• The Korean Journal of Physiology and Pharmacology
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• v.18 no.2
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• pp.109-120
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• 2014

The epothilones are a class of microtubule inhibitors that exhibit a strong antitumor activity. UTD2 is a novel epothilone analog generated by genetic manipulation of the polyketide biosynthetic gene cluster. This study investigated the effects of UTD2 on the actin cytoskeleton and its critical regulators, and the signaling pathways which are essential for cell motility, growth and survival in MCF-7 breast cancer cells. Results showed that UTD2 inhibited the cellular functions of actin cytoskeleton, such as wound-closure, migration and invasion, as well as adhesion. Our study further demonstrated that UTD2 suppressed Rac1 GTPase activation and reduced the activity of PAK1, which is a downstream effector of Rac1, while the activity of Cdc42 was not affected. Additionally, the phosphorylation of p38 and ERK were significantly inhibited, but the phosphorylation of JNK remained the same after UTD2 treatment. Moreover, UTD2 inhibited the activity and mRNA expression of MMP-2, which plays a key role in cell motility. UTD2 also reduced the phosphorylation of Akt, which is an important signaling kinase regulating the cell survival through Rac1. Furthermore, UTD2 interrupted the synergy between Rac1 and Raf in focus formation assays. Taken together, these results indicated that UTD2 exerted multiple effects on the actin cytoskeleton and signaling pathways associated with Rac1. This study provided novel insights into the molecular mechanism of the antineoplastic and antimetastatic activities of epothilones. Our findings also suggest that the signaling pathways regulated by Rac1 may be evaluated as biomarkers for the response to therapy in clinical trials of epothilones.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.3
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• pp.359-367
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• 1999

The analysis of a surface wave antenna with the corrugated ground plane fed by a parallel-plate waveguide is considered. An equivalent theorem Is employed to subdivide the original problem into three regions for the simple analysis : one concerning the geometry inside the shorted parallel-plate(Internal region 1), one concerning the geometry of the corrugation(Internal region 2), and one concerning the geometry of the conducting wedge(External region). The hybrid method of moment(MOM)/uniform geometrical theory of diffraction(UTD) method is applied to analyze a corrugated surface wave antenna with the end-fire radiation. Our numerical results are very well matched with those of the previous experiment, better results are obtained when compared with those of the previous simple equivalent current approach. Also, we can obtain the parameters to design an effective end-fire corrugated surface wave antenna.

• The Journal of Natural Sciences
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• v.8 no.2
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• pp.101-109
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• 1996

In this paper, using the derived formula based on field theory both geometrical optics and diffraction theory, several features of same buildings of Bertoni's construction that influence the propagation of signals between antennas located on the same floor have been investigated theoretically and compared with previously studied results.

• Journal of Advanced Navigation Technology
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• v.24 no.2
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• pp.155-162
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• 2020

Recently, with the development of computer vision and deep learning technology, research on human action recognition has been actively conducted for video analysis, video surveillance, interactive multimedia, and human machine interaction applications. Diverse techniques have been introduced for human action understanding and classification by many researchers using RGB image, depth image, skeleton and inertial data. However, skeleton-based action discrimination is still a challenging research topic for human machine-interaction. In this paper, we propose an end-to-end skeleton joints mapping of action for generating spatio-temporal image so-called dynamic image. Then, an efficient deep convolution neural network is devised to perform the classification among the action classes. We use publicly accessible UTD-MHAD skeleton dataset for evaluating the performance of the proposed method. As a result of the experiment, the proposed system shows better performance than the existing methods with high accuracy of 97.45%.

• The Proceeding of the Korean Institute of Electromagnetic Engineering and Science
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• v.2 no.4
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• pp.47-54
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• 1991

본 논문에서는 전자파 해석에 관련된 기존의 해석 기법들을 간략하게 비교, 검토하고 GTD / UTD를 기본으로하여 고주파 해석 기법에 관련된 몇가지 문제들을 다룬다. 전자파 해석이란 전자파의 복사(radiation), 산란(scattering) 및 결합(coupling)에 관련된 문제의 해석을의미 한다. 전자파 해석은 여러 목적을위해 응용되고 있으며 EMC / EMI문제의 분석 및 대책 수립에도 응용될 수 있다. EMC / EMI 문제의 근원은 전자파의 간섭(interference) 현상이다. Emitting source로부터 복사(radiation)되는 간섭파는 여러 경로를 통해서 receptor로 coupling된다. 일반적으로 emitter와 receptor사이에는 여러 복잡한 구조물이 산란체로 작용하고 있으므로, emitter와 receptor사이의 직접경로(direct path)를 통한 coupling과 함께 구조물에 의한 전자파의 반사 및 회절을 통한 간접경로(indirect path)의 coupling도 고려되어야 한다. 따라서 EMC / EMI문제는 자유공간(free space)상에 있는 antenna 사이의 송수신 문제보다 매우 복잡하고 정확한 couplin의 계 산에 적지않은 어려움이 있다. EMC / EMI대책수립은 일차적으로 coupling path의 차단을 통해서 가능하므로 전자 파의 coupling path의 분석과 전자파의 복사 및 산란 mechanism에 대한 해석이 필수적이다.

• Applied Chemistry for Engineering
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• v.17 no.3
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• pp.235-242
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• 2006

Liquid phase alkylation of biphenyl (BP) was studied over large pore zeolites. Selective formation of the least bulky products, 4,4'-diisopropylbiphenyl (4,4'-DIPB) occurred only in the isopropylation of BP over some large pore molecular sieves. H-mordenites (MOR) gave the highest selectivity among them. The dealumination of MOR enhanced catalytic activity and the selectivity of 4,4'-DIPB because of the decrease of coke-deposition. Non-selective catalysis occurs on external acid sites over MOR with the low $SiO_2/Al_2O_3$ ratio because severe coke-deposition deactivates the acid sites inside the pores by blocking pore openings. The selectivity of DIPB isomers was changed with reaction temperature. Selective formation of 4,4'-DIPB was observed at moderate temperatures such as $250^{\circ}C$, whereas the decrease of the selectivity of 4,4'-DIPB occurred at higher temperatures as $300^{\circ}C$. However, 4,4'-DIPB was almost exclusive isomer in the encapsulated DIPB isomers inside the pores even at high temperatures. These decreases of the selectivity of 4,4'-DIPB are due to the isomerization of 4,4'-DIPB on the external acid sites. Some 12-membered molecular sieves, such as SSZ-24, MAPO-5 (M:Mg, Zn, Si), SSZ-31, and ZSM-12, which have straight channels, gave 4,4'-DIPB with moderate to high selectivity; however; SSZ-55, SSZ-42, and MAPO-36 (M: Mg, Zn) gave lower selectivity because of cages in 12-membered one dimensional channels. Three dimensional H-Y and Beta zeolites also yield 4,4'-DIPB in low yield because of their wide circumstances for the isopropylation of BP. The increasing the size of alkylating agent enhanced the shape-selective alkylaiton even for the zeolites, such as UTD-1. The ethylation of BP to ethylbiphenyls (EBPs) and diethylbiphenyls (DEBPs) over MOR was non-selective. The ethylation of BP to EBPs was controlled kinetically. However, there was difference in reactivity of EBPs and DEBPs for their further ethylation. 4-EBP was ethylated preferentially among the isomers, although the formation of 4,4'-DEBP was less selective. The least bulky 4-EBP and 4,4'-DEBP have the highest reactivity among EBPs and DEBPs for the ethylation to polyethylbiphenyls (PEBPs). These results show that the environments of MOR pores are too loose for shape selective formation of the least bulky isomers, 4-EBP and 4,4'-DEBP in the ethylation of BP, and that MOR pores have enough space for the further ethylation of 4,4'-DEBP.