘 적용될 수 있음을 알 수 있었다. 또한 이들 두 식중의 원위치전단강도를 위한 한계상태간극수압정수 A.값은 조금 과압밀된 점토의 경우(OCR< 3) 표준압밀시험에 의해서 구할 것을 제안하였다.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2007년도 추계 종합학술대회 논문집
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• pp.837-841
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• 2007

최근 영상을 중심으로 여러 형태의 정보를 결합하여 저장하거나 전송하는 멀티미디어가 많은 관심을 받고 있다. 현재 카메라와 관련된 동영상 캡처기술은 Motion JPEG이 주류를 이루고 있으며, 텔레비전, DMB 등의 방송 분야 및 DVD, VCR 분야에서는 MPEG-2, MPEG-4, H.264 및 WMV9 등의 압축 코덱이 채용되고 사용되고 있다. 그러나 이러한 다양한 영상 표준방식은 디코딩시 호환성 문제가 발생하게 되고 이에 따라 통합 코덱 연구가 필요하다. 이에 본 논문은 일반적 스텝 양자화외에 데드존 양자화를 사용하고 "$4{\times}4$", "$4{\times}8$", "$8{\times}4$", "$8{\times}8$"의 다양한 블록크기의 변환을 지원하는 VC-1을 기반으로 한 ITIQ C언어를 통해 시뮬레이션하고 최적화된 결과를 VHDL로 구현하여 향후 통합코덱 연구에 응용 가능하도록 연구 및 분석평가 하였다. 설계결과 4:2:0의 YCbCr포맷의 최초 $16{\times}16$블록을 복원하는데 483~510클록이 소요되었고 Xilinx XCVPC100 FF1696-6 환경에서 93,128개의 게이트 수와 71.469MHz의 동작속도를 나타내었다. 이는 640*480 크기의 컬러영상을 디코딩 하는데 프레임 당 최대 0.0074초가 소요됨을 의미하며 초당 30프레임의 영상에서도 0.222초면 디코딩이 가능한 결과이다.

• 센서학회지
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• 제30권1호
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• pp.51-55
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• 2021

We demonstrated a polymer dielectric with low leakage characteristics through an optimal blade coating method for low-cost and large-scale fabrication of metal-insulator-metal (MIM) capacitors. Cross-linked poly(4-vinylphenol) (C-PVP), which is a typically used polymer dielectric, was coated on a 10 × 10 cm indium-tin-oxide (ITO) deposited glass substrate by changing the deposition temperature (TD) and coating velocity (VC) in the blade coating. During the blade coating, the thickness of the thin c-PVP varied depending on TD and VC owing to the 'Landau-Levich (LL) regime'. The c-PVP-dielectric-based MIM capacitor fabricated in this study showed the lowest leakage current characteristics (10-6 A/㎠ at 1.2 MV/㎠, annealing at 200 ℃) and uniform electrical characteristics when TD was 30 ℃ and VC was 5 mm/s. In addition, at TD = 30 ℃, stable leakage characteristics were confirmed when a different electric field was applied. These results are expected to positively contribute to applications with next-generation electronic devices.

• 한국수산과학회지
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• 제36권2호
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• pp.100-106
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• 2003

This study was conducted to investigate the supplementary effects of vitamin C and E to moist pellet on growth and body composition in juvenile olive flounder (Paralichthys olivaceus). Four groups of diet made : moist pellet (MP) diet group was used as the control group where the ratio of raw feed and commercial compound meal is 5:5 $(CP\;30\%,\;CL\;17\%),$ vitamin C added group (VC), vitamin I added group (VE) and vitamin C and I added group (VCE). The supplementary amount of vitamin C and E corresponded to 1000 mg/kg (dry wt.) and 220mg/kg (dry wt.), respectively. Vitamin C was destroyed $50\%$ and vitamin E was destroyed $20\%$ for manufacturing process. After 8 weeks feeding trial, weight gain was $121.9\%$ in MP group, while it ranged from 180.5 to $184.9\%$ in the VC, VE and VCE group. Feed efficiency was $71.\6%$ in MP group, whereas it ranged from 78.7 to $80.6\%$ in the VC, VE and VCE group, weight gain and feed efficiency of fish fed vitamin supplemented diets were significantly higher than control group and no significant difference among the vitamin added groups was observed (p>0.05). There were no significant differences in moisture, crude protein, crude lipid, crude ash, condition factor (CF), hepatosomatic index (HSI), and visceraweight index (VWI) of body composition. Hemoglobin (Hb) was $3.79\%$ in MP group, whereas $4.99\%$ in VC group, $4.55\%$ in VE group and $5.07\%$ in VCE group; Hb was significantly higher in the vitamin added groups than the control group (p<0.05). Vitamin C retention in liver was 18.1, 20.7, 46.6, 54.0 mg/kg in MP, VE, VC and VCE groups, respectively. Vitamin E retention in liver was 25.9, 53.8, 88.2, 124.5 mg/kg in MP, VC, VE and VCE groups, respectively. These results indicate that supplementation of vitamin C and E to moist pellet diet significantly improved growth and feed efficiency of olive flounder, and the mixed addition of vitamin C (1,000 mg/kg dry wt.) and vitamin E (220 mg/kg dry wt.) did not lead to the synergy effect.

• Journal of Microbiology and Biotechnology
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• 제29권4호
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• pp.651-657
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• 2019

Although smallpox was eradicated in 1980, it is still considered a potential agent of biowarfare and bioterrorism. Smallpox has the potential for high mortality rates along with a major public health impact, eventually causing public panic and social disruption. Passive administration of neutralizing monoclonal antibodies (mAbs) is an effective intervention for various adverse reactions caused by vaccination and the unpredictable nature of emerging and bioterrorist-related infections. Currently, vaccinia immune globulin (VIG) is manufactured from vaccinia vaccine-boosted plasma; however, this production method is not ideal because of its limited availability, low specific activity, and risk of contamination with blood-borne infectious agents. To overcome the limitations of VIG production from human plasma, we isolated two human single-chain variable fragments (scFvs), (SC34 and SC212), bound to vaccinia virus (VACV), from a scFv phage library constructed from the B cells of VACV vaccine-boosted volunteers. The scFvs were converted to human IgG1 (VC34 and VC212). These two anti-VACV mAbs were produced in Chinese Hamster Ovary (CHO) DG44 cells. The binding affinities of VC34 and VC212 were estimated by competition ELISA to $IC_{50}$ values of $2{\mu}g/ml$ (13.33 nM) and $22{\mu}g/ml$ (146.67 nM), respectively. Only the VC212 mAb was proven to neutralize the VACV, as evidenced by the plaque reduction neutralization test (PRNT) result with a $PRNT_{50}$ of ~0.16 mg/ml (${\sim}1.07{\mu}M$). This VC212 could serve as a valuable starting material for further development of VACV-neutralizing human immunoglobulin for a prophylactic measure against post-vaccination complications and for post-exposure treatment against smallpox.

• Tuberculosis and Respiratory Diseases
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• 제42권6호
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• pp.900-912
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• 1995

연구배경: 최대운동부하 검사는 심폐기능의 종합적인 평가를 위하여 널리 이용되고 있으나 아직 우리나라에는 최대운동시의 호흡성 가스교환이나 폐기능의 정상치가 제대로 확립되어 있지 않은 설정이다. 본 연구의 목적은 한국성인에서 최대운동시의 이들 지표의 연령과 성별에 따른 정상치 내지 참고치를 마련하는 동시에 이들 중 일부지표의 추정정상치를 산출하는 회귀방정식을 구하는데 있다. 방법: 건강한 성인 남성 603명, 여성 397명, 합계 1,000명(20~66세)을 대상으로 Bruce법으로 증상제한성 최대운동부하 검사를 실시하였으며, 이중 885명에서는 VC, $FEV_1$ 및 MVV도 측정하였다 대상자들은 모두 전문체육인이 아닌 스포츠센터의 회원이었으며, 운동부하검사 중에는 안전상의 문제 때문에 부득이 트레드밀의 손잡이를 잡는 것을 허용하였다. 곁과: $VO_2\;max/m^2$, $VCO_2\;max/m^2$ 및 VE max/$m^2$는 모두 남성에서 뚜렷이 컸으며, 남녀에서 모두 연령의 증가에 따라 감소하였다. 한편 RR max는 성별에 따른 차이는 없었으나, 연령의 증가에 따라 약간씩 감소하였으며, $V_T$ max는 남성에서 월등히 많았으나 남녀에서 다같이 연령에 따른 일정한 경향의 변화는 없었다. 그리고 $V_T$ max/VC, $V_E$ max/MVV 및 BR의 평균은 최대운동시에 나이가 많은 여성에서도 상당한 환기예비가 있음을 보여주었다. 저자들은 성적을 토대로 운동시간(분), 나이(세), 시장(cm), 체중(kg), 성별(남=0, 여=1), VC(L), $FEV_1$(L) 및 VE max(L) 등을 변수로 해서 구한 주요 지표들의 회귀방정식은 다음과 같다. $VO_2\;max/m^2(L/min)=1.449+0.073{\times}$운동시간-$0.007{\times}$연령+$0.010{\times}$체중-$0.006{\times}$신장-$0.209{\times}$성별, $VCO_2\;max/m^2(L/min)=1.672+0.063{\times}$운동시간-$0.008{\times}$연령+$0.010{\times}$체중-$0.005{\times}$신장-$0.319{\times}$성별, $V_E\;max/m^2(L/min)=58.161+1.503{\times}$운동시간-$0.315{\times}$연령-$9.871{\times}$성별 또는 $V_E\;max/m^2(L/min)=47.873+6.458{\times}FEV_1-5.715{\times}$성별 및 $V_T\;max(L)=1.497+0.223{\times}VC-0.493{\times}$성별. 결론: 본 연구에서 얻은 최대운동시의 호흡성 가스 교환 및 환기기능에 관한 성적은 건강과 체력에 대해서 일반인보다 관심이 높을 것으로 생각되는 스포츠센터 회원들을 대상으로 한 것이기 때문에, 안전상의 문제로 트레드밀의 손잡이를 잡고 검사를 해야하는 환자나 건강인을 위한 이상적인 목표치 내지 정상치를 제공한 것으로 생각된다. Background: Although graded exercise stress tests are widely used for the evaluation of cardiorespiratory performance, normal standards on respiratory gas exchange and ventilatory functions at maximal exercise in Koreans have not been well established. The purpose of this study is to provide reference values on these by sex and age, along with derivation of some of their prediction equations. Method: Symptom-limited maximal exercise test was carried out by Bruce protocol in 1,000 healthy adults consisting of 603 males and 397 females, aged 20~66 years. Among them VC, $FEV_1$ and MVV were also determined in 885 cases. All the subjects were members of a health center, excluding athletes. During the exercise, subjects were allowed to hold on to front hand rail of the treadmill for safety purpose. Results: The $VO_2\;max/m^2$, $VCO_2\;max/m^2$ and $V_E\;max/m^2$ were greater in males than in females and decreased with age. The RR max in men and women was similar but decreased slightly with age. The $V_T$ max was markedly greater in men but showed no significant changes with age in either gender. The mean of $V_T$ max/VC, $V_E$ max/MVV and BR revealed that there were considerable ventilatory reserves at maximal exercise even in older females. The regression equations of the cardinal parameters obtained using exercise time(ET, min), age(A, yr), height(Ht, cm), weight(W, kg), sex(S, 0=male; 1=female), VC(L), $FEV_1$(L) and $V_E$ max(L) as variables are as follows: $VO_2\;max/m^2$(L/min)=1.449+0.073 ET-0.007A+0.010W-0.006Ht-0.209S, $VCO_2\;max/m^2$(L/min)=1.672+0.063ET-0.008A+0.010W-0.005Ht-0.319S, VE max/$m^2$(L/min)=58.161+1.503ET-0.315A-9.871S or VE max/$m^2$(L/min)=47.873+6.548 $FEV_1$-5.715 S, and VT max(L)=1.497+0.223VC-0.493S. Conclusion: Respiratory gas exchange and ventilatory variables at maximal exercise were studied in 1,000 non-athletes by Bruce protocol. During exercise, the subjects were allowed to hold on to hand rail of the treadmill for safety purpose. We feel that our results would provide ideal target values for patients and healthy individuals to be achieved, since our study subjects were members of a health center whose physical fitness levels were presumably higher than ordinary population.

• 한국정보과학회논문지:정보통신
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• 제27권3호
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• pp.348-359
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• 2000

인터넷에서의 대부분의 중요한 실시간 멀티미디어 응용들은 멀티캐스트 서비스를 요구하므로 이들 응용을 ATM 기반의 인터넷에서 지원하기 위해서는 IP 멀티캐스트의 효율적인 처리가 필수적이다. IETF에서는 UNI 3.0/3.1 기반 ATM 망에서 연결형 일대다. ATM VC로 비연결형 IP 멀티캐스트를 지원하기 위해 MARS(Multicast Address Resolution Server)모델을 제안하였다. UNI 3.0/3.1 시그널링으로는 동적으로 멀티캐스트 그룹에 참여하려는 수신원을 VC 연결의 주체인 송신원에게 알릴 수 없기 때문에, MARS는 동적으로 멀티캐스트 그룹에 참여하려는 수신원을 멤버들의 요청을 받아 이를 송신원에게 알려주는 오버레이 서비스를 제공한다. 그런데 ATM Forum이 UNI 3.0/3.1 시그널링을 수정, 보완하여 표준화한 UNI 4.0 시그널링에서는 일대다 ATM VC에 참여하기 위해 수신원이 직접 송신원으로 신호할 수 있는 LIJ(Leaf Initiated Join)기능이 제안되었다. 본 논문에서는 UNI 4.0 기반의 ATM 망에서 LIJ 기능을 이용하여 IP 멀티캐스트 서비스를 제공하는 UNI4MARS 모델을 제안한다. MARS 서버와는 대조적으로, 제안하는 UNI4MARS 서버는 수신원이 LIJ 요청을 할 때 필요로 하는 송신원 정보를 알려주기 위하여 멀티캐스트 그룹에 대한 송신원의 등록/탈퇴 정보를 유지한다. 시뮬레이션을 통하여 비교해 본 결과, 제안하는 UNI4MARS모델은 동적인 IP 멀티캐스트를 지원하는 기능적인 면에서는 기존의 MARS 모델과 동일하지만 송신원에 비하여 수신원의 수가 많은 비대칭적 다중점 대 다중점 응용의 경우 구현에 필요한 프로세싱 오버헤드 및 메모리와 대역폭 요구량 측면에서 MARS 모델보다 유리함을 알 수 있었다.