• Environmental Mutagens and Carcinogens
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• v.18 no.1
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• pp.9-14
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• 1998

By far, the largest known preventable cause of cancer is cigarette smoking. The percentage of cancer deaths in Korea due to tobacco is still increasing. Smoking cigarette at an early age has become more common among women. Tobacco consumption is related causally to cancer to the lung, mouth, larynx, esophagus, bladder, kidney, uterine cervix, and pancreas. Recently, several studies demonstrated that there is very strong correlation between cigarette smoking and p53 mutations in lung cancer, head and neck cancer, and bladder cancer. The recent findings of cigarette smoking and cancer, p53 and bcl-2 mutations, adverse effects of smoking on the effects of radiotherapy, and benefits of quitting will be discussed.

• Journal of Microbiology and Biotechnology
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• v.12 no.3
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• pp.503-507
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• 2002

Chitosan oligosaccharides (COSs) were prepared and fractionated into three groups of COS [a high molecular weight COS (HMWCOS), medium molecular weight COS (LMWCOS), and low molecular weight COS (LMWCOS)] according to their molecular weight, using an ultrafiltration membrane enzymatic bioreactor designed earlier [8]. Antitumor activity of these COSs was then examined against Sarcoma 180 solid (S180) or Uterine cervix carcinoma No. 14 (Ul4) tumor cell-bearing mice. Among these COSs, MMWCOS with molecular weight range from 1.5 to 5.5 kDa effectively inhibited the growth of both tumor cells in the mice. In addition, the administration of MMWCOS resulted in increased thymus weight among lymphoid organs. The mice treated with MMWCOS showed improved survival rate and larger number of survivors after 40 days of feeding. The most effective of MMWCOS far antitumor activity in the S180- or U14-bearing mice was 20 mg/kg/day or more.

• Journal of Haehwa Medicine
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• v.14 no.2
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• pp.213-218
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• 2005

Fluor genitalis(帶下) apply to secretions of the vaginal canal except bleeding. These secretions of the vaginal canal are excessive volume of secretions or abnomal conditions which were progressed exudate of diseased genital atrium. The greater parts of flour genitalis are not critically ill. The greater parts of flour genitalis are continuous with simple infections of cervix, vagina and uterine tube. Fluor genitalis is met with everywhere at gynecology disease and is frequently broken out at least one third of women. This study is designed to find best way of evaluation about the clinical treatment effect of fluor genitalis.

• The Korean Journal of Cytopathology
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• v.4 no.2
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• pp.150-155
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• 1993

We report a case of placental site trophoblastic tumor with cytologic features of cervico-vaginal smear. The smear revealed several loose clusters of atypicai cells in slightly hemorrhagic and inflammatory background. Tumor cells were large in size and polyhedral to round with abundant cytoplasm Nuclei revealed consider-able variation in size, shape, and degree of chromatin clumping. Cytologically, it was difficult to differentiate from squamous cell carcinoma of uterine cervix. Curettage and hysterectomy specimen revealed typical histologic features of placental site trophoblastic tumor composed of intermediate type trophoblasts.

• Radiation Oncology Journal
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• v.2 no.1
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• pp.123-128
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• 1984

To determine the effectiveness of radiotherapy for pain control in metastatic bone disease, we retrospectively analyzed the treatment results in 126 patients who received short-course radiotherapr(2,000 rad/1wk vs 3,000 rad/2wks) in the Department of Therapeutic Radiology, Seoul National University Hospital from Feb. 1979 to July 1983. Pain relief was obtained in $82\%$ of patients and complete Pain relief was obtained in $35.3\%$ of patients. The incidence of metastatic bone tumor was highest in spine and pelvis, $43.7\%\;and\;26.3\%$>, respectively. Primary sites of metastasia were lung, breast, unknown primary, stomach, uterine cervix, in order of frequency. There was no significant difference in the response to treatment between 2,000 rad in 1 week and 3,000 rad in 2 weeks.

• Radiation Oncology Journal
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• v.7 no.1
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• pp.81-83
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• 1989

This study, involving thirty-two patients with carcinoma of uterine cervix treated by high dose rate intracavitary irradiation using a remotely controlled afterloading system, compares the doss at point A and 8 with the Curie-minutes prescription. A linear least-square regression analysis was used to compare the two sets of date. Correlation coefficients between doses at points A and B and the Ci-min prescription are 0.92 (p<0.001) and 0.90 (p<0.001), respectively, and linear relationship is observed between these two system. The limitation and significance of the comparison of the two approaches to intracavitary dosimetry is discussed.

• Archives of Pharmacal Research
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• v.23 no.5
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• pp.477-481
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• 2000

The cytotoxicity of crude insect drugs was measured using HeLa cells originating from human cervix and uterine cancer. using the dye uptake assay in order to find potential anticancer agents. Three kinds of extracts (buffer, methanol and ethylacetate) were prepared from 26 insects and used as raw materials for the activity assay. Among these, the buffer extracts from Tabanus, Mylabris and Huechys showed a potent anticancer activity, and those from Catharsius, Red ant, Scorpion, Tabanus and Vespae Nidus showed a strong L-amino acid oxidase (AAO) activity as well as cytotoxicity. In contrast, buffer extracts from Gryllotalpa orientalis and Apriona germari larvae showed greater/more rapid Hela cell growth than that of other insects.

• Journal of Haehwa Medicine
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• v.16 no.2
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• pp.235-239
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• 2007

Flour genitalis(대하) apply to secretions of vaginal canal exept bleeding. Fluor genitalis is met with everywhere at gynecology disease and is frequently broken out at least one third of women. The greater parts of flour genitalis are not critically ill. The greater parts of flour genitalis are continuous with simple infections of cervix, vagina and uterine tube. Nowadays women increase Bihuh formed flour genitalis(비허형 대하), of which the reasons are stress by vigorous social activity, malnutrition due to harsh diet. so this study has determined that WandaeTang(완대탕) would be effective for recente women flour genitalise which is Bihuh formed flour genitalis.

• The Korean Journal of Cytopathology
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• v.2 no.1
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• pp.56-61
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• 1991

Curschmann's spirals morphologically similar to those seen in sputum were found in cervico-vaginal smears of six patients ranged from 28 to 40 years of age, during 18 months from January. 1985 to June 1986. The prevalence was 1 in 2147 smears in that period. All of them had gynecologic disorders without systemic effect such as chronic cervictis in three, leiomyoma in one, pelvic inflammatory disorder in one, and primary infertility in one. The Curshmann's spirals in the smear showed varying degrees of maturation from wavy incipient ones to highly celled mature ones, admixed with thick mucinous back-ground, suggesting of their production in the uterine cervix itself. Also the recent history of undergone cryocautery, electrocautery or parturition suggest its production in the endocervical gland due to mechanical obstruction and/or change in biochemical composition of mucus.

• Proceedings of the Korea Multimedia Society Conference
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• 2003.05b
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• pp.242-245
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• 2003

현미경을 통해 획득한 세포영상이나 조직영상은 질병의 유무나 암의 진행 정도를 파악하여 환자를 치료하기 위한 매우 중요한 요소이다. 하지만 현재 세포나 조직영상에 대한 분석은 광학현미경을 통해 얻어진 2차원 영상분석방법을 주로 이용하고 있으므로 잘린 단면의 각도나 두께에 따라 서로 다른 분석결과를 나타내는 문제점을 가지고 있다 따라서 본 연구에서는 콘포컬 현미경을 사용하여 50nm 두께의 연속적 섹션 영상을 획득한 후, 이를 바탕으로 자궁경부암세포를 3차원으로 재구성 방법을 제안한다. 본 연구의 결과는 2차원 정량분석에 대한 한계를 극복하고 정확한 진단과 예후 추정으로 환자에게 최적의 임상적 치료를 제공할 수 있는 기반을 마련하는데 활용하고자 한다