• Tuberculosis and Respiratory Diseases
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• 제87권2호
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• pp.165-175
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• 2024

Background: The prevalence of small airway dysfunction (SAD) in patients with chronic obstructive pulmonary disease (COPD) across different ethnicities is poorly understood. This study aimed to estimate the prevalence of SAD in stable COPD patients. Methods: We conducted a cross-sectional study of 196 consecutive stable COPD patients. We measured pre- and post-bronchodilator (BD) lung function and respiratory impedance. The severity of COPD and lung function abnormalities was graded in accordance with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. SAD was defined as either difference in whole-breath resistance at 5 and 19 Hz > upper limit of normal or respiratory system reactance at 5 Hz < lower limit of normal. Results: The cohort consisted of 95.9% men, with an average age of 66.3 years. The mean forced expiratory volume 1 second (FEV₁) % predicted was 56.4%. The median COPD assessment test (CAT) scores were 14. The prevalence of post-BD SAD across the GOLD grades 1 to 4 was 14.3%, 51.1%, 91%, and 100%, respectively. The post-BD SAD and expiratory flow limitation at tidal breath (EFL_T) were present in 62.8% (95% confidence interval [CI], 56.1 to 69.9) and 28.1% (95% CI, 21.9 to 34.2), respectively. COPD patients with SAD had higher CAT scores (15.5 vs. 12.8, p<0.01); poor lung function (FEV₁% predicted 46.6% vs. 72.8%, p<0.01); lower diffusion capacity for CO (4.8 mmol/min/kPa vs. 5.6 mmol/min/kPa, p<0.01); hyperinflation (ratio of residual volume to total lung capacity % predicted: 159.7% vs. 129%, p<0.01), and shorter 6-minute walk distance (367.5 m vs. 390 m, p=0.02). Conclusion: SAD is present across all severities of COPD. The prevalence of SAD increases with disease severity. SAD is associated with poor lung function and higher symptom burden. Severe SAD is indicated by the presence of EFL_T.

• 대한임상검사과학회지
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• 제47권4호
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• pp.237-242
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• 2015

aPTT 참고치의 정상범위 내에서 하한 측 10% (29.1~30.9 sec)와 상한 측 10% (38.0~41.9 sec)에 포함된 정상성인의 혈액응고인자 활성도를 분석하여 하한 측과 상한 측간에 혈액응고인자의 종류와 각각의 활성도가 성별, 연령 및 ABO 혈액형 등에 통계학적으로 유의한 차이를 보이는지 알아보고자 하였다. 성별에 따른 혈액응고인자들의 활성도 차이를 분석한 결과 하한 측에서 IX (p=0.0088)만 남성이 여성보다 높았으며, 상한 측에서 IX (p<0.0001)와 X (p=0.0013)은 남성이 여성보다 높았다. 연령군간 혈액응고인자들의 활성도 차이 검정은 하한 측에서 VIII (p<0.0001), IX (p=0.0050)는 60세 이상이 60세 미만보다 높았으며, XII (p=0.0285)는 60세 이상보다 60세 미만이 높았다. 상한 측에서 V (p=0.0219), VIII (p=0.0005), IX (p=0.0014)는 60세 이상이 60세 미만보다 높았다. O형과 non-O형의 혈액형 구분에 의한 혈액응고인자들의 활성도 차이는 VIII (p<0.001)은 양쪽 그룹에서 non-O형이 O형보다 높았으며, XII (p=0.016)는 상한 측에서 non-O형이 O형보다 낮았다.

• 셀메드
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• 제7권1호
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• pp.1.1-1.10
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• 2017

Minerals are individual of the components of foods and are not produced in the body but essential for best possible health. Several essential metals are vital for the appropriate performance of various enzymes, transcriptional factors and proteins that are essential in various biochemical paths. Metals like zinc (Zn), magnesium (Mg), and manganese (Mn) are cofactors of hundreds of enzymes. Zn is involved in the synthesis and secretion of insulin from the pancreatic ${\beta}-cells$. Chromium (Cr) increases the insulin receptors activity on target tissues, mainly in muscle cells. Insulin hormone is required to maintain the blood glucose amount in normal range. Continual increase of blood serum glucose level leads to marked chronic hyperglycemia or diabetes mellitus. Deficiency of insulin or its resistance, blood glucose level exceeds the upper limit of the common range of 126 mg/dl. Poor glucose control and diabetes changes the levels of essential trace elements such as Zn, Mg, Mn, Cr, iron etc. by rising urinary excretion and their related decrease in the blood. The aim of this article to discusses the important roles of essential trace elements in particular perspective of type 2 diabetes.

• 대한핵의학회지
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• 제6권1호
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• pp.33-39
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• 1972

This is an attempt to evaluate normal spleen size in the Koreans. Spleen scans were obtained in 29 patients who were admitted to the Seoul National University Hospital because of trivial illnesses. All scans were performed by use of $^{51}Cr$-labelled, heat-treated erythrocyte. As a simple screening criteria for the presence of splenomegaly, vertical height of the spleen was considered to be the best one. After statistical analysis it was concluded that the upper limit of normal spleen height is 13cm in anterior view and 14cm in lateral view.

• 한국IT서비스학회지
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• 제8권4호
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• pp.175-185
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• 2009

Objectifying claims filed during the warranty period, analyzing the current circumstances and improving on the problem in question is an activity worth doing that could reduce the likelihood of claims to occur, cut down on the costs, and enhance the corporate image of the manufacturer. Existing analyses of claims are confronted with two problems. First, you can't precisely assess the risks of claims involved by means of the value of claims per 100 products alone. Second, even in a normal state, the existing approach fails to capture the probabilistic conflicts that escape the upper control limit of claims, thus leading to wrong control activities. To solve the first problem, this paper proposed that a time series detection concept where the claim rate is monitored based on the date when problems are processed and a hazard function for expression of the claim rate be utilized. For the second problem, this paper designed a model whereby to define a normal state by making use of PID (Proportion, Integral, Differential) and infer by way of a fuzzy concept. This paper confirmed the validity and applicability of the proposed approach by applying methods suggested in the actual past data of warranty claims of a large-scaled automotive firm, unlike hypothetical simulation data, in order to apply them directly in industrial job sites, as well as making theoretical suggestions for analysis of claims.

• Journal of Korean Neurosurgical Society
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• 제58권2호
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• pp.159-162
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• 2015

Neurological deficits after brain surgery are not uncommon, and correct and prompt differential diagnosis is essential to initiate appropriate treatment. We describe a patient suffering from loss of consciousness due to hyperammonemia, following valproic acid treatment after surgery for an unruptured cerebral aneurysm. A 57-year-old female patient underwent successful aneurysmal neck clipping to correct an unruptured aneurysm. Her postoperative course was good, and she received anti-epileptic therapy (valproic acid) and a soft diet. Within a few days the patient experienced mental deterioration. Her serum valproic acid reached toxic levels (149.40 mg/L), and serum ammonia was fifteen times the upper normal limit (553 mmol/L; normal range, 9-33 mmol/L). After discontinuation of valproic acid and with conservative treatment, the patient recovered without any complications. Valproate-induced hyperammonemic encephalopathy is an unusual but serious neurosurgical complication, and should not be disregarded as a possible cause of neurological deficits after neurovascular surgery. Early diagnosis is crucial, as discontinuation of valproic acid therapy can prevent serious complications, including death.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제15권2호
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• pp.63-73
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• 2012

Development of antiviral resistance to lamivudine is the most important factor for the treatment failure. It is necessary to establish proper guidelines to overcome drug resistance for children with chronic hepatitis B. Primary treatment with lamivudine should be considered if patients are in immune-clearance phase and have persistently elevated ALT levels more than twice the upper limit of normal value. Before initiating the therapy, careful consideration of the patient's status is required to exclude abnormal liver function tests due to other causes. The treatment option should be carefully decided to suppress the viral replication effectively. To obtain good compliance, clinicians should educate patients and their parents. Appropriate monitoring for virologic breakthrough and genotypic resistance is important in deciding to change the treatment plan. Sequential monotherapy should be avoided and a combination of drugs in other categories is recommended. New antiviral agents, such as entecavir and tenofovir, which have high potency and high genetic barrier, are soon expected to be available for use with children.

• 대한수학회지
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• 제32권2호
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• pp.289-300
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• 1995

Every group G has a unique maximal normal locally nilpotent subgroup $\Phi(G)$, called the Hirsh-Plotkin radical of G [9]. If G is a group, we define the upper Hirsh-Plotkin series of G to be the ascending series $1 = R_0 \leq R_1 \leq \ldots$ in which $R_{\alpha+1}/R_\alpha = \{Phi(G/R_\alpha)$ for each ordinal $\alpha and R_\beta = \cup_{\alpha<\beta}R_\alpha$ for each limit ordinal $\beta$. If $R_r = G$ for some natural number r, then G is said to have locally nilpotent length r. $(LN)^r$ denotes the calss of groups of locally nilpotent length at most r.

• 한국대기환경학회지
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• 제11권2호
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• pp.199-209
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• 1995

The variations of TSP concentrations observed at Air Quality Monitoring Stations(AQMSs) in Seoul were analysed from 1986 to 1993. And those of Yellow Sand period were investigated to find out the characteristics between normal and Yellow Sand period. The TSP concentrations have begun lower than 150.mu.g/m$^{3}$ annual mean concentration at Gwanghwamun, Hannam-dong, and south river region since 1989, and air quality in Seoul was improved in 1991, but polluted again in Hannam-dong, and Seongsu-dong in 1992. Yellow sand phenomena of 1990 and 1993 were selected for case study. During the whole period in 1990, the TSP concentrations were exceeded over 300.mu.g/m$^{3}$, which is the upper limit of 24 hour concentration, at the center of city such as Mapo, Gileum-dong, sinseol-dong. But in 1993, the TSP concentrations got lower than 24 hour concentration, and air quality was highly improved.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2019년도 추계 학술논문 발표대회
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• pp.128-129
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• 2019

In this study, after exposing the normal concrete outside at $-20^{\circ}C$, when the above scored $20^{\circ}C$, we analyzed the limit points of the initial early frost damage to the concrete. As a result, it was confirmed that the degree of the upper part of the concrete when it was exposed outside the freezing point for 6 hours was zero.