• Asia pacific journal of information systems
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• v.31 no.3
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• pp.358-377
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• 2021

Knowledge drives business innovation. However, even if companies have the same knowledge element in the business ecosystem, innovation performance varies depending on the structural position of the technical knowledge network. This study investigated whether there is a difference in exploitative innovation according to the structural position of the AI technical knowledge network. We collected patents from the top 100 digital companies registered with the US Patent Office from 2015 to 2019 and classified the companies into knowledge producer-based brokers, knowledge absorber-based brokers, knowledge absorbers, and knowledge producers from the perspective of knowledge creation and flow. The analysis results are as follows. First, a few of the top 100 digital companies disseminate, absorb, and mediate knowledge, while the majority do not. Second, exploitative innovation is the largest, in the order of knowledge producer, knowledge absorber-based broker, knowledge absorber, and knowledge producer-based broker. Finally, patents for industrial intelligence occupy a large proportion, and knowledge producers are leading exploitative innovation. Therefore, latecomers need to expand their resources and capabilities by citing patents owned by leading companies and converge with existing industries into AI-based industries.

• Asian Journal of Innovation and Policy
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• v.5 no.2
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• pp.146-184
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• 2016

This paper analyzes the major comparisons and contrasts in entrepreneurship among technology-based university alumni over multiple decades from Tsinghua University in China and the Massachusetts Institute of Technology in the United States. In doing so, we ask two related research questions: (1) Who enters entrepreneurship and with what types of ideas and founding teams? (2) How do the innovation and other firm performance outcomes compare? We find that the sources of venture ideas and the composition of founding teams differ as well as the initial capital levels and revenues. This research provides a step toward a better understanding of high-tech entrepreneurship in developing vs. developed institutional environments. Furthermore, while MIT and Tsinghua University are unique in the programs they offer and in their historical cultures of entrepreneurship, both Tsinghua University and MIT provide benchmarks by which other institutions can gauge their alumni entrepreneurs and the types of ventures that they create.

• Journal of Digital Convergence
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• v.15 no.10
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• pp.133-150
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• 2017

In this study, the performance of the technological innovation of small and medium enterprises is divided into short-term aspects of technological innovation and long-term aspects of ambidextrous innovation, and the effects of dynamic capabilities affecting these achievements are explored. For the purpose of conducting empirical analysis, the survey conducted a survey of 219 small businesses belonging to various industries, and dynamic capabilities performed a parallel multi-parameter analysis to demonstrate the effectiveness of technological innovation performance, including exploratory innovation and exploitative innovation. Through this study, it aims to understand the dynamic capabilities of the small and midsize enterprises and provide suggestions on how to manage of the company, thereby improving the understanding of dynamic capabilities and helping to improve the management of small and medium-sized enterprises.

• Journal of Microbiology and Biotechnology
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• v.25 no.5
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• pp.606-611
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• 2015

As Salmonella enterica serovar Pullorum remains a major economic problem for the poultry industries of countries with no efficient control measures, we presented a multidrug resistance strain S06004 (isolated from a clinically sick chicken in China in 2006) for genome sequencing. The genome comparison showed that the strain contained two prophages, the ST104 and prophage-4 (Fels2) of E. coli LF82, which were not detected in the only published genomes of S. Pullorum RKS5078 and CDC1983-67. In addition, the GyrA Ser83 point mutation, drugresistant genes, and many antibiotic pump systems that are present in S06004 may be contributing to the multidrug resistance of this strain.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2006.11a
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• pp.93-100
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• 2006

This paper deals with Government-Industry-University-Academy (G-I-U-A) collaboration mechanism in China from the perspective of National Innovation Systems (NIS) theory. The focus of the article is on the analytical and methodological issues arising from the G-I-U-A collaboration. How the O-I-U-A collaboration changes in China is identified here. After some review of academic research, the paper reveals the key roles which Government, Industry, University and Academy should play. According to the government behavior in innovation activities, a G-I-U-A collaboration mechanism with Chinese characteristics is provided in the paper.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.7 s.98
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• pp.760-767
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• 2005

In this paper, we proposed a new type SIR bandpass filter using DAMLs. This filter is consisted of 2 layers with MEMS resonator layer and CPW feed line. DAMLs ring resonator is elevated with $10{\mu}m$ height from GaAs substrate. Using MEMS processing, we are able to realize SIR bandpass filter easily. Furthermore it is useful to integrate on conventional MMICs because it has CPW interfaces and ring resonator is isolated from substrate by air-gap. We optimized and measured the results that $S_{21}$ attenuation at rejected band is over 15 dB, insertion loss is inside the limit of 3 dB, and relative bandwidth is about $10\%$ at 60 GHz.

• Journal of Microbiology and Biotechnology
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• v.30 no.2
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• pp.187-195
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• 2020

To understand the molecular mechanism involved in the survivability of cold-tolerant lactic acid bacteria was of great significance in food processing, since these bacteria play a key role in a variety of low-temperature fermented foods. In this study, the cold-stress response of probiotic Lactobacillus plantarum K25 isolated from Tibetan kefir grains was analyzed by iTRAQ proteomic method. By comparing differentially expressed (DE) protein profiles of the strain incubated at 10℃ and 37℃, 506 DE proteins were identified. The DE proteins involved in carbohydrate, amino acid and fatty acid biosynthesis and metabolism were significantly down-regulated, leading to a specific energy conservation survival mode. The DE proteins related to DNA repair, transcription and translation were up-regulated, implicating change of gene expression and more protein biosynthesis needed in response to cold stress. In addition, two-component system, quorum sensing and ABC (ATP-binding cassette) transporters also participated in cell cold-adaptation process. These findings provide novel insight into the cold-resistance mechanism in L. plantarum with potential application in low temperature fermented or preserved foods.

• Microbiology and Biotechnology Letters
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• v.41 no.2
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• pp.253-262
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• 2013

In this study, we analyzed the anti-oxidative and anti-inflammatory activities of seven medicinal herbs. All extracts of the tested herbs, Euryale ferox Salisbury, Echinops setifer Iljin, Amomum cardamomum Linne, Tetrapanax papyriferus, Illicium verum Hook. f., Typha orientalis Presl, and Piper longum Linne, exhibited potent anti-oxidative activity as confirmed by DPPH radical scavenging capacity. Lipopolysaccharide (LPS) induced nitric oxide (NO) production, in the RAW 264.7 cell line, was also ameliorated by all extracts' treatments in a dose dependent manner. NO suppressive activity originated from the inhibition of inducible nitric oxide synthase (iNOS) protein expression by the extracts. Three extracts, E. ferox S., I. verum Hook. f., and P. longum L., possessed suppressive activity against, not only iNOS, but also cycloxygenase 2 (COX-2) protein expression. These three extracts may then serve as potential candidates for non steroidal analgesic inflammation drugs (NSAIDs). Furthermore, all extracts induced anti-oxidative enzyme, heme oxygenase 1, protein expression. Taken together, these results provide an important new insight into the fact that various medicinal herbs possess potent anti-oxidative and anti-inflammatory activities and might be utilized as promising agents in the field of health products. Further studies for the identification of the active compounds from medicinal herbs are clearly needed.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6347-6350
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• 2013

Post-transplant lymphoproliferative disorder (PTLD) is a common complication of therapeutic immunosuppression after organ transplantation. Gene expression profile facilitates the identification of biological difference between Epstein-Barr virus (EBV) positive and negative PTLDs. Previous studies mainly implemented variance/regression analysis without considering unaccounted array specific factors. The aim of this study is to investigate the gene expression difference between EBV positive and negative PTLDs through partial least squares (PLS) based analysis. With a microarray data set from the Gene Expression Omnibus database, we performed PLS based analysis. We acquired 1188 differentially expressed genes. Pathway and Gene Ontology enrichment analysis identified significantly over-representation of dysregulated genes in immune response and cancer related biological processes. Network analysis identified three hub genes with degrees higher than 15, including CREBBP, ATXN1, and PML. Proteins encoded by CREBBP and PML have been reported to be interact with EBV before. Our findings shed light on expression distinction of EBV positive and negative PTLDs with the hope to offer theoretical support for future therapeutic study.

• Food Science and Biotechnology
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• v.17 no.1
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• pp.188-190
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• 2008

In east Asia, the leaves of various Sasa species have been used in folk medicine for centuries. The effects of the methanolic extract and its subsequent fractions derived from the leaves of Sasa quelpaertensis Nakai on cell proliferation in human leukemia HL-60 cells were evaluated. The ethyl acetate fraction of this extract (ESQL) significantly reduced cell viability in a dose-dependent manner ($0-250\;{\mu}g/mL$). ESQL ($IC_{50}=24.8\;{\mu}g/mL$) exhibited growth inhibition comparable to the main constituent of green tea, epigallocatechin ($IC_{50}=26.2\;{\mu}g/mL$), which was used as a positive control. ESQL treatment induced apoptosis, which was confirmed by the presence of nuclear condensation and annexin V-staining. These results demonstrate that ESQL contains chemopreventive phytochemicals that may be useful in neutraceutical applications.