• Communications for Statistical Applications and Methods
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• v.25 no.5
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• pp.559-568
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• 2018

Gene classification can involve complex order-restricted inference. Examining gene expression pattern across groups with order-restriction makes standard statistical inference ineffective and thus, requires different methods. For this problem, Roy's union-intersection principle has some merit. The M-estimator adjusting for outlier arrays in a microarray study produces a robust test statistic with distribution-insensitive clustering of genes. The M-estimator in conjunction with a union-intersection principle provides a nonstandard robust procedure. By exact permutation distribution theory, a conditionally distribution-free test based on the proposed test statistic generates corresponding p-values in a small sample size setup. We apply a false discovery rate (FDR) as a multiple testing procedure to p-values in simulated data and real microarray data. FDR procedure for proposed test statistics controls the FDR at all levels of ${\alpha}$ and ${\pi}_0$ (the proportion of true null); however, the FDR procedure for test statistics based upon normal theory (ANOVA) fails to control FDR.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.4 no.2
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• pp.66-74
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• 1971

The general morphological characteristics of scales on the body surface in Cyprininae fishes can be summarized as follows: 1) The lentic and lotic habitats have no relation to the phase of scales. 2) The scales in the anterior body parts have transverse diameters longer than their longi-tudinal diameters: in the posterior body parts, the opposite holds true. 3) The scales having the largest diameters, both longitudinal and transverse, are the lateral line scales. 4) The position of the focus on each scale move posteriorly as the scale grows. In other words, the forward growth of the scales exceeds the backward. 5) The number of ridges in each scale is in proportion to longitudinal diameter. 6) In Cyprinus, the scales on the middle part of the body surface have more grooves than those on the other parts. All scales on this species commonly show incompleted grooves on the anterior and posterior areas, but the lateral area lacks grooves entirely. 7) In Carassius, there are more completed grooves than incompleted grooves. All grooves are arranged in radial patterns on the scales.

• Journal of the Korean Data and Information Science Society
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• v.11 no.2
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• pp.279-293
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• 2000

This article suggests two change-point estimators which are modifications of Carlstein(1988) change-point estimators with rank functions and mean functions where there is one change-point in a mean function. A comparison study of Carlstein(1988) estimators and proposed estimators is done by simulation on the mean, the MSE, and the proportion of matching true change-point.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.8 s.111
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• pp.732-738
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• 2006

Divide-by-2 and divide-by-4 circuits which can operate up to 10 GHz are designed. A design method used in these circuits is the TSPC(True Single Phase Clocking) topology. The structure of the TSPC dividers is very simple because they need only a single clock and purely consist of smalt sized cmos devices. Through measurements, we find the fact that in proportion to the bias voltage, the free running frequency increases and the operation region also moves toward a higher frequency region. For operating conditions of bias voltage $3.0{\sim}4.0V$, input power 16dBm and dcoffset $1.5{\sim}2.0V$, 5 GHz and 2.5 GHz output signals divided by 2 and 4 are measured. The layout size of the divide-by-2 circuit is about $500{\times}500 um^2$($50{\times}40um^2$ except pad interconnection part).

• Genomics & Informatics
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• v.12 no.4
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• pp.187-194
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• 2014

Metabolic syndrome (METS) is a disorder of energy utilization and storage and increases the risk of developing cardiovascular disease and diabetes. To identify the genetic risk factors of METS, we carried out a genome-wide association study (GWAS) for 2,657 cases and 5,917 controls in Korean populations. As a result, we could identify 2 single nucleotide polymorphisms (SNPs) with genome-wide significance level p-values (< $5{\times}10^{-8}$), 8 SNPs with genome-wide suggestive p-values ($5{\times}10^{-8}{\leq}$ p < $1{\times}10^{-5}$), and 2 SNPs of more functional variants with borderline p-values ($5{\times}10^{-5}{\leq}$ p < $1{\times}10^{-4}$). On the other hand, the multiple correction criteria of conventional GWASs exclude false-positive loci, but simultaneously, they discard many true-positive loci. To reconsider the discarded true-positive loci, we attempted to include the functional variants (nonsynonymous SNPs [nsSNPs] and expression quantitative trait loci [eQTL]) among the top 5,000 SNPs based on the proportion of phenotypic variance explained by genotypic variance. In total, 159 eQTLs and 18 nsSNPs were presented in the top 5,000 SNPs. Although they should be replicated in other independent populations, 6 eQTLs and 2 nsSNP loci were located in the molecular pathways of LPL, APOA5, and CHRM2, which were the significant or suggestive loci in the METS GWAS. Conclusively, our approach using the conventional GWAS, reconsidering functional variants and pathway-based interpretation, suggests a useful method to understand the GWAS results of complex traits and can be expanded in other genomewide association studies.

• Journal of the Korean earth science society
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• v.40 no.6
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• pp.561-571
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• 2019

To understand the genesis of tropical cyclones (TC), we computed TC genesis probability (GPr) by partitioning a highly localized genesis frequency (GFq) into nearby grid boxes in proportion to the spatial coherence of genesis potential index (GPI). From the analysis of TCs simulated by the Seoul National University Atmosphere Model Version 0 and the observed TCs, it was shown that GPr reasonably converges to GFq when averaged over a long-term period in a decent grid size, supporting its validity as a proxy representing a true TC GPr. The composite anomalies of the gridded GPr in association with the Asia summer monsoon, El Nino-Southern Oscillation (ENSO), and the Madden-Julian Oscillation (MJO) are much less noisy than those of GFq, and consequently are better interpretable. In summary, GPr converges to GFq, varies more smoothly than GFq, represents the spatiotemporal variations of GFq better than GPI, and depicts GFq with greater spatial details than other spatially smoothed GFqs.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2004.11a
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• pp.249-254
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• 2004

The pressing of car body parts is one of the most important sheet metal drawing processes. The corrosion protection oil applied by the steel mills plays a part in every sheet metal forming operation and also makes up the largest proportion of lubricants used. The idea to combine the corrosion protection properties of a corrosion preventive oil with the lubricity of a drawing oil lead to the development of the Anticorit prelubes. Applied at the finishing lines of the steel mills, they finally serve as lubricant in the press shops. A prerequisite for the suitability of a prelube-type oil is the absolute compatibility with all single processes from the coil to the Body in White. The use of prelubes in steel mills reduces the number and quantity of spot lubricants for additional press shop oiling dramatically. But their true benefits can only be fully achieved if the compatibility principle is applied throughout the manufacturing chain. Therefore, modem prelubes systems are modular, even different viscosities can be part of the same concept. This results in a far-reaching multifunctionality of the Anticorit prelube system for all applications.

• Journal of Plant Biology
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• v.26 no.2
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• pp.53-71
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• 1983

Physicochemical properties of soil, mineral cyclings, production of plants, and relationship between sodium(Na) content and progresses of plant communities were studied in a coastal salt marsh in Incheon. Contents of Na, available phosphorus(A-P) and value of electric conductivity of soil decreased in order of Salicornia herbacea, Limonium tetragonum, Phragmites communis and Zoysia sinica communities, but contents of organic matter, total nitrogen(T-N) and calcium(Ca) of soil were vice versa. Specise diversity index decreased with increase of Na content of soil with correlation coefficient of -0.82. The aboveground biomass of plant communities were 2,981 g.dw/$m^2$ in P. communis, 1,471 g.dw/$m^2$ in Z. sinica, 189g.dw/$m^2$ in S. herbacea and 71 g.dw/$m^2$ L. tetragonum, respectively. Seasonal changes of contents of inorganic nutrients per unit land area coincided with those of biomass of plant communities, however, the maximum contents of K occured earlier than the maximum biomass. Amounts of inorganic nutrients absorbed by plant were directly proportion to its biomass and it was true to reverse in restored amounts of them to soil. In turnover times of nutrients of the communities, it took the shortest time for P but the longest for Ca and P. communis community took the shortest but L. tetragonum the longest. For example, in P. communis turover time of P took one year and that of Na 1,440 years. Lack of P element, therefore, was expected in this study area.

• Korean Institute of Interior Design Journal
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• v.17 no.2
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• pp.122-129
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• 2008

Rudolph Michael Schindler(1887-1953) has been known as one of the pioneering modem architects who pursued not merely stylistic expression but a true embodiment for the human life. His furniture design is particularly noteworthy in Schindler's building. He designed numerous furniture designs where it serves as a core principal of his interior design of each building. Nevertheless, despite his architectural accomplishments, his furniture design has less been discussed. This research focuses on investigating the notion and the characteristics of Schindler's furniture designs based on his architectural language. For an in depth study of Schindler's furniture, this study reconstructs the archival material by analyzing drawings and by fabricating scaled models to reveal the characteristics of Schindler's furniture. To do so, it concentrates on two things: On the one hand, the stylistic characteristics that have to do with simple geometry, human proportion, the use of material and visual technique; on the other hand, different furniture types. This article concludes by describing Schindler's furniture design that has grown from his unique design approach and its underlying formal and spatial design principles.

• Korean Journal of Food Science and Technology
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• v.11 no.1
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• pp.1-7
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• 1979

This experiment was carried out to investigate the nutritive value of brewery's activated sludge on the performance and nutrients utilization of egg type chicken of babcock fed the different levels of sludge. The chemical composition, content of amino acids and mineral in brewery's activated sludge were also analyzed. 3,6,9 and 12% of brewery's activated sludge were supplemented with basal ration as a substituted ingredient to soybean oil meal in experimental ration. The results obtained were as follow: 1. Chemical composition analysis 1) Brewery's activated sludge had 42.50% of crude protein on the air dried basis, and had 15,69% of crude ash, and had 2,060 kcal of metabolizable energy per kg of sludge. 2) Total amino acid content of brewery's activated sludge was 42.50% and 99% crude protein of brewery's activated sludge was a true amino acid, and brewery's activated sludge contained especially more methionine and threonine that those of soybean oil meal. 3) In case of mineral content of brewery's activated sludge, phosphorus, magnesium, copper and iron were plentifully included. However, calcium content in brewery's activated sludge was very low. 2. Feeding trial 1) Body gain of chicken fed the different levels of sludge was decreased in proportion to increasing level of sludge was decreased in proportion to increasing level of sludge. However, no statistical differences were found out between treatments. 2) Diet intake of chicken fed the different levels of sludge was significantly (p<0.05) increased as the supplementation level of sludge in ration increased. 3) Feed conversion of chicken fed the different levels of sludge was high in proportion to increasing level of sludge in ration. However, there were no significant differences between treatments. 3. Digestion trial 1) Utilization of dry matter of chicken fed the different levels of sludge was decreased as the level of sludge in ration increased. However, no statistical differences were found out between treatments. 2) Utilization of crude protein of chicken fed the different levels of sludge was significantly (p<0.01) increased as the level of sludge was higher. Utilization of crude protein of control treatment and of sludge 3% treatment was higher than that of other treatments. 3) Utilization of crude ash of chicken fed the different levels of sludge was significantly (p<0.05) decreased in proportion to increasing level of sludge in ration. 4) Utilization of NFE of chicken fed the different levels of sludge was slightly decreased in proportion to increasing level of sludge in ration. However, no statistical differences were found out between treatments. Therefore according to this experiment, it may be concluded that brewery's activated sludge can be supplemented with chicken ration by $6{\sim}9%$.