• Journal of Korean Neurosurgical Society
• /
• v.29 no.6
• /
• pp.731-737
• /
• 2000

Objective : Growth factor receptors on the tumor cells are known to be expressed highly allowing the tumor cells to bind growth factors to stimulate cellular division. Immunotoxin therapy is one of the novel approaches to the primary malignant brain tumor, and expression of cell-surface receptor is essential for the immunotoxin to have specific anti-tumor activity. Despite promising cytotoxic activity of immunotoxin, tumor responses are not curative on clinical trials, and additional studies are needed regarding various factors influencing the efficacy of the immunotoxin. The purpose of this study is to detect the expression of various growth factor receptors on brain tumor cell lines which are going to be used in these studies. Materials and Methods : The authors detected transferrin receptor(TR), insulin-like growth factor-1 receptor(IGF-1R), and interleukin-4 receptor(IL-4R) on medulloblastoma cell line(Daoy) and glioblastoma cell lines(U373 MG and T98 G) by flow cytometric analysis. Results : TR was expressed on Daoy, U373 MG, and T98 G. IGF-1R was expressed on Daoy and U373 MG, but not on T98 G. IL-4R was expressed on all cell lines tested. Conclusion : The transferrin and interleukin-4 receptors might be good targets for immunotoxin therapy. The results should be considered in additional in vitro and in vivo studies regarding immunotoxin and in establishing the proper treatment model of the immunotoxin therapy including selection of the adequate immunotoxin.

• Korean Journal of Soil Science and Fertilizer
• /
• v.35 no.2
• /
• pp.87-92
• /
• 2002

Soil erosion is detrimental to sustain soil productivity in north Korea, since agriculture of this country depends largely upon the slope land in mountainous area. Taking any measure for protection from erosion should be based on prediction of soil loss. Estimation of rainfall factor, R, in north Korea for the Universal Soil Loss Equation was attempted. The monthly precipitation data of the twenty six locations provided by the Korean Meteorological Adminstration were used. From the relationship between II_30 and the July-August precipitation concentration percents, the regional adjustment factor was obtained. The rainfall factor was calculated with the monthly precipitation data and the regional adjustment factor. The annual precipitation in north Korea ranged from 606 to 1,520mm, and the July-August precipitation concentration percents were 34.4 to 53.8. The regional adjustment factor ranged from 0.53 to 1.33 showing lower value in the highland and east coastal region than in the mid mountainous inland and west region. The R-factor value estimated from the monthly precipitation and the regional adjustment factor ranged from 107 to 483, which was lower than average value in south Korea.

• Kyungpook Mathematical Journal
• /
• v.46 no.4
• /
• pp.581-589
• /
• 2006

We characterize the linear operators which preserve the factor rank of integer matrices. That is, if $\mathcal{M}$ is the set of all $m{\times}n$ matrices with entries in the integers and min($m,n$) > 1, then a linear operator T on $\mathcal{M}$ preserves the factor rank of all matrices in $\mathcal{M}$ if and only if T has the form either T(X) = UXV for all $X{\in}\mathcal{M}$, or $m=n$ and T(X)=$UX^tV$ for all $X{\in}\mathcal{M}$, where U and V are suitable nonsingular integer matrices. Other characterizations of factor rank-preservers of integer matrices are also given.

• Journal of Haehwa Medicine
• /
• v.18 no.2
• /
• pp.95-104
• /
• 2009

This study was carried out through the investigation of Oriental and Western medical literature and we was discovered these conclusions about the etiology, treatment, prescription of habitual abortion. The result of this study were as follows : 1. The habitual abortion does agree with 'Hwaltae(滑胎)' and means that spontaneous abortion repeats three times or more. 2. The etiology of habitual abortion is divided 'Deficiency of kidney'(腎虛), 'Deficiency of vital energy and blood'(氣血虛弱), 'Deficiency of yin'(陰虛), 'Clotted blood'(瘀血). 3. By means of cause, the treatment of habitual abortion was mainly made use of 'Tonifying kidney and promoting spleen'(補腎健脾), 'Invigorating vital energy and nourishing blood'(補氣補血), 'Supplementing yin fluid and alleviating fever'(滋陰淸熱), 'Resuscitating blood and removing clotted blood'(活血祛瘀). 4. By means of cause, the prescription of habitual abortion was frequent made use of Bosingochunghwan(補腎固沖丸), Bosingotae$\breve{u}$m(補腎固胎飮), Taesanbans$\breve{o}$ksan(泰山磐石散), $Ch\breve{o}ng\breve{u}mboinghwan$(千金保孕丸), Agyotang(阿膠湯), Gungguibojungtang(芎歸補中湯), Taewon$\breve{u}$m(胎元飮), Gotaej$\breve{o}$n(固胎煎), Baekchulj$\breve{o}$n(白朮煎), Sas$\breve{o}$ngsan(四聖散), Gyegibokryonghwan(桂枝茯苓丸), $Dangguich\breve{o}ng\breve{u}mtang$(當歸千金湯). 5. The Western medical etiology of habitual abortion(recurrent spontaneous early pregnancy loss) is divided Genetic factor(Chromosome aberration), Anatomical deformity, Endocrinologic disorder, Infection, Immunologic factor, Unknown factor(Others).

• Geomechanics and Engineering
• /
• v.29 no.5
• /
• pp.487-496
• /
• 2022

Most of the pile's vertical static load tests in construction sites are the proof load tests, which is difficult to accurately estimate the ultimate bearing capacity and analyze the reliability of piles. Therefore, a reliability analysis method based on the proof load-settlement (Q-s) data is proposed in this study. In this proposed method, a simple ultimate limit state function based on the hyperbolic model is established, where the random variables of reliability analysis include the model factor of the ultimate bearing capacity and the fitting parameters of the hyperbolic model. The model factor M = R_uR / R_uP is calculated based on the available destructive Q-s data, where the real value of the ultimate bearing capacity (R_uR) is obtained by the complete destructive Q-s data; the predicted value of the ultimate bearing capacity (R_uP) is obtained by the proof Q-s data, a part of the available destructive Q-s data, that before the predetermined load determined by the pile test report. The results demonstrate that the proposed method can easy and effectively perform the reliability analysis based on the proof Q-s data.

• 전기의세계
• /
• v.25 no.4
• /
• pp.53-58
• /
• 1976

Criteria and significance of the factor .root..mu..$R_{u}$ or ($R_{u}$/.root.p) in Hall element material selection are discussed. And the chart which is useful to compare the figure of merit F=.root..mu..$R_{u}$ in Hall element materials is presented with the F's for some practical Hall device materials.als.

• KSBB Journal
• /
• v.24 no.5
• /
• pp.425-431
• /
• 2009

Hepatocyte growth factor (HGF) and its receptor play an important role in the formation and progression of glioma. In this study, I investigated the ability of HGF to recover of the PSA siRNA-suppressed cell proliferation, migration and invasion in U-251-MG cells. PSA siRNA-transfected U-251-MG cells showed the reduction of the proliferation, migration and invasion with compared to control. Treatment of HGF on the PSA siRNA-transfected U-251-MG cells recovered the ability of proliferation, migration and invasion. These data suggest that PSA and HGF may use unique and parallel signaling cascade leading to the proliferative, migrative and invasive phenotype of U-251-MG cells. I also showed that PSA cooperated with HGF to a migrative and invasive phenotype via the increased secretion of matrix metalloproteinase-2 (MMP-2) and MMP-9.

• Nuclear Engineering and Technology
• /
• v.35 no.5
• /
• pp.442-453
• /
• 2003

This study investigates the safety assessment of the potential for fretting-wear damages on steam generator (SG) U-tubes caused by foreign object in operating nuclear power plants. The operating SG shell-side flow field conditions are obtained from three-dimensional SG flow calculation using the ATHOS3 code. Modal analyses are performed for the finite element modelings of U-tubes to get the natural frequency, corresponding mode shape and participation factor. The wear rate of U-tube caused by foreign object is calculated using the Archard formula and the remaining life of the tube is predicted. Also, discussed in this study is the effect of the flow velocity and vibration of the tube on the remaining life of the tube.

• Journal of Advanced Marine Engineering and Technology
• /
• v.24 no.6
• /
• pp.24-33
• /
• 2000

This paper investigates the relationship between J-integral and crack tip opening displacement, ${\delta}_t$ using Gordens results of numerical analysis. Estimation were carried out for several strength levels such as ultimate, flow, yield, ultimate-flow, flow-yield stress to determine the influence of strain hardening and the ratio of crack length to width on the $J-{\delta}_t$ relationship. It was found that for SE(B) specimens, the $J-{\delta}_t$ relationship can be applied to relate J to ${\delta}_t$ as follows $J=m_j{\times}{\sigma}_i{\times}{\delta}_t$ where $m_j=1.27773+0.8307({\alpha}/W)$, ${\sigma}_i:{\sigma}_U$, ${\sigma}_{U-F}={\frac{1}{2}} ({\sigma}_U+{\sigma}_F$), ${\sigma}_F$, ${\sigma}_F}$ $Y=({\sigma}_F+{\sigma}_Y)$, ${\sigma}_Y$

• Proceedings of the KIEE Conference
• /
• 1983.07a
• /
• pp.46-47
• /
• 1983