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A Cholesterol Biosynthesis Inhibitor from Rhizopus oryzae  

Kim, Hyun-Jung (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
Yim, Soon-Ho (Jeonnam Biotechnology Center for Biaindustry)
Lee, Ik-Soo (College of Pharmacy and Research Institute of Drug Development, Chonnam National University)
Publication Information
Archives of Pharmacal Research / v.27, no.6, 2004 , pp. 624-627 More about this Journal
Abstract
A bile acid derivative, methyl chalate （1）, was isolated from EtOAc extract of the fungus Rhizopus oryzae as a cholesterol biosynthesis inhibitor. It showed moderate inhibitory activity on cholesterol biosynthesis in human Chang liver cells. Compound 1 exhibited inhibitory effect on the later step of cholesterol biosynthesis, indicating that its action mode is different from that of statins that act on the HMG-CoA reductase.
Keywords
Cholesterol biosynthesis inhibitor; Methyl cholate; Rhizopus oryzae;
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