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Automated Lung Segmentation on Chest Computed Tomography Images with Extensive Lung Parenchymal Abnormalities Using a Deep Neural Network

  • Seung-Jin Yoo;Soon Ho Yoon;Jong Hyuk Lee;Ki Hwan Kim;Hyoung In Choi;Sang Joon Park;Jin Mo Goo
    • Korean Journal of Radiology
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    • v.22 no.3
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    • pp.476-488
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    • 2021
  • Objective: We aimed to develop a deep neural network for segmenting lung parenchyma with extensive pathological conditions on non-contrast chest computed tomography (CT) images. Materials and Methods: Thin-section non-contrast chest CT images from 203 patients (115 males, 88 females; age range, 31-89 years) between January 2017 and May 2017 were included in the study, of which 150 cases had extensive lung parenchymal disease involving more than 40% of the parenchymal area. Parenchymal diseases included interstitial lung disease (ILD), emphysema, nontuberculous mycobacterial lung disease, tuberculous destroyed lung, pneumonia, lung cancer, and other diseases. Five experienced radiologists manually drew the margin of the lungs, slice by slice, on CT images. The dataset used to develop the network consisted of 157 cases for training, 20 cases for development, and 26 cases for internal validation. Two-dimensional (2D) U-Net and three-dimensional (3D) U-Net models were used for the task. The network was trained to segment the lung parenchyma as a whole and segment the right and left lung separately. The University Hospitals of Geneva ILD dataset, which contained high-resolution CT images of ILD, was used for external validation. Results: The Dice similarity coefficients for internal validation were 99.6 ± 0.3% (2D U-Net whole lung model), 99.5 ± 0.3% (2D U-Net separate lung model), 99.4 ± 0.5% (3D U-Net whole lung model), and 99.4 ± 0.5% (3D U-Net separate lung model). The Dice similarity coefficients for the external validation dataset were 98.4 ± 1.0% (2D U-Net whole lung model) and 98.4 ± 1.0% (2D U-Net separate lung model). In 31 cases, where the extent of ILD was larger than 75% of the lung parenchymal area, the Dice similarity coefficients were 97.9 ± 1.3% (2D U-Net whole lung model) and 98.0 ± 1.2% (2D U-Net separate lung model). Conclusion: The deep neural network achieved excellent performance in automatically delineating the boundaries of lung parenchyma with extensive pathological conditions on non-contrast chest CT images.

Genetic Studies of Major Agronomic Traits in Hybrid Populations of Maize Inbred Lines. (옥수수 유망자식계통들의 잡종집단에서 주요 농업형질들의 유전분석)

  • 김남수;이주경;박종열;박기진;류시환;신지현;이명숙;민황기
    • Korean Journal of Plant Resources
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    • v.17 no.3
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    • pp.304-313
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    • 2004
  • This study was conducted to find out the scientific maize breeding protocol for developing high performing single cross hybrid using introduced U.S. elite inbred lines; the pattern of inheritance, heterosis and heritabilities of six agronomic traits were studied in the progenies derived from five crosses (Mo17/B14A, Va85/B73, C103/ND203, FR35/Oh43, Wf9/A632). Among the five cross combinations, the cross combination of Mo17/B14A showed the highest heterosis for the most agronomic traits. Among 6 agronomic traits, the grain yield showed the highest heterosis effect in most cross combinations. Most of the agronomic traits in this study showed more than 50% heritability for six cross combinations, with an exception of the ear length trait. In conclusion, since Mo17/B14A showed excellent performance for most of the agronomic traits, these inbred lines were desirable combination and regarded as superior germ plasm sources for F1 hybrid development. The results of current studies will be utilized for developing high performing single cross hybrid from maize inbred lines, and will be used for the further genetic analysis of agronomic traits and maize breeding programs.

Compact Complementary Quadtree for Binary Images (이진 영상을 위한 Compact Complementary Quadtree의 구성)

  • Jo, Yeong-U;Kim, Yeong-Mo
    • The Transactions of the Korea Information Processing Society
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    • v.4 no.1
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    • pp.209-214
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    • 1997
  • In this paper, we propose a new preorder tree method for binary images, named the Compact Complementary Quadtree (CCQ). In the proposed method we use type codes for representing nodes in the quadtree instead of using the symbols G, B, and W. From the experimental results, we have confirmed that the CCQ has a higher compression ratio than of the DF-expression. CCQ can be effectively applied to progressive transmission of binary images such as line drawings, geographical maps, and halftones.

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3GPP 표준 로드맵 및 LTE 기술 개요

  • Lee, Hyeon-U;Ji, Hyeong-Ju
    • Information and Communications Magazine
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    • v.25 no.9
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    • pp.3-8
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    • 2008
  • 본고에서는 1998년 말부터 시작된 3GPP의 표준인 WCDMA, HSPA 및 LTE로의 진화 로드맵을 알아보고, 특히 최근의 중점 이슈인 LTE에 대한 추진 배경, 일반적 요구사항 및 기술적 요구사항의 개요에 대해 알아본다. LTE는 2004년 말에 필요성이 제기되어 2005년부터 본격 추진되었고 2008년 말이면 무선접속 분야는 표준이 거의 완료될 전망이다. 과거 WCDMA 에서 HSPA로 진화 시 호환성을 고려해서 조심스럽게 접근했던 것과는 달리 LTE에서는 호환성의 제약을 받지 않는 완전히 새로운 표준을 지향하여, 단순하면서도 효율적이고 유연한 기술표준을 목표로 작업이 수행되어 왔다. 무선통신 분야의 주류 기술이 되고 있는 OFDM, MIMO기술을 바탕으로 LTE기술은 Vodafone, Verizon, NTT DoCoMo등 많은 대형사업자로부터 차세대 기술로 선택되고 있으며 2010년경부터 상용화가 예상되고 있다.

Broadband U-Shaped RFID Tag Antenna with Near-Isotropic Characteristic (광대역에서 일정한 준 등방성 특성을 가지는 U-형태의 RFID 태그 안테나)

  • Lee, Sang-Woon;Jung, Hak-Joo;Choo, Ho-Sung;Park, Ik-Mo
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.20 no.5
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    • pp.480-492
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    • 2009
  • In this paper, we proposed a broadband U-shaped RFID tag antenna with near-isotropic characteristic at UHF band. The proposed tag antenna is composed of the U-shaped half wavelength dipole and a rectangular shaped feed. The rectangular shaped feed that is located inside U-shaped dipole is connected for conjugate impedance matching with the commercial tag chip. A better constant gain deviation characteristic in the operating frequency band is achieved by inserting a rectangular slit in the lower center of the U-shaped antenna body. On the condition of VSWR<2, the tag antenna had the measured bandwidth of 10.36%, from 860.5 to 954.5 MHz, and 9.84%, from 864.5 to 954 MHz, for antenna without slit and with slit, respectively. On the condition of VSWR<5.8, the tag antennas had the measured bandwidth of 15.78%, from 835.5 to 979.5 MHz, and 15.89%, from 837 to 981.5 MHz, for antenna without slit and with slit, respectively. The difference between the maximum and minimum gain deviations of tag antenna without slit in the operating frequency band is 0.53 dB since the maximum and minimum gain deviations are 3.86 dB and 3.33 dB, respectively. Whereas the difference between the maximum and minimum gain deviations of tag antenna with slit in the operating frequency is 0.06 dB since the maximum and minimum gain deviations are 3.60 dB and 3.54 dB, respectively.

Cholinesterase Activities in Blood and Nervous Tissues of Rats following Intraperitoneal Repetitive Injection of Parathion (Parathion의 복강내 반복투여로 인한 Rat의 혈액 및 신경조직내 Cholinesterase 활성변화)

  • Do, Jae Cheul;Mo, Ki Chul;Kim, Young Hong;Huh, Rhin Sou
    • Current Research on Agriculture and Life Sciences
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    • v.6
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    • pp.171-180
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    • 1988
  • Parathion is widely used in agriculture, but it is highly toxic and now clear that parathion behaves like a cholinergic drug by inhibiting the enzyme cholinesterase. In order to know the effect of toxicity and cholinesterase activity in rats injected repeatedly with parathion, cholinesterase activity in plasma, whole brain and spinal cord, and the subacute toxicity after repetitive intraperitoneal injection of parathion 20 times every 3 days were investigated. The results obtained were summerized as follows ; $LD_{50}$ value of parathion given intraperitoneally to rats was 10.5mg/kg(95% confidence limits, 6.6-16.8mg/kg). In subacute toxicity test of parathion injected intraperitoneally, mortality of parathion-pretreated rats(B : 57%, C : 83%) were increased in comparison with the control(50%). Cholinesterase activities in plasma of parathion-pretreated rats(B : 0.47 U/ml, C : 0.36 U/ml, AA : 0.31 U/ml, B : 0.26 U/ml, CC : 0.17 U/ml) were significantly decreased in comparison with the control(0.58 U/ml). Cholinesterase activities in spinal cord of parathion-pretreated rats(B : 1.87 U/g, C : 1.29 U/g, AA : 1.27 U/g, BB : 0.71 U/g, CC : 0.25 U/g) were decreased in comparison with the control(2.48 U/g). Cholinesterase activities in whole brain of parathion-pretreated rats(B : 2.52 U/g, C : 1.32 U/g, AA : 2.48 U/g, BB : 1.08 U/g, CC : 0.51 U/g) were significantly inhibited in comparison with the control(4.67 U/g). However, there were no differences in the urea nitrogen and creatinine concentrations between parathion-pretreated rats and control.

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A Study on the Com positive Beauty of Back-Jae Stone Pagodas by means of Photogrammetry (사진측정(寫眞測定)에 의한 백제석탑(百濟石塔)의 조형미(造形美)에 관한 연구(硏究))

  • Yeu, Bock Mo;Kang, In Joon;Jong, Chang Sik;Song, In Seong
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.5 no.1
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    • pp.141-148
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    • 1985
  • This paper is a study on a analysis of geometrical composition about two Back-Jae stone pagodas-stone pagoda at the site of Mir$\bar{u}$k-Sa Temple in Iksan and five storied stone pagoda at the site of Ch$\check{o}$ngrim-Sa Temple in Puy$\check{o}$, existing stone pagodas which Were built in Back-Jae Dynasty. By using P31 terrestrial metric camera and A-10 for precision stereo plot, Ch$\check{o}$ngrim-Sa stone pagoda which has Bock-bal and Mir$\bar{u}$k-Sa stone pagoda which has many broken area are analyzed comparatively. From this result same geometric composition principle; orthotrigon is drawn in respect to module and the length ratio of the widths of Okgesuks which exist at the end-point of the orthotrigon, is found to be decrease as 9 : 8 : 7 : 6 : (5) also the height up to Bock-bal before broken, is able to estimate.

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Isolation, Identification and Enzyme Properties of a Bacterium producing Alkaline Protease (Alkaline protease를 생산하는 미생물의 분리, 동정 및 효소성질)

  • Shin, Kong-Sik;Kang, Sang-Mo;Ko, Jung-Youn
    • Applied Biological Chemistry
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    • v.43 no.3
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    • pp.169-173
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    • 2000
  • For the development of enzyme detergent capable of effectively washing at low temperature, a bacterium producing alkaline protease was isolated from soil samples, and properties of the enzyme were investigated. The selected strain was Gram negative, rod shape$(0.6{\sim}0.7{\times}1.3{\sim}2.6\;{\mu}m\;in\;size)$ and motile. It had the degradation activity of aesculin, gelatin and casein, and was catalase-positive. The cell wall components was meso-DAP, and G+C mole contents was 43.3%. From these results, the strain was identified as Acinetobacter sp. KN-27. The activity of alkaline protease by this strain peaked with 3,300 D.U/mL after 36 hours in the liquid culture at $40^{\circ}C$. The optimal pH and temperature of the enzyme were pH 9 and $60^{\circ}C$, respectively. Alkaline protease produced by Acinetobacter sp. KN-27 has shown two active bands on the electrophoresis of native gel.

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Fabrication of YB $a_2$C $u_3$ $O_{7-x}$ film on a (100) SrTi $O_3$ single crystal substrate by single liquid source MOCVD method ((100) SrTi $O_3$ 단결정 기판위에 단일 액상 원료 MOCVD 법에 의한 YB $a_2$C $u_3$ $O_{7-x}$ 박막 제조)

  • Jun Byung-Hyuk;Choi Jun-Kyu;Kim Ho-Jin;Kim Chan-Joong
    • Progress in Superconductivity and Cryogenics
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    • v.6 no.3
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    • pp.16-20
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    • 2004
  • YB $a_2$C $u_3$$O_{7-x}$ (YBCO) films were deposited on (100) SrTi $O_3$ single crystal substrates by a metal organic chemical vapor deposition (MOCVD) system of hot-wall type using single liquid source. Under the condition of the mole ratio of Y(tmhd)$_3$:Ba(tmhd)$_2$:Cu(tmhd)$_2$= 1:2.1:2.9. the deposition pressure of 10 Torr. the MO source line speed of 15 cm/min. the Ar/ $O_2$ flow rate of 800/800 sccm. YBCO films were prepared at the deposition temperatures of 780∼89$0^{\circ}C$. In case of the YBCO films with 2.2 ${\mu}{\textrm}{m}$ thickness deposited for 6 minutes at 86$0^{\circ}C$. XRD pattern showed complete c-axis growth and SEM morphology showed dense and crack-free surface. The atomic ratios of Ba/Y and Cu/Ba in the film were 1.92 and 1.56. respectively. The deposition rate of the film was as high as 0.37 ${\mu}{\textrm}{m}$/min. The critical temperature ( $T_{c.zero}$) of the film was 87K. The critical current of the film was 104 A/cm-width. and the critical current density was 0.47 MA/$\textrm{cm}^2$. For the thinner film of 1.3 ${\mu}{\textrm}{m}$ thickness. the critical current density of 0.62 MA/$\textrm{cm}^2$ was obtained.d.

The Effect of Ligand's Spin-Orbit Coupling and the Intermixing of │3d 〉 and │4p 〉 Cu Atomic Orbitals on Zero-Field Splitting in the Tetragonally Distorted Tetrahedral $CuCl_4^{2-}\;Complex^\ast$ (Cu 3d 와 4p 궤도함수의 혼성과 리간드의 Spin-Orbit Coupling 이 Tetragonally 일그러진 $CuCl_4^{2-}$ 착물의 Zero-Field Splitting에 미치는 영향)

  • Lee, Wang No;Choe, U Seong;Baek, U Hyeon;Kim, Dong Hui;Choe, Chang Jin;Lee, Gi Gye
    • Journal of the Korean Chemical Society
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    • v.34 no.1
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    • pp.37-43
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    • 1990
  • An effect of the spin-orbit coupling interaction of ligand orbitals and the intermixing │3d 〉and│4p > transition metal atomic orbitals on the ground state for a 3$d^9$ system in a strong crystal field of tetragonally distorted tetrahedral symmetry that belongs to the $D_{2d}$ point group has been investigated in this work, applying the degenerate perturbation theory. An LCAO-MO analysis in terms of the known energies of the d-d transitions for the tetragonally distorted $CuCl_4^{2-}$ ion in a single crystal of$Cs_2CuCl_4$shows that the covalent mixing of Cu 3d and ligand Cl 3p orbitals decreases dramatically with increasing Cu 4p contribution. The extent of effect on the energy level splitting for the ground state by the spin-orbit coupling interaction of ligand orbitals decreases significantly in orderTEX>$\Gamma_7(E)\;\to\;\Gamma_6(E)\; >\;\Gamma_7(B_2)\;\to\;\Gamma_6(E)\; >\;\Gamma_7(B_2)\;\to\;\Gamma_7(E)$.

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