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Studies on the Synthesis and in vitro anti-Tumor Activity of Dihydroberberine Derivatives

  • Kim, In-Jong;Park, Yea-Jin;Kim, Joo-il;Lee, Kyung-Tae;Kim, Sin-Kyu
    • Archives of Pharmacal Research
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    • v.20 no.5
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    • pp.476-479
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    • 1997
  • Three types of dihydroberberine derivatives such as spirobenzylisoquinoline, benzindenoazepine and cyclopropanated quinolizine species were synthesized from dihydroberberine for the investigation on their anti-tumor activity. Among them, cyclopropanated quinolizine species were more effective than spirobenzylisoquinoline and benzindenoazepine against P-388 and L-1210 leukemia cell.

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Flavonoids from the leaves of rhododendron brachycarpum

  • Choi, Jae-Sue;Young, Han-Suk;Park, Jong-Cheol;Choi, Jin-Ho;Woo, Won-Sick
    • Archives of Pharmacal Research
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    • v.9 no.4
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    • pp.233-236
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    • 1986
  • The flavonoids isolated form the leaves of rhododendron brachycarpum were identified as quercetin, avicularin, quercitrin and hyperin.

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Antitumor and Antiinflammatory Constituents from Celtis sinensis

  • Kim Dae Keun;Lim Jong Pil;Kim Jin Wook;Park Hee Wook;Eun Jae Soon
    • Archives of Pharmacal Research
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    • v.28 no.1
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    • pp.39-43
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    • 2005
  • Eight compounds were isolated from the methanolic extract of the twigs of Celtis sinensis through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as two triterpenoids, germanicol and epifriedelanol, two amide compounds, trans-N-caffeoyltyramine and cis-N-coumaroyltyramine, two lignan glycoside, pinoresinol glycoside and pinoresinol rutinoside, and two steroids by spectroscopic analysis.