Melatonin protects endothelial progenitor cells against AGE-induced apoptosis via autophagy flux stimulation and promotes wound healing in diabetic mice |
Jin, Haiming
(Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University)
Zhang, Zengjie (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Wang, Chengui (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Tang, Qian (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Wang, Jianle (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Bai, Xueqin (Department of Radiology, First Affiliated Hospital of Wenzhou Medical University) Wang, Qingqing (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Nisar, Majid (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Tian, Naifeng (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Wang, Quan (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Mao, Cong (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Zhang, Xiaolei (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) Wang, Xiangyang (Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University) |
1 | Klionsky, D. J. et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12, 1-222 (2016). DOI |
2 | Chen, Y. et al. Paeoniflorin protects HUVECs from AGE-BSA-induced injury via an autophagic pathway by acting on the RAGE. Int J. Clin. Exp. Pathol. 8, 53-62 (2015). |
3 | Li, Y. et al. Advanced glycation end products inhibit the proliferation of human umbilical vein endothelial cells by inhibiting cathepsin D. Int J. Mol. Sci. 18, E436 (2017). pii. DOI |
4 | Li, M. et al. Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells. J. Pineal Res. 61, 353-369 (2016). DOI |
5 | Rui, B. B. et al. Melatonin upregulates the activity of AMPK and attenuates lipid accumulation in alcohol-induced rats. Alcohol Alcohol 51, 11-19 (2016). DOI |
6 | Lee, S. J., Jung, Y. H., Oh, S. Y., Yun, S. P. & Han, H. J. Melatonin enhances the human mesenchymal stem cells motility via melatonin receptor 2 coupling with Galphaq in skin wound healing. J. Pineal Res. 57, 393-407 (2014). DOI |
7 | Asai, J., Takenaka, H., Katoh, N. & Kishimoto, S. Dibutyryl cAMP influences endothelial progenitor cell recruitment during wound neovascularization. J. Invest Dermatol. 126, 1159-1167 (2006). DOI |
8 | Takahashi, T. et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat. Med. 5, 434-438 (1999). DOI |
9 | Patschan, D. et al. The hormone melatonin stimulates renoprotective effects of "early outgrowth" endothelial progenitor cells in acute ischemic kidney injury. Am. J. Physiol. Ren. Physiol. 302, F1305-1312 (2012). DOI |
10 | Choi, S. I. et al. Melatonin induces autophagy via an mTOR-dependent pathway and enhances clearance of mutant-TGFBIp. J. Pineal Res. 54, 361-372 (2013). DOI |
11 | Mizushima, N. & Yoshimori, T. How to interpret LC3 immunoblotting. Autophagy 3, 542-545 (2007). DOI |
12 | Lee, H. M. et al. Autophagy negatively regulates keratinocyte inflammatory responses via scaffolding protein p62/SQSTM1. J. Immunol. 186, 1248-1258 (2011). DOI |
13 | Huynh, K. K. et al. LAMP proteins are required for fusion of lysosomes with phagosomes. EMBO J. 26, 313-324 (2007). DOI |
14 | McWilliams, T. G. & Muqit, M. M. PINK1 and Parkin: emerging themes in mitochondrial homeostasis. Curr. Opin. Cell Biol. 45, 83-91 (2017). DOI |
15 | Guo, S. & Dipietro, L. A. Factors affecting wound healing. J. Dent. Res 89, 219-229 (2010). DOI |
16 | Wang, P., Xing, Y., Chen, C., Chen, Z. & Qian, Z. Advanced glycation endproduct (AGE) induces apoptosis in human retinal ARPE-19 cells via promoting mitochondrial dysfunction and activating the Fas-FasL signaling. Biosci. Biotechnol. Biochem. 80, 250-256 (2016). DOI |
17 | World Health Organization. Global Report on Diabetes 6 (WHO: Geneva, 2016). |
18 | Chen, D. et al. Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo. Cell Death Dis. 7, e2441 (2016). DOI |
19 | Zhang, D. et al. Metformin improves functional recovery after spinal cord injury via autophagy flux stimulation. Mol. Neurobiol. 54, 3327-3341 (2017). DOI |
20 | Modi, P. Diabetes beyond insulin: review of new drugs for treatment of diabetes mellitus. Curr. Drug Discov. Technol. 4, 39-47 (2007). DOI |
21 | Falanga, V. Wound healing and its impairment in the diabetic foot. Lancet 366, 1736-1743 (2005). DOI |
22 | Mangrulkar, S. & Khair, P. S. Comparison of healing of surgical wounds between diabetics and non-diabetics. J. Indian Med. Assoc. 107, 765-770 (2009). |
23 | Basile, D. P. & Yoder, M. C. Circulating and tissue resident endothelial progenitor cells. J. Cell Physiol. 229, 10-16 (2014). |
24 | Huang, S., Dang, H., Huynh, W., Sambrook, P. J. & Goss, A. N. The healing of dental extraction sockets in patients with type 2 diabetes on oral hypoglycaemics: a prospective cohort. Aust. Dent. J. 58, 89-93 (2013). DOI |
25 | Zimny, S. & Pfohl, M. Healing times and prediction of wound healing in neuropathic diabetic foot ulcers: a prospective study. Exp. Clin. Endocrinol. Diabetes 113, 90-93 (2005). DOI |
26 | Velnar, T., Bailey, T. & Smrkolj, V. The wound healing process: an overview of the cellular and molecular mechanisms. J. Int. Med. Res. 37, 1528-1542 (2009). DOI |
27 | Asahara, T. et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ. Res. 85, 221-228 (1999). DOI |
28 | Loomans, C. J. et al. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 53, 195-199 (2004). DOI |
29 | Carrillo-Vico, A., Guerrero, J. M., Lardone, P. J. & Reiter, R. J. A review of the multiple actions of melatonin on the immune system. Endocrine 27, 189-200 (2005). DOI |
30 | Ganguly, K., Sharma, A. V., Reiter, R. J. & Swarnakar, S. Melatonin promotes angiogenesis during protection and healing of indomethacininduced gastric ulcer: role of matrix metaloproteinase-2. J. Pineal Res. 49, 130-140 (2010). |
31 | Pugazhenthi, K., Kapoor, M., Clarkson, A. N., Hall, I. & Appleton, I. Melatonin accelerates the process of wound repair in full-thickness incisional wounds. J. Pineal Res. 44, 387-396 (2008). DOI |
32 | Song, R. et al. Melatonin promotes diabetic wound healing in vitro by regulating keratinocyte activity. Am. J. Transl. Res. 8, 4682-4693 (2016). |
33 | Mizushima, N. Autophagy: process and function. Genes Dev. 21, 2861-2873 (2007). DOI |
34 | Cheng, Y., Ren, X., Hait, W. N. & Yang, J. M. Therapeutic targeting of autophagy in disease: biology and pharmacology. Pharmacol. Rev. 65, 1162-1197 (2013). DOI |
35 | Kongsuphol, P., Mukda, S., Nopparat, C., Villarroel, A. & Govitrapong, P. Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells. J. Pineal Res. 46, 199-206 (2009). DOI |
36 | Yoo, Y. M. & Jeung, E. B. Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells. J. Pineal Res. 48, 204-211 (2010). DOI |
37 | Chang, C. F. et al. Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and alpha-synuclein aggregation. J. Pineal Res. 52, 312-321 (2012). DOI |
38 | Areti, A., Komirishetty, P., Akuthota, M., Malik, R. A. & Kumar, A. Melatonin prevents mitochondrial dysfunction and promotes neuroprotection by inducing autophagy during oxaliplatin-evoked peripheral neuropathy. J. Pineal Res. 62, e12393 (2017). DOI |