• 제목/요약/키워드: University hospital

검색결과 49,111건 처리시간 0.061초

Asparagus Polysaccharide and Gum with Hepatic Artery Embolization Induces Tumor Growth and Inhibits Angiogenesis in an Orthotopic Hepatocellular Carcinoma Model

  • Weng, Ling-Ling;Xiang, Jian-Feng;Lin, Jin-Bo;Yi, Shang-Hui;Yang, Li-Tao;Li, Yi-Sheng;Zeng, Hao-Tao;Lin, Sheng-Ming;Xin, Dong-Wei;Zhao, Hai-Liang;Qiu, Shu-Qi;Chen, Tao;Zhang, Min-Guang
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권24호
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    • pp.10949-10955
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    • 2015

  • Liver cancer is one of leading digestive malignancies with high morbidity and mortality. There is an urgent need for the development of novel therapies for this deadly disease. It has been proven that asparagus polysaccharide, one of the most active derivates from the traditional medicine asparagus, possesses notable antitumor properties. However, little is known about the efficacy of asparagus polysaccharide as an adjuvant for liver cancer chemotherapy. Herein, we reported that asparagus polysaccharide and its embolic agent form, asparagus gum, significantly inhibited liver tumor growth with transcatheter arterial chemoembolization (TACE) therapy in an orthotopic hepatocellular carcinoma (HCC) tumor model, while significantly inhibiting angiogenesis and promoting tumor cell apoptosis. Moreover, asparagine gelatinous possessed immunomodulatory functions and showed little toxicity to the host. These results highlight the chemotherapeutic potential of asparagus polysaccharide and warrant a future focus on development as novel chemotherapeutic agent for liver cancer TACE therapy.

  • https://doi.org/10.7314/APJCP.2014.15.24.10949 인용 PDF KSCI

Melatonin protects endothelial progenitor cells against AGE-induced apoptosis via autophagy flux stimulation and promotes wound healing in diabetic mice

  • Jin, Haiming;Zhang, Zengjie;Wang, Chengui;Tang, Qian;Wang, Jianle;Bai, Xueqin;Wang, Qingqing;Nisar, Majid;Tian, Naifeng;Wang, Quan;Mao, Cong;Zhang, Xiaolei;Wang, Xiangyang
    • Experimental and Molecular Medicine
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    • 제50권11호
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    • pp.13.1-13.15
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    • 2018

  • Wound healing is delayed in diabetic patients. Increased apoptosis and endothelial progenitor cell (EPC) dysfunction are implicated in delayed diabetic wound healing. Melatonin, a major secretory product of the pineal gland, promotes diabetic wound healing; however, its mechanism of action remains unclear. Here, EPCs were isolated from the bone marrow of mice. Treatment of EPCs with melatonin alleviated advanced glycation end product (AGE)-induced apoptosis and cellular dysfunction. We further examined autophagy flux after melatonin treatment and found increased light chain 3 (LC3) and p62 protein levels in AGE-treated EPCs. However, lysosome-associated membrane protein 2 expression was decreased, indicating that autophagy flux was impaired in EPCs treated with AGEs. We then evaluated autophagy flux after melatonin treatment and found that melatonin increased the LC3 levels, but attenuated the accumulation of p62, suggesting a stimulatory effect of melatonin on autophagy flux. Blockage of autophagy flux by chloroquine partially abolished the protective effects of melatonin, indicating that autophagy flux is involved in the protective effects of melatonin. Furthermore, we found that the AMPK/mTOR signaling pathway is involved in autophagy flux stimulation by melatonin. An in vivo study also illustrated that melatonin treatment ameliorated impaired wound healing in a streptozotocin-induced diabetic wound healing model. Thus, our study shows that melatonin protects EPCs against apoptosis and dysfunction via autophagy flux stimulation and ameliorates impaired wound healing in vivo, providing insight into its mechanism of action in diabetic wound healing.

  • https://doi.org/10.1038/s12276-018-0177-z 인용 KSCI

Staged Repair of Truncus Arteriosus Associated with Complete Atrioventricular Septal Defect

  • Lim, Mi Hee;Sung, Si Chan;Kim, Hyung Tae;Choi, Kwang Ho;Lee, Hyoung Doo;Kim, Geena
    • Journal of Chest Surgery
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    • 제51권5호
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    • pp.356-359
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    • 2018

  • We report a case of successful repair of truncus arteriosus (TA) associated with complete atrioventricular septal defect (c-AVSD) using a staged approach. TA associated with c-AVSD is a very rare congenital cardiac anomaly. No report of successful staged repair in South Korea has yet been published. We performed bilateral pulmonary artery banding when the patient was 33 days old, and total correction using an extracardiac conduit was performed at the age of 18 months. The patient recovered uneventfully and is doing well.

  • https://doi.org/10.5090/kjtcs.2018.51.5.356 인용 PDF KSCI

불완전하게 결찰된 뇌동맥류의 혈관내치료 - 증 례 보 고 - (Endovascular Treatment of Incompletely Clipped Cerebral Aneurysm - Case Report -)

  • 임동준;정용구;조태형;이훈갑;김세훈;김근회;권택현;정흥섭;박정율;박윤관;이기찬;서중근
    • Journal of Korean Neurosurgical Society
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    • 제30권4호
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    • pp.533-536
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    • 2001

  • Residual aneurysm is a challenging problem after clipping procedure for the aneurysms. The anthors describe one patient in whom endovascular treatment was sucessfully done to treat residual aneurysm after surgical clipping. We discussed the role of endovascular coil occlusion in case of incomplete surgical obliteration of aneurysms.

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