• Parasites, Hosts and Diseases
• /
• v.60 no.4
• /
• pp.295-299
• /
• 2022

Malaria elimination and control require prompt and accurate diagnosis for treatment plan. Since microscopy and rapid diagnostic test (RDT) are not sensitive particularly for diagnosing low parasitemia, highly sensitive diagnostic tools are required for accurate treatment. Molecular diagnosis of malaria is commonly carried out by nested polymerase chain reaction (PCR) targeting 18S rRNA gene, while this technique involves long turnaround time and multiple steps leading to false positive results. To overcome these drawbacks, we compared highly sensitive cytochrome oxidase gene-based single-step multiplex reaction with 18S rRNA nested PCR. Cytochrome oxidase (cox) genes of P. falciparum (cox-III) and P. vivax (cox-I) were compared with 18S rRNA gene nested PCR and microscopy. Cox gene multiplex PCR was found to be highly specific and sensitive, enhancing the detection limit of mixed infections. Cox gene multiplex PCR showed a sensitivity of 100% and a specificity of 97%. This approach can be used as an alternative diagnostic method as it offers higher diagnostic performance and is amenable to high throughput scaling up for a larger sample size at low cost.

• Journal of Yeungnam Medical Science
• /
• v.41 no.2
• /
• pp.113-119
• /
• 2024

Background: Missing isoniazid (INH) resistance during tuberculosis (TB) diagnosis can worsen the outcomes of INH-resistant TB. The BD MAX MDR-TB assay (BD MAX) facilitates the rapid detection of TB and INH and rifampin (RIF) resistance; however, data related to its performance in clinical setting remain limited. Moreover, its effect on treatment outcomes has not yet been studied. Methods: We compared the performance of BD MAX for the detection of INH/RIF resistances to that of the line probe assay (LPA) in patients with pulmonary TB (PTB), using the results of a phenotypic drug sensitivity test as a reference standard. The treatment outcomes of patients who used BD MAX were compared with those of patients who did not. Results: Of the 83 patients included in the study, the BD MAX was used for an initial PTB diagnosis in 39 patients. The sensitivity of BD MAX for detecting PTB was 79.5%. The sensitivity and specificity of BD MAX for INH resistance were both 100%, whereas these were 50.0% and 95.8%, respectively, for RIF resistance. The sensitivity and specificity of BD MAX were comparable to those of LPA. The BD MAX group had a shorter time interval from specimen request to the initiation of anti-TB drugs (2.0 days vs. 5.5 days, p=0.001). Conclusion: BD MAX showed comparable performance to conventional tests for detecting PTB and INH/RIF resistances. The implementation of BD MAX as a diagnostic tool for PTB resulted in a shorter turnaround time for the initiation of PTB treatment.

• Journal of Navigation and Port Research
• /
• v.30 no.9
• /
• pp.741-748
• /
• 2006

Number of researches on efficient terminal operation system applying RFID(Radio Frequency Identification) are in progress. However, RFID has limitations on tracking and providing accurate positions of containers. In this paper, to enhance the performance of the integrated terminal operation system, an efficient loading management of yard is proposed by applying RFID based RTLS(Real Time Locating System) that provides real time accurate positions of containers. It was found that a group based sequence system is more efficient than the existing individual sequence number system in the container yard In the group based sequence system, the containers in the same group should have similar characteristics such as port of destination(POD), size, weight, etc. In order to run this system, we proposed the parameters to the unspecified N bytes of RFID tag which are specified in ISO 18000 7. And then, we developed an integrated operation system of container terminal using RFID. The proposed system reduces the ship turnaround time in ubiquitous port environments.

• Journal of the Korean Institute of Telematics and Electronics B
• /
• v.31B no.11
• /
• pp.11-19
• /
• 1994

Turnaround time of a job performing frequent disk I/O operations is greatly affected by I/O bottleneck which incurs due to the large gap in the speeds of I/O devices and the CPU. This paper proposes to employ a Write Dedicated Buffer(WDB) in disk arrays to improve the response time for read requests and analyzes the scheduling policies and the efficiency of the WDB. Through a series of simulations we show that, among the three policies examined, the partial stripe join(PSJ) policy is the most effective in terms of response time for both read and write requests and that, especially when using a WDB on declustered arrays, improvement of response time for read requests becomes greater as the request rate increases.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• v.1
• /
• pp.343-348
• /
• 2006

Number of researches on efficient terminal operation system applying RFID(Radio Frequency Identification) are on progress. However, RFID has limitations on tracking and providing accurate positions of containers. In this paper, to enhance the performance of the integrated terminal operation system, an efficient loading management of yard is proposed by applying RFID-based RTLS(Real Time Locating System) that provides real-time accurate positions of containers. We found that a group-based sequence system is more efficient than the existing individual sequence number system in the container yard. In the group-based sequence system, the containers in the same group should have similar characteristics such as port of destination(POD), size, weight, etc. In order to run this system, we have proposed the parameters to the unspecified N bytes of RFID tag which are specified in ISO 18000-7. And, this paper proposed a development of integrated operation system of container terminal using RFID for reducing the ship turnaround time in ubiquitous port environment.

• Korean Journal of Radiology
• /
• v.21 no.10
• /
• pp.1150-1160
• /
• 2020

Objective: To describe the experience of implementing a deep learning-based computer-aided detection (CAD) system for the interpretation of chest X-ray radiographs (CXR) of suspected coronavirus disease (COVID-19) patients and investigate the diagnostic performance of CXR interpretation with CAD assistance. Materials and Methods: In this single-center retrospective study, initial CXR of patients with suspected or confirmed COVID-19 were investigated. A commercialized deep learning-based CAD system that can identify various abnormalities on CXR was implemented for the interpretation of CXR in daily practice. The diagnostic performance of radiologists with CAD assistance were evaluated based on two different reference standards: 1) real-time reverse transcriptase-polymerase chain reaction (rRT-PCR) results for COVID-19 and 2) pulmonary abnormality suggesting pneumonia on chest CT. The turnaround times (TATs) of radiology reports for CXR and rRT-PCR results were also evaluated. Results: Among 332 patients (male:female, 173:159; mean age, 57 years) with available rRT-PCR results, 16 patients (4.8%) were diagnosed with COVID-19. Using CXR, radiologists with CAD assistance identified rRT-PCR positive COVID-19 patients with sensitivity and specificity of 68.8% and 66.7%, respectively. Among 119 patients (male:female, 75:44; mean age, 69 years) with available chest CTs, radiologists assisted by CAD reported pneumonia on CXR with a sensitivity of 81.5% and a specificity of 72.3%. The TATs of CXR reports were significantly shorter than those of rRT-PCR results (median 51 vs. 507 minutes; p < 0.001). Conclusion: Radiologists with CAD assistance could identify patients with rRT-PCR-positive COVID-19 or pneumonia on CXR with a reasonably acceptable performance. In patients suspected with COVID-19, CXR had much faster TATs than rRT-PCRs.

• The Journal of Korean Association of Computer Education
• /
• v.11 no.1
• /
• pp.97-107
• /
• 2008

The result verification that determines correctness for the work results calculated in each PC is one of the most important issues in PC grid environments. In this literature, voting-based and trust-based schemes have been mainly used to guarantee the correctness of work results. However, these schemes suffer from both waste of resource utilization and high computation delay because they can not effectively cope with dynamic computational environments. To overcome these shortcomings, we introduce the distribution information of PC resources based on credibility and availability into result verification phase. Using this information, we propose a new result verification scheme, which can determine the correctness of work results by each PC resources' credibility and cope with the dynamic changing environments by each PC resources' availability. To demonstrate the efficiency of our result verification scheme, we evaluate the performance of our scheme from the viewpoints of turnaround time and resource utilization, utilizing resource distribution information in the Korea@Home that is a representative PC grid system in domestic. We also compare the performance of our scheme with that of other ones.

• Journal of the Korea Society of Computer and Information
• /
• v.14 no.2
• /
• pp.37-44
• /
• 2009

In this paper, we propose an efficient method which improves the performance of transmission of PGA which is essential data for real-time earthquake monitoring system. Currently, above 120 earthquake stations were installed nationwide and additional installation is expected because the social interesting of earthquake hazard is rising. Real-time earthquake monitoring system checks earthquake occurrence by using PGA were calculated from acceleration data of each seismic station. An efficient method of PGA data transmission is key factor of real-time monitoring. The key idea of proposed method is to deal with each seismic station using an unique ID, to assign one bit to indicate whether a packet include a station's data or not. Proposed method can contain more station data and decrease the data loss compared to current method. To verify proposed method, we investigate the turnaround time and ratio of data loss using above 91000 packets. As results of experiment. the proposed method is proven that the method need more time about 50% but reduce the data loss about 87% as compared to previous method.

• Korean Journal of Veterinary Research
• /
• v.63 no.2
• /
• pp.19.1-19.6
• /
• 2023

Rapid immunochromatography test (RICT) kits are commonly used for the diagnosis of canine parvovirus (CPV) because of their rapid turnaround time, simplicity, and ease of use. However, the potential for cross-reactivity and low sensitivity can yield false-positive or false-negative results. There are 4 genotypes of CPV. Therefore, evaluating the performance and reliability of RICT kits for CPV detection is essential to ensure accurate diagnosis for appropriate treatment. In this study, we evaluated the performance of commercial RICT kits in the diagnosis of all CPV genotypes. The cross-reactivity of 6 commercial RICT kits was evaluated using 8 dog-related viruses and 4 bacterial strains. The limit of detection (LOD) was measured for the 4 genotypes of CPV and feline panleukopenia virus. The tested kits showed no cross-reactivity with the 8 dog-related viruses or 4 bacteria. Most RICT kits showed strong positive results for CPV-2 variants (CPV-2a, CPV-2b, and CPV-2c). However, the 2 kits produced negative results for CPV-2 or CPV-2b at a titer of 10⁵ FAID₅₀/mL, which may result in inaccurate diagnoses. Therefore, some kits need to improve their LOD by increasing their binding efficiency to detect all CPV genotypes.

• Journal of Korea Society of Industrial Information Systems
• /
• v.29 no.1
• /
• pp.63-76
• /
• 2024

In this study, we analyzed queue length and sojourn time of discrete-time BMAP/G/1 queues under the workload control. Group customers (packets) with correlations arrive at the system following a discrete-time Markovian arrival process. The server starts busy period when the total service time of the arrived customers exceeds a predetermined workload threshold D and serves customers until the system is empty. From the analysis of workload and waiting time, distributions of queue length at the departure epoch and arbitrary time epoch and system sojourn time are derived. We also derived the mean value as a performance measure. Through numerical examples, we confirmed that we can obtain results represented by complex forms of equations, and we verified the validity of the theoretical values by comparing them with simulation results. From the results, we can obtain key performance measures of complex systems that operate similarly in various industrial fields and to analyze various optimization problems.