• Title/Summary/Keyword: Trial effect

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Influence of implant-abutment connection structure on peri-implant bone level in a second molar: A 1-year randomized controlled trial

  • Kim, Jin-Cheol;Lee, Jungwon;Kim, Sungtae;Koo, Ki-Tae;Kim, Hae-Young;Yeo, In-Sung Luke
    • The Journal of Advanced Prosthodontics
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    • v.11 no.3
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    • pp.147-154
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    • 2019
  • PURPOSE. This study aimed to evaluate the effect of two different implant-abutment connection structures with identical implant design on peri-implant bone level. MATERIALS AND METHODS. This clinical study was a patient-blind randomized controlled trial following the CONSORT 2010 checklists. This trial was conducted in 24 patients recruited between March 2013 and July 2015. Implants with internal friction connection were compared to those with external hex connection. One implant for each patient was installed, replacing the second molar. Implant-supported crowns were delivered at four months after implant insertion. Standardized periapical radiographs were taken at prosthesis delivery (baseline), and one year after delivery. On the radiographs, distance from implant shoulder to first bone-to-implant contact (DIB) and peri-implant area were measured, which were the primary and secondary outcome, respectively. RESULTS. Eleven external and eleven internal implants were analyzed. Mean changes of DIB from baseline to 1-year postloading were 0.59 (0.95) mm for the external and 0.01 (0.68) mm for the internal connection. Although no significant differences were found between the two groups, medium effect size was found in DIB between the connections (Cohen's d = 0.67). CONCLUSION. Considering the effect size in DIB, this study suggested the possibility of the internal friction connection structure for more effective preservation of marginal bone.

Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial

  • Yang, Yi;Wang, Hong;Zhang, Ming;Shi, Mengxue;Yang, Cailing;Ni, Qiang;Wang, Qi;Li, Jing;Wang, Xuemei;Zhang, Chen;Li, Zhi
    • Journal of Ginseng Research
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    • v.46 no.4
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    • pp.543-549
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    • 2022
  • Background: In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110 subjects who passed physical examination were included according to the scheme design, and randomly divided into a test group which was given KRG and a placebo control group. The calculation is carried out according to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. After KRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acid content is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significant lower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful on relieving physical fatigue.

Effects of Neuromuscular Electrical Stimulation on Muscle Wasting with Cancer Patient: Study Protocol for a Systematic Review (신경근전기자극치료가 암환자의 근육 손실에 미치는 영향: 체계적 문헌고찰을 위한 프로토콜)

  • Eun Soo Park;Jong Hee Kim;Soo Dam Kim;Dong Hyun Kim;Min Seok Oh;Eun Jung Lee;Hwa Seung Yoo
    • Journal of Korean Medicine Rehabilitation
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    • v.33 no.2
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    • pp.49-55
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    • 2023
  • Objectives The purpose of this study is to analyze randomized controlled trials about neuromuscular electrical stimulation for muscle wasting with cancer patient and evaluate it's motor functionality effect. Methods Studies will be searched from 7 online databases (PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure [CNKI], Korean studies Information Service System [KISS], Research Information Sharing Service [RISS], Oriental Medicine Advanced Searching Integrated System [OASIS]). Participants will be cancer patients with muscle loss, regardless of cause, gender, race or age, interventions will be neuromuscular electrical stimulation. Other treatments than interventions will be the control group and the main outcome will be reviewed by motor functionality effect. Results Randomized controlled trials about neuromuscular electrical stimulation for muscle wasting should be included in the study. Primary outcomes include motor functionality effect. Secondary outcomes evaluate adverse event. The data uses Review Manager Software 5.4. Conclusions The conclusion of this study will provide a basis for determining whether neuromuscular electrical stimulation treatment for muscle wasting with cancer patient treatment is an effective and safe treatment method in clinical practice.

The Effect of Attitude toward Parent Brand on Trial Intention of Brand Extensions and the Moderating Role of Perceived Similarity and Consumption Experience of Parent (모브랜드 태도가 브랜드확장 제품의 시용의도에 미치는 영향과 지각된 유사성과 모브랜드 소비경험의 조절역할)

  • Park, JI-Yeon
    • Journal of Convergence for Information Technology
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    • v.9 no.4
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    • pp.59-67
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    • 2019
  • Most of the prior researches in brand extension evaluation have utilized purchase intention as a n effective variable to assess the effectiveness of brand extensions. In contrast, the author proposes that trial intention is to better predict consumers' behavioral response in the newly launched brand extension markets where relate to high risk and uncertainty. Furthermore, the study explores the effects of attitude toward parent brand and consumers' characteristics (perceived similarity and consumption experience) on trial intention of brand extensions. In order to achieve the purpose of the study, the data collection was conducted for actual consumers who had experience using parent brand products. This study employed experiment and questionnaire survey and collected data of 186 was analyzed using clustering analysis and regression analysis. The main results are as follows. First, attitude toward parent brand has a positive effect on trial intention of the extensions. Second, perceived similarity and consumption experience of parent brand have moderating effects on the relation of attitude toward parent brand and trial intention of brand extensions. The results provide that both industry and academic researchers with a guide to process trial intention of brand extension from a comprehensive perspective.

The Study on the Effect of Loading Condition on Ship Manoeuvrability (흘수변화가 선박 조종 성능에 미치는 영향에 관한 연구)

  • Im, Nam-Kyun;Kweon, Suk-Am;Kim, Se-Eun
    • Journal of the Society of Naval Architects of Korea
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    • v.42 no.2 s.140
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    • pp.105-112
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    • 2005
  • IMO standards for ship manoeuvrability were applied from January 1, 2004. Though model test or sea trial in full load condition is needed, it is not always possible to get such data for every ships. Therefore it is required to study the effect of loading conditions on ship manoeuvrability. Approximate formulae to estimate the hydrodynamic forces acting on a ship and the 2nd overshoot angle of $10^{\circ}$/$10^{\circ}$ zig-zag test in certain loading condition are proposed in this study These were derived from the results of model test and sea trial data. Captive model tests for 7 ships with 15 different loading conditions and sea trial data including free running test of 6 cases were used. Compared with experiment data and prediction formulae already proposed by others, the approximate formulae in this study show good agreement with model test results.

Recent Clinical Research of Acupuncture for the Treatment of Tinnitus (이명의 침 치료에 관한 최근 임상 연구 동향)

  • Lee, Kyou-Young;Hong, Chul-Hee
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.28 no.3
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    • pp.48-65
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    • 2015
  • Objectives : The aim of this study is to analyze recent clinical research of the acupuncture for the treatment of tinnitus.Methods : We searched pubmed for foreign journals with the title/abstract 'tinnitus, acupuncture' published in the last 10 years, and for domestic journals we searched NDSL, RISS, KISS, The National Assembly Library, The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology with the same conditions as foreign journals.Results : We selected total 10 papers: 7 RCTs, 1 RCT protocol, 1 clinical trial, 1 Systematic Review. In RCT, all studies showed positive effect, however in comparison with the control groups, only 2 studies showed meaningful effects.Conclusions : Positive effect of the acupuncture on tinnitus is expected, but because of several limits observed in many papers, we can't draw defined conclusions. Further well-designed researches are needed.

The Effect of Lysine to Protein Ratio on Growth Performance and Efficiency of Nitrogen Utilization in Pigs

  • Li, Defa;Xi, Pengbin;Wang, Junxun;Wang, Jitan;Ren, Jiping;Kang, Yufan;Thacker, P.
    • Asian-Australasian Journal of Animal Sciences
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    • v.14 no.9
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    • pp.1282-1289
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    • 2001
  • One feeding trial and two metabolic trials were conducted to investigate the effects of lysine to protein ratio in practical swine diets on growth performance and efficiency of nitrogen retention and utilization in different growing phases. In Trial one (the feeding trial), 90 mixed sex pigs weighing $9.1{\pm}1.4kg$ (Duroc ${\times}$ Landrance ${\times}$ Beijing Black) were used to study the effects of concentrations of 5.2, 5.3, 5.8, 6.4 and 7.2 g lysine/100 g CP in diets containing 1.2% lysine on growth performance and serum urea nitrogen. The results showed that feed conversion efficiency and economic efficiency were best for pigs fed the diet containing the lysine concentration of 5.8 g /100 g crude protein. Serum urea nitrogen concentration decreased linearly (p=0.0009) and serum free lysine content increased linearly (p=0.0017) as the lysine to protein ratio in diets increased from 5.2 to 7.2 g/100 g. In Trials two and three (the metabolic trials), five growing barrows (Duroc ${\times}$ Landrance ${\times}$ Beijing black), with initial body weights of approximately $26{\pm}2.4kg$ and $56.3{\pm}3.5kg$, respectively, were allotted to five dietary treatments according to a $5{\times}5$ Latin square design. Trial two contained 5.2, 5.7, 6.1, 6.7 and 6.8 g lysine/100 g CP treatments. Trial three contained 4.6, 5.0, 5.6, 6.1 and 6.6 g lysine/100 g CP treatments. The results showed that nitrogen retention in growing pigs decreased linearly (p=0.0011 in Trial two; p=0.0099 in Trial three) as the lysine to protein ratio in diets increased. The ratio of lysine to protein in diets resulting in maximum nitrogen retention was 5.2 g/100 g and 5.0 g/100 g in Trial two and Trial three, respectively. In Trial two, apparent biological value and gross nitrogen efficiency increased linearly (p=0.0135 and p=0.0192, respectively) as the lysine to protein ratio increased from 5.2 to 6.8 g lysine/100 g CP. In summary, we concluded that the optimal Lysine to Protein Ratios for 8-20 kg and 20-80 kg pigs were 5.8 g/100 g and 5.0 to 5.2 g/100 g, respectively.

Turmeric (Curcuma longa) Root Powder and Mannanoligosaccharides as Alternatives to Antibiotics in Broiler Chicken Diets

  • Samarasinghe, K.;Wenk, C.;Silva, K.F.S.T.;Gunasekera, J.M.D.M.
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.10
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    • pp.1495-1500
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    • 2003
  • Two bio-assays were conducted to evaluate turmeric root powder and mannan-oligosaccharides (MOS) as alternatives to feed antibiotics for broilers. In one trial, one hundred and eighty 19-days old broilers assigned to 18 groups of 10 were fed on one of six experimental diets with three replicates during four weeks. The diets included a basal feed without additives and with either virginiamycin, MOS, or turmeric at 1, 2 and 3 g/kg, respectively. In the second trial, one hundred and forty four 21-days old broilers arranged in 16 groups of nine were fed on the first four diets with four replicates for a similar period. Virginiamycin, MOS and turmeric (1 g/kg) in the first trial generally improved the weight gain of broilers by 3.4, 6.2 and 5.3%, respectively. In the second trial they increased the weight gain significantly (p<0.05) by 8.8, 8.0 and 15.1%, respectively. Additives improved the feed efficiency up to 15.1% and carcass recovery up to 3.1% (p<0.05). Virginiamycin, MOS and turmeric (1 g/kg) markedly reduced the abdominal fat content from 1.91% BW in the control to 1.44, 0.97 and 1.2% BW, respectively, in the first trial. The corresponding values obtained in the second trial were 1.01, 0.55 and 0.6%, respectively as compared to 1.22% in the control group. All additives showed a remarkable inhibition of duodenal coliform bacteria, yeast and mould in the caecum, and all viable microbes in the ileum. A significant (p<0.05) improvement in energy and protein utilization could be recorded with supplemented diets except for high turmeric diets. Dietary 2 and 3 g/kg addition of turmeric reduced energy and protein utilization as well as fat deposition. Present results reveal that turmeric and MOS are satisfactory alternatives to antibiotics in broiler feeds. Both MOS and turmeric possess an antimicrobial effect in vivo. Turmeric may also depress fat deposition in broilers.

Speed Trial Analysis of Korean Ice Breaking Research Vessel 'Araon' on the Big Floes (큰 빙판에서 아라온 호 쇄빙 속도 성능 해석)

  • Kim, Hyun Soo;Lee, Chun-Ju;Choi, Kyungsik
    • Journal of the Society of Naval Architects of Korea
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    • v.49 no.6
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    • pp.478-483
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    • 2012
  • The speed performances of ice sea trial on the Arctic(2010 & 2011) area were shown different results depend on the ice floe size. Penetration phenomena of level ice was not happened on medium ice floe and tore up by the impact force because the mass of medium ice floe is similar to the mass of Araon which is Korean ice breaking research vessel and did not shut up by the ice ridge or iceberg. The sea trial on the Amundsen sea was performed at the big floe which is classified by WMO(World Meteorological Organization). Three measurements of ice properties and five results of speed trial were obtained with different ice thicknesses and engine powers. To evaluate speed of level ice trial and model test results at the same ice thickness and engine power, the correction method of HSVA(Hamburg Ship Model Basin) was used. The thickness, snow effect, flexural strength and friction coefficient were corrected to compare the speed of sea trial. The analyzed speed at 1.03m thickness of big floe was 5.85 knots at 10MW power and it's 6.10 knots at 1.0m ice thickness and the same power. It's bigger than the results of level ice because big floe was also slightly tore up by the impact force of vessel based on the observation of recorded video.