• Bulletin of the Korean Space Science Society
• /
• 2011.04a
• /
• pp.28.4-29
• /
• 2011

Solar Proton Events (SPEs, ${\geq}\;10\;cm^{-1}s^{-1}sr^{-1}$ with >10 MeV) are very important for space weather forecasting. It is well known that they are associated with solar flares and/or CME-driven shocks. Especially, the CME-driven shocks have been observed as solar and interplanetary type II bursts. In this study, we estimated the occurrence probability of SPEs depending on three groups: (1) metric, (2) decameter-hectometric (D-H), and (3) meter-to-kilometric (m-to-km) type II bursts. For this work, we used SPEs and all available type II burst data in 1996-2004. The primary findings of this study are as follows. First, the majority (77%) of the m-to-km type II bursts are associated with SPEs and its probability is noticeably higher than D-H type II bursts probability strongly depend on longitude: eastern (0%), center(45%), and western (33%) for X-class associated metric type II bursts, eastern (15%), center (55%), and western (50%) for X-class associated D-H type II bursts, eastern (17%), center (77%), and western (64%) for X-class associated m-to-km type II bursts. Third, for m-to-km type II bursts, the SPE probability increases with CME speed: 400km/s${\leq}$V <1000km/s (36%), 1000km/s ${\leq}$V<1500km/s (40%), 1500km/s${\leq}$V (66%). Finally, we expect that these results will be used for setting up more reasonable solar proton event forecasting models.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 2007.11a
• /
• pp.410-411
• /
• 2007

To investigate the ZnO LED which are interested in the next generation of short wavelength LEDs and Lasers, the ZnO thin films were deposited by RF magnetron sputtering system. The p-type ZnO thin film, fabricated by means of the ampoule-tube method, was used to make the ZnO p-n junction, and its characteristics was analyzed. The ampoule-tube method was used to make the p-type ZnO based on the As diffusion, and the hall measurement was used to confirm that the p-type is formed. the current-voltage characteristics of the ZnO p-n junction were measured to confirm the rectification characteristics of a typical p-n junction and the low leakage voltage characteristics. Analysis of ZnO LED V-I curve will provide a very useful technology for producing the UV ZnO LED and ZnO-based devices.

• The Journal of the Acoustical Society of Korea
• /
• v.30 no.4
• /
• pp.231-237
• /
• 2011

The purpose of this study is to examine the correlation between the preferred sensation type and speech sounds, especially on $F_0$ and the speech rates. Data for the sensation types and speech sounds were collected from 36 undergraduate and graduate students (17 male, 19 female). Subjects were asked to read a given text (400 syllables), describe a drawing, and give answers to some questions. We measured speakers' $F_0$ and speech rates. The results show that type V (Visual) has the correlation with the speech rates when type D (Digital) was ruled out, and type A (Auditory) has the correlation with the speech rates when type D was included. Furthermore, the analysis of the mean values of V, A, K (Visual, Auditory, Kinethetic) indicates that type V is characterized with faster speech rates and higher $F_0$ in all parts except for interview and the same is true for that of V, A, K, D (Visual, Auditory, Kinethetic, Digital) in all parts. In conclusion, this study proved that the preferred sensation type has the correlation with $F_0$ and speech rates. Based on the results of this study, $F_0$ and speech rates can be used to analyze the sensation types for individualized education as well as consultation. In addition, this study has great significance in that it lays a foundation for the study on the correlation between a preferred sensation type and speech sounds.

• Biomolecules & Therapeutics
• /
• v.26 no.5
• /
• pp.439-445
• /
• 2018

T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder and neural tube defects. However, their function during embryonic development is largely unknown. Here, we investigated the function and expression of T-type calcium channels in embryonic neural progenitor cells (NPCs). First, we compared the expression of T-type calcium channel subtypes (CaV3.1, 3.2, and 3.3) in NPCs and differentiated neural cells (neurons and astrocytes). We detected all subtypes in neurons but not in astrocytes. In NPCs, CaV3.1 was the dominant subtype, whereas CaV3.2 was weakly expressed, and CaV3.3 was not detected. Next, we determined CaV3.1 expression levels in the cortex during early brain development. Expression levels of CaV3.1 in the embryonic period were transiently decreased during the perinatal period and increased at postnatal day 11. We then pharmacologically blocked T-type calcium channels to determine the effects in neuronal cells. The blockade of T-type calcium channels reduced cell viability, and induced apoptotic cell death in NPCs but not in differentiated astrocytes. Furthermore, blocking T-type calcium channels rapidly reduced AKT-phosphorylation (Ser473) and $GSK3{\beta}$-phosphorylation (Ser9). Our results suggest that T-type calcium channels play essential roles in maintaining NPC viability, and T-type calcium channel blockers are toxic to embryonic neural cells, and may potentially be responsible for neurodevelopmental disorders.

• Fisheries and Aquatic Sciences
• /
• v.26 no.9
• /
• pp.558-568
• /
• 2023

Vibrio vulnificus is an aquatic bacterium causing septicemia and wound infection in humans. To understand this pathogen at the genomic level, it was performed whole genome sequencing of a cefoxitin-resistant strain, V. vulnificus 1908-10 possessing virulence-related genes (vvhA, viuB, and vcgC) isolated from Gadeok island coastal seawater in South Korea. The genome of V. vulnificus 1908-10 consisted of two circular contigs and no plasmid. The total genome size was estimated to be 5,018,425 bp with a guanine-cytosine (GC) content of 46.9%. We found 119 tRNA and 34 rRNA genes respectively in the genome, along with 4,352 predicted protein sequences. Virulence factor (VF) analysis further revealed that V. vulnificus 1908-10 possess various virulence genes in classes of adherence, antiphagocytosis, chemotaxis and motility, iron uptake, quorum sensing, secretion system, and toxin. In the comparison of the presence/absence of virulence genes, V. vulnificus 1908-10 had fur, hlyU, luxS, ompU, pilA, pilF, rtxA, rtxC, and vvhA. Of the 30 V. vulnificus comparative strains, 80% of the C-genotype strains have all of these genes, whereas 40% of the E-genotype strains have all of them. In particular, pilA were identified in 80% of the C-type strains and 40% of the E-type strains, showing more difference than other genes. Therefore, V. vulnificus 1908-10 had similar VF characteristics to those of type C strains. Multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin of V. vulnificus 1908-10 contained 8 A-type repeats (GXXGXXXXXG), 25 B.1-type repeats (TXVGXGXX), 18 B2-type repeats (GGXGXDXXX), and 7 C-type repeats (GGXGXDXXX). The National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool (BLAST) showed that the RtxA protein of V. vulnificus 1908-10 had the effector domain in the order of cross-liking domain (ACD)-C58_PaToxP-like domain- α/β hydrolase-C58_PaToxP-like domain.

• Journal of Life Science
• /
• v.14 no.2
• /
• pp.362-367
• /
• 2004

For better understanding of the host infection mechanism of Vibrio, a Vibrio parahaemolyticus collagenase mutant was generated by insertional inactivation of a vppC gene encoding extracellular collagenase. A recombinant DNA containing vppC::nptII was cloned into a suicide plasmid pDMS197, resulted in pVCM03. The recombinant suicide plasmid pVCM03 contained in E. coli $\chi$7213 was transferred to a wild-type V. parahaemolyticus 04 through conjugation. The recombinant vppC::nptII DNA in pVCM03 was exchanged with wild-type allele by homologous recombination resulting vppC mutant, V. parahaemolyticus CM. The mutant was selected and screened on TCBS media containing 10% sucrose and kanamycin. The mutation by allele exchange was confirmed with the comparison of the size of DNAs amplified by PCR. V. parahaemolyticus CM showed at least 4-fold less collagen-degrading activity than those of wild-type, and the mutant exhibited less cytotoxicity than that of wild-type in MTT assay.

• Journal of The Korean Astronomical Society
• /
• v.37 no.4
• /
• pp.143-149
• /
• 2004

We present photometric results for four new variable stars discovered in the vicinity of the ZZ Ceti-type pulsating white dwarf BR Cam. Observations were performed on 5 nights in November 2003 using the 1.8m telescope at Bohyunsan Optical Astronomy Observatory with no filter, on 3 nights in December 2003 using the 0.61m telescope at Sobaeksan Optical Astronomy Observatory with V, I filters, and on 3 nights in October 2004 using the 1.0m telescope at Mt. Lemmon Optical Astronomy Observatory with V, I filters. We estimated their periods from the phase-match technique for one eclipsing binary and the multiple frequency analysis for three pulsating stars. By considering the light curve shape, period and amplitude difference between two passbands, we classified the objects by their variability types as follows: V1 (USNO-A2.0 1425-05691757) is a W UMa-type eclipsing binary with an orbital period of $0^d.4641$; V2 (USNO-A2.0 1425-05703335) is a multi-periodic $\delta$ Set-type pulsating star with a dominant period of $0^d.0649$; V3 (USNO-A2.0 1425-05699659) is also a $\delta$ Set-type pulsating star with a period of $0^d.1408$; and V 4 (USNO-A2.0 1425-05707705) is a RR Lyr-type pulsating star with a period of $0^d.2643$.

• The Korean Journal of Physiology and Pharmacology
• /
• v.14 no.1
• /
• pp.45-49
• /
• 2010

R-type $Ca_v2.3$ high voltage-activated $Ca^{2+}$ channels in peripheral sensory neurons contribute to pain transmission. Recently we have demonstrated that, among the six $Ca_v2.3$ isoforms ($Ca_v2.3a{\sim}Ca_v2.3e$), the $Ca_v2.3e$ isoform is primarily expressed in trigeminal ganglion (TG) nociceptive neurons. In the present study, we further investigated expression patterns of $Ca_v2.3$ isoforms in the dorsal root ganglion (DRG) neurons. As in TG neurons, whole tissue RT-PCR analyses revealed the presence of two isoforms, $Ca_v2.3a$ and $Ca_v2.3e$, in DRG neurons. Single-cell RT-PCR detected the expression of $Ca_v2.3e$ mRNA in 20% (n=14/70) of DRG neurons, relative to $Ca_v2.3a$ expression in 2.8% (n=2/70) of DRG neurons. $Ca_v2.3e$ mRNA was mainly detected in small-sized neurons (n=12/14), but in only a few medium-sized neurons (n=2/14) and not in large-sized neurons, indicating the prominence of $Ca_v2.3e$ in nociceptive DRG neurons. Moreover, $Ca_v2.3e$ was preferentially expressed in tyrosine-kinase A (trkA)-positive, isolectin B4 (IB4)-negative and transient receptor potential vanilloid 1 (TRPV1)-positive neurons. These results suggest that $Ca_v2.3e$ may be the main R-type $Ca^{2+}$ channel isoform in nociceptive DRG neurons and thereby a potential target for pain treatment, not only in the trigeminal system but also in the spinal system.

• Journal of The Korean Astronomical Society
• /
• v.26 no.2
• /
• pp.89-98
• /
• 1993

Magnetostatic models of starspots of late type main sequence stars$(G5V\~K5V)$ have been constructed to investigate their physical characteristics by using the similarity law suggested by Schluter and Temesvary(1958) and later employed by Deinzer(1965) and Yun(1968). The starspots are assumed to be single, circular and in horizontal magnetostatic equilibrium. In the present study we considered only those model spots whose area covers less than $12\%$ of the entire stellar surface as suggested by observations. The computed surface field strength of our model spots ranges from $10^3$\;to\;several\;10^3$ gauss and their magnetic flux is found to be $10\~100$ times that of sunspots. The field strength is sensitive to spectral type, which increases with later spectral type. In contrast to the field strength, the area of starspots depends strongly on the total magnetic flux. Finally, it is noted that the computed field strength of model spots belonging to $G0V\~G5V$ falls below the equipartition field strength at their parent stellar surface unless the coverage is less than $2\%$. This suggests that the observed spot on $G0V\~G5V$ stars is likely to be a group of small starspots.

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.5 no.2
• /
• pp.302-312
• /
• 2013

While displacement type Deep-V mono hulls have superior seakeeping behaviour at speed, catamarans typically have modest behaviour in rough seas. It is therefore a logical progression to combine the superior seakeeping performance of a displacement type Deep-V mono-hull with the high-speed benefits of a catamaran to take the advantages of both hull forms. The displacement Deep-V catamaran concept was developed in Newcastle University and Newcastle University's own multi-purpose research vessel, which was launched in 2011, pushed the design envelope still further with the successful adoption of a novel anti-slamming bulbous bow and tunnel stern for improved efficiency. This paper presents the hullform development of this unique vessel to understand the contribution of the novel bow and stern features on the performance of the Deep-V catamaran. The study is also a further validation of the hull resistance by using advanced numerical analysis methods in conjunction with the model test. An assessment of the numerical predictions of the hull resistance is also made against physical model test results and shows a good agreement between them.