• Korean Journal of Radiology
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• 제19권6호
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• pp.1161-1171
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• 2018

Objective: The aim of this study was to investigate diffusion tensor (DT) imaging-derived properties of benign oligemia, true "at risk" penumbra (TP), and the infarct core (IC) during the first 3 hours of stroke onset. Materials and Methods: The study was approved by the local animal care and use committee. DT imaging data were obtained from 14 rats after permanent middle cerebral artery occlusion (pMCAO) using a 7T magnetic resonance scanner (Bruker) in room air. Relative cerebral blood flow and apparent diffusion coefficient (ADC) maps were generated to define oligemia, TP, IC, and normal tissue (NT) every 30 minutes up to 3 hours. Relative fractional anisotropy (rFA), pure anisotropy (rq), diffusion magnitude (rL), ADC (rADC), axial diffusivity (rAD), and radial diffusivity (rRD) values were derived by comparison with the contralateral normal brain. Results: The mean volume of oligemia was $24.7{\pm}14.1mm^3$, that of TP was $81.3{\pm}62.6mm^3$, and that of IC was $123.0{\pm}85.2mm^3$ at 30 minutes after pMCAO. rFA showed an initial paradoxical 10% increase in IC and TP, and declined afterward. The rq, rL, rADC, rAD, and rRD showed an initial discrepant decrease in IC (from -24% to -36%) as compared with TP (from -7% to -13%). Significant differences (p < 0.05) in metrics, except rFA, were found between tissue subtypes in the first 2.5 hours. The rq demonstrated the best overall performance in discriminating TP from IC (accuracy = 92.6%, area under curve = 0.93) and the optimal cutoff value was -33.90%. The metric values for oligemia and NT remained similar at all time points. Conclusion: Benign oligemia is small and remains microstructurally normal under pMCAO. TP and IC show a distinct evolution of DT-derived properties within the first 3 hours of stroke onset, and are thus potentially useful in predicting the fate of ischemic brain.

• 대한방사선치료학회지
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• 제14권1호
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• pp.109-116
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• 2002

The mordem linear accelerators are equipped with X-ray collimators that can be moved independently to allow asymmetric fields with field centers positioned away from the true central axis of the beam. We have studied the dosimetric of an independent collimator system using measurements performed quarter fields. The field size factors for asymmetric fields are compared to those for symmetric fields. Dosimetric measurements include portent depth don, beam penumbra and shape of isodose curves for symmetric and quarter fields.

• 대한방사선기술학회지:방사선기술과학
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• 제39권1호
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• pp.99-105
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• 2016

잡음전력스펙트럼 (noise power spectrum, NPS)는 noise 진폭의 측정과 균일한 방사선 영역으로부터 획득된 영상의 품질에 가장 일반적인 방법 중 하나이다. 이 연구의 목적은 megavoltage X-ray 에너지를 사용하여 다른 잡음 전력스펙트럼 방법론들을 비교하는 것이다. 진단 영역에서의 잡음전력스펙트럼 평가 방법들은 국제 전기 규격 international electro-technical commission(IEC 62220-1) 기준을 사용하여 치료 영역에 적용되었다. 우리가 사용한 전자포털영상장치(electronic portal imaging device, EPID)는 Varian TrueBeam$^{TM}$, Siemens BEAMVIEW$^{PLUS}$, Elekta iViewGT 그리고 Varian Clinac$^R$ iX aS1000이었다. 잡음전력스펙트럼의 관심영역을 측정하기 위해, 우리는 겹침 (overlapping), 비겹침 (non-overlapping), 평탄도 (flatness), 반음영 (penumbra) 4가지 인자를 사용하였다. 결과적으로는 Siemens BEAMVIEW$^{PLUS}$, Varian TrueBeam$^{TM}$ flattening filter, Varian Clinac$^R$ iX aS1000, Varian TrueBeam$^{TM}$ flattening filter free에서의 잡음 (noise) 분포는 기존의 첫번째, 두번째, 세번째 실험방법보다는 Elekta iViewGT보다 현격하게 높은 noise 분포가 나타남을 알 수 있다. 이번 연구는 다양한 인자들이 잡음전력스펙트럼의 megavoltage imaging (MVI)영상에서 MVI영역에서 잡음전력 스펙트럼의 기준의 방법론으로 사용되어질 수 있다는 것을 보여주었다.

• 한국의학물리학회지:의학물리
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• 제34권1호
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• pp.1-9
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• 2023

Purpose: Although ionization chambers are widely used to measure beam commissioning data, point-by-point measurements of all the profiles with various field size and depths are time-consuming tasks. As an alternative, we investigated the feasibility of a linear diode array for commissioning a treatment planning system. Methods: The beam data of a Varian TrueBeam^® radiotherapy system at 6 and 10 MV with/without a flattening filter were measured for commissioning of an Eclipse Analytical Anisotropic Algorithm (AAA) ver.15.6. All of the necessary beam data were measured using an IBA CC13 ionization chamber and validated against Varian "Golden Beam" data. After validation, the measured CC13 profiles were used for commissioning the Eclipse AAA (AAA_CC13). In addition, an IBA LDA-99SC linear diode array detector was used to measure all of the beam profiles and for commissioning a separate model (AAA_LDA99). Finally, the AAA_CC13 and AAA_LDA99 dose calculations for each of the 10 clinical plans were compared. Results: The agreement of the CC13 profiles with the Varian Golden Beam data was confirmed within 1% except in the penumbral region, where ≤2% of a discrepancy related to machine-specific jaw calibration was observed. Since the volume was larger for the CC13 chamber than for the LDA-99SC chamber, the penumbra widths were larger in the CC13 profiles, resulting in ≤5% differences. However, after beam modeling, the penumbral widths agreed within 0.1 mm. Finally the AAA_LDA99 and AAA_CC13 dose distributions agreed within 1% for all voxels inside the body for the 10 clinical plans. Conclusions: In conclusion, the LDA-99SC diode array detector was found to be accurate and efficient for measuring photon beam profiles to commission treatment planning systems.