• Archives of Pharmacal Research
• /
• v.10 no.4
• /
• pp.203-207
• /
• 1987

Sedative principles of the seeds of Zizyphus vulgaris var. sphinosus have been characterized as sanjoinine-A (frangufoline), nuciferine and their congeners. Also, heat treatment of sanjoinine-A-produced a more active artifact, sanjoinine-Ahl, which provides a scientific basis for heat-processing (roasting) of this Oriental medicine.

• Archives of Pharmacal Research
• /
• v.22 no.4
• /
• pp.391-397
• /
• 1999

The quaternary ammonium cephalosporin derivatives were prepared with various pyridines substituted at the 3 or/and 4 position. Their in vitro antibacterial activities were determined and substituent effect on pyridine nucleus was studied. Preparation of substituted pyridines are also described.

• Archives of Pharmacal Research
• /
• v.22 no.4
• /
• pp.401-403
• /
• 1999

In continued studies on cultivated Korean rhubarb rhizomes (Rheum undulatum), three known stillbenes (desoxyrhapontigenin, rhapontigenin, piceatannol) have been screened for activity on blood platelet aggregation. Both rhapontigenin and desoxyrhapontigenin exhibited strong inhibition on the aggregation induced by arachidonic acid collagen. However, piceatannol did not show inhibition. These inhibitory effects may partially contribute to anti-blood stagnancy activity of rhubarb.

• Archives of Pharmacal Research
• /
• v.28 no.11
• /
• pp.1219-1223
• /
• 2005

6-[2-(Benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acids were designed and synthesized as $\beta$-amyloid (A$\beta$) fibril assembly inhibitors. Their inhibitory activity on A$\beta$, aggregation was evaluated by thioflavin T assay although their activities were insignificant.

• Archives of Pharmacal Research
• /
• v.23 no.5
• /
• pp.425-437
• /
• 2000

As we enter the new millennium, there have been dramatic improvements in the care of patients with HIV infection. These have prolonged life and decreased morbidity and mortality. There are fourteen currently available antiretrovirals approved in the United States for the treatment of this infection. The medications, including their pharmacokinetic properties, side effects, and dosing are reviewed. In addition, the current approach to the use of these medicines is discussed.

• Archives of Pharmacal Research
• /
• v.27 no.6
• /
• pp.624-627
• /
• 2004

A bile acid derivative, methyl chalate （1）, was isolated from EtOAc extract of the fungus Rhizopus oryzae as a cholesterol biosynthesis inhibitor. It showed moderate inhibitory activity on cholesterol biosynthesis in human Chang liver cells. Compound 1 exhibited inhibitory effect on the later step of cholesterol biosynthesis, indicating that its action mode is different from that of statins that act on the HMG-CoA reductase.

• Archives of Pharmacal Research
• /
• v.17 no.6
• /
• pp.476-479
• /
• 1994

Five pohenolic compounds were isolated from 80% aq. acetone extract of Duchesnea chyrysantha. Their crytotoxicities were screened by the colorimetric tetrazolium assay (MIT assay). Gallic acid, methyl caffeate, protocatechuic acid and pedunculagin mildly inhibited the survival of $PC_{14}{\;}and{\;}MKN_{45}$ human cancer cell. Brevifolin carboxylic acid showed a strong cytotoxic activity.

• Archives of Pharmacal Research
• /
• v.18 no.1
• /
• pp.48-50
• /
• 1995

The $^1H NMR singls of three 6{\alpha}-bromopenicillanates$ have been assigned and the Nuclear Overthauser Effect(NOE) study of these compounds was undertaken.

• Archives of Pharmacal Research
• /
• v.8 no.2
• /
• pp.77-84
• /
• 1985

[$^{2}$H$_{2}$] Tranylcypromine hydrochloride (trans-3, 3-dideuterio-2-phenylcyclopropylamine HCL) was synthesized for application to the metabolic studies. Mass fragmentation processes for the tranylcypromine and its two synthetic intermediates .gamma-phenyl-.gamma.-butyrolactone and trans-2-phenylcyclopropanecarboxylic acid were described based upon comparisons between labeled and unlabeled compounds.

• Archives of Pharmacal Research
• /
• v.21 no.5
• /
• pp.549-554
• /
• 1998

Tissue factor (TF), a principal initiator of the veertebrate coagulation cascade, is expressed in organ tissues, cells and blood. TF is konwn to be induced in endothelial cells, monocytes and macrophages by inflammatory stimuli and in many pathologic conditions. By using the modified method for in vido TF activity assay, we found that turpentine oil injection as an inflamatory stimulus also induced the TF activity in lung and brain tissues of rats. And the age-related increase in Tf activity was observed in healthy rat brain tissue.