• 제목/요약/키워드: U/F

검색결과 1,924건 처리시간 0.026초

Anti-angiogenic, Anti-cell Adhesion Switch from Halophilic Enterobacteria

  • Lim, Jong Kwon;Seo, Hyo Jin;Kim, Eun Ok;Meydani, Mohsen;Kim, Jong Deog
    • 한국해양바이오학회지
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    • 제1권3호
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    • pp.156-162
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    • 2006
  • The halophilic enterobacteria, Enterobacteria cancerogenus, was isolated from the intestines of the fusiform fish (Trachurus japonicus) to yield a protein-like material termed PLM-f74. PLM-f74 was characterized by strong inhibition ratios to angiogenesis (82.8% at the concentration of $18.5{\mu}g/mL$) and elevated antioxidative capacities with low toxicity. The PLM-f74 is a glycoprotein comprised of saccharides and amino acids. PLM-f74 inhibited non-activated U937 monocytic cell adhesion to HUVECs activated with IL-$1{\beta}$ by 78.0%, and the adherence of U937 cells treated with the PLM-f74 and stimulated with IL-$1{\beta}$ to unstimulated HUVECs decreased by 102%. When both cell types were pretreated with PLM-f74, the adhesion of U937 cells to IL-$1{\beta}$ stimulated HUVECs was completely suppressed by 121% at a concentration of 18.5 ug/mL. PLM-f74 blocked signal pathways from VEGFR2, PI3K, ${\beta}$-catenin and VE-cadherin to NF-kB based on western bolt analysis. And also inhibited IL-1-stimulated HUVEC expression of the adhesion molecules, ICAM-1 by 40%, VCAM-1 by 60%, and E-selectin by 70% at the same concentration noted above. New anti-angiogenic and anti-cell adhesion materials showing elevated antioxidative capacities and non-toxicity may be expected from these results.

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Identification of Anti-Angiogenic and Anti-Cell Adhesion Materials from Halophilic Enterobacteria of the Trachurus japonicus

  • Lim, Jong-Kwon;Seo, Hyo-Jin;Kim, Eun-Ok;Meydani, Mohsen;Kim, Jong-Deog
    • Journal of Microbiology and Biotechnology
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    • 제16권10호
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    • pp.1544-1553
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    • 2006
  • The halophilic enterobacteria, Enterobacteria cancerogenus, was isolated from the intestines of the fusiform fish (Trachurus japonicus) to yield a protein-like material termed PLM-f74. PLM-f74 was characterized by strong inhibition ratios to angiogenesis (82.8% at the concentration of $18.5{\mu}g/ml$) and elevated antioxidative capacities with low toxicity. The PLM-f74 is a glycoprotein comprised of saccharides and amino acids. PLM-f74 inhibited cell adhesion that non-activated U937 monocytic cell adhesion to HUVECs activated with $IL-1{\beta}$ by 78.0%, and the adherence of U937 cells treated with the PLM-f74 and stimulated with $IL-1{\beta}$ to unstimulated HUVECs decreased by 102%. When both cell types were pretreated with PLM-f74, the adhesion of U937 cells to $IL-1{\beta}$-stimulated HUVECs was completely suppressed by 121% at a concentration of $18.5{\mu}g/ml$. PLM-f74 blocked signal pathways from VEGFR2, PI3K, ${\beta}$-catenin, and VE-cadherin to NF-kB, based on western bolt analysis. It also inhibited IL-l-stimulated HUVEC expression of the adhesion molecules, ICAM-l by 40%, VCAM-l by 60%, and E-selectin by 70% at the same concentration noted above. New anti-angiogenic and anti-cell adhesion materials showing elevated antioxidative capacities, and non-toxicity may be expected from these results.

요소수지(尿素樹脂)를 이용(利用)한 전작용(田作用) 완효성(緩效性) 복비(複肥) 개발(開發) I. 제조시험(製造試驗) (Development of Slow-Release Compound Fertilizer Used Urea-Resin for Upland Crop I. Manufacture of Slow-Release Compound Fertilizer)

  • 성기석;김복진;신제성
    • 한국토양비료학회지
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    • 제23권3호
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    • pp.193-198
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    • 1990
  • 완효성(緩效性) 전작물(田作用) 복비(複肥)를 개발(開發)하고자 삼요소원(三要素源)으로 유안(硫安), DAP, 염화가리(鹽化加里)와 증수제(增量劑)로 석고(石膏)를 사용(使用)하고 U/F 반응(反應) mole비(比)가 0.5, 1.0, 1.5인 요소수지(尿素樹脂) 3종(種)을 점결제(粘結劑) 및 완효성(緩效性) 요소원(尿素源)으로 이용(利用)하여 복비(複肥) 제조시험(製造詩驗)을 실시(實施)한 결과(結果)는 다음과 같다. 1. 시제품(試製品) 제조시(製造時) 점결제(粘結劑) 및 첨가제(添加劑)로 사용(使用)한 요소수지(尿素樹指)는 U/F반응(反應) mole비(比)가 높을수록 A. I. 값, 전질소(全窒素) 및 미반응요소(未反應尿素) 함량(合量)이 높은 경향(傾向)이었다. 2. 시제품(試製品)은 첨가(添加)된 요소수지(尿素樹指)의 U/F반응(反應) mole 비(比)가 낮을수록 첨가량(添加量)이 많을수록 전질소(全窒素)의 수중용출속도(水中溶出速度)가 늦어지는 경향(傾向)이었으며 특(特)히 U/F반응(反應) mole비(比)는 전질소(全窒素)의 늦출속도(出速度)를, 첨가량(添加量)은 Ammonia 태(態) 질소(窒素)의 용출속도(溶出速度)를 지연(遲延)시키는 효과(效果)가 있었다. 3. 시제품(試製品)의 24 시간후(時間後) 전질소(全窒素) 용출률(溶出率)은 69~83%로 높은 것은 재배기간(栽培期間)이 짧은 작물(作物)에 낮은 것은 재배기간(栽培期間)이 긴 작물(作物)에 전량기비용(全量基肥用)으로 가능(可能)할 것으로 사료(思料)된다.

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내부피폭 감시주기 및 섭취형태가 방사성핵종 섭취량 평가에 미치는 영향 (Influence of the Monitoring Interval and Intake Pattern for the Evaluation of Intake)

  • Jong-Il Lee;Tae-Young Lee;Si-Young Chang;Jai-Ki Lee
    • 방사성폐기물학회지
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    • 제2권1호
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    • pp.53-59
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    • 2004
  • 방사성핵종의 특성, 섭취형태 그리고 내부피폭 감시주기는 작업자의 방사성핵종 섭취량 및 내부피폭선량 평가 결과에 중요한 영향을 줄 수 있다. 따라서 방사성핵종이 흡입섭취 될 경우 섭취형태(급성 또는 만성) 및 내부피폭 감시주기에 따른 섭취량 평가 오차를 계산하였다. 섭취 핵종으로는 $^{125}$/I(Type F), $^{137}$Cs(Type F), $^{235}$ U(Type M, Type S)를 고려하였고, 방사능입자크기(AMAD)는 1 $\mu\textrm{m}$와 5 $\mu\textrm{m}$를 고려하였다. 섭취형태에 따라 평가된 섭취량의 상대오차는 방사성핵종, 흡수형태 그리고 내부피폭 감시주기에 따라 달랐으나, 입자크기에 의한 영향은 거의 없었다. 섭취형태 가정에 따른 섭취량 평가 오차를 10% 미만으로 줄일 수 있는 내부피폭 최대감시주기는 $^{125}$/I(Type F)에 대해 60일, $^{137}$Cs(Type F)에 대해 180일, $^{235}$ U(Type M)에 대해 90일, 그리고 $^{235}$ U(Type S)에 대해 360일로 나타났다.

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편지글 읽기에 나타난 한국어 모음 /오/-/우/의 세대간 차이 (Cross-Generational Differences of /o/ and /u/ in Informal Text Reading)

  • 한정임;강현숙;김주연
    • 말소리와 음성과학
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    • 제5권4호
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    • pp.201-207
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    • 2013
  • This study is a follow-up study of Han and Kang (2013) and Kang and Han (2013) which examined cross-generational changes in the Korean vowels /o/ and /u/ using acoustic analyses of the vowel formants of these two vowels, their Euclidean distances and the overlap fraction values generated in SOAM 2D (Wassink, 2006). Their results showed an on-going approximation of /o/ and /u/, more evident in female speakers and non-initial vowels. However, these studies employed non-words in a frame sentence. To see the extent to which these two vowels are merged in real words in spontaneous speech, we conducted an acoustic analysis of the formants of /o/ and /u/ produced by two age groups of female speakers while reading a letter sample. The results demonstrate that 1) the younger speakers employed mostly F2 but not F1 differences in the production of /o/ and /u/; 2) the Euclidean distance of these two vowels was shorter in non-initial than initial position, but there was no difference in Euclidean distance between the two age groups (20's vs. 40-50's); 3) overall, /o/ and /u/ were more overlapped in non-initial than initial position, but in non-initial position, younger speakers showed more congested distribution of the vowels than in older speakers.

STABILITY RESULTS OF POSITIVE WEAK SOLUTION FOR SINGULAR p-LAPLACIAN NONLINEAR SYSTEM

  • KHAFAGY, SALAH;SERAG, HASSAN
    • Journal of applied mathematics & informatics
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    • 제36권3_4호
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    • pp.173-179
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    • 2018
  • In this paper, we investigate the stability of positive weak solution for the singular p-Laplacian nonlinear system $-div[{\mid}x{\mid}^{-ap}{\mid}{\nabla}u{\mid}^{p-2}{\nabla}u]+m(x){\mid}u{\mid}^{p-2}u={\lambda}{\mid}x{\mid}^{-(a+1)p+c}b(x)f(u)$ in ${\Omega}$, Bu = 0 on ${\partial}{\Omega}$, where ${\Omega}{\subset}R^n$ is a bounded domain with smooth boundary $Bu={\delta}h(x)u+(1-{\delta})\frac{{\partial}u}{{\partial}n}$ where ${\delta}{\in}[0,1]$, $h:{\partial}{\Omega}{\rightarrow}R^+$ with h = 1 when ${\delta}=1$, $0{\in}{\Omega}$, 1 < p < n, 0 ${\leq}$ a < ${\frac{n-p}{p}}$, m(x) is a weight function, the continuous function $b(x):{\Omega}{\rightarrow}R$ satisfies either b(x) > 0 or b(x) < 0 for all $x{\in}{\Omega}$, ${\lambda}$ is a positive parameter and $f:[0,{\infty}){\rightarrow}R$ is a continuous function. We provide a simple proof to establish that every positive solution is unstable under certain conditions.

경도 마비말장애 환자의 발화 유형에 따른 모음 특성 비교 (The change of vowel characteristics for the dysarthric speech along with speaking style)

  • 김지연;성철재
    • 말소리와 음성과학
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    • 제8권3호
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    • pp.51-59
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    • 2016
  • The purpose of present study is to examine differences between habitual speech (HS) and clear speech (CS) in individuals with mild dysarthria. Twelve speakers with mild dysarthria and twelve healthy control speakers read sentences in two speaking styles. Formant and intensity related values, triangular area, and center of gravity of /a/, /i/, and /u/ were measured. In addition, formant-ratio variables such as vowel space area(VSA), vowel articulatory index (VAI), formant centralization ratio (FCR) and F2i/F1u ratio (F2 ratio) were calculated. The results of repeated-measures ANOVA showed a significant difference in F2 of vowel /i/ and F2 energy of vowel /a/ between groups. Regarding formant energy, F2 energy of vowel /a/ were observed as meaningful variables between speaking styles. There were significant speaking style-by-group interactions for F2 energy of vowel /a/. These findings indicated that current parameters could discriminate healthy group and mild dysarthria group meaningfully and that speaker with dysarthria had larger clear speech benefit than healthy talkers. We also claim that various acoustic changes of clear speech may contribute to improving vowel intelligibility.

ON A CLASS OF MULTIVALENT FUNCTIONS WITH NEGATIVE COEFFICIENTS

  • Shukla, S.L.;Chaudhary, A.M.;Owa, S.
    • Kyungpook Mathematical Journal
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    • 제28권2호
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    • pp.129-139
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    • 1988
  • Let $T^{\alpha}_{\lambda}$(p, A, B) denote the class of functions $$f(z)=z^p-{\sum\limits^{\infty}_{k=1}}{\mid}a_{p+k}{\mid}z^{p+k}$$ which are regular and p valent in the unit disc U = {z: |z| <1} and satisfying the condition $\left|{\frac{{e^{ia}}\{{\frac{f^{\prime}(z)}{z^{p-1}}-p}\}}{(A-B){\lambda}p{\cos}{\alpha}-Be^{i{\alpha}}\{\frac{f^{\prime}(z)}{z^{p-1}}-p\}}}\right|$<1, $z{\in}U$, where 0<${\lambda}{\leq}1$, $-\frac{\pi}{2}$<${\alpha}$<$\frac{\pi}{2}$, $-1{\leq}A$<$B{\leq}1$, 0<$B{\leq}1$ and $p{\in}N=\{1,2,3,{\cdots}\}$. In this paper, we obtain sharp results concerning coefficient estimates, distortion theorem and radius of convexity for the class $T^{\alpha}_{\lambda}$(p, A, B). It is further shown that the class $T^{\alpha}_{\lambda}$(p, A, B) is closed under "arithmetic mean" and "convex linear combinations". We also obtain class preserving integral operators of the form $F(z)=\frac{p+c}{z^c}{\int^z_0t^{c-1}}f(t)dt$, c>-p, for the class $T^{\alpha}_{\lambda}$(p, A, B). Conversely when $F(z){\in}T^{\alpha}_{\lambda}$(p, A, B), radius of p valence of f(z) has also determined.

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The k-Rainbow Domination and Domatic Numbers of Digraphs

  • Sheikholeslami, S.M.;Volkmann, Lutz
    • Kyungpook Mathematical Journal
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    • 제56권1호
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    • pp.69-81
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    • 2016
  • For a positive integer k, a k-rainbow dominating function of a digraph D is a function f from the vertex set V (D) to the set of all subsets of the set $\{1,2,{\ldots},k\}$ such that for any vertex $v{\in}V(D)$ with $f(v)={\emptyset}$ the condition ${\cup}_{u{\in}N^-(v)}$ $f(u)=\{1,2,{\ldots},k\}$ is fulfilled, where $N^-(v)$ is the set of in-neighbors of v. A set $\{f_1,f_2,{\ldots},f_d\}$ of k-rainbow dominating functions on D with the property that $\sum_{i=1}^{d}{\mid}f_i(v){\mid}{\leq}k$ for each $v{\in}V(D)$, is called a k-rainbow dominating family (of functions) on D. The maximum number of functions in a k-rainbow dominating family on D is the k-rainbow domatic number of D, denoted by $d_{rk}(D)$. In this paper we initiate the study of the k-rainbow domatic number in digraphs, and we present some bounds for $d_{rk}(D)$.

번역 교육을 위한 대안사전 개발의 방법론적 고찰 (Eine methodologische Untersuchung zur Erstellung eines Ersatzlexikons zum Zweck der $\"{U}bersetzungserziehung$)

  • 최병진
    • 한국독어학회지:독어학
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    • 제9집
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    • pp.281-300
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    • 2004
  • Ziel diesel Albeit ist os, Lexkion zu erstellen, das nicht nur der menschlichen $\"{U}bersetzung$, sondern auch der $nat\"{u}rlichsprachlichen$ Verarbeitung dienen soll. Um eine automatische maschinelle $\"{U}bersetzung$ $durchf\"{u}hren$ zu iassen, braucht man noch ein umfangreiches Wissen in Lunguistik und Informatik. Bei der Verarabeitung, aufgrund derer ein Wort oder eine Phrase aus der Ausgangssprache durch ein passendes $\"{A}quivalent$ der Zielsprache $\"{u}berstzt$ wird, sollte man auch auf die kuiturellen Hintergrunde $R\"{u}cksicht$ nehmen. $W\"{a}hrend$ des $\"{U}bersetzens$ versuchen $\"{U}bersetzer$ odor Dolmetscher, zweisprachige $W\"{o}rterbucher$ zu konsultieren, urn die angemessensten $\"{A}quivalente$ der Zielsprache zu finden. In vielen $F\"{a}llen$ aber macht man die Erfahrung, dass solche $Bem\"{u}hungen$ vergeblich sind In dieser Albeit wird $zun\"{a}chst$ das parallele Korpus (Koreanisch-Deutsch) untersucht, um das Desiderat der $herk\"{o}mmlichen$ $W\"{o}rterb\"{u}cher$ festzustelien. In den parallenen Koreanisch-Deutsch Korpora wird die $W\"{o}lter$ oder Phrasen der Ausgangssprache mit denen der Zielsprache verglichen und auf diesel Grundlage eine Liste von $M\"{a}ngeln$ erstellt. Die Ergebnisse diesel Untersuchung sollten nicht nur auf die menschliche $\"{U}bersetzung$, sondern auch auf die $nat\"{u}rlichsprachliche$ Verarbeitung angewendet werden, damit die Effizienz der $\"{U}bersetzung$ nock erheht wird. $Au{\ss}erdem$ soll die weitere Untersuchung mit den Korpora auch $f\"{u}r$ den Fremdsprachenunterricht $Anwendungsm\"{o}glichkeiten bieten.

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