• Molecules and Cells
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• 제37권6호
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• pp.467-472
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• 2014

Obesity is known to be strongly associated with cardiovascular disease and cancer, the leading causes of mortality worldwide, and develops owing to interactions between genes and the environment. DNA methylation can act as a downstream effector of environmental signals, and analysis of this process therefore holds substantial promise for identifying mechanisms through which genetic and environmental factors jointly contribute to disease risk. Global DNA methylation of peripheral blood cells has recently been proposed as a potential biomarker for disease risk. Repetitive element DNA methylation has been shown to be associated with prominent obesity-related chronic diseases, but little is known about its relationship with weight status. In this study, we quantified the methylation of Alu elements in the peripheral blood DNA of 244 healthy women with a range of body mass indexes (BMIs) using pyrosequencing technology. Among the study participants, certain clinical laboratory parameters, including hemoglobin, serum glutamic oxaloacetic transaminase, serum glutamic- pyruvic transaminase, total cholesterol, and triglyceride levels were found to be strongly associated with BMI. Moreover, a U-shaped association between BMI and Alu methylation was observed, with the lowest methylation levels occurring at BMIs of between 23 and $30kg/m^2$. However, there was no significant association between Alu methylation and age, smoking status, or alcohol consumption. Overall, we identified a differential influence of BMI on global DNA methylation in healthy Korean women, indicating that BMI-related changes in Alu methylation might play a complex role in the etiology and pathogenesis of obesity. Further studies are required to elucidate the mechanisms underlying this relationship.

• 한국철도학회논문집
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• 제15권5호
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• pp.459-466
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• 2012

기존의 철도교량 유지관리체계는 주로 정보누락, 문서위주 관리 및 유선기반의 정보수집 등으로 인하여 다양한 현장의 환경변화에 실시간 대응이 곤란하여 능동적인 철도교량 유지관리 전략 수립에 제약을 갖고 있다. 본 연구에서는 유비쿼터스 기반의 철도교량 유지관리 정보운용체계 구축을 위한 실무 활용모형과 건설 생애주기의 통합 정보관리체계인 BIM (Building Information Modeling) 개념을 적용하여 유지관리 통합 운용모형을 제안하고 있다. 이의 개발 및 실무적 적용의 타당성 확보를 위해 설문분석에 의한 정량적 평가를 수행하였다. 최근 철도교량의 지능형 유지관리 운영체계가 확대될 것을 고려하면, 본 연구의 제안사항은 운영체계 구축을 위한 통합 프레임워크로 활용될 수 있을 것이다.

• 보건교육건강증진학회지
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• 제32권3호
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• pp.33-42
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• 2015

Objectives: This study was conducted to investigate the correlation between the health-related quality of life assessment according to socio-demographic characteristics, health behavior, and BMI for Gyeonggi-do community population. Methods: The 2012 Community Health Survey data was used. The data were collected by using a cross-sectional study with face-to-face interview. The variables of smoking, AUDIT, exercise, BMI, and Euroqol EQ-5D instrument were selected for analyses. The Difference on the EQ-5D index among groups were tested with Mann-Whitney U test and Kruskal Wallis test. Results: The EQ-5D index for Gyeonggi-do community was 0.951(${\pm}0.104$). The index were significantly different by sex, age, marital status, education level, and occupation. The health-related quality of life showed lower EQ-5D index in women than men, older than young, and less educated. The index were significantly different by health behavior (smoking, drinking, moderate physical activity and exercise) for both men and women). For BMIs, the index was lower to under-weighted male and over-weighted female. Conclusions: The findings suggest that the future intervention of health promotion programs should be carefully designed and tailored by health behavior and obese groups.