• Title/Summary/Keyword: UL

Search Result 1,137, Processing Time 0.028 seconds

Inhibition Effect of Human Cytomegalovirus Replication by Peptide nucleic acids (PNA)

  • Park, Young-Doo;Eum, Jin-Seong;Paik, Soon-Young;Hong, Seong-Karp
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
    • /
    • 2008.05a
    • /
    • pp.971-975
    • /
    • 2008
  • Human cytomegalovirus (HCMV) provokes fatal infections in AIDS patients that have deficient immune functions and patients that have cellular immune responses repressed after bone marrow transplantation. A new candidate for therapeutic against HCMV is needed because conventional treatments as ganciclovir, acyclovir, cidofovir, and foscarnet cytosine used currently are improper due to their side effects and advent of resistant HCMV. In this study, peptide nucleic acids (PNAs) against UL54 (DNA polymerase) and UL97 (phosphotransferase) that were essential in replication of HCMV were applied in inhibition of replication of HCMV. From the results of this study, 4 PNAs $_{PNA}UL97-1$, $_{PNA}UL97-2$, $_{PNA}UL54-3$, and $_{PNA}UL54-4$ showed 3.7, 3.1, 1.7, and 1.6 folds of inhibition effect against replication of HCMV in the human fibroblast cells. These PNA suggest a novel possibility as therapeutic against HCMV.

  • PDF

An Axiomatic Extension of the Uninorm Logic Revisited (유니놈 논리의 확장을 재고함)

  • Yang, Eunsuk
    • Korean Journal of Logic
    • /
    • v.17 no.2
    • /
    • pp.323-349
    • /
    • 2014
  • In this paper, we show that the standard completeness for the extension of UL with compensation-free reinforcement (cfr) $(({\phi}&{\psi}){\rightarrow}({\phi}{\wedge}{\psi})){\vee}(({\phi}{\vee}{\psi}){\rightarrow}({\phi}&{\psi}))$ can be established. More exactly, first, the compensation-freely reinforced uninorm logic $UL_{cfr}$ (the UL with (cfr)) is introduced. The algebraic structures of $UL_{cfr}$ are then defined, and its algebraic completeness is established. Next, standard completeness (i.e. completeness on [0, 1]) is established for $UL_{cfr}$ by using the method introduced in Yang (2009).

  • PDF

Electrical Stimulation Can Facilitate Vestibular Compensation Following Unilateral Labyrinthectomy in Rats

  • Park, Byung-Rim;Kim, Jin-Ok;Kim, Min-Sun;Lee, Moon-Young;Kim, Jae-Hyo;Jin, Yuan-Zhe;Choi, Myung-Ae
    • The Korean Journal of Physiology and Pharmacology
    • /
    • v.5 no.2
    • /
    • pp.123-131
    • /
    • 2001
  • To investigate the effects of electrical stimulation on vestibular compensation, which is the recovery of vestibular symptoms following unilateral labyrinthectomy (UL), intermittent electrical stimulation was applied to the injured vestibular portion in Sprague-Dawley rats. Vestibuloocular and vestibulospinal reflexes, electrical activity and expression of c-Fos protein in medial vestibular nuclei (MVN) were measured with time following UL. Spontaneous nystagmus occurred with frequency of $2.9{\pm}0.2$ beats/sec at 2 hours after UL and disappeared after 72 hours. Electrical stimulation decreased the frequency of nystagmus significantly till 24 hours after UL. Roll head deviation was $107{\pm}9.7^{\circ}$ at 2 hours after UL and the deviation was maintained till 72 hours, but electrical stimulation decreased the deviation significantly 6 hours after UL. Resting activity of type I neurons in ipsilateral MVN to the injured vestibular side decreased significantly compared with control at 6 and 24 hours after UL, but the activity of type I neurons was recovered to control level by electrical stimulation at 24 hours after UL. Gain of type I neurons induced by sinusoidal rotation of 0.1 Hz decreased significantly till 24 hours after UL, but electrical stimulation restored the activity at 24 hours. The gain of type II neurons decreased significantly at 6 hours after UL, but electrical stimulation restored the activity. Expression of c-Fos protein was asymmetric between bilateral MVN till 24 hours after UL, but the asymmetry disappeared by electrical stimulation 6 hours after UL. These results suggest that electrical stimulation to the injured vestibular portion facilitates vestibular compensation following UL by restoration of symmetry of neuronal activity between bilateral vestibular nuclei resulting from increased activity in ipsilateral vestibular nuclei to the injured side.

  • PDF

A new proof of standard completeness for the uninorm logic UL (Uninorm 논리 UL을 위한 새로운 표준 완전성 증명)

  • Yang, Eun-Suk
    • Korean Journal of Logic
    • /
    • v.13 no.1
    • /
    • pp.1-20
    • /
    • 2010
  • This paper investigates a new proof of standard completeness (i.e. completeness on the real unit interval [0, 1]) for the uninorm (based) logic UL introduced by Metcalfe and Montagna in [15]. More exactly, standard completeness is established for UL by using nuclear completions method introduced in [8, 9].

  • PDF

Design of HDD Load/Unload Suspension Using Shape Memory Alloy (형상기억합금을 이용한 HDD Load/Unload 서스펜션의 설계)

  • Lim S. C.;Park Y. P.;Park N, C.;Choi S, B.
    • 정보저장시스템학회:학술대회논문집
    • /
    • 2005.10a
    • /
    • pp.163-170
    • /
    • 2005
  • In this work, we propose a new type of HDD Load/unload (L/UL) suspension featuring shape memory alloy (SMA). The mechanical and thermal properties of the SMA film with respect to the material phase states are experimentally estimated and the SMA film is carefully integrated to the suspension. In order to obtain the desirable dynamic characteristics of the suspension during L/UL process, the design parameters of the SMA film such as geometric properties are determined by considering the vibration modes of the suspension related to the L/UL performance. After analyzing the modal characteristics of the proposed suspension, L/UL performance is evaluated through L/UL simulation by observing the vibration motion and minimum flying height of the slider during L/UL process.

  • PDF

Design of HDD Load/Unload Suspension Using Shape Memory Alloy (형상기억합금을 이용한 HDD Load/Unload 서스펜션의 설계)

  • Lim, Soo-Cheol;Park, Young-Pil;Park, No-Cheol;Choi, Seung-Bok
    • Transactions of the Society of Information Storage Systems
    • /
    • v.2 no.1
    • /
    • pp.71-78
    • /
    • 2006
  • In this work, we propose a new type of HDD Load/Unload(L/UL) suspension featuring shape memory alloy(SMA). The mechanical and thermal properties of the SMA film with respect to the material phase states are experimentally estimated and the SMA film is carefully integrated to the suspension. In order to obtain the desirable dynamic characteristics of the suspension during L/UL process, the design parameters of the SMA film such as geometric properties are determined by considering the vibration modes of the suspension related to the L/UL performance. After analyzing the modal characteristics of the proposed suspension, L/UL performance is evaluated through L/UL simulation by observing the vibration motion and minimum flying height of the slider during L/UL process.

  • PDF

On the Standard Completeness of an Axiomatic Extension of the Uninorm Logic

  • Yang, Eun-Suk
    • Korean Journal of Logic
    • /
    • v.12 no.2
    • /
    • pp.115-139
    • /
    • 2009
  • This paper investigates an extension of the uninorm (based) logic UL, which is obtained by adding (t-weakening, $W_t$) (($\phi$ & $\psi$) ${\wedge}$ t) $\rightarrow$ $\phi$ to UL introduced by Metcalfe and Montagna in [8]. First, the t-weakening uninorm logic $UL_{Wt}$ (the UL with $W_t$) is introduced. The algebraic structures corresponding to $UL_{Wt}$ is then defined, and its algebraic completeness is established. Next standard completeness (i.e. completeness on the real unit interval [0, 1]) is established for this logic by using Jenei and Montagna-style approach for proving standard completeness in [3, 6].

  • PDF

A Study on Jeongho Kim′s Cheonggudo (김정호의 『청구도』 제작 과정과 지도적 특징에 관한 연구)

  • 이기봉
    • Journal of the Korean Geographical Society
    • /
    • v.39 no.3
    • /
    • pp.473-493
    • /
    • 2004
  • In Korea, Jeongho Kim is the most noted scholar who studied on a map and a topography during the 19th century. He arranged the merit and the defect of the former maps systematically through such studies and made Cheonggudo(‘do’ means an atlas) in 1834. Accordingly, it reflected the result of many scholars's efforts to make accurate a complete map of Joseon. Especially, it referred to Haedongyeojido which had been made during 1776-1787. Of course, Haedongyeojido also referred to Joseonjido which had been made by Gyeongjun Sin(1712-1781) in 1770. Jeongho Kim did not copy Haedongyeojido as it was but edited it newly.