• Title/Summary/Keyword: US3

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Expression of Human Cytomegalovirus Immediate Early US3 Gene in Human Fibroblast Cells

  • Lee, Gyu-Cheol;Lee, Chong-Kyo;Ahn, Jin-Hyun;Lee, Chan-Hee
    • Journal of Microbiology
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    • v.38 no.1
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    • pp.24-30
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    • 2000
  • US3 gene is a member of the human cytomegalovirus (HCMV) immediate early gene. Although the precise functions of the US3 gene in HCMV replication and pathogenesis are not known, it has been reported to play a role in inhibiting major histocompatibility class I antigen presentation. For further knowledge of US3 gene expression, rabbit polyclonal antiserum of the US3 gene product was used for indirect immunofluorescence assay. In permissive human foreskin fibroblast (HFF) cells, US3 gene expression was detectable as crescent or half-moon shape in the perinuclear region at immediate early times after virus infection. HFF cells infected with mutant HCMV lacking US3 open reading frames were negative for US3 immunofluorescence assay. Double immunofluorescence assay using monoclonal antibody to gamma adaptin (specific for the Golgi complex) and rabbit anti-US3 antiserum revealed that US3 gene product could be localized to the Golgi complex. At later time after HCMV infection, US3 gene products were detected as globular aggregates in the cytosol. These aggregates were positive for gamma adaptin and stained with preimmune serum, suggesting a nonspecific reaction to the Golgi complex. Northern blot analysis revealed that transcription of US3 was observed only during immediate early times after virus infection (until 6 h postinfection). Therefore US3 gene expression appears to be confined to immediate early time and its gene products are localized to the Golgi complex as crescent shaped forms in the perinuclear cytoplasm.

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US Purchasing Managers' Index and its Impact on Korea and US

  • Jeon, Ji-Hong
    • Journal of Distribution Science
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    • v.15 no.3
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    • pp.17-25
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    • 2017
  • Purpose - The study is to examine the impact of the US Purchasing Managers' Index (PMI) on Korea and the US industrial economy including the distribution industry. We analyze its effect on the industrial economy centered on the distribution industry using economy indices in Korea and the US. Research design, data, and methodology - The variables are used to analyze the dynamic relationship which occurs among the US PMI, the industrial production index, producer price index, unemployment rate, and manufacturing Inventories Index in Korea and the US from January 1990 to July 2016 using Vector Error Correction Model. Results - As a main result, the impact of the US PMI on all the economy indices both Korea and the US has the same cyclical movement. The US PMI is positively related to the producer price and the industrial production index of Korea and the US, while it is negatively related to unemployment rate, and the manufacturing inventories index in Korea and the US. Conclusions - The US PMI as an advanced index has a power to predict the economies on Korea and the US. In the end, we find that the US PMI has a great impact on Korea and the US industrial economy.

Effects of Therapeutic Ultrasound on Experimental Induced Rectal Sarcoma(CT-26) (실험적으로 유발된 직장종양에 대한 치료적 초음파의 효과)

  • Cheong, Mee-Sun;Oh, Myoung-Hwa;Kim, Gye-Yeop;Kim, Chan-Kyu
    • Journal of Korean Physical Therapy Science
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    • v.11 no.3
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    • pp.5-13
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    • 2004
  • The use of therapeutic ultrasound(US) in humans with malignant neoplasms has been contra-indicated in physical therapy practice. Some studies have shown the results after application of US inhibited of tumor growth but some studies have shown the results facilitated of tumor growth in mouse. The purpose of this study were to determine the effects of US on rectal sarcoma(CT-26) in mouse and to determine the histological change of tumor. Thirty-five female BALB/C mouse, age 6 to 8 weeks received subcutaneous injection of 0.1 105 tumor cells. When tumors grew to 5 mm in diameters, the mouse were randomly assigned to control group(n=7) and high powered continuous US group(n=7) and low powered continuous US group(n=7) and high powered pulsed US group(n=7) and low powered pulsed US group(n=7). The experimental group (four groups) received 10 treatments over a 10-day period of 3 MHz ultrasound. Tumor dimension were measured on days 1(start of treatment), 5(midtreatment), and 10(end of treatment, preexcision and postexcision). Tumors were weighed after excision and the mouse were observated histological change of tumor. All tumors grew larger over time. Mean tumor weights(in grams) and volumes(in cubic millimeters) were 2.063 g and $2729.313\;mm^3$ for the high powered continuous US group 1.881 g and $2428.002\;mm^3$ for the low powered continuous US group 1.730 g and $2381.002\;mm^3$ for the high powered pulsed US 1.673 g and $2289.562\;mm^3$ for the low powered pulsed US group 1.670 g and $2297.333\;mm^3$ for the control group. Ultrasound increased the weight and volume of subcutaneous tumor in mouse. We urge caution in the use of ultrasound in the areas of tumors.

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Ultrasonographic Indeterminate Lymph Nodes in Preoperative Thyroid Cancer Patients: Malignancy Risk and Ultrasonographic Findings Predictive of Malignancy

  • Roh-Eul Yoo;Ji-hoon Kim;Jeong Mo Bae;Inpyeong Hwang;Koung Mi Kang;Tae Jin Yun;Seung Hong Choi;Chul-Ho Sohn;Jung Hyo Rhim;Sun-Won Park
    • Korean Journal of Radiology
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    • v.21 no.5
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    • pp.598-604
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    • 2020
  • Objective: Proper management of lymph nodes (LNs) with ultrasonographic (US) indeterminate features in thyroid cancer patients remains elusive. We aimed to evaluate the malignancy risk and US findings predictive of malignancy for US indeterminate LNs in preoperative thyroid cancer patients through node-by-node correlation. Materials and Methods: A total of 348 LNs in 284 thyroid cancer patients, who underwent fine-needle aspiration or core-needle biopsy between December 2006 and June 2015, were included. We determined the malignancy risks for US probably benign, indeterminate, and suspicious categories. For US indeterminate LNs, which had neither echogenic hilum nor hilar vascularity in the absence of any suspicious finding, US findings were compared between benign and metastatic LNs using Mann-Whitney U test and Fisher's exact test. Results: US imaging diagnoses were probably benign in 20.7% (n = 72) cases, indeterminate in 23.6% (n = 82), and suspicious in 55.7% (n = 194). Malignancy risk of US indeterminate LNs (19.5% [16/82]) differed from those of the US probably benign (2.8% [2/72]) (p = 0.002) and US suspicious LNs (78.4% [152/194]) (p < 0.001). Among US indeterminate LNs, there were no significant differences in short, long, and long-to-short diameter (L/S) ratios between benign and metastatic LNs (3.9 vs. 3.8 mm, p = 0.619; 7.3 vs. 7.3 mm, p = 0.590; 1.9 vs. 1.9, p = 0.652). Conclusion: US indeterminate LNs were frequently encountered during preoperative evaluation and had intermediate malignancy risk. Given the lack of discriminative power of size criteria and L/S ratio, clinical factors such as surgical strategy and node size should be considered for proper triage of US indeterminate LNs in thyroid cancer.

A Study on the Synergistic Effects of Hybrid System Simultaneously Irradiating the UV and US (자외선과 초음파를 동시에 조사하는 연계 공정의 시너지 효과에 관한 연구)

  • Lee, Hanuk;Han, Jonghun;Yoon, Yeomin;Lee, Jongyeol;Park, Jaewoo;Her, Namguk
    • Journal of the Korean GEO-environmental Society
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    • v.15 no.7
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    • pp.5-11
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    • 2014
  • Both ultraviolet (UV) and ultrasound (US) systems are used in degrading of organic contaminants and they can thus be applicable simultaneously as an UV/US hybrid system in attempts further to increase the degradation efficiency. The pseudo-first order degradation rate constants with the UV, US and UV/US hybrid irradiation were 2.60, 10.34, and $14.81{\times}10^{-3}min^{-1}$, respectively. It was observed that the synergistic effect of UV/US hybrid system for degrading the bis (2-ethylhexyl) phthalate (DEHP). The highest rate of DEHP degradation was found during UV/US hybrid irradiation and the synergistic effect factor (SEF) was calculated to be 1.15 based on the pseudo-first order degradation rate constants. Results indicate that synergistic effect of UV/US hybrid system is closely correlated to the enhancement of sonochemical reactivity with the UV-US interaction of increasing the formation rate of OHby providing additional $H_2O_2$ production through the pyrolysis of water molecules during UV/US hybrid irradiation.

US-China Trade War and Game Theory in Asymmetric Bargaining Power (미중 무역전쟁과 게임이론: 협상력 비대칭 상황에서의 협조적 균형 가능성)

  • Kim, Hong-Youl
    • Korea Trade Review
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    • v.44 no.3
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    • pp.105-121
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    • 2019
  • This study applies diverse game theories to the US-China Trade War. The US-China Trade War can be analyzed as a game situation because the strategic decision-making process to maximize one's profit while considering the reaction of the other party is a game situation. However, related research suffered from some mistakes in applying the US-China Trade War as it is to classic game theory, because while the prisoners dilemma is based on the situation of No Communication, No Trust, No Cooperation, the US-China Trade War has a precondition different from that of prisoners dilemma, since it mutually communicates information and negotiation is repeated several times in a cooperative situation. The result of the trade negotiation will likely end as 'cooperate-cooperate'. Further, considering trade volume, trade interdependence, bargaining power based on economy, and the scale of damage caused by the Trade War, the US-China Trade War is progressing with the bargaining power of the US being higher than that of China. Since the current US-China Trade War is in an asymmetrical situation under the dominant bargaining power of the US, it is likely to reach 'US defect-China cooperative' in the long run.

Exports to the US and Imports from China during the US-China Tariff War: Evidence from Regional Trade Data in Vietnam

  • KAZUNOBU HAYAKAWA
    • KDI Journal of Economic Policy
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    • v.46 no.3
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    • pp.49-66
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    • 2024
  • This study empirically investigates how the exports of downstream products to the US change the imports of their upstream products from China during the US-China tariff war. To accomplish this, we use province-level trade data in Vietnam, known to be a country that increased its exports to the US market in place of China, i.e., known to enjoy a trade diversion in the US market. The use of regional trade data enables us to capture the input-output linkages more precisely. Specifically, focusing on the trade in general and electrical machinery industries from January of 2019 to December of 2023, we regress imports of upstream products from China on exports of their downstream products to the US, finding that the rise of exports of downstream products to the US significantly increases imports of their upstream products from China. On the other hand, the rise in these products does not significantly increase the imports of upstream products from Japan, Korea, and Taiwan. Furthermore, the input-output linkage between exports to the US and imports from China was found to be greater in provinces with better business environments in terms of entry costs, transparency in public services, and public support to businesses.

Structure Activity Relationships of Thiazole and Thiadiazole Derivatives as Potent and Selective Human Adenosine $A_3$ Receptor Antagonists

  • Jung, Kwan-Young;Kim, Soo-Kyung;Gao, Zhan-Guo;Gross-Ariel-S.;Melman-Neli;Jacobson-Kenneth-A.;Kim, Yong-Chul
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.189.1-189.1
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    • 2003
  • 4-(4-Methoxyphenyl)-2-aminothiazole and 3-(4-methoxyphenyl)-5-aminothiadiazole derivatives have been synthesized and evaluated as selective antagonists for human adenosine A$_3$ receptors. A methoxy group in the 4-position of the phenyl ring and N-acetyl or propionyl substitutions of the aminothiazole and aminothiadiazole templates displayed great increases of binding affinity and selectivity for human adenosine A$_3$ receptors. The most potent A$_3$ antagonist of the present series, N-[3-(4-methoxy-phenyl)-[1,2,4]thiadiazol-5-yl]-acetamide exhibiting a K$\_$i/ value of 0.79 nM at human adenosine A$_3$ receptors, showed antagonistic property in functional assay of cAMP biosynthesis involved in one of the signal transduction pathways of adenosine A$_3$ receptors. (omitted)

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Isolation and Identification of Serratia marcescens strain US50-3 Producing Water-Soluble Red Pigment (수용성 적색 색소를 생산하는 Serratia marcescens US50-3 균주의 분리 및 동정)

  • 양인영;황순욱
    • Microbiology and Biotechnology Letters
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    • v.23 no.6
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    • pp.777-780
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    • 1995
  • A strain US50-3 producing water-soluble red pigment was isolated from the pond separating oil from water near the oil storage tanks. The strain US50-3 was identified as a strain of Serratia marcescens considering its morphological and physiological characteristics, and DNA G+C contents. It showed a little difference comparing to the Type strain and was considered to be another biotype strain.

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The Use of Contrast-Enhanced Color Doppler Ultrasound in the Differentiation of Retinal Detachment from Vitreous Membrane

  • Sang-Suk Han;Seung-Kook Chang;Jung-Hee Yoon;Young-Joon Lee
    • Korean Journal of Radiology
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    • v.2 no.4
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    • pp.197-203
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    • 2001
  • Objective: To compare the clinical utility of contrast-enhanced color Doppler US in the differentiation of retinal detachment (RD) from vitreous membrane (VM) with that of various conventional US modalities, and to analyze the enhancement patterns in cases showing an enhancement effect. Materials and Methods: In 32 eyes examined over a recent two-year period, RD (n=14) and VM (n=18) were confirmed by surgery (n=28) or clinical follow-up (n=4). In all cases, gray-scale, color Doppler, and power Doppler US were performed prior to contrast injection, and after the intravenous injection of Levovist (Schering, Berlin) by hand for 30 seconds at a dose of 2.5 g and a concentration of 300 mg/mL via an antecubital vein, contrast-enhanced color Doppler US was performed. At Doppler US, the diagnostic criterion for RD and VM was whether or not color signals were visualized in membranous structures. Results: Diagnostic accuracy was 78% at gray-scale US, 81% at color Doppler US, 59% at power Doppler US, and 97% at contrast-enhanced color Doppler US. The sensitivity of color Doppler US to color signals in RD increased from 57% to 93% after contrast enhancement. The enhancement patterns observed were signal accentuation (n=3), signal extension (n=2), signal addition (n=3), and new signal visualization (n=5). Conclusion: Contrast-enhanced color Doppler US was the most accurate US modality for differentiating RD from VM, showing a significantly increased signal detection rate in RD.

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