• Nutrition Research and Practice
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• 제17권6호
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• pp.1043-1055
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• 2023

BACKGROUND/OBJECTIVES: The fruit of Cydonia oblonga Miller (COM) is used traditionally in Mediterranean region medicine to prevent or treat obesity, but its mechanism of action is still unclear. Beyond a demonstrated anti-obesity effect, the fruit was tested for the mechanism of adipogenesis in 3T3-L1 preadipocytes. MATERIALS/METHODS: 3T3-L1 preadipocytes were cultured for 8 days with COM fruit extract (COME) at different concentrations (0-600 ㎍/mL) with adipocyte differentiation medium. The cell viability was measured using an MTT assay; triglyceride (TG) was stained with Oil Red O. The expression levels of the adipogenesis-related genes and protein expression were analyzed by reverse transcription polymerase chain reaction and Western blotting, respectively. RESULTS: COME inhibited intracellular TG accumulation during adipogenesis. A COME treatment in 3T3-L1 cells induced upregulation of the adenosine monophosphate-activated protein kinase (AMPK)α phosphorylation and downregulation of the adipogenic transcription factors, such as sterol regulatory element-binding protein 1c, peroxisome proliferator-activated receptor γ, and CCAAT/enhancer binding protein α. The COME treatment reduced the mRNA expression of fatty acyl synthetase, adenosine triphosphate-citrate lyase, adipocyte protein 2, and lipoprotein lipase. It increased the mRNA expression of hormone-sensitive lipase and carnitine palmitoyltransferase I in 3T3-L1 cells. CONCLUSIONS: COME inhibits adipogenesis via the AMPK signaling pathways. COME may be used to prevent and treat obesity.

• 한국산학기술학회논문지
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• 제18권12호
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• pp.473-484
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• 2017

본 연구는 한국 정부에서 '13~'15년에 지원한 정부연구개발사업중 산학연 협력연구 과제를 대상으로 협력유형을 주관기관별로 유형화하여 효율성을 분석하였다. 효율성 분석을 위해 6단계에 걸쳐 순수연구개발과제만을 분류하였으며, 투입과 산출변수를 다양한 조합의 투입과 산출변수를 분해 모형을 만들어 투입과 산출변수간의 효율성 차이점을 분석하기 위해 하여 산출지향 규모수익가변(VRS: Variable Return to Scale)의 DEA 모형으로 효율성을 분석하였다. 또한, 산출변수와 관련 있는 과학적, 기술적, 경제적 성과 모형의 효율성 분석결과를 활용하여 계층적 군집분석으로 클러스터를 확인하고, 클러스터별 강점과 약점에 맞는 산학연 협력유형별 정부 연구개발예산의 투자 포트폴리오 및 투자전략을 제시하였다. 효율성 분석결과 주관기관별 산학연 협력유형의 효율성은 각 모형별로 차이가 있었으나 전반적으로 대기업과 출연연구기관이 상대적으로 효율적이고, 중견기업, 중소기업, 그리고 대학은 상대적으로 비효율적인 것으로 분석되었다. 계층적 군집분석결과 3개 유형의 클러스터가 형성되었으며, 클러스터별로 논문, 특허, 기술료 사업화에서 강점과 약점이 있는 협력유형이 나타나서, 이에 대한 차별적인 투자전략을 제시하였다.

• 한국가금학회지
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• 제44권4호
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• pp.225-233
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• 2017

Chicken production remains the foremost endeavor in the Nigerian livestock industry. However, disease incidence has been a major constraint on the growth of this subsector. This study assessed health management practices and disease incidence in smallholder chicken production enterprise in Southwest Nigeria using data from a farm survey of 240 farmers selected using a multistage sampling technique from 5 of 6 states in Southwest Nigeria. The study showed that vaccination was given by 96.8% of the famers, 97.8% dewormed their chickens, and 92.9% disinfected the coops against diseases. However, 37% of the farmers regularly consulted veterinarians, 25.7% consulted them during disease outbreaks, and 34.2% occasionally consulted veterinarians. Infectious bursal disease (IBD), coccidiosis, and chronic respiratory disease (CRD) were the major diseases reported by 17.1%, 12.9%, and 7.1% of the farmers, respectively. Mortality rate was 37.8%, although this varied with disease. However, there was a growth of 157.4% in stock size between the establishment of the farms and the survey period.

• 한국정보통신학회논문지
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• 제19권11호
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• pp.2739-2744
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• 2015

혁신적인 경제에서 정책 인센티브와 정책방향의 개발은 항상 중요하다. 혁신정책은 특화산업의 시장구조를 선도하면서 산업의 역동성을 결정하기 때문이다. 본 연구는 대전지역의 무선통신산업의 변화를 이해하기 위해 산업융합의 발전을 탐색한다. 초기의 관심은 기업자체의 R&D센터였지만, 비즈니스 모델은 자체적인 상품의 연구개발보다 외부 수요에 대응하는 연구개발이 대부분이었다. 지역혁신을 위해서, 무선통신융합산업의 정책은 자체 제품개발패턴이 되어야 한다.

• 한국산업융합학회 논문집
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• 제25권1호
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• pp.27-35
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• 2022

A systematic support system that develops technology support policies for SMEs (Small and Medium sized Enterprises) and solves technical problems faced by SMEs will increase the productivity and competitiveness of SMEs. To this end, it is necessary to identify the types and level of technology required for SMEs, and to find ways to utilize the technologies possessed by government-funded research institutes leading technology development. It is important to develop a new production technology and to establish a cooperation system between SMEs and government- funded research institutes to solve various pending problems.

• Interdisciplinary Bio Central
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• 제2권4호
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• pp.11.1-11.8
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• 2010

Indonesia is a mega-biodiversity country having at least one trillion US Dollars value of biological resources per year over the next 20 years. Indonesia is home to 11 percent of the world's flowering plant species and 12 percent of all mammals. Many of Indonesia's species and more than half of the archipelago's endemic plant species are found nowhere else on the Earth. This information is just a small portion of all higher plants and animals being found in Indonesia. Former studies described that total number of species in Indonesia is estimated more than 1,000,000 and most of them remain unknown scientifically. Most of lower plants and animals have not been studied yet, so that greatest portion of Indonesia's biological resources has never been assessed with respect to its economic value or conservation status. Many developed countries are building cooperation with Indonesia on resources, mainly in the fields of grant aid, socio-economic services, R & D, researcher exchange, technology transfer, infrastructure, education/training, finance, etc. Indonesia will obtain greater benefits and management of its biological richness via increasing its international capacity to add value and information to its biological diversity. These goals can be achieved by close international collaboration on search of important biological resources and other bioactive products that have potential economic values. Development of biological resource-based technology stands as the industry of the $21^{st}$ century and, therefore, Indonesia has a unique opportunity to lead the process in the world.

• 대한예방한의학회지
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• 제24권3호
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• pp.15-25
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• 2020

Background : Mutual understanding between North and South Korea is essential for the engagement of Inter-Korean exchange and cooperation. However, the two Koreas have been divided for 70 years where Korean evolved differently within the two countries. This created a gap in the most basic foundation for mutual understanding, language. Fostering exchange and cooperation in the traditional medicine field requires a higher understanding of the specialized traditional medicine terminologies. Objectives : The purpose of this study is to formulate a future management plan for the "Comparative Terminology of Korean Medicine in South and North Korea," providing a foundation for standardizing Korean medicine terminology of the two Koreas. Methods : The study collected case studies of Korean medicine terminology management and standardization from government and international organization websites and documents. It provided future terminology management strategies based on this data. Results : The project for the standardization of Korean medicine terminology between North and South Korea can be divided into 4 stages according to the level of exchange and cooperation. The first step is to "establish a foundation for terminology standardization." The second step is "term comparison." If the exchanges and cooperation between North and South Korea, the third step will be to promote the "terminology standardization" project through Inter-Korean dialogue. Finally, after incorporating discussion on terminology standardization, the Inter-Korean Medicine Terminology can be published. Conclusions : This requires a system to support and facilitate Inter-Korean medicine exchange and cooperation. It is important to provide a support system that can provide results in a timely fashion by training relevant experts, collecting data and information, communicating with experts in the industry, academia and research institutes. This system will be able to ensure the continuity of the terminology standardization project.

• 생명과학회지
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• 제18권6호
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• pp.770-775
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• 2008

돼지 2번 염색체의 육질 관련 양적 경제형질에 관한 연구보고가 몇몇 이루어 지고 있다. 양돈업계에서 DNA 기술을 이용한 염색체 정보를 활용하기 위해 본 연구에서는 13개의 후보 유전자에서 생성된 중합효소연쇄반응(PCR) 생성물을 비교 재서열 함으로써 단일염기변이(SNP) 표지들을 개발했다. 11개의 중합효소연쇄반응 생성물에서 296 bp마다 에서 평균 하나의 SNP, 총 34개의 SNP를 발견하였다. 또한 11개의 SNP에 대한 PCR 제한효소길이 절편길이 다형성(RFLP) 분석을 전개한 후, 이를 대한민국 상업돈 4품종 개체군의 유전자형을 분석하는데 활용하였다. 본 연구는 유용한 단일염기변이를 식별하고 돼지 개체군 내 경제적으로 중요한 특성들과 SNP의 연관성을 확인하는 데 그 목적이 있다.

• 한국환경과학회지
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• 제22권4호
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• pp.425-433
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• 2013

A mass balance of process was calculated by using the analysis of basic unit and environmental assessment of all the processes of Busan fashion color industry cooperative that operates a combined heat and power plant and a bio treatment plant. The mass balance for the combined heat and power plant was done, based on boiler and water treatment processes while each unit reactor was used for the bio treatment plant. From the results above, a resource recycle network, a treatment flowchart for food waste water/wastewater treatment and a carbon reduction program were established.

• 한국환경과학회지
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• 제23권12호
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• pp.2035-2044
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• 2014

Taking sample processes from the combined heat and power plant in Busan Fashion Color Industry Complex, the characteristics and amounts of greenhouse gas (GHGs) emissions were analysed and calculated, respectively. Based on the results, environmental assessment was evaluated for recent 3 years. The amounts of GHG emissions from 2011 to 2013 were estimated at 182,750, 184,384 and 190,250 $Ton.CO_2eq/year$, respectively. GHG emissions from stationary combustion sources were found to be more than 99 % of the total emissions. Also, the overall eco-efficiency indicator for environmental assessment was more than 1, suggesting that these results would be beneficial for GHG emissions allowance allocations.