• BMB Reports
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• 제53권2호
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• pp.118-123
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• 2020

Cardiac regeneration with adult stem-cell (ASC) therapy is a promising field to address advanced cardiovascular diseases. In addition, extracellular vesicles (EVs) from ASCs have been implicated in acting as paracrine factors to improve cardiac functions in ASC therapy. In our work, we isolated human cardiac mesenchymal stromal cells (h-CMSCs) by means of three-dimensional organ culture (3D culture) during ex vivo expansion of cardiac tissue, to compare the functional efficacy with human bone-marrow derived mesenchymal stem cells (h-BM-MSCs), one of the actively studied ASCs. We characterized the h-CMSCs as CD90^low, c-kit^negative, CD105^positive phenotype and these cells express NANOG, SOX2, and GATA4. To identify the more effective type of EVs for angiogenesis among the different sources of ASCs, we isolated EVs which were derived from CMSCs with either normoxic or hypoxic condition and BM-MSCs. Our in vitro tube-formation results demonstrated that the angiogenic effects of EVs from hypoxia-treated CMSCs (CMSC-Hpx EVs) were greater than the well-known effects of EVs from BM-MSCs (BM-MSC EVs), and these were even comparable to human vascular endothelial growth factor (hVEGF), a potent angiogenic factor. Therefore, we present here that CD90^lowc-kit^negativeCD105^positive CMSCs under hypoxic conditions secrete functionally superior EVs for in vitro angiogenesis. Our findings will allow more insights on understanding myocardial repair.

• 지역사회간호학회지
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• 제19권2호
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• pp.157-166
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• 2008

This study was conducted with whole home care nurses nationwide to provide secondary analyzed data to understand on their usage of medical equipments and their need of them for a month. This study found that treatments given by home care nurses were nelaton catheterization, bladder washing/urethral washing, newborn care, exchange and care for nasogastric tube and suction in that order of frequency. Second, instruments and equipments used for home care were reported to be stethoscope, patient monitor, blood pressure measuring equipment, air flotation mattresses, beds for patients, mattresses, suctioning device sets, enteral feeding equipment and dressing set in that oder of frequency. Moreover, need assessment of medical instruments and equipments showed renal dialysis was most needed and patient monitor, blood pressure measuring equipment, enteral feeding equipment, solution and other supplies for renal dialysis and beds for patient were necessary in that order. In conclusion, the results of this study investigating special treatments and medical instruments and equipments used for home care patients and analyzing patients' need, were expected to be useful for expansion of application of long-term care insurance for the elderly and health insurance as well as for quality control of home care and development of medial instruments and equipments used at home.

• 한국항공우주학회지
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• 제42권7호
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• pp.552-560
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• 2014

Pulse Detonation Engine (PDE)는 압축 효과에 따른 효율 증가와 정지 상태로부터 높은 초음속구간까지 작동가능하다는 등의 장점으로 인해 차세대 고속추진기관으로 많은 연구가 진행되고 있다. 본 연구에서는 Chapman-Jouguet 데토네이션 이론과 일정 단면적의 관내 압축성 기연 가스 팽창과정을 연계한 Endo 이론을 바탕으로 실제 추진제에 대한 효율적인 PDE 이론 성능 예측 프로그램을 개발하였다. 성능 예측 프로그램은 탄도진자 측정을 통하여 얻은 실험 결과와 비교를 통하여 검증하였다. 이 프로그램을 이용하여 당량비, 초기압력 및 초기 온도 및 압력에 대한 성능 특성을 살펴보았고 다양한 탄화수소 연료, 산화제 조성에 대한 성능을 해석하여 PDE 이론 성능 데이터베이스를 구축하였다.

• Animal cells and systems
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• 제12권1호
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• pp.23-33
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• 2008

The Zic family is a group of genes encoding zinc finger proteins that are highly expressed in the mammalian cerebellum. Zic genes are the vertebrate homologue of Drosophila pair-rule gene, odd-paired(opa), which plays important roles in the parasegmental subdivision as well as in the visceral mesoderm development of Drosophila embryos. Recent studies on human, mouse, frog, fish and ascidian Zic homologues support that Zic genes are involved in a variety of developmental processes, including neurogenesis, myogenesis, skeletal patterning, and left-right axis establishment. In an effort to explore possible functions of Zic proteins during vertebrate embryogenesis, we initially examined more detailed expression pattern of zebrafish homologue of zic3(zic3z). zic3z transcripts are detected in the neuroectoderm, neural plate, dorsal neural tube, and brain regions including eye field during early embryonic development. Marker DNA studies found that zic3z transcription is modulated by BMP, Wnt, and Nodal signals particularly in the dorsal and vegetal neuroectoderm at gastrula. Interfering with zic3z translation with zic3z-specific morpholino causes abnormal brain formation and expansion of the optic stalk cells. Retinal ganglion cells(RGCs) undergo abnormal neuronal differentiation. These findings suggest that zic3z defines the dorsal and vegetal neuroectoderm to specify brain formation and retinal neurogenesis during early embryonic development.

• Tuberculosis and Respiratory Diseases
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• 제39권1호
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• pp.95-101
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• 1992

저자들은 최근 심한 늑막액이 반복되는 환자에서 재발성 일측성 폐정맥 폐쇄증을 진단후 추적관찰하였기에 문헌고찰과 함께 보고하였다.

• 대한기계학회논문집B
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• 제20권9호
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• pp.2953-2964
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• 1996

왕복유동에 의한 순간 열전달현상은, 왕복유동의 두가지 특성인 왕복주파수와 왕복거리를 나타내는 .betha.와 .gamma.에 의하여 결정되고, 그 특성에 따라 세영역으로 나누어짐을 확인하였다. 영역 I에서는 일방향유동에서와 마찬가지로 열유속이 평균온도차에 비례하고, 영역 II에서는 열유속과 평균온도차간에 약 45.deg.의 위상차가 발생하지만 모두 1차 조화성분이 주로 나타났다. 한편 영역 III의 경우에는 위상차가 생길뿐만 아니라 평균온도차에 고차 조화성분이 나타났다. 기존의 방법인 복소 Nusselt수를 고차 조화성분까지 확장하면 열유속을 평균온도차로 나타낼 수 있지만 각 조화성분의 정보를 다 알아야하므로 실제 적용이 불가능하였다.

• 동력기계공학회지
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• 제21권2호
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• pp.64-69
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• 2017

The purpose of this study is to investigate the performance characteristics of seawater cooling system for a fishing vessel. The circulation amount of refrigerant, condensation capacity, evaporation capacity, compression work and coefficient of performance(COP) were analyzed as the heat source temperature changed. The experimental setup consisted of an open-type compressor, a shell&tube type condenser, an evaporator and an expansion valve. The heat source was controlled by a constant temperature chamber. The main results of this study are summarized as follows. The condensation capacity increased with increasing heat source temperature, and it was confirmed that the effect of circulating amount of refrigerant was dominant. The amount of heat for vaporization was almost constant even though the temperature of the heat source increased. On the other hand, the compression power was increased. This is because the compression ratio increases as the condensation pressure, the enthalpy difference between inlet and outlet, the amount of circulating refrigerant increases. The performance coefficient of this system showed a tendency decreasing with increasing heat source temperature. Therefore, the basic data of the seawater cooling system for the maintenance of the catch line of the shore fishing boats was acquired through this study, and it is considered that it will be sufficient for the actual design.

• 한국분말재료학회지
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• 제22권4호
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• pp.240-246
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• 2015

Anodic aluminum oxide (AAO) has been widely used for the development and fabrication of nano-powder with various morphologies such as particle, wire, rod, and tube. So far, many researchers have reported about shape control and fabrication of AAO films. However, they have reported on the shape control with different diameter and length of anodic aluminum oxide mainly. We present a combined mild-hard (or hard-mild) anodization to prepare shape-controlled AAO films. Two main parameters which are combination mild-hard (or hard-mild) anodization and run-time of voltage control are applied in this work. The voltages of mild and hard anodization are respectively 40 and 80 V. Anodization was conducted on the aluminum sheet in 0.3 mole oxalic acid at $4^{\circ}C$. AAO films with morphologies of varying interpore distance, branch-shaped pore, diameter-modulated pore and long funnel-shaped pore were fabricated. Those shapes will be able to apply to fabricate novel nano-materials with potential application which is especially a support to prevent volume expansion of inserted active materials, such as metal silicon or tin powder, in lithium ion battery. The silicon powder electrode using an AAO as a support shows outstanding cycle performance as 1003 mAh/g up to 200 cycles.

• 한국항공우주학회지
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• 제30권5호
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• pp.24-31
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• 2002

축 대칭 원형노즐 출구에 삼각형 형태의 작은 탭이나 얇은 테이프가 부착되었을 때 나타나는 초음속 제트유동장의 변화에 관한 연구가 쉴리렌 영상과 피토압력 측정을 통하여 수행되었다. 노즐 출구면적의 1 %에 해당하는 작은 탭에서 나타나는 유동방향 와류에 의한 제트유동 변화는 유동이 과소팽창 될 때 완전팽창과 과대팽창의 경우에 비하여 더 크게 나타나며 이로 인한 유동유입이 더 크게 나타남을 알 수 있었다. 탭의 설치각도 변화에 의한 영향도 평가되었으며, 유동이 과대팽창 될 때 노즐 안으로 구부러진 탭의 설치가 충격파의 간섭강도를 약화시키고 이로 인한 마하디스크의 소멸현상을 관찰할 수 있었다. 아울러 노즐내부 낮은 높이의 돌출부가 후방 유동장의 원주방향으로 압력변화를 나타내고, 이러한 압력변화는 유동의 팽창 정도에 영향을 받음을 알 수 있었다.

• Journal of Chest Surgery
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• 제44권3호
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• pp.225-228
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• 2011

Background: Conventional treatment (i.e. chest tube insertion and chemical pleurodesis) still remains standard for patients with secondary spontaneous pneumothorax because the risk of surgical bullectomy is deemed high in this subset. However, it has been suggested that surgical treatment using thoracoscopy may expedite postoperative recovery and, thus, may reduce hospital stay. Materials and Methods: Retrospective review of 61 patients with secondary spontaneous pneumothorax, who underwent conventional treatment (n=39) or video-assisted thoracoscopic surgery (VATS) (n=22) between January 2007 and December 2009, was performed. Talc was used for chemical pleurodesis in both groups. Results: Hospital stay of conventional treatment group and VATS group was $14.2{\pm}14.2$ days (4~58 days) and $10.6{\pm}5.8$ days (5~32 days), respectively, with statistically significant difference (p=0.033). Recurrence rate of conventional treatment group was also significantly higher (12/39, 30%) compared to VATS group (1/22, 4.5%) (p=0.016). Conclusion: In selected patients with secondary spontaneous pneumothorax with continuous air leak or inadequate lung expansion, thoracoscopic surgery with chemical pleurodesis using talc results in shorter hospital stay and lower recurrence rate compared to conventional approach.