• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.2
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• pp.17-32
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• 2013

Objectives: The purpose of this study was to investigate whether Lonicera japonica(LJ) could inhibit LPS-induced type I IFN production. Methods: To evaluate inhibitory effect of LJ on type I IFN, we examined type I IFN, IRF-1, 7 and IL-10 production on LPS-induced macrophages using real time RT-PCR. Next, we observed the interaction of type I IFN, IRF-1, 7 and IL-10 using IL-10 neutralizing antibody. Finally we examined the activation of STAT-1, 3 using western blot. Results: LJ inhibited Type I IFN expression of mRNA and increased IL-10 expression of mRNA. Also LJ inhibited the level of IRF-1, 7 mRNA and the nuclear translocation of IRF-3. Further more, LJ reduced the activation of STAT-1, 3 which are involved in continuous secretion of immune cytokines. Blockade of IL-10 action caused a significant reduction of type I IFN and IRF-1, 7 than LPS-induced LJ pretreatment. Conclusions: LJ inhibits LPS-induced production of type I IFN by IL-10. This study may provide a clinical basis for anti-inflammatory properties of LJ.

• Journal of Biomedical Engineering Research
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• v.37 no.5
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• pp.186-194
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• 2016

In this study, a co-axial flow induced microfluidic chip to fabricate pure collagen type I microfiber via the control of collagen type I and Na-alginate gelation process. The pure collagen type I microfiber was generated by selective degradation of Ca-alginate from 'Core-Shell' structured hydrogel microfiber. To make 'Core-Shell' structure, collagen type I solution was introduced into core channel and 1.5% Na-alginate solution was injected into side channel in microfluidic chip. To evaluatethe 'Core-Shell' structure, the red and green fluorescence substances were mixed into collagen type I and Na-alginate solution, respectively. The fluorescence substances were uniformly loaded into each fiber, and the different fluorescence images were dependent on their location. By immoblizing EpH4-Ras and C6 cells within collagen type I and Na-alginate solution, we sucessfully demonstrated the co-culture of EpH4-Ras and C6 cells with 'Core-Shell' like hydrogel microfiber for 5 days. Only to produce pure collagen type I hydrogel fiber, tri-sodium citrate solution was used to dissolve the shell-like Ca-alginate hydrogel fiber from 'Core-Shell' structured hydrogel microfiber, which is an excellent advantage when the fiber is employed in three-dimensional scaffold. This novel method could apply various application in tissue engineering and biomedical engineering.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.6
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• pp.879-888
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• 1999

A Study on the ARQ scheme of data error control is important for more reliable information transmission. Since performance difference is large by the long transmission delay time in satellite communication, the performances of SR ARQ and conventional type-I hybrid ARQ with fixed code rate are investigated by using the parameters of packet length, channel capacity, BER, and transmission delay time especially. BCH code is used in type-I hybrid ARQ for FEC method. This paper presents the throughput analyses according to such various parameters as BCH code rate, window size, data rate and round-trip delay time. Especially we derive a performance equation of type-I hybrid ARQ with the factor of the transmission delay time using the equation of SAW ARQ. Also, the performance of type-I hybrid ARQ specially considering transmission delay time is analyzed through numerical analysis and computer simulation so we can get a important characteristics variation.

• Journal of Microbiology and Biotechnology
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• v.10 no.5
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• pp.620-627
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• 2000

To determine the prevalence of genetic polymorphisms in Epstein-Barr virus (EBV) strains in the Korean population, the restriction site polymorphisms for BamHI and XhoI enzymes were analyzed with 16 EBV isolates from cancer patients and 7 EBV isolates from healthy carriers, using polymerase chain reaction techniques. None of the 23 isolates were found to carry an extra BamHI site in the BamHI F-fragment (f-variant). Of the 12 type-1 isolates from the cancer patients, 10 lost both the LMP1 XhoI site and the BamHI site between the BamHi W1* and I1* fragments (a W1*I1* fusion variant or type C). The latter W1*I1* fusion variant was due to a mutation of thymidine to adenine, as evidenced by a sequence analysis. The remaining two type-1 isolates showed either no variation at both sites or the loss of only the XhoI site. In contrast, two type-2 isolates and two intertypic recombinants with a type-1 allele at the EBNA2 locus and type-2 alleles at all or some of the EBNA3 loci retained both enzyme sites. In similar analyses of the 7 isolates from the healthy carriers, five of six type-1 isolates lost these two sites, however, one type-2 isolate did not. These results clearly indicate a strong association of both the LMP1 XhoI site loss and the W1*I1* fusion variant with the type-1 rather than the type-2 EBV strains circulating in the immunocompetent Korean carriers.

• Journal of the Korean Society of Costume
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• v.58 no.5
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• pp.13-34
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• 2008

In Headgear and Ornaments for Diadem in the Period of the Three States there was Conical Cap(or Pointed Cap), Feathered Cap(Trim), and Crown[Tree-typed Diadem and Tree and Antler-typed Diadem] was excavated from the tombs. Feathered Trim is 5 types, Feathered Trim I-A, Feathered Trim I-B, Feathered Trim II-A, Feathered Trim II-B, Feathered Trim II-C in according to upper part of central insert plate style. Feathered Trim I-A, I-B, II-B type was general style that was found in most of the old tombs in ancient Silla, Gaya. Feathered Trim II-A type was excavated from the only Silla tombs and II-C type was excavated from Gaya tombs. The Ornaments for Diadem in Baekje was excavated from the tombs is adorned with a arranged leaf-stems on either sides and the flower-shaped. They were distinguished with the original mode of Goguryeo and ancient Silla at the time. Tree-typed Diadem is five part in according to the Mountain(;山)-typed piled up. Only one Mountain(;山)-typed one in three stand-up ornament(I-1 type), and three step one in three stand-up one(I-2 type), modification one (I-3 type), three step one of four and five stand-up ones(I-4 type), and four step one of four and five stand-up ones (I-5 type). Tree and Antler-typed Diadem is three part in according to the step of Mountain(; 山)-typed and cross-shaped of the upper part. Three one of three step one of Mountain(;山)-typed and two Antler- typed (II-1 type), cross-shaped one(II-2 type), four step one(II-3 type).

• Korean Journal of Biological Psychiatry
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• v.18 no.4
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• pp.260-266
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• 2011

Objectives The second to fourth digit ratio (2D : 4D) is known to reflect testosterone level during intrauterine period. Testosterone is essential for masculinization of brain. Cloninger's type II alcoholism is characterized by early age at onset and largely limited to males. Compared with type I alcoholism, type II alcoholism is thought to be masculine. There is a possibility that the digit ratio of type II alcoholism is low compared with type I. We examined digit length ratio in Cloninger's type I and II alcoholism to understand the effects of intrauterine testosterone on the development of alcoholism. Methods The participants were 87 alcohol dependent patients. We divided two subtypes of patients by Irwin's symptom list, based on Cloninger's concept. We captured the images of both palms by the scanner and measured the lengths of digits by the graphic program. Then we analyzed the digit ratios by independent-sample t-test. Results The mean 2D : 4D of type I was 0.942 (right), 0.952 (left). The mean 2D : 4D of type II was 0.927 (right), 0.940 (left). In both hands, 2D : 4D of type II was significantly lower than type I. Conclusions Type II alcoholism showed masculine type of digit length ratio compared with type I. It suggests the exposure of testosterone during intrauterine period might play an important role in determining the course and feature of alcoholism.

• Journal of the Korean Data and Information Science Society
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• v.23 no.6
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• pp.1271-1277
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• 2012

In this paper, we propose an estimation method of the parameter in an exponential distribution based on a progressive Type I interval censored sample with semi-missing observation. The maximum likelihood estimator (MLE) of the parameter in the exponential distribution cannot be obtained explicitly because the intervals are not equal in length under the progressive Type I interval censored sample with semi-missing data. To obtain the MLE of the parameter for the sampling scheme, we propose a method by which progressive Type I interval censored sample with semi-missing data is converted to the progressive Type II interval censored sample. Consequently, the estimation procedures in the progressive Type II interval censored sample can be applied and we obtain the MLE of the parameter and survival function. It will be shown that the obtained estimators have good performance in terms of the mean square error (MSE) and mean integrated square error (MISE).

• Journal of the Korean Society of Costume
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• v.45
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• pp.29-40
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• 1999

The purpose of this study is to classify of the Heart shaped Earring in old tombs of Three Kingdom States. First Heart shaped Earring is 7 part in according to heart styles. I-A type was original style and that was influenced by scythe style. I-A II-A type was general style that was found in most of the old tombs in Kokuryo Pacijae ancient Silla Gaya. I-B II-2-A type was also found in most of the old tombs except Kokuryo. Then II-2-A type was transmitted to Japanese Heart shaped Earring. I-A, I-B, II-1, II-2-A type was general style in ancient Silla gaya. Ii-1-B, II-2-B. II-3-A type was excavated from the only Pacjae tombs and II-3-B type was excavated from Kokuryo tombs. II-3-A, II-3-B type was unique style that was found in old tombs in Kokuryo, Pacjae.

• Journal of the Korean Orthopaedic Association
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• v.54 no.6
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• pp.519-527
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• 2019

Purpose: To evaluate the treatment result in polyostotic fibrous dysplasia classified according to the involvement of the femoral head. Materials and Methods: Twenty-three patients from March 1987 to March 2014 were reviewed retrospectively. Patients with no involvement of the physeal scar in the femoral head were classified as Type I, and those with involvement of the physeal scar were classified as Type II. A plain radiograph was used to measure the femoral neck shaft angle, articulo-trochanteric distance (ATD), and anterior bowing through the lateral view. A teleoroentgenogram of the lower limb was used to measure the leg length discrepancy and lower extremity mechanical axis. The pre- and postoperative femoral neck-shaft angle and ATD were compared to assess the degree of correction of the deformity. Results: Among a total of 46 cases (23 patients), 28 cases (23 patients) had lesions in the proximal femur. Type I were 16/28 cases (15/23 patients) and Type II were 12/28 cases (9/23 patients). The preoperative proximal femoral neck-shaft angle was 116.8° in Type I and 95.3° in Type II. The ATD was 12.08 mm in Type I and -5.54 mm in Type II. The deformity correction showed significant improvement immediately after surgery, the deformity correction was lost in Type II (neck shaft angle Type I: 133.8°-130.8°, Type II: 128.6°-116.9°, and ATD Type I: 17.66-15.72 mm, Type II: 7.44-4.16 mm). The extent of anterior bowing was 12.74° in Type I and 20.19° in Type II. The mean differences of 12 mm between the 9 patients who showed a leg length discrepancy and the lower extremity mechanical axis showed 4 cases of lateral deviation and 7 cases of medial deviation. Conclusion: In polyostotic fibrous dysplasia, when the femur head is involved, the femur neck shaft angle, ATD, and anterior bowing of the femur had more deformity, and the postoperative correction of deformity was lost, suggesting that the involvement of the femoral head was an important factor in the prognosis of the disease.

• Journal of the Korean Wood Science and Technology
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• v.38 no.6
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• pp.532-540
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• 2010

The strength properties of wooden model retaining wall made of pitch pine (Pinus rigida Miller) was evaluated. Three different types of wooden model retaining wall were made of the 11cm square timber treated with CUAZ-2 (Copper Azole). The retaining wall was made into the 4 layers of crossbar and the 3 layers of vertical-bar, of which the size was 86 cm high, 200 cm long and 96 cm wide. Type I was control and in Type II 20 cm vertical-bars and 93 cm vertical-bars were arranged alternately to decrease wood usage. TypeIII was similar to TypeII except that the connection between crossbars was reinforced with the wooden armature. In each type, the strength properties of retaining wall were investigated by horizontal loading test and the deformation of structure by image processing (AICON 3D DPA-PRO system). In horizontal loading test of Type I, Type II and Type III was 63.17, 57.80, and 60.97 kN/m, respectively. The deformation of the top layer in Type II was 1.5 times larger than in Type I and Type III. Consequently, the economic efficiency and strength performance were better in Type III than in Type I and Type II.