• 한국환경성돌연변이발암원학회지
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• 제26권4호
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• pp.113-115
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• 2006

Ecklonia cava is a brown alga(Laminariaceae) that is abundant in the subtidal regions of Jeju island in Korea. Phlorotannins were identified to be responsible for the biological activities in Ecklonia species. In the present study, triphlorethol-A, a phlorotannin, was isolated from Ecklonia cava and its anticancer properties were investigated. Triphlorethol-A was investigated whether it may show cytotoxicity effects against U937, HeLa, NCI-H460 and MCF-7 cancer cells by MTT test. As a result, triphlorethol-A did not show cytotoxic effects against tested four cell lines.

• 대한약학회:학술대회논문집
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• 대한약학회 2005년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.135-135
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• 2005

• 생명과학회지
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• 제28권10호
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• pp.1170-1178
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• 2018

갈조류인 감태(Ecklonia cava)의 에틸아세테이트 분획으로부터 phloroglucinol, eckol, eckstolonol, triphlorethol-A, phlorofucofuroeckol A, dieckol의 6종의 phlorotannin이 분리되었으며, NMR 및 MS분석으로 구조가 규명되었다. 감태의 주요 활성물질 분석을 위하여, 분리된 6종 물질에 대한 항산화, 항염증 및 항알러지 효과를 평가하였다. 그 중 phlorofucofuroeckol A와 triphlorethol-A가 라디컬(DPPH, ABTS) 소거 활성이 높았으며, 염증 반응에 대한 활성을 분석하기 위하여 LPS를 처리한 대식세포주인 Raw264.7에서 산화질소(NO) 생성 억제활성을 측정한 결과, phlorofucofuroeckol A의 NO 생성 억제 효과가 가장 큰 것으로 나타났다. 또한, 알러지 반응에 대한 억제활성을 분석하기 위하여 IgE-항체로 활성화시킨 비만세포주 RBL-2H3에서 분비되는 ${\beta}-Hexosaminidase$를 측정한 결과, dieckol이 농도의존적으로 가장 높은 억제 효과를 나타냈다. 따라서, 본 연구에서 항염증 및 항알러지 활성을 중심으로 분리된 6종의 플로로탄닌 중 phlorofucofuroeckol A와 dieckol은 감태의 알러지 염증 억제활성을 나타내는 주요 물질로 사료된다.

• Nutrition Research and Practice
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• 제5권2호
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• pp.93-100
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• 2011

Inhibition of angiotensin I-converting enzyme (ACE) activity is the most common mechanism underlying the lowering of blood pressure. In the present study, five organic extracts of a marine brown seaweed Ecklonia cava were prepared by using ethanol, ethyl acetate, chloroform, hexane, and diethyl ether as solvents, which were then tested for their potential ACE inhibitory activities. Ethanol extract showed the strongest ACE inhibitory activity with an $IC_{50}$ value of 0.96 mg/ml. Five kinds of phlorotannins, phloroglucinol, triphlorethol-A, eckol, dieckol, and eckstolonol, were isolated from ethanol extract of E. cava, which exhibited potential ACE inhibition. Dieckol was the most potent ACE inhibitor and was found to be a non-competitive inhibitor against ACE according to Lineweaver-Burk plots. Dieckol had an inducible effect on the production of NO in EAhy926 cells without having cytotoxic effect. The results of this study indicate that E. cava could be a potential source of phlorotalnnins with ACE inhibitory activity for utilization in production of functional foods.