• 제목/요약/키워드: Unreported

검색결과 227건 처리시간 0.028초

Synthesis and in vitro cytotoxicity of a homologous series of 5-halosubstituted $1,3-Bis(\omega-cyanoalkyl)$uracil analogues

  • Kim, Jack-C.;Dong, Eun-Soo;Park, Jin-Il;Kim, Young-Hyeun;Choi, Soon-Kyu
    • Archives of Pharmacal Research
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    • 제19권1호
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    • pp.62-65
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    • 1996
  • A homologous series of twenty, hitherto unreported, analogues of 5-halosubstituted $1, 3-Bis(\omega-cyanoalkyl)uracil$acyclic nucleosides were synthesized by the series of alkylation reactions of 5-halouracils with the corresponding chloroacetonitrile, chloropropionitrile, chlorobutyronitrile and 5-chlorovaleronitrile $(Cl-(C_ 2)_n-CN: n=l, 2, 3, 4)\; in\; anhydrous\; DMSO\; (or DMF)/K_2CO_3(or NaH)\; under\; 75^{\circ}C$ temperature. Antitumor activities for the synthesized compounds were determined against three cell lines (FM-3A cell, P-388 cell and U-938 cell lines). The compounds that exhibited moderate activity to significant activity, included la-b, 2a-b, 3a-c, and 4a, whose compounds were active against P-388, FM-3A and U-937 cell lines with the compounds la, lb, and 2a, showing significant antitumor activity (inhibitory concentrations $(IC_{50})$ ranged from 2.2 to $7.0\mug/ml$). Their strucrure-activity relationship did not show any activity differences in their effective chain length (methyl, ethyl, propyl, butyl) in 1, 3-bis(.omega.-cyanoalkyl) uracils.

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Double-diffusive convection affected by conductive and insulating side walls during physical vapor transport of Hg2Br2

  • Kim, Geug Tae;Kwon, Moo Hyun
    • 한국결정성장학회지
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    • 제30권3호
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    • pp.117-122
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    • 2020
  • In last few decades, although thermal and/or solutal buoyancy-driven recirculating flows in a closed ampoule have been intensively studies as a model problem, there exist interesting total molar flux of Hg2Br2 that have been unreported in the literature. It is concluded that the total molar flux of Hg2Br2(A) increases linearly and directly as the temperature difference regions in the range of 10℃ ≤ ΔT ≤ 50°, 3.5 × 103 ≤ Grt ≤ 4.08 × 103, 4.94 × 104 ≤ Grs ≤ 6.87 × 104. For the range of 10 Torr ≤ PB ≤ 150 Torr, the total molar flux of Hg2Br2(A) decays second order exponentially as the partial pressure of component B (argon as an impurity), PB increases. From the view point of energy transport, the fewer the partial pressure of component B (argon), PB is, the more the energy transport is achieved.

Synthesis of New Pyrazolo[5,1-c]triazine, Triazolo[5,1-c]triazine, Triazino[4,3-b]indazole and Benzimidazo[2,1-c]triazine Derivatives Incorporating Chromen-2-one Moiety

  • Khalil, Mohamed A.;Sayed, Samia M.;Raslan, Mohamed A.
    • 대한화학회지
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    • 제57권5호
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    • pp.612-617
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    • 2013
  • The versatile, hitherto unreported 3-(4-(2-phenyldiazenyl)-2-oxo-2H-chromen-3-yl)-3-oxopropanenitrile 3 was prepared by two convenient routes: either by the reaction of ethyl 4-(2-phenyldiazenyl)-2-oxo-2H-chromen-3-carboxylate 2 with acetonitrile in the presence of sodium hydride or by treatment of 4-(2-phenyldiazenyl)-3-(2-bromoacetyl)-2H-chromen-2- one 5 with potassium cyanide. Reaction of 3 with heterocyclic diazonium salts 6, 7, 14 and 17 furnished the corresponding hydrazones 8, 9, 15 and 18. The latter hydrazones underwent intramolecular cyclization into the corresponding pyrazolo[5,1- c]-1,2,4-triazine 10, 1,2,4-triazolo[5,1-c]-1,2,4-triazine 11, 1,2,4-triazino[4,3-b]indazole 16 and imidazo[2,1-c]-1,2,4-triazine 19 derivatives, respectively upon refluxing in pyridine.

Aminoalkylphosphonic Acid를 가지는 Dipeptide의 합성 (Synthesis of Dipeptides Containing Aminoalkylphosphonic Acid)

  • 홍석인;노만균;김용준
    • 대한화학회지
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    • 제19권2호
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    • pp.134-141
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    • 1975
  • 1-Aminoalkylphosphonic acid인 DL-1-aminoethylphosphonic acid(1-AEP)와 DL-1-aminopropylphosphonic acid(1-APP)를 아미노산인 glycine, DL-alanine, DL-phenylalanine과 염기성 수용액 상에서 반응시켜 아직까지 발표되지 않은 다음의 dipeptide 들을 합성하였다. N-Phthalylglycyl-1-AEP, N-phthalyl-dl-alanyl-1-AEP, N-phthalyl-dl-phenylalanyl-1-AEP, N-phthalylglycyl-1-APP, N-tosylglycyl-1-App 및 N-tosyl-dl-alanyl-1-AEP 위의 화합물들은 모두 흰색의 고체로 얻어졌으며 ninhydrine test, IR spectra, 전위차적정, 원소분석에 의해 확인되었다.

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구상나무의 잎에서 분리한 두 종의 국내 미기록 내생균 (Two Unreported Species of Endophytic Fungi Isolated from Leaves of Abies koreana in Korea)

  • 박혁;김동여;엄안흠
    • 한국균학회지
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    • 제46권1호
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    • pp.22-27
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    • 2018
  • 제주도 한라산 구상나무의 잎에서 내생균을 분리하여 다양성을 확인하는 과정에서 두 종의 국내 미기록 균주를 확인하였다. 분리된 균주는 형태적 특징과 internal transcribed spacer (ITS) 지역, large subunit (LSU) rDNA 지역 염기서열의 계통분석을 통해 동정하였다. 확인된 두 미기록종 균주는 Coleophoma parafusiformis와 Coniochaeta ligniaria이며, 두 균주에 대한 형태적 특징과 염기서열의 분석 결과를 제시하였다.

눈향나무의 잎에서 분리된 4종의 국내 미기록 내생균 (First Report on Four Novel Endophytic Fungal Species Isolated from Leaves of Juniperus chinensis var. sargentii in Korea)

  • 박혁;엄안흠
    • 한국균학회지
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    • 제46권2호
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    • pp.114-121
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    • 2018
  • 한라산에 서식하는 눈향나무의 침엽에서 내생균을 분리하였다. 분리된 균주들은 형태적 특성과 internal transcribed spacer 영역, large subunit rDNA 영역, translation elongation factor 영역 및 ${\beta}$-tublin 영역 염기서열의 계통분석을 이용하여 동정하였다. 그 결과 국내 미기록 내생균인 Allantophomopsis lycopodina, Epicoleosporium ramularioides, Kabatina juniperi, Seiridium podocarpi 4종의 균주를 확인하였다. 4종의 미기록 균주에 대한 형태적 특성 및 계통분석의 결과에 대해 기술하였다.

A report of 37 unrecorded anaerobic bacterial species isolated from the Geum River in South Korea

  • Lee, Changsu;Kim, Joon Yong;Kim, Yeon Bee;Kim, Juseok;Ahn, Seung Woo;Song, Hye Seon;Roh, Seong Woon
    • Journal of Species Research
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    • 제9권2호
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    • pp.105-116
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    • 2020
  • A total of 37 anaerobic bacteria strains within the classes Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Bacteroidia, Flavobacteriia, Bacilli, Clostridia, and Fusobacteriia were isolated from freshwater and sediment of the Geum River in Korea. The unreported species were related with Rhizobium and Oleomonas of the class Alphaproteobacteria; Acidovorax, Pseudogulbenkiania, and Aromatoleum of the class Betaproteobacteria; Tolumonas, Aeromonas, Cronobacter, Lonsdalea, and Phytobacter of the class Gammaproteobacteria; Bacteroides, Dysgonomonas, Macellibacteroides, and Parabacteroides of the class Bacteroidia; Flavobacterium of the class Flavobacteriia; Bacillus and Paenibacillus of the class Bacilli; Clostridium, Clostridioides, Paraclostridium, Romboutsia, Sporacetigenium, and Terrisporobacter of the class Clostridia; and Cetobacterium and Ilyobacter of the class Fusobacteriia. A total of 37 strains, with >98.7% 16S rRNA gene sequence similarity with validly published bacterial species, but not reported in Korea, were determined to be unrecorded anaerobic bacterial species in Korea.

A report of 35 unreported bacterial species in Korea, belonging to the phylum Firmicutes

  • Baek, Min-gyung;Kim, Wonyong;Cha, Chang-Jun;Joh, Kiseong;Kim, Seung-Bum;Kim, Myung Kyum;Seong, Chi-Nam;Yi, Hana
    • Journal of Species Research
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    • 제8권4호
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    • pp.337-350
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    • 2019
  • In an investigation of indigenous prokaryotic species in Korea, a total of 35 bacterial strains assigned to the phylum Firmicutes were isolated from diverse habitats including natural and artificial environments. Based on their high 16S rRNA gene sequence similarity (>98.7%) and formation of robust phylogenetic clades with species of validly published names, the isolates were identified as 35 species belonging to the orders Bacillales (the family Bacillaceae, Paenibacillaceae, Planococcaceae, and Staphylococcaceae) and Lactobacillales (Aerococcaceae, Enterococcaceae, Lactobacillaceae, Leuconostocaceae, and Streptococcaceae). Since these 35 species in Korean environments has not been reported in any official report, we identified them as unrecorded bacterial species and investigated them taxonomically. The newly found unrecorded species belong to 20 species in the order Bacillales and 15 species in the order Lactobacillales. The morphological, cultural, physiological, and biochemical properties of the isolates were examined and the descriptive information of the 35 previously unrecorded species is provided here.

Genetic characterization of H9N2 avian influenza virus previously unrecognized in Korea

  • Heo, Gyeong-Beom;Kye, Soo-Jeong;Sagong, Mingeun;Lee, Eun-Kyoung;Lee, Kwang-Nyeong;Lee, Yu-Na;Choi, Kang-Seuk;Lee, Myoung-Heon;Lee, Youn-Jeong
    • Journal of Veterinary Science
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    • 제22권2호
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    • pp.21.1-21.6
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    • 2021
  • In this study, we describe the isolation and characterization of previously unreported Y280-lineage H9N2 viruses from two live bird markets in Korea in June 2020. Genetic analysis revealed that they were distinct from previous H9N2 viruses circulating in Korea and had highest homology to A/chicken/Shandong/1844/2019(H9N2) viruses. Their genetic constellation showed they belonged to genotype S, which is the predominant genotype in China since 2010, where genotype S viruses have infected humans and acted as internal gene donors to H5 and H7 zoonotic influenza viruses. Active surveillance and control measures need to be enhanced to protect the poultry industry and public health.

Isolation and Identification of Two Unreported Fungi in Korea: Dothidea insculpta and Metarhizium rileyi

  • Moe, Than Naing;Das, Kallol;Diane, Avalos-Ruiz;Kang, In-Kyu;Lee, Seung-Yeol;Jung, Hee-Young
    • 한국균학회지
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    • 제49권3호
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    • pp.315-324
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    • 2021
  • In this study, the fungal strains KNU-Gunwi 2B and KNU-SOT5 were isolated from root-soil in a hillside and the cherry tree bark (Prunus serrulata), respectively from Gyeongbuk province in Korea. The strain KNU-SOT5 produced dark brown chlamydospores that were smooth to lightly rough-walled, globose to ellipsoidal, and the conidia were aseptate, guttulate, mostly fusiform with a diameter of 5.3-17.6×4.2-7.0 ㎛. Strain KNU-Gunwi 2B produced phialides that were smooth-walled, cylindrical with semi-papillate apices and the conidia were pale-green, broadly ellipsoid, and sometimes cylindrical with a diameter of 4.4-8.0×2.3-4.0 ㎛. The strain KNU-SOT5 and KNU-Gunwi 2B were resolved based on cultural and morphological characteristics, along with the phylogenetic analysis using the small subunit (SSU), large subunit (LSU), and internal transcribed spacers (ITS) regions. The fungal strains KNU-SOT5 and KNU-Gunwi 2B were identified as Dothidea insculpta and Metarhizium rileyi, which have not been reported in Korea.