• Journal of the Society of Naval Architects of Korea
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• v.42 no.5 s.143
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• pp.458-465
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• 2005

Sensitivity Analysis(SA) is used to predict how the model response varies according to changes in the model parameters. With SA, confidences in models which are developed to approximate certain processes and their predictions can be increased. The influences of hydrodynamic coefficients on the prediction of manoeuvrability are examined by SA of direct method. The equations of motion used are the standard equations of motion for submarine(Gertler 1967), and submerged bodies with three different appendages are considered. Through numerical simulations of three kinds of sea trials, the sensitivities of motions to hydrodynamic coefficients are found. Changes of sensitivities during trials are found to be highly dependent on the actuator scenarios and geometry of submerged body.

• Journal of Korean Medicine for Obesity Research
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• v.12 no.2
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• pp.1-7
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• 2012

Objectives: The purpose of this report was to review the clinical trials of the catgut embedding for obesity treatment. Methods: We searched the clinical trial papers with key words of obesity and catgut embedding via searching Pubmed, Scopus and KISS etc. Results: We reviewed 8 searched articles, 7 articles were conducted in China and only 1 article was published in Korea. Most of Chinese articles used acupuncture as a control group and revealed the equality or superiority of catgut embedding in body weight loss. The only Korean article, which was uncontrolled, implanted catgut in localized fat area, it had changes partially in fat thick, body size. Conclusions: The acupoint catgut embedding has the efficacy of body weight loss, but to confirm the efficacy of localized fat loss, more randomized controlled trials are needed.

• Journal of Ginseng Research
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• v.43 no.3
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• pp.361-367
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• 2019

Panax ginseng, known as Koran ginseng, one of the most commonly used traditional plants, has been demonstrated to show a wide range of pharmacological applications. Ginsenosides are the major active ingredients found in ginseng and are responsible for the biological and pharmacological activities, such as antioxidation, antiinflammation, vasorelaxation, and anticancer actions. Existing studies have mostly focused on identifying and purifying single ginsenosides and investigating pharmacological activities and molecular mechanisms in cells and animal models. However, ginsenoside studies based on clinical trials have been very limited. Therefore, this review aimed to discuss the currently available clinical trials on ginsenosides and provide insights and future directions for developing ginsenosides as efficacious and safe drugs for human disease.

• International Journal of Naval Architecture and Ocean Engineering
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• v.13 no.1
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• pp.396-404
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• 2021

It is important to verify that the contracted speed-power performance of a ship is satisfied in sea trials. International Organization for Standardization (ISO) has published the procedure for measuring and assessing ship speed during sea trials. The results obtained from actual sea conditions inevitably include various uncertainty factors. In this study, double run tests were performed on one container ship to analyze the uncertainty of sea trial on three maximum continuous rating conditions. The uncertainty factors and scale of uncertainty were examined based on the measured raw data during sea trial. The results indicate that the expanded uncertainty for ideal power performance is approximately ±1.4% at 95% confidence level (coverage factor k = 2) and most of the uncertainty factors were because of the shaft power measurement system.

• Medical Lasers
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• v.9 no.2
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• pp.95-102
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• 2020

Phototherapy has a profound immunosuppressive effect and is widely used for the treatment of inflammatory skin diseases. Since allergic rhinitis (AR) shares several common pathologic features with atopic dermatitis, intranasal phototherapy is a novel approach for treating AR. Phototherapy reduces the antigen presenting capacity of dendritic cells, induces apoptosis of immune cells, and inhibits synthesis and release of pro-inflammatory mediators from inflammatory cells. The effectiveness of phototherapy for AR has been extensively researched: from in vitro studies to several clinical trials. Data indicates the potential of intranasal phototherapy as an alternative treatment for AR as well as other inflammatory mucosal diseases. In this review, we introduce the in vitro, in vivo studies, and clinical trials which demonstrated the effect of phototherapy on AR.

• IMMUNE NETWORK
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• v.16 no.1
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• pp.44-51
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• 2016

Dendritic cells (DCs) are professional antigen presenting cells, and play an important role in the induction of antigen-specific adaptive immunity. However, some DC populations are involved in immune regulation and immune tolerance. These DC populations are believed to take part in the control of immune exaggeration and immune disorder, and maintain immune homeostasis in the body. Tolerogenic DCs (tolDCs) can be generated in vitro by genetic or pharmacological modification or by controlling the maturation stages of cytokine-derived DCs. These tolDCs have been investigated for the treatment of rheumatoid arthritis (RA) in experimental animal models. In the last decade, several in vitro and in vivo approaches have been translated into clinical trials. As of 2015, three tolDC trials for RA are on the list of ClinicalTrial.gov (www.clinicaltrials.gov). Other trials for RA are in progress and will be listed soon. In this review, we discuss the evolution of tolDC-based immunotherapy for RA and its limitations and future prospects.

• Communications for Statistical Applications and Methods
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• v.31 no.6
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• pp.613-625
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• 2024

A general non-inferiority (NI) clinical trial is typically conducted using parametric testing methods with large samples. However, patient recruitment challenges often hinder rare disease trials, leading to enrollment failures. In this study, we introduce current parametric and nonparametric NI trial testing methods and propose modifications to enhance the performance of the nonparametric approach. Through a comprehensive simulation study with various sample sizes, data distributions, and sample ratios, we compare empirical levels and statistical powers as criteria for evaluating performance. Our findings indicate that the modified nonparametric methods outperformed the existing methods, particularly under conditions of small sample sizes and non-normal distributions, offering valuable insights for improving the reliability and sensitivity of NI trials in the context of rare diseases.

• Journal of Acupuncture Research
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• v.41
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• pp.228-244
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• 2024

This study was conducted to analyze research trends, quality, and bias of pharmacopuncture studies, etc., on domestic randomized controlled trials (RCTs) using hominis placenta pharmacopuncture (HPP). A total of 13 domestic RCTs were selected by searching two domestic online databases (Research Information Sharing Service and Oriental Medicine Advanced Searching Integrated System). The publication of domestic RCTs using HPP began in 2000, and most studies targeted peripheral facial paralysis and gynecological diseases. Most studies have shown the Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) checklist reporting rate of > 50.0%; however, four subitems, including "depth of insertion," showed a reporting rate < 50.0%. Some studies have shown significant improvement in the HPP group; however, the sample size was diverse, the observation period was short, the effect of stimulation of the same acupoint between the two groups could not be ruled out, and the overall risk of bias was mostly "some concern." In addition, further development of STRICTA that reflects the characteristics of pharmacopuncture therapy is necessary.

• Korean Journal of Acupuncture
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• v.29 no.4
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• pp.519-536
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• 2012

Objectives : The purpose of this study is to figure out which acupoints are selected to treat low back pain and attempt to analyze the effectiveness of those acupoints in current clinical trials. Methods : We searched the three electronic databases(PUBMED, RISS, KISS) and manually checked related Korean journals and reference lists up to April 2012. We included randomized controlled trials, clinical controlled trials, and case reports/series using needle type acupuncture( manual acupuncture, electronic acupuncture) to treat low back pain in English and Korean. We investigated the frequency of selected acupoints, change of visual analogue scale of low back pain and statistical significance in each study among trials. Results : We included 37 articles(Domestic 17, International 20) 53 studies(Domestic 28, International 25) in this study. The most frequently adopted acupoints were BL23, BL24, BL25, GB30, BL26, BL60, BL32, BL40, KI3, GV3, ST36 in domestic studies and BL23, BL25, BL40, BL60, GB30, GB34, BL32, BL26 in international studies. There were differential effectiveness of acupoints between domestic and the international studies using statistical significance of visual analog scale for low back pain. Conclusions : These results suggest that both proximal and distal acupoints based on meridian theory were used in clinical trials to treat low back pain. It would be helpful to provide clinical guideline, evaluate the results of clinical trials appropriately, and reveal the effectiveness of acupoints.

• Journal of Gastric Cancer
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• v.8 no.2
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• pp.57-64
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• 2008

In gastric cancer, the only potentially curative treatment is surgery that attempts to achieve curative (R0) resection. However, despite the use of curative resection, a recurrence develops in a high percentage of patients, especially in cases of serosa and/or lymph node involvement. As a strategy to improve the survival of the patients with resectable advanced gastric cancer, neoadjuvant chemotherapy has been evaluated in several phase II trials and a few phase III trials. The results of these trials have confirmed the feasibility and safety of this approach with no apparent increase in surgical complications. Recently, the findings of a large phase III randomized trial (MAGIC trial) have indicated that compared to the use of surgery alone, perioperative chemotherapy, using both a neoadjuvant and adjuvant strategy, decreased the number of T and N stage cancers and improved survival. The results of another recent phase III trial (FNLCC 94012/FFCD 9703) also showed that compared to the use of surgery alone, perioperative chemotherapy improved the R0 resection rate and survival. In both trials, the improved outcomes may be attributed to the use of neoadjuvant chemotherapy because of poor compliance with adjuvant chemotherapy. These results cannot be directly translated to clinical practice in Korea due to differences in surgical techniques and outcomes. However, the findings of a few small phase II and III trials performed in patients with locally advanced gastric cancer in Korea have also suggested that neoadjuvant chemotherapy would result in the improvement of the R0 resection rate and down-staging of the disease. More effective chemotherapy regimens are needed in future large randomized trials to determine the subset of patients that will benefit from neoadjuvant chemotherapy and to determine the extent of benefit.