• Journal of Chest Surgery
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• 제16권2호
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• pp.213-220
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• 1983

Pulmonary function is the determinant of blood gas tension. However, Acid-Base disturbances can also alter partial pressures of oxygen and carbon dioxide in arterial blood. During respiratory acidosis $PO_2$ will be lowered and reverse changes will be produced during respiratory alkalosis. On the other hand, in metabolic acidosis $PO_2$ will be elevated and $PCO_2$ will be lowered by the respiratory compensation, and reverse response will be induced in metabolic alkalosis. Urinary gas tension has many influencing factors than arterial blood and difficult to estimate the tendency of its alterations. Urinary $PO_2$ and $PCO_2$ are not always identical level as venous blood. It is to be altered by blood gas tension, flow rate of urine, metabolic rate of kidney, and Acid-Base status of blood. Particularly countercurrent exchange of oxygen and carbon dioxide in the renal medulla will make larger alteration of gas tension than venous blood. After induction of Acid-Base disturbances [disturbances] arterial and urinary $PCO_2$, $PO_2$, urinary volume, and osmolarity were determined in dogs, and the relationships between arterial and urinary $PCO_2$ , $PO_2$ Acid-Base disturbances, urinary volume, and osmolarity were investigated. 1. During the acute Metabolic and Respiratory disturbances urinary pH did not respond on respiratory origin. However, there were immediate urinary response in pH on metabolic origin. 2. Urinary $PO_2$, $PCO_2$, did not always follow arterial or venous gas tension and Acid-Base disturbance. Urinary $PCO_2$, correlate well with the urinary volume. The larger the urinary volume, $PCO_2$ lowered to the venous level. The smaller the urinary volume, urinary $PCO_2$ tends to be higher. However urinary $PO_2$ did not have any particular correlation with urinary volume. 3. Correlation between urinary $PCO_2$ and $PO_2$ were inversely proportional to arterial blood. Differences of $PCO_2$ between arterial blood and urine also did not have any particular correlation with urinary volume. This may suggest that changes on blood gas tensions can influence on urinary $PCO_2$. 4. There were eminent clear inverse correlation between urinary $PCO_2$ and osmolar concentrations of urine. Above results strongly suggest that partial pressure of gas in urine primarily depend upon counter-current exchanges in renal medullary tissues.

• 대한간호학회지
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• 제27권3호
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• pp.683-693
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• 1997

Urinary incontinence is defined as the involuntary and inappropriate loss of urine to failure to emit normal responses as the bladder fills, or inability to reach the bathroom in sufficient time. This study was undertaken to estimate the incidence of urinary incontinence and to determine the correlates of urinary incontinence among women. Subjects of this survey consisted of 408 women, 26 to 83 years old in Incheon. The results of this study are as follows. 1. Of the subjects 50.7% reported urine loss once or twice per year and 28.5% reported incontinence on a regular basis at least once per month. 2. 40.5% of women reported small volume accidents of only 1 to 2 drops, 31.4% ; 1 t-spoon, 16.9% : 1 T-spoon, while 10.1% of women couldn't estimate the volume of urine loss. 3. The volume of urine loss was great enough to require a change of garment (undergarments or outer garments) in 73%. But only 3.8% of those used some type of pads. 4. 56.5% of incontinent women didn't talk about their urinary incontinence with other persons because they felt that urinary incontinence was shameful(38.4%), was not a disease(31.6%), was incurable in spite of treatment(27.4%) and was fearful of being uncured (2.6%). 5. Only 15.5% of urinary incontinent women had sought treatment. 6. The incidence of urinary incontinence was significantly higher in women who had more pariety and uterine-ovarian disease, older age, worrying about where toilets were when they visited new places or voiding anxiety, nocturia and frequency, but was significantly lower in women who had coffee intake. The incidence of urinary incontinence was not related to smoking and enuresis. The results indicate that urinary incontinence is common among young and middle-aged women. That few seek treatment for urinary incontinence suggests a need for more information about women's attitudes toward urinary incontinence and more attention to this problem by health care providers.

• 생약학회지
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• 제15권4호
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• pp.179-187
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• 1984

To investigate the recorded efficacy in Oriental medical references and effects in clinics, experimental studies were undertaken to estimate 'Palmiwhan' to the diuretic effect in normal rats, rabbits and rats with $HgCl_2-induced$ acute renal failure and hypotensive effects on the nephrogenous hypertension in rabbits with $HgCl_2-induced$ acute renal failure. The results of this study were summarized as follows; Increase in urinary volume, urinary $Na^+\;and\;Cl^-$ excretions were significantly recognized in normal rats and rabbits. Increase in urinary volume, urinary $Na^+\;and\;Cl^-$ excretions were significantly shown in rats with 2mg/kg $HgCl_2-induced$ acute renal failure. Although plasma electrolyte and creatinine levels were little affected, plasma urea nitrogen levels were significantly elevated in normal rats and 2mg/kg $HgCl_2-induced$ acute renal failure of rats. Although the blood pressure was not affected in normal rabbits and cats, hypotensive actions due to the diuretic effect were recognized in rabbits $HgCl_2-induced$ acute renal failure.

• 대한한의학회지
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• 제21권1호
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• pp.99-102
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• 2000

Central diabetes insipidus(CDI) results from deficient vasopressin(antidiuretic hormone) secretion and causes polydipsia and polyuria. Its etiologic diagnosis is confirmed with an increase of urine osmolality by administering desmopressin(DDAVP) after water restriction. Because cm is caused by deficiency of vasopressin, up to now, desmopressin, a synthetic analog of vasopressin, has been the drug of choice in the treatment of CDI. However, under such treatment, CDI patients suffer from the continual administration of DDAVP throughout one's life and high cost of the treatment We administrated oriental herb medicine on a cm patient in a state of discontinuance of DDAVP. Prior to the study, brain sella MRI was scanned to exclude germinoma. In addition, urine analysis, serum and urinary osmolality, daily urinary volume, serum electrolyte levels were measured. Chungsimyunjatang was administered for 15 days, and urine analysis, urine osmolality, daily urinary volume, serum Na were measured several times again during the therapy, As a result, urinary frequency increased, serum Na slightly elevated, but specific gravity of urine, urinary osmolality severely decreased and daily urinary volume substantially increased. However, the frequency of DDAVP treatment was reduced from four times per day to once or twice a day with the continual administration of the Chungsimyunja-tang for two months after the discharge.

• 동의생리병리학회지
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• 제16권2호
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• pp.257-261
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• 2002

This experimental study was designed to investigate the effect of water extracts of Chukchunwhan on the urine metabolism in rat. The results are summarized as follows ; 1. Treatment with Chukchunwhan-extracts increased excreted-urine volume of rat at the first week, however markedly decreased the excreted-urine volume at 2nd week. 2. Chukchunwhan-extracts inhibited the high level of excreted-urinary protein from rat for two weeks. 3. Chukchunwhan-extracts did not affect on the excreted-urine components of rat except for urinary protein. The results suggest that water-extracts of Chukchunwhan can be applicable to the abnormal volume of urine without medical poisoning, which have been used in the all sort of urinary diseases.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.209.1-209.1
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• 2003

Polygoni cuspidatum has been used as treatments of dermatitis, inflammation and hyperlipidemia, and diuretic in folk medicine. In order to evaluate the urinary effect of Polygoni cuspidati Radix, its MeOH extract was administered in rats by in vivo test. We measured urine volume, chemical parameters, and electrolytes in serum and urine of the rats.The results showed that Polygoni cuspidati Radix MeOH extract had urinary volume increase and normal level parameters in rats.

• 성인간호학회지
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• 제25권6호
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• pp.679-689
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• 2013

Purpose: This prospective study was designed to investigate the prevalence of urinary incontinence (UI), voided volume, post void residual volume (PVRV), daytime frequency and nocturia in women over 40 years. Methods: The sample comprised of 302 women over 40 years.The study lasted from February 2008 to November 2009. Data about daytime frequency and nocturia were gathered from 48 hour bladder diary. Further, a PVRV was assessed through a bladder ultrasonography. Data were analyzed using the t-test, Mann Whitney test, Kruskal Wallis test and multiple regression. Results: Although the prevalence of UI among the women was as high as 70.5%, the perception rate of UI was as low as 10.8%.Single voided volume of women without or with UI was 223 mL or 198 mL (p<.001), respectively; PVRV, 25.8 mL or 23.6 mL (p=.055); daytime frequency, 5.89 or 6.96 (p<.001); nocturia, 0.99 or 1.23 (p=.040). Age (${\beta}$=0.19, p=.001), single voided volume (${\beta}$=-0.16, p=.006), and nocturia (${\beta}$=0.12, p=.034) were associated with UI. Conclusion: The prevalence of UI was found to be 70.5% among the participants. The assessment of single urinary volume and nocturia through a bladder diary lends support to identifying UI for women over 40 years.

• PNF and Movement
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• 제16권1호
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• pp.19-26
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• 2018

Purpose: The purpose of this study was to investigate changes in urinary frequency, residual urine volume, and quality of life following pelvic floor exercises using proprioceptive neuromuscular facilitation (PNF) exercise patterns and EMG biofeedback training in patients with stress urinary incontinence. Methods: The subjects were male patients diagnosed with stress urinary incontinence. This study used a single system design (A-B-C.) At baseline, the patients' symptoms prior to the treatment intervention were recorded (A section). Next, the patients performed the PNF exercise (B section). Thereafter, they performed the PNF exercise, with EMG biofeedback (C section). The subjects performed the exercises in each section for 1 week for a total of 3 weeks. Urinary frequency, residual urine volume, and quality of life of the subjects were measured. Results: The frequency of urination was 9 times in A, 8 times in A 'and B, and 7 times in C. The amount of residual urine decreased from 23.78ml in A to 21.85ml in A ', 14.85ml in B, and 14.63ml in C. The international prostate symptom score was 16 points in A, 14 points in A ', 11 points in B, and 7 points at A. The quality of life score was 4 points in A, 4 points in A ', 3 points in B, and 2 points in A. Conclusion: Both the PNF exercise and EMG biofeedback decreased urination frequency and residual urine volume and improved the quality of life of patients with stress urinary incontinence. EMG biofeedback training using the PNF technique was the most effective.

• Journal of Acupuncture Research
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• 제15권2호
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• pp.255-277
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• 1998

The aim of this experiment was to investigate the effects of Aqua-Acupuncture of Yukmijiwangtang(六味地黃湯) and Palmijihwang-tang(八味地黃湯) water extracts applied at the meridian points BL 23(賢兪) and GV 4(命門) to test the renal function in normal rats. The results obtained were as follows; 1. Among the effects of Aqua-Acupuncture of Yukmijihwangtang water extract at the merdian point BL 23 group, there were significant changes in water balance and urine volume over a 1 week period; Both decreasing and decreasing trends were exihibited. Urinary excretion of sodium and free water clearance changed significantly over a 2 week period; Both decreasing and increasing trends were exihibited, Urinary excretion of potassium, chloride and creatinine, plasma renin activity, plasma levels of aldosterone and atrial natriuretic peptide showed no significant differences compared to the contral group. 2. Among the effects of Aqua-Acupuncture of Palmljihwangtang water extract at the merdian point BL 23 group, there were significant changes in water balance and free water clearance over a 2 week period; a decreasing trend. Urinary excretion of creatinine changed significantly over a 2 week period; an increasing trend. Urinary excretion of chloride changed significantly over 1 week period; an increasing trend. The plasma levels of atrial natriuretic peptide changed significantly over 1 and 2 week period; an increasing trend. Urine volume, urinary excretion of sodium and pottasium, plasma renin activity and plasma level of aldosterone showed no significant differences compared to the control group. 3. Among the effects of Aqua-Acupuncture of Yukmijihwangtang water extract at the meridian point GV 4 group, there was significant decrease in water balance over a 2 week period; there was significant decrease in urine volwne and urinary excretion of sodium and creatinine over a 1 week period, followed by an increasing trend after 2 weeks. Urinary excretion of free water clearance demonstrated significant changes over both 1 and 2 week period; both increasing and decreasing trends were exihibited. Urinary excretion of chloride and plasma levels of aldosterone increased significantly over 1 and 2 week period. Plasma levels of atrial natriuretic peptide also decreased significantly. Plasma renin activity showed no significant differences compared to the control group. 4. Among the effects of Aqua-Acupuncture of Palmijihwangtang water extract at the meridian point GV 4 group, water balance and urinary excretion of chloride, plasma levels of aldosterone decreased significantly over both 1 and 2 week period. Urine volume and urinary excretion of pottasium decreased significantly. Urinary excretion of creatinine and urinary excretion of sodium changed significantly over both 1 and 2 week period. Urinary excretion of free water clearance, plasma renin activity and plasma level of atrial natriuretic peptide showed no significant differences compared to the control group. Seeing these results, I come to know that the effects Aqua-Acupuncture of Yukmijihwangtang and Palmijihwangtang water extracts at the meridian point BL 23 and GV 4 have affected the renal function differently. Seeing the results that BL 23 is a meridian point for Aqua-Acupuncture directly related to the kidney, I think, we can use Aqua-Acupuncture of Yuk-mijihwangtang and Palmijihwangtang water extracts to prevent and to treat the diseases related to kidney.

• Radiation Oncology Journal
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• 제26권4호
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• pp.237-246
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• 2008

목 적: 국소적 전립선암에 대한 근치적 목적의 방사선치료시 3차원 입체조형방사선치료(3-dimensional conformal radiotherapy, 3DCRT) 또는 세기조절방사선치료(intensity modulated radiotherapy, IMRT)를 시행하면 직장의 부작용이 현저히 감소하지만 비뇨기계 부작용의 발생률은 감소하지 않는다. 방사선 치료로 인한 급성 비뇨기계 부작용은 환자의 삶의 질을 저하시킬 뿐 아니라 만성 비뇨기계 부작용의 발생을 증가시킨다. 따라서 비뇨기계 부작용을 줄이기 위해 방광을 채운 상태에서 방사선치료를 하는 방법이 제안되었는데 이 경우 방사선 조사야에 포함되는 방광의 면적이 줄어들어 부작용이 감소한다고 알려져 있다. 본 연구에서는 전립선암의 방사선치료시 방광의 부피가 급성 비뇨기계 부작용에 미치는 영향에 대하여 알아보고자 한다. 대상 및 방법: 전립선암으로 근치적 목적의 방사선치료를 받은 환자 42명을 대상으로 하였으며 대조군과 실험군이 각각 21명씩 포함되었다. 대조군은 본 연구가 계획되기 전에 방광 조절을 하지 않고 방사선치료를 시행 받은 환자 중 무작위로 추출하였고, 실험군은 치료 1시간 전 450 ml의 물을 마셔 방광을 채운 상태에서 방사선치료를 받은 환자들이었다. 모의치료시 설계용 CT와 초음파를 이용하여 방광의 부피를 측정하였고, 실험군에서는 방사선 치료 기간 동안 초음파로 매주 방광의 부피를 측정하였다. 결 과: 모의치료시 초음파로 측정한 방광의 부피와 CT로 측정한 방광의 부피는 유의한 상관성을 보여(r=0.679) 방광 부피를 측정하는 데 있어 초음파의 정확성을 확인하였다. 실험군에서 같은 양의 물을 마셔도 방광의 부피는 환자에 따라 차이가 컸고(범위 $22{\sim}352\;ml$), 방사선치료 기간 동안 방광의 부피는 일정하게 유지되지 않았다. 그러나 모의치료시 방광의 부피가 컸던 환자는 치료기간 중에도 방광의 부피가 큰 경향을 보였다. 실험군의 방광 부피는 평균 $299{\pm}155\;mL$이었고 대조군은 평균 $187{\pm}155\;ml$로, 일정량의 물을 마시면 방광 조절을 하지 않았을 때보다 방광 부피가 유의하게 증가하였고(p=0.009), 실험군에서 급성 비뇨기계 부작용이 대조군보다 감소하였지만 통계적으로 유의하지는 않았다 또한 방광의 부피가 클수록 부작용이 감소하는 경향을 보였고, 모의치료시 CT로 측정한 방광의 부피가 150 ml 이상이면 1등급과 2등급의 비뇨기계 부작용이 현저히 감소하였다(p=0.023). 치료 기간 중의 방광 부피에 따른 부작용 발생률은 통계적으로 유의한 변화를 보이지 않았으나 방광의 부피가 클수록 1등급 부작용이 감소하는 경향을 보였고, 100 ml 이상인 경우에는 모든 등급의 부작용이 감소하는 경향을 보였다. 결 론: 방광을 채우고 방사선치료를 할 때 치료 기간 중 방광의 부피가 일정하게 유지되지 않았음에도 불구하고 방광 조절을 하지 않았을 때보다 비뇨기계 급성 부작용이 감소하는 경향을 보였고, 모의치료시 방광 부피가 150 mL 이상인 경우 부작용은 현저히 감소하였다. 따라서 전립선암 환자에서 방사선치료를 할 때 방광을 채우는 것이 급성 비뇨기계 부작용을 줄이는 데 도움이 될 것으로 생각한다.