• 대한유전성대사질환학회지
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• 제13권1호
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• pp.48-53
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• 2013

Tyrosinemia I (fumarylacetoacetate hydrolase deficiency) is an autosomal recessive inborn error of tyrosine metabolism that produces liver failure in infancy or a more chronic course of liver disease with cirrhosis, often complicated by hepatocellular carcinoma in childhood or early adolescence. We studied a 37-year-old woman with tyrosinemia I whose severe liver disease in infancy and rickets during childhood were resolved with dietary therapy. From 14 years of age, she resumed unrestricted diet with the continued presence of the biochemical features of tyrosinemia, yet maintained normal liver function. In adult years, she accumulated only a small amount of succinylacetone. Despite this evolution to a mild biochemical and clinical phenotype, she eventually developed hepatocellular carcinoma. Her fumarylacetoacetate hydrolase genotype consists of a splice mutation, IVS6-1G>T, and a novel missense mutation, p.Q279R. Studies of resected liver revealed the absence of hydrolytic activity and immunological expression of fumarylacetoacetate hydrolase in tumour. In the non-tumoral areas, however, 53% of normal hydrolytic activity and immunologically present fumarylacetoacetate hydrolase were found. This case demonstrates the high risk of liver cancer in tyrosinemia I even in a seemingly favorable biological environment. In this study of tyrosinemia I, Case 2 with negative succinylacetone accumulation and the recovery of acute liver failure was compared with Case 1. Diet restriction and NTBC treatment are crucial to prevent hepatocellular carcinoma until liver transplant can take place and cure the condition. Further studies are needed to examine cases where liver cancer did not result despite clinical symptoms/signs of tyrosinemia type I.

• 대한전자공학회논문지TC
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• 제37권1호
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• pp.66-75
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• 2000

본 논문에서는 광대역 코드분할 다중접속방식(W-CDMA : Wideband-Code Division Multiple Access)을 이용하는 전력제어된 이동통신 시스템에서 영상전송을 위한 채널모형을 설계하고, 영상 소스 데이터와 결합된 채널 부호화에 대한 설계를 하고 전송성능을 검증하고자 한다. 웨이브릿 변환 알고리즘을 이용하여 각 대역별 중요도에 따라 차등적인 크기의 블록 단위로 세분화하여 독립적으로 부호화 하였고, 영상정보의 전송에러에 대한 감응도를 고려하여 RS(Reed-Solomon)부호화시에 각각의 신호대역에 따라 분리된 RS 부호화율을 적용하여 W-CDMA 페이딩 채널 에러에 대하여 동일한 데이터율로서 더 나은 PSNR 이득을 얻도록 하였다. 또한 Truncated Hybrid Type I ARQ 방식에 의한 재전송과정에서 재전송 프레임간 Combine하여 성능을 향상시킬 수 있는 장점이 있다. 시뮬레이션을 통해 차세대 영상전송 시스템으로서 기존의 독립적인 영상-채널 부호화방식에 비해 무선채녈의 열화에서도 성능의 감소가 크지 않아 효과적인 영상전송 방법임을 알 수 있었다.

• Journal of Preventive Medicine and Public Health
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• 제37권4호
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• pp.366-372
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• 2004

Objectives : This study was conducted to propose a new transmission/disequilibrium test(TDT) to test the linkage between genetic markers and disease-susceptibility genes based on haplotypes. Simulation studies were performed to compare the proposed method with that of Zhao et al. in terms of type I error probability and powers. Methods : We estimated the haplotype frequencies using the expectation-maximization(EM) algorithm with parents genotypes taken from a trio dataset, and then constructed a two-way contingency table containing estimated frequencies to all possible pairs of parents haplotypes. We proposed a score test based on differences between column marginals and their corresponding row marginals. The test also involved a covariance structure of marginal differences and their variances. In simulation, we considered a coalescent model with three genetic markers of biallele to investigate the performance of the proposed test under six different configurations. Results : The haplotype-based TDT statistics, our test and Zhao et al.'s test satisfied a type I error probability, but the TDT test based on single locus showed a conservative trend. As expected, the tests based on haplotypes also had better powers than those based on single locus. Our test and that of Zhao et al. were comparable in powers. Conclusion : We proposed a TDT statistic based on haplotypes and showed through simulations that our test was more powerful than the single locus-based test. We will extend our method to multiplex data with affected and/or unaffected sibling(s) or simplex data having only one parent s genotype.

• 한국통신학회논문지
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• 제38A권9호
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• pp.750-758
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• 2013

본 논문은 type I 혼합-자동 반복 요구 (hybrid automatic repeat request: H-ARQ) 시스템에서 저밀도 패리티검사 (low-density parity-check: LDPC)로 부호화된 직교 주파수 분할 다중화 (orthogonal frequency division multiplexing: OFDM) 서브프레임의 전송 순서를 균등 결합 전력이 할당되도록 조정한 재전송 방법을 기초로 성능 개선을 채널 용량을 사용하여 분석하고, 계층 복호 방법을 적용하여 H-ARQ 재전송 기법의 수렴 속도 개선을 확인한다. 구체적으로 임의의 서브프레임 재전송 패턴에 대하여 채널 용량이 클수록 비트오류율 (bit error rate: BER) 성능도 우수하다는 사실을 검증한다. 그러므로 각 서브프레임에 대하여 균등 결합 전력 할당을 보장하는 서브프레임 재전송 패턴은 채널 용량을 최대로 하며, 임의의 다른 서브프레임 전송 순서 조정을 통한 재전송 패턴보다 성능이 우수하다. 결국 균등 결합 전력 할당을 만족하도록 서브프레임 순서를 조정하는 재전송 방법은 기존 체이스 결합 (Chase combining)보다 복호 복잡도를 증가시키지 않으면서도 주목할 만한 성능 개선을 보인다.

• 대한치과교정학회지
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• 제51권2호
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• pp.95-104
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• 2021

Objective: To evaluate the trueness and precision of full-arch scans acquired using five intraoral scanners and investigate the factors associated with the dimensional accuracy of the intraoral scan data. Methods: Nine adult participants (mean age, 34.3 ± 8.3 years) were recruited. Four zirconium spheres (Ø 6 mm) were bonded to the canines and the molars. Following acquisition of reference scans using an industrial-grade scanner, five intraoral scanners, namely i500, CS3600, Trios 3, iTero, and CEREC Omnicam, were used to scan the arches. Linear distances between the four reference spheres were automatically calculated, and linear mixed model analysis was performed to compare the trueness and precision of the intraoral scan data among the different scanners. Results: The absolute mean trueness and precision values for all intraoral scanners were 76.6 ± 79.3 and 56.6 ± 52.4 ㎛, respectively. The type of scanner and the measured linear distances had significant effects on the accuracy of the intraoral scan data. With regard to trueness, errors in the intermolar dimension and the distance from the canine to the contralateral molar were greater with Omnicam than with the other scanners. With regard to precision, the error in the linear distance from the canine to the molar in the same quadrant was greater with Omnicam and CS3600 than with the other scanners. Conclusions: The dimensional accuracy of intraoral scan data may differ significantly according to the type of scanner, with the amount of error in terms of trueness being clinically significant.

• Journal of the Korean Data and Information Science Society
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• 제25권5호
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• pp.971-986
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• 2014

동시에 여러 개의 가설검정 수행시 귀무가설이 참일 경우 귀무가설을 기각할 확률이 커지는 문제가 발생한다. 이러한 다중검정 문제 해결을 위해 여러 연구에서는 가설검정시 필요한 집단별 오류율(FWER; family-wise error rate), 위발견율 (FDR; false discovery rate) 또는 위비발견율 (FNR; false nondiscovery rate) 과 통계량을 고려하여 검정력을 높이고자 하였다. 본 연구에서는 T 통계량, 수정된 T 통계량, 그리고 LPE (local pooled error) 통계량 기반 P값을 이용한 Bonferroni (1960) 방법, Holm (1979) 방법, Benjamini와 Hochberg (1995) 방법과 Benjamini와 Yekutieli (2001) 방법 그리고 Z 통계량 기반 Sun과 Cai (2007) 방법을 고찰하고 모의실험을 통해 다중검정 능력을 비교하였다. 또한 실제 데이터로 애기장대 유전자 발현 데이터에 대해 여러 가지 다중검정법을 통해 유의한 유전자들을 선별하였다.

• 전기전자학회논문지
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• 제13권1호
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• pp.11-18
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• 2009

In this paper, the stability of second order uncertain systems with regulation of PID type controllers is analyzed by using Lyapunov second method for the first time in the time domain. The property of the stability of PID regulation servo systems is revealed in sense of Lyapunov, i.e., bounded stability due to the disturbances and uncertainties. By means of the results of this stability analysis, the maximum norm bound of the error from the output without variation of the uncertainties and disturbances is determined as a function of the gains of the PID control, which make it enable to analyze the effect resulted from the variations of the disturbances and uncertainties using this norm bound for given PID gains. Using the relationship of the error from the output without variation of the uncertainties and disturbances and the PID gain with maximum bounds of the disturbances and uncertainties, the robust gain design rule is suggested so that the error from the output without the variation of the disturbances and uncertainties can be guaranteed by the prescribed specifications as the advantages of this study. The usefulness of the proposed algorithm is verified through an illustrative example.

• 한국전문물리치료학회지
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• 제23권2호
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• pp.93-99
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• 2016

Background: Parametric statistical procedures are typically conducted under the condition in which a sample distribution is statistically identical with its population. In reality, investigators use inferential statistics to estimate parameters based on the sample drawn because population distributions are unknown. The uncertainty of limited data from the sample such as lack of sample size may be a challenge in most rehabilitation studies. Objects: The purpose of this study is to review the bootstrapping method to overcome shortcomings of limited sample size in rehabilitation studies. Methods: Articles were reviewed. Results: Bootstrapping method is a statistical procedure that permits the iterative re-sampling with replacement from a sample when the population distribution is unknown. This statistical procedure is to enhance the representativeness of the population being studied and to determine estimates of the parameters when sample size are too limited to generalize the study outcome to target population. The bootstrapping method would overcome limitations such as type II error resulting from small sample sizes. An application on a typical data of a study represented how to deal with challenges of estimating a parameter from small sample size and enhance the uncertainty with optimal confidence intervals and levels. Conclusion: Bootstrapping method may be an effective statistical procedure reducing the standard error of population parameters under the condition requiring both acceptable confidence intervals and confidence level (i.e., p=.05).

• Journal of Information Technology Applications and Management
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• 제28권4호
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• pp.13-20
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• 2021

In this paper, I was applied the life distribution following linear failure rate distribution, Lindley distribution and Burr-Hatke exponential distribution extensively used in the arena of software reliability and were associated the reliability possessions of the software using the nonhomogeneous Poisson process with finite failure. Furthermore, the average value functions of the life distribution are non-increasing form. Case of the linear failure rate distribution (exponential distribution) than other models, the smaller the estimated value estimation error in comparison with the true value. In terms of accuracy, since Burr-Hatke exponential distribution and exponential distribution model in the linear failure rate distribution have small mean square error values, Burr-Hatke exponential distribution and exponential distribution models were stared as the well-organized model. Also, the linear failure rate distribution (exponential distribution) and Burr-Hatke exponential distribution model, which can be viewed as an effectual model in terms of goodness-of-fit because the larger assessed value of the coefficient of determination than other models. Through this study, software workers can use the design of mean square error, mean value function as a elementary recommendation for discovering software failures.

• 한국전기전자재료학회논문지
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• 제19권9호
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• pp.825-831
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• 2006

As an increase of chip complexity and level of chip integration, chip input/output (I/O) pad pitches are also drastically reduced. With arrival of high complexity SoC (System on Chip) and SiP (System in Package) products, conventional horizontal type probe card showed its limitation on probing density for wafer level test. To enhance probing density, we proposed new vertical type probe card that has the $70{\mu}m$ probe needle with tungsten wire in $80{\mu}m$ micro-drilled hole in ceramic board. To minimize alignment error, micro-drilling conditions are optimized and epoxy-hardening conditions are also optimized to minimize planarity changes. To apply wafer level test for target devices (T5365 256M SDRAM), designed probe card was characterized by probe needle tension for test, contact resistance measurement, leakage current measurement and the planarity test. Compare to conventional probe card with minimum pitch of $50{\sim}125{\mu}m\;and\;2\;{\Omega}$ of average contact resistance, designed probe card showed only $22{\mu}$ of minimum pitch and $1.5{\Omega}$ of average contact resistance. And also, with the nature of vertical probing style, it showed comparably small contact scratch and it can be applied to bumping type chip test.