Objective: In vitro fertilization (IVF) is a well-known method for the treatment of infertility. The present study aimed to compare the differences between infertile women with successful and unsuccessful IVF outcomes regarding the expression of T helper (Th) cell transcription factors and a group of related cytokines before and after exposure to their husbands' seminal plasma. Methods: This study was performed on 19 couples with unexplained infertility undergoing IVF treatment. Among the studied group, nine and 10 couples had successful and unsuccessful IVF outcomes, respectively. This study was carried out using real-time polymerase chain reaction. Results: Before seminal plasma exposure, the expression levels of T-bet (p< 0.007), $interferon-{\gamma}$ (p= 0.013), and tumor necrosis factor $(TNF)-{\alpha}$ (p= 0.017) were higher in the infertile women with IVF failure than in those with successful IVF outcomes, while those of GATA3 (p< 0.001), Foxp3 (p= 0.001), and interleukin (IL)-35 (p< 0.003) were lower. After seminal exposure, the expression of T-bet (p= 0.02), Rorc (p< 0.001), $TNF-{\alpha}$ (p= 0.001), Foxp3 (p= 0.02), and $interferon-{\gamma}$ (p= 0.001) increased in the unsuccessful IVF group, while the expression of Foxp3 (p= 0.02), Rorc (p< 0.001), IL-23 (p= 0.04), IL-17 (p= 0.02), IL-6 (p< 0.001), transforming growth $factor-{\beta}$ (p= 0.01), and IL-35 (p< 0.001) increased in the successful IVF group. Conclusion: In summary, IVF failure was associated with imbalanced Th1/Th2/Th17/Treg responses. Moreover, our results show that seminal plasma might have a positive effect on IVF outcomes via changes in peripheral blood T cell subsets.
A data stream is a series of tuples which are generated in real-time, incessant, immense, and volatile manner. As new information technologies are actively emerging, stream processing methods are being needed to efficiently handle data streams. Especially, finding out an efficient evaluation for a multi-way join would make outstanding contributions toward improving the performance of a data stream management system because a join operation is one of the most resource-consuming operators for evaluating queries. In this paper, in order to evaluate efficiently a multi-way join continuous query, we propose a novel method to decrease the cost of a query by eliminating unsuccessful intermediate results. For this, we propose a matrix-based structure for monitoring data streams and estimate the number of final result tuples of the query and find out unsuccessful tuples by matrix multiplication operations. And then using these information, we process efficiently a multi-way join continuous query by filtering out the unsuccessful tuples in advance before actual evaluation of the query.
Considerable research in dieting has examined the goal priming effect that promotes successful dieting. However, priming literature found that the process of which priming is led to behaviors involves not only the priming construct itself but the momentary self-concept activated by the priming. Based on this notion, studies examined whether the active self-concept as an "unsuccessful dieter" or "successful dieter" determines the priming-to-behavior effect in dieting. Study 1 used contexts of the prime as manipulation for participants' active-self following the prime and measured their chronic self-concept in dieting (rated on the Perceived Self-Regulation Success [PSRS] in dieting scale) as a moderator. The result supported the active-self account for the effect of the dieting prime. The interaction of the PSRS scores and the priming contexts was found in the dieting behavior of participants. Participants whose chronic self-concept in dieting is unsuccessful (the low PSRS) showed the goal-congruent priming effect only in the condition where the priming context reminded them of their self-concept in favor of dieting success. In the context where their dieting failure in the past became salient, however, the participants with the low PSRS were more likely to succumb to tempting food. In contrast, eating behaviors of the high PSRS participants were independent of the contexts. Study 2 tested a possible mechanism from the active-self to the behaviors. It is concluded that the active-self operates in the priming process by influencing anticipatory thoughts rather than automatic responses toward foods. The implications for understanding repeated dieting failures and designing practical interventions to help dieters are discussed.
The purpose of this study is to provide the primary sources to improve the problem solving performance by analyzing the errors and the strategies selection of the high school students when solving given algebraic problems. To attain the purpose of this study, the questions for investigation in this study are : 1. What are the differences / similarities in the patterns of errors committed by successful and unsuccessful problem-solvers when solving particular algebraic problems ? 2. What are the error types chosen by unsuccessful problem-solvers when solving particular algebraic problems? 3. Do students utilize checking, either locally or globally, when solving particular algebraic problems? Twenty students were drawn out of 10th grade students in J girls' high school in Yengi -gun, Chung-Nam, for this study. The problem-solving test was used as a test instrument. From the data, the verbal protocols and the written protocols were analyzed by the patterns. The conclusions drawn from the results obtained in the present study are as follows: First, in solving particular algebraic problems, when the problems were solved with one strategy, most students didn't give any consideration to other strategies. So mathematics teachers should teach them to use the various strategies, and should develop the problems to be used the various strategies. Second, in solving particular algebraic problems, errors on notions or transformations of equations were found. Thus, the basic knowledges related to equation should be taught. In addition, most unsuccessful students seleted the strategies inadequately to solve the problems because of misunderstanding the problems. So, to improve the problem solving performance the processes of 'understanding problem' should be emphasized to students. Third, although the unsuccesful students used the 'checking' processes when solving the problems, most of them did not find the errors because of misconceptions related to the problems, carelessness, and unskillfulness of checking. Thus, students must be taught more carefully and encouraged to use the checking.
Objective: This study aimed to determine the threshold of $anti-M{\ddot{u}}llerian$ hormone (AMH) as predictor of follicular growth failure in polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC). Methods: Fifty female subjects with PCOS were recruited and divided into two groups based on successful and unsuccessful follicular growth. Related variables such as age, infertility duration, cigarette smoking, use of Moslem hijab, sunlight exposure, fiber intake, body mass index, waist circumference, AMH level, 25-hydroxy vitamin D level, and growth of dominant follicles were obtained, assessed, and statistically analyzed. Results: The AMH levels of patients with successful follicular growth were significantly lower (p= 0.001) than those with unsuccessful follicular growth ($6.10{\pm}3.52$ vs. $10.43{\pm}4.78ng/mL$). A higher volume of fiber intake was also observed in the successful follicular growth group compared to unsuccessful follicular growth group (p= 0.001). Our study found the probability of successful follicle growth was a function of AMH level and the amount of fiber intake, expressed as Y =-2.35+($-0.312{\times}AMH\;level$)+($0.464{\times}fiber\;intake$) (area under the curve, 0.88; 95% confidence interval, 0.79-0.98; p< 0.001). Conclusion: The optimal threshold of AMH level in predicting the failure of follicle growth in patients with PCOS treated with CC was 8.58 ng/mL.
This study measured variables influencing the breast feeding patterns of lactating mothers over a 40 day period In 1993 in the Jeonla area. The Methodology used was a questionnaire covering 92 items based on statistical discriminant analysis. The results were as follows : The successful group was measured against the unsuccessful group over a 4month lactation period ; The successful group was measured over a 4month lactation period ; the unsuccessful less than 4month lactation period. Principal factor analysis was used to generate comparative data factors which were ; 1) nonunderstanding of mother's breast feeding, 2) physical and psychological stress, 3) insufficient milk supply, 4) mother's negative acceptance of baby, 5) lack of spousal support, 6) sore nipple and breast pain, 7) baby's negative acceptance, 8) lack of familial support, 9) baby's diarrhea and watery milk. Discriminant statistical analysis of sever factors included ; 1) insufficient milk supply 2) sore nipple and breast pain, 3) pre-natal planning of breast feeding method, 4) mother's occupation 5) breast feeding method of previous infant, 6) nipple type, and 7) infant birth order. This analysis predicted a 78.9% successful breast feeding. Criterion correlation analysis revealed ; D=-1.780+.165$\times$(Fac3)+.135$\times$(Fac6)+.927$\times$(prenatal planning of breast feeding method)+.900$\times$(mother's occupation)+.675$\times$ (breast feeding method of previous infant)+1.0l4$\times$(nipple type)+.378$\times$(infant birth order). We classified the unsuccessful group as more than .63937 and the successful group less than -.82742 of the D value obtained from the above criterion correlation in order to check the success or the non-success of breast feeding mothers. The rate of correct classification of the grouped cases employing a statistical discriminant analysis was significantly improved to 78.9% when these cases were compared with the actual grouped classification.
Journal of The Korean Association For Science Education
/
v.16
no.4
/
pp.389-400
/
1996
The purposes of this study were to analyze chemistry problem solving processes of middle school students and to compare their problem solving behaviors in the aspects of the cognitive developmental level of student, the success in problem solving, and the context of problem. Their failures in solving problems were also analyzed in the aspects of problem solving stage and prior knowledge. Forty-two students individually solved four problems regarding density and solubility using a think-aloud method. Students' responses were analyzed after intercoder agreement for analyzing problem-solving processes had been established to be 0.94. The results were as follows: 1. Most students solved chemistry problems following the stages of understanding, planning, and solving, while few exhibited the behaviors of the reviewing stage. There was also individual difference in the number of the stages repeated and their behaviors at each stage. 2. Most students were successful in understanding problems. However, unsuccessful and/or concrete-operational students had more difficulties in understanding problems than successful and/or formal-operational students, and students tended to have more difficulties in understanding problems in everyday contexts than in scientific contexts. 3. Successful and/or formal-operational students exhibited more behaviors of the planning stage than unsuccessful and/or concrete-operational students. Students showed more behaviors of the planning stage, but failed more at this stage, in everyday contexts than in scientific contexts. 4. Most students did not review their solutions. Successful and/or formal-operational students exhibited these behaviors more than unsuccessful and/or concrete-operational students. Students tended to exhibit the behaviors more in everyday contexts than in scientific contexts. 5. Many students failed to solve problems correctly due to the lack of prior knowledge and the inability to plan appropriately.
Objective: The purpose of this study was to determine the factors of successful and unsuccessful movements through the analysis of kinematics and muscle activity of the Free Aerial Cartwheel on the balance beam. Method: Subjects (Age: 22.8 ± 2.4 yrs., Height: 158.7 ± 5.0 cm, Body mass: 54.1 ± 6.4 kg, Career: 13 ± 2.4 yrs.) who were currently active as female gymnasts participated in the study. They had no history of surgical treatment within 3 months. Subject criteria included more than 10 years of professional experience in college and professional level of gymnastics and the ability to conduct the Free Aerial Cartwheel on the Balance Beam. Each subject performed 10 times of Free Aerial Cartwheel on the balance beam. One successful trial and one unsuccessful trial (failure) among 10 trials were selected for the comparison. Results: It was found that longer time required in case of unsuccessful trial when performing the Free Aerial Cartwheel on the balance beam compared with successful trial. It is expected to be the result of movement in the last landing section (i.e. phase 5). In addition, it was found that the center of gravity of the body descends at a high speed to perform the jump (i.e. phase 2) in order to obtain a sufficient jumping height when the movement is successful while the knee joint is rapidly extended to perform a jump when movement fails. In the single landing section after the jump (i.e. phase 4), if the ankle joint rapidly dorsiflexed after take-off and the hip joint rapidly flexed, so landing was not successful. Conversely, in a successful landing movement, muscle activity of the biceps femoris was greatly activated resulting no shaking in the last landing section (i.e. phase 5). Conclusion: In order to succeed in this movement, it is necessary to perform a strong jump after rapidly descending the center of gravity of the body using the force of the biceps femoris muscle. Further improvement of the skills on the balance beam requires the analysis of the game-like situation with continuous research on kinematic and kinematic analysis of various techniques, jumps, turns, etc.
Escandon, Joseph M.;Mohammad, Arbab;Mathews, Saumya;Bustos, Valeria P.;Santamaria, Eric;Ciudad, Pedro;Chen, Hung-Chi;Langstein, Howard N.;Manrique, Oscar J.
Archives of Plastic Surgery
/
v.49
no.5
/
pp.617-632
/
2022
Tracheoesophageal puncture (TEP) and voice prosthesis insertion following laryngectomy may fail to form an adequate seal. When spontaneous closure of the fistula tract does not occur after conservative measures, surgical closure is required. The purpose of this study was to summarize the available evidence on surgical methods for TEP site closure. A comprehensive search across PubMed, Web of Science, SCOPUS, and Cochrane was performed to identify studies describing surgical techniques, outcomes, and complications for TEP closure. We evaluated the rate of unsuccessful TEP closure after surgical management. A meta-analysis with a random-effect method was performed. Thirty-four studies reporting on 144 patients satisfied inclusion criteria. The overall incidence of an unsuccessful TEP surgical closure was 6% (95% confidence interval [CI] 1-13%). Subgroup analysis showed an unsuccessful TEP closure rate for silicone button of 8% (95% CI < 1-43%), 7% (95% CI < 1-34%) for dermal graft interposition, < 1% (95% CI < 1-37%) for radial forearm free flap, < 1% (95% CI < 1-52%) for ligation of the fistula, 17% (95% CI < 1-64%) for interposition of a deltopectoral flap, 9% (95% CI < 1-28%) for primary closure, and 2% (95% CI < 1-20%) for interposition of a sternocleidomastoid muscle flap. Critical assessment of the reconstructive modality should take into consideration previous history of surgery or radiotherapy. Nonirradiated fields and small defects may benefit from fistula excision and tracheal and esophageal multilayer closure. In cases of previous radiotherapy, local flaps or free tissue transfer yield high successful TEP closure rates. Depending on the defect size, sternocleidomastoid muscle flap or fasciocutaneous free flaps are optimal alternatives.
In this paper, authors focused on the difference between successful and unsuccessful items in terms of the innovation and imitation parameters of Bass diffusion model. Each item was scraped by members directly from the minihompies they visit. Top 50 items in terms of total number of adoption are classified as successful items and the 50 items whose total number of adoption was just below the average are classified as unsuccessful items. In particular, authors are interested in investigating the role of influentials in the diffusion process. Influentials are defined as those people whose network centrality (Indegree, Outdegree, and Betweeness centrality) was larger than the mean centrality in their social network. Figure 1 shows the plots of number of scraping, cumulative scraping, indegree, outdegree and betweenness of the people who scraped the most popular item among 100 items.
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