• 제목/요약/키워드: Use dependent

검색결과 2,256건 처리시간 0.031초

음주 동기, 문제음주 및 음주 가족력과 대학생의 데이트 폭력 (Motivation for Alcohol Use, Problem Drinking, Family Alcohol Use and Dating Violence among College Students)

  • 서경현
    • 한국심리학회지 : 문화 및 사회문제
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    • 제9권2호
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    • pp.61-78
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    • 2003
  • 본 연구에서는 한국 대학생의 음주 행동과 데이트 폭력의 관계를 검증하였다. 연구 참여자는 이성과의 데이트 경험이 있는 440명의 대학생이었는데, 남학생이 184명이고 여학생이 256명이었다. 이들의 연령 분포는 17세에서 30세까지이었으며, 평균 연령은 20.08세(SD=1.89)였다. Straus의 갈등 책략척도(CTS), 알코올장애분류검사(AUDIT), Cooper의 음주동기 설문지(DMQ), 및 음주가족력목록(IFAU)을 참여자에게 주었다. 주요 통계분석은 2(성별) × 2(데이트 폭력 가해 경험) 이원변량분석 이었다. 분석 결과, 일주일에 한번 이상 술을 마시는 대학생이 그렇지 않은 대학생보다 데이트를 하면서 이성친구에게 폭력을 행할 가능성이 높았다. 여학생보다는 남학생들이 음주에 더 동기화가 되어 있었으며, 데이트 폭력 가해 경험이 있는 학생이 그렇지 않은 학생보다 대처동기를 가지고 술을 마시는 것으로 나타났다. 남학생은 여학생보다 문제음주, 즉 위험음주, 의존음주, 유해음주를 더 하고, 데이트 폭력 가해 경험이 있는 학생이 그렇지 않은 학생보다 문제음주를 더 하는 경향이 있었다. 또한, 데이트 폭력 가해 경험이 있는 학생이 그렇지 않은 학생보다 음주 가족력 검사에서 더 높은 점수를 보였다. 의존음주와 유해음주에는 성별과 데이트 폭력 가해 여부의 유의한 이원 상호작용이 발견되었다. 단순주효과 분석 결과, 데이트 폭력 가해 여부에 따른 의존음주 혹은 유해음주의 차이는 여성보다 남성에게서 더 현저하게 나타났다.

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OIQ와 CIO의 경영자 역할이 정보시스템의 전략적 활용에 미치는 영향 연구 (A Study on the Effects of Organizational Intelligence Quotient and CIO's Management Roles on Strategic Application of Information Systems)

  • 김한성;채명신
    • 한국정보시스템학회지:정보시스템연구
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    • 제17권3호
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    • pp.255-287
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    • 2008
  • This study examined the relationship among constructs that impact on strategic use of IS(Information Systems). Independent variables were OIQ(Organizational Intelligence Quotient) and role of CIO(Chief of Information Officer) as a top manager, and dependent variable are strategic use of IS. The dependent variable has three-sub constructs: 1) IT infrastructure flexibility; 2) operation-orientation; and 3) market-orientation. Seven research hypotheses derived from the research model, and were empirically tested using the PLS (Partial Least Squares) method. The research results confirmed that both OIQ and CIO's roles have strong impact on organizations' strategic use of IS. Communication and business network among the sub-constructs of OIQ have effect on strategic use of IS. CIO's role as a top manager was found to be significant. CIO's role as a resource allocator and innovator among the CIO's roles showed significant influence on strategic use of IS. OIQ was also significantly related to CIO's role as a top manager. This study suggests practical implications and insights to the enterprises which aim to apply IT strategically.

Open channel block of Kv1.4 potassium channels by aripiprazole

  • Park, Jeaneun;Cho, Kwang-Hyun;Lee, Hong Joon;Choi, Jin-Sung;Rhie, Duck-Joo
    • The Korean Journal of Physiology and Pharmacology
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    • 제24권6호
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    • pp.545-553
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    • 2020
  • Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2 receptors. Although it is known to be relatively safe for patients with cardiac ailments, less is known about the effect of aripiprazole on voltage-gated ion channels such as transient A-type K+ channels, which are important for the repolarization of cardiac and neuronal action potentials. Here, we investigated the effects of aripiprazole on Kv1.4 currents expressed in HEK293 cells using a whole-cell patch-clamp technique. Aripiprazole blocked Kv1.4 channels in a concentration-dependent manner with an IC50 value of 4.4 μM and a Hill coefficient of 2.5. Aripiprazole also accelerated the activation (time-to-peak) and inactivation kinetics. Aripiprazole induced a voltage-dependent (δ = 0.17) inhibition, which was use-dependent with successive pulses on Kv1.4 currents without altering the time course of recovery from inactivation. Dehydroaripiprazole, an active metabolite of aripiprazole, inhibited Kv1.4 with an IC50 value of 6.3 μM (p < 0.05 compared with aripiprazole) with a Hill coefficient of 2.0. Furthermore, aripiprazole inhibited Kv4.3 currents to a similar extent in a concentration-dependent manner with an IC50 value of 4.9 μM and a Hill coefficient of 2.3. Thus, our results indicate that aripiprazole blocked Kv1.4 by preferentially binding to the open state of the channels.

Encainide, a class Ic anti-arrhythmic agent, blocks voltage-dependent potassium channels in coronary artery smooth muscle cells

  • Hongliang Li;Yue Zhou;Yongqi Yang;Yiwen Zha;Bingqian Ye;Seo-Yeong Mun;Wenwen Zhuang;Jingyan Liang;Won Sun Park
    • The Korean Journal of Physiology and Pharmacology
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    • 제27권4호
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    • pp.399-406
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    • 2023
  • Voltage-dependent K+ (Kv) channels are widely expressed on vascular smooth muscle cells and regulate vascular tone. Here, we explored the inhibitory effect of encainide, a class Ic anti-arrhythmic agent, on Kv channels of vascular smooth muscle from rabbit coronary arteries. Encainide inhibited Kv channels in a concentration-dependent manner with an IC50 value of 8.91 ± 1.75 μM and Hill coefficient of 0.72 ± 0.06. The application of encainide shifted the activation curve toward a more positive potential without modifying the inactivation curve, suggesting that encainide inhibited Kv channels by altering the gating property of channel activation. The inhibition by encainide was not significantly affected by train pulses (1 and 2 Hz), indicating that the inhibition is not use (state)-dependent. The inhibitory effect of encainide was reduced by pretreatment with the Kv1.5 subtype inhibitor. However, pretreatment with the Kv2.1 subtype inhibitor did not alter the inhibitory effects of encainide on Kv currents. Based on these results, encainide inhibits vascular Kv channels in a concentration-dependent and use (state)-independent manner by altering the voltage sensor of the channels. Furthermore, Kv1.5 is the main Kv subtype involved in the effect of encainide.

2차원 관리도와 관리도를 이용한 독립변수와 종속변수의 관계연구 (Study on 2 dimensional Control Chart and Search interrelation Independent variable and dependent variable by using control chart considered simultaneously)

  • 이상복;김명훈
    • 한국품질경영학회:학술대회논문집
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    • 한국품질경영학회 2006년도 추계 학술대회
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    • pp.195-198
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    • 2006
  • In this paper, we propose a 2dimension Control Chart. Suggested which Control chart augments Schwart Control chart which is 1-dimensional and Independent variable and dependent variable interrelationship by using control chart. Schwart control chart cannot use input variable and output variable together. In this paper, we try to analysis input variable and output variable dependent and effect. So called 2-dimensional control char.

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CAPPI 반사도의 오차구조 및 지구곡률효과로 인한 거리오차 보정 (The Error Structure of the CAPPI and the Correction of the Range Dependent Error due to the Earth Curvature)

  • 유철상;윤정수
    • 대기
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    • 제22권3호
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    • pp.309-319
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    • 2012
  • It is important to characterize and quantify the inherent error in the radar rainfall to make full use of the radar rainfall. This study verified the error structure of the reflectivity and corrected the range dependent error in the CAPPI using a VPR (vertical profile of reflectivity) model. The error of the CAPPI to display the reflectivity data becomes bigger for the range longer than 100 km. This range dependent error, however, is significantly improved by corrected the CAPPI data using the VPR model.

높이 맵의 효율적인 뷰 의존적 표현 (Efficient View-dependent Refinement of a Height Map)

  • 정용호;함원경;박상철
    • 한국CDE학회논문집
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    • 제19권1호
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    • pp.61-67
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    • 2014
  • This paper proposes a procedure enabling the extraction of view-dependent triangular approximations from a height map. In general, procedures to approximate a height map use tree hierarchies. These methods, however, have a limitation in terms of accuracy, because they depend on tree hierarchy than terrain features. To overcome the difficult, we apply the simplification method for triangular meshes to a height map. The proposed procedure maintains full decimation procedure to support multiresolution. The maintenance of decimation procedure results in creation of the groups (trees), each of which consists of vertices that can be merged into one vertex (root node). As the groups have tolerance which is determined by some tests, they support the generation of view-dependent arbitrary triangular meshes.

주파수 의존적인 회로상수를 이용한 시변자장 시스템의 과도상태 해석 (Transient Analysis of Magnetodynamic Systems Using Frequency-dependent Circuit Parameters)

  • 최명준;이세희;박일한
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 1999년도 하계학술대회 논문집 A
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    • pp.61-63
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    • 1999
  • This paper presents an efficient method for analysis of magnetodynamic system using frequency-dependent parameters. In equivalent electric circuit of linear magnetodynamic system, parameters of inductance and resistance are not constant since they vary with its driving frequency. Once frequency-dependent parameters of equivalent electric circuit for a given system are extracted, they can be used to analyze various characteristics of system. We use the Fourier transform, the high-order sensitivity method and Taylor series in order to efficiently extract the frequency-dependent parameters of magnetodynamic system. The proposed algorithm is applied to an induction heating system to validate its numerical efficiency.

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Generalized methods of moments in marginal models for longitudinal data with time-dependent covariates

  • Cho, Gyo-Young;Dashnyam, Oyunchimeg
    • Journal of the Korean Data and Information Science Society
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    • 제24권4호
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    • pp.877-883
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    • 2013
  • The quadratic inference functions (QIF) method proposed by Qu et al. (2000) and the generalized method of moments (GMM) for marginal regression analysis of longitudinal data with time-dependent covariates proposed by Lai and Small (2007) both are the methods based on generalized method of moment (GMM) introduced by Hansen (1982) and both use generalized estimating equations (GEE). Lai and Small (2007) divided time-dependent covariates into three types such as: Type I, Type II and Type III. In this paper, we compared these methods in the case of Type II and Type III in which full covariates conditional mean assumption (FCCM) is violated and interested in whether they can improve the results of GEE with independence working correlation. We show that in the marginal regression model with Type II time-dependent covariates, GMM Type II of Lai and Small (2007) provides more ecient result than QIF and for the Type III time-dependent covariates, QIF with independence working correlation and GMM Type III methods provide the same results. Our simulation study showed the same results.

전자기 과도현상 해석을 위한 S 영역 등가시스템 PART I : 주파수 의존 시스템 등가 (S-Domain Equivalent System for Electromagnetic Transient Studies PART I : Frequency Dependent Network Equivalent)

  • 왕용필
    • 대한전기학회논문지:전력기술부문A
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    • 제52권11호
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    • pp.632-638
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    • 2003
  • Modern power systems are very complex and to model them completely is impractical for electromagnetic transient studies. Therefore areas outside the immediate area of interest must be represented by some form of frequency dependent equivalent. The s-domain rational function form of frequency dependent equivalent does not need refitting if the simulation time-step is changed in the electromagnetic transient program. This is because the s-domain rational function coefficients are independent of the simulation time-step, unlike the z-domain rational function coefficients. S-domain rational function fitting techniques for representing frequency dependent equivalents have been developed using Least Squares Fitting(LSF). However it does not suffer the implementation error that exited in this work as it ignored the instantaneous term. This paper Presents the formulation for developing 1 Port Frequency Dependent Network Equivalent(FDNE) with the instantaneous term in S-domain and illustrates its use. This 1 port FDNE have been applied to the CIGRE Benchmark Rectifier test AC system. The electromagnetic transient package PSCAD/EMTDC is used to assess the transient response of the 1 port (FDNE) developed with Thevenin and Norton Equivalent network. The study results have indicated the robustness and accuracy of 1 port FDNE for electromagnetic transient studies.