• The World Journal of Men's Health
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• 제34권2호
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• pp.137-144
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• 2016

Purpose: We compared a transperineal ligation model and a transperitoneal ligation model in male rats to determine which animal model of overactive bladder (OAB) was more useful based on cystometrography, estimations of oxidative stress, and measurements of pro-inflammatory cytokine levels. Materials and Methods: Male rats were randomly divided into three groups (n=15 in each): the control group, the transperineal ligation group, and the transperitoneal ligation group. Four weeks after the ligation procedure, cystometrography was performed and oxidative stress, pro-inflammatory cytokine levels, and histologic changes were evaluated. Oxidative stress was assessed by measuring 8-hydroxy-20-deoxyguanosine and superoxide dismutase, and pro-inflammatory cytokine activity was investigated by measuring levels of interleukin (IL)-6, IL-8, and tumor necrosis $factor-{\alpha}$. Results: The transperineal model led to results similar to those observed for the transperitoneal model, namely (1) increased voiding frequency and reductions in the non-voiding contraction interval and the maximal vesical pressure, (2) increased levels of oxidative stress markers, (3) increased pro-inflammatory cytokine levels, and (4) fibrotic changes in the bladder tissue. Conclusions: We suggest that the transperineal procedure can be used as an alternative OAB model in male rats.

• 대한융합한의학회지
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• 제3권1호
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• pp.29-38
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• 2022

Objectives : The purpose of this study is to investigate the effect of Sa-am acupuncture and Moxibustion on urgency by Overactive bladder in a 79-year-old female patient who has undergone Tension-free Vaginal Tape (TVT) operation. Methods : Patient was treated with Sa-am acupuncture on four acupoints including 太淵(LU9), 太白(SP3), 魚際(LU10) and 少府(HT8) and Moxibustion on two acupoints including 水道(ST28) and 中極(CV12). Patient's symptom was assessed Overactive Bladder Symptom Score(OABSS), Bladder diary and King's Health Questionnaire (KHQ). The treatment was executed once everyday from June, 13th to June, 22th of 2017. Patient was observed from June, 11th to June, 22th. Results : After ten sessions of Sa-am acupuncture and Moxibustion, patient's urinary symptoms were evaluated by OABSS, Bladder diary, and KHQ. After the treatment, total OABSS score decreased from 9 to 5. The frequency of Urgency decreased from 4 to 1. The Urgency grade decreased 4~5 to 1. The mean number of pad changing decreased 3.5 to 1. The score of Role Limitations, Physical Limitations, Social Limitations, Emotions in KHQ decreased. Conclusions : The results suggest that Sa-am acupuncture and Moxibustion can be a valuable option in treating urgency by OAB.

• 대한한방부인과학회지
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• 제33권3호
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• pp.1-19
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• 2020

Objectives: The purpose of this study is to assess the efficacy and safety of electroacupuncture for women with overactive bladder (OAB) comparing with sham- acupuncture, and electroacupuncture plus drugs. Methods: We searched 8 databases upto May 26, 2020. Randomised controlled trials (RCTs) were eligible. The risk of bias was assessed by two independent authors using the Cochrane risk of bias tool. Study outcomes were calculated by standardized mean differences (SMD) with 95% confidence intervals (Cls) and mean differences (MD) with 95% Cls. Results: Of 146 screened, 5 RCTs were included. Number of participants per study ranged from 5 to 57. The combined results showed that electroacupuncture (EA) may be more effective than sham acupuncture or enhance solifenacin succinates in improving Overactive Bladder Symptom Score (OABSS) and urination frequency of 24 h. However, more trials with high quality and larger sample sizes will be needed to provide sufficient evidence. Only 5 of 187 OAB patients from the included studies reported mild adverse reactions related to EA, therefore, electroacupuncture is safe for treating OAB. Conclusions: Electroacupuncture might have effect in decreasing urination frequency of 24 h and OABSS. However, the evidences ins in sufficient to show the effect using electroacupuncture alone or additional effect to drugs in treating OAB.

• 대한한의학회지
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• 제45권1호
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• pp.240-250
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• 2024

Objectives: The purpose of this study is to report a case of Korean medicine treatment accompaning myofascial trigger-point accupuncture for severe & persistent lower urinary tract symptoms after radical prostatectomy. Materials and Methods: A prostate cancer patient with severe & persistent lower urinary tract symptoms after radical prostatectomy conducted 26 months ago, was treated with Korean medicine accompaning myofascial trigger-point accupuncture. The International Prostate Symptom Score(IPSS), the IPSS Quality of Life(IPSS-QoL) and the Overactive Bladder Symptom Score(OABSS) questionaires were administered to evaluate the effect of treatment for lower urinary tract symptoms. Results: After 5 month treatment with Korean medicine accompaning myofascial trigger-point accupuncture, IPSS, IPSS-QoL and OABSS progressed from 28 to 8, from 5 to 2 and from 12 to 4 respectively. Conclusion: This case study suggests that Korean medicine accompaning myofascial trigger-point accupuncture may contribute to treat severe & persistent lower urinary tract symptoms after radical prostatectomy.

• 여성건강간호학회지
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• 제19권4호
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• pp.295-305
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• 2013

Purpose: The objective of this study was to identify the relationships among symptom bother, physical and mental stress and health-related quality of life (HRQoL) in women with overactive bladder (OAB) syndrome. Methods: The participants were 106 women who were diagnosed with OAB (urgency, urge urinary incontinence, frequency, and/or nocturia) at P university hospital. Data were collected from Dec 23, 2011 to Aug 31, 2012. Results: The mean score for symptom bother was 43.1 points, for physical stress, 12.8 which was slightly higher than mental stress (11.8), and for HRQoL, 63.9. For symptom type, there were statistically significant differences in the symptom bother (F=8.67, p<.001) and HRQL (F=3.32, p=.023). The Symptom bother of OAB was positively correlated with physical stress (r=.23, p=.014) and mental stress (r=.33, p<.001) and negatively correlated with the subscales of HRQoL; coping (r=-.66, p<.001), concern (r=-.71, p<.001), sleep (r=-.59, p<.001), and social interaction (r=-.58, p<.001). Conclusion: From the results, bother symptom was associated with physical, mental stress and HRQoL. These results suggest that nursing intervention programs for OAB should be developed not only to relieve the symptoms but also to reduce stress and improve the quality of life.

• Natural Product Sciences
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• 제27권3호
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• pp.193-200
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• 2021

Sophora flavescens Ait. (Fabaceae) is a medicinal plant widely founded in Northeast Asia, and its dried root (Kushen) has been used as a traditional Chinese herbal medicine. The therapeutic effects of Kushen in micturition disorder was not investigated comprehensively yet. In the present study, we examined and compared the efficacy of three batches of Kushen extract using different ethanol content through an in vitro cell-based assay. Among them, we chose the batch with the highest efficacy and augmented the volume of extract for industrial purpose. The bulk extract was examined in its efficacy in the in vitro cell-based assay, and the therapeutic effects through an in vivo behavioral assay of OAB rats. The main components of the extracts were analyzed by liquid chromatography. Cytotoxicity of the extracts was investigated by MTT assay. The overall efficacy of the extract was as much as, or more than, kurarinone, a potent BK_Ca channel activator. Thus, the extract was a potent relaxant of urinary smooth muscle by upregulating the activity of BK_Ca channel. The Kushen extract could be explored as an alternative medicine against overactive bladder patients indicating severe dysfunction of BK_Ca channel.

• Journal of Medicine and Life Science
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• 제20권4호
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• pp.166-171
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• 2023

Mixed urinary incontinence (UI) is common in women. This study aimed to assess the efficacy of anti-incontinence surgery in female patients with equally severe stress UI (SUI) and urge UI (UUI). All patients had equal severity of SUI and UUI. The postoperative cure rate was categorized into the cure group (CG) and failure group (FG). Postoperative satisfaction was categorized into the satisfaction group (SG) and the dissatisfaction group (DG). Statistical significance was set at P<0.05. Ninety patients (SG, 73.3%; DG, 26.7%; CG, 93.3%; FG, 6.7%) were included in the study. In the univariate analysis, body mass index (BMI), total bladder capacity, and overactive bladder symptom score (OABSS) were significantly different between the SG and DG groups. Peak urinary flow, Valsalva leak point pressure (VLPP), and OABSS were significantly different between the CG and FG groups. In the multivariate analysis, OABSS (P=0.001) and BMI (P=0.032) were independent predictors of postoperative satisfaction. VLPP (P=0.023) was the only independent factor associated with the postoperative cure rate. In equal severity of SUI and UUI, VLPP was found to be the only independent factor associated with postoperative cure rates. Higher VLPP values were associated with higher cure rates. BMI and OABSS were identified as independent predictors of postoperative satisfaction, with lower BMI and OABSS associated with higher postoperative satisfaction.

• 사상체질의학회지
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• 제33권3호
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• pp.16-28
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• 2021

Introduction The Sasang Urination Defecation Inventory was developed to analyze Sasang-type specific pathophysiological clinical symptoms, and its revised Sasang Urination Inventory (SUI) illustrated its clinical usefulness in Sasang type differentiation. However, the correlation with established clinical measures for its concurrent validity were not provided yet. Methods Total of 48 healthy university students were recruited to response Urogenital Distress Inventory-6 (UDI-6) and Overactive Bladder Symptom Score (OABSS) of Western medicine along with the SUI of traditional Korean medicine. The correlation coefficients between UDI-6 and OABSS and SUI were acquired with Pearson's correlation, and Analysis of Variance (ANOVA) and Profile Analysis were used to analyze significant differences in SUI subscale profiles of each Sasang types. Results The SUI-HSS of urogenital hypersensitivity correlated positively with OABSS (r=0.442, p<0.01), and the SUI-DIS of urinary discomfort positively with UDI-6 (r=0.289, p<0.05). Interestingly, the SUI-total was correlated positively with age (r=0.326), height (r=0.318) and weight (r=0.304). The SUI-DIS for urinary discomfort of So-Yang (9.48±2.11) type was significantly (p<0.05) higher than that of Tae-Eum (7.2±2.90) type. And SUI subscale profiles of each Sasang type were significantly (Wilks' Lambda=0.792, F=2.723, p=0.034) distinctive to each other. Discussion The acceptable convergent validity of SUI was shown using established measures of urogenital symptoms. The SUI might be used as an objective traditional Korean clinical measure for Sasang type differentiation and urological patients.

• 대한한방부인과학회지
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• 제33권3호
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• pp.187-197
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• 2020

Objectives: This case report aims to report the clinical effectiveness of the combination treatment of Korean medicine on a post-laparoscopic myomectomy patient's lower urinary symptoms (LUTS). Methods: The patient who diagnosed with uterine myoma had Laparoscopic myomectomy. After the operation, the patient complained of dysuria, nocturia, frequent urination, urgent urination and urinary retention. The patient received combination treatment of Korean medicine during 14 days of hospitalization. The treatment included Ohrim-san, acupuncture, moxibustion, and pharmacoacupuncture. The effects were evaluated through the Numeric Rating Scale (NRS), Overactive Bladder Symptom Score (OABSS), Frequency-Volume chart, and 5-Level version of EuroQol-Five Dimension (EQ-5D-5L). Results: After the treatment, the clinical symptoms such as dysuria, nocturia, frequent urination, urgent urination, urinary retention were improved. Also, the quality of life was enhanced. Conclusions: This case report shows that the combination treatment of Korean Medicine with Ohrim-san may be effective for treating lower urinary tract symptoms (LUTS) after laparoscopic myomectomy.