• 농업과학연구
• /
• 제48권4호
• /
• pp.831-842
• /
• 2021

Accurate measurements of feed energy values have a positive effect on the control of feed intake for animals, the formation of prices, and on economic profits. However, few studies have attempted to measure the energy values of domestic roughages and to validate an energy value prediction model. The purpose of this study is to build a database through measurements of the nutrient digestibility and digestible energy results of roughages used in Korea and to evaluate the domestic applicability of the National Research Council (NRC) estimation model. Oat hay, annual ryegrass, tall fescue, barnyard millet, and concentrates for beef cattle were used in the test. As a result of an in vivo digestibility trial, the total digestible nutrients (TDN) of oat hay, annual ryegrass, tall fescue, and barnyard millet were found to be 68.73, 55.02, 55.71, and 52.89%, respectively. As a result of comparing the estimated values using the NRC equation with the in vivo results, there was a difference of 3.55 to 6.84%P in the TDN. Inferred from this result, it is considered that TDN calculations using the NRC equation can be reasonable for the test feeds used in this study. These results can be utilized when revising the Korean Standard Tables of Feed Composition, which provides a comprehensive overview of Korean feed.

• 식물병연구
• /
• 제20권1호
• /
• pp.31-36
• /
• 2014

우리나라 수박 재배지에서 발생하고 있는 흰가루병 방제를 위한 아인산칼륨-살균제 교차방제체계를 개발하였다. 2010년 시험에서는, 우리나라에서 수박 흰가루병 방제를 위하여 등록되어 합법적으로 사용 가능하며, 농가에서 사용중인 6종류의 살균제를 이용하여 9가지 처리조합을 구성하여 시험하였다. 그 결과 클로로탈로닐(Chl)-마이클로뷰타닐(My)-페나리몰(Fen)-헥사코나졸(Hex)의 처리가 가장 효과가 우수한 것으로 나타났으나, My, Fen, Hex의 작용 기작이 동일하다는 문제점이 있었다. 따라서 2년차 시험에서는 처리조합을 개선하고 농약사용을 줄이기 위하여 이들 살균제 외에 작용기작이 다르면서도 친환경적인 약제인 아인산칼륨을 이용하여 살균제-아인산칼륨 교차 살포 조합을 선발하기 위한 포장시험을 수행하였다. 10간격처리에서, Chl-My-Fen-P는 31.8%의 방제효과를 나타낸 반면, Chl-My-Fen-P는 75.6%의 비교적 높은 방제효과를 나타냈다. 방제효과를 개선하기 위하여 3년차 시험에서는 살균제와 아인산칼륨을 7일 간격으로 살포하였다. Chl-My-Fen-Hex가 가장 높은 89.6%의 방제효과를 나타냈으나, 65.9%의 방제효과를 나타낸Chl-My-Fen-P와 달리 P-My-Fen-Hex 또한 83.5%의 비교적 높은 방제효과를 나타냄으로써, 수박 흰가루병 방제를 위하여 Chl-My-Fen-Hex의 방제체계는 P-My-Fen-Hex로 대체할 수 있음을 시사하고 있다.

• 대한기관윤리심의기구협의회지
• /
• 제4권2호
• /
• pp.36-41
• /
• 2022

Purpose: The purpose of this study is to evaluate how university hospital Institutional Review Boards (IRBs) in Korea classify risk when reviewing clinical trial protocols. Methods: IRB experts (IRB chairman, vice chairman, IRB administrator) in the university hospitals obtaining a Human research protection program (HRPP) or IRB accreditation in Korea were asked to fill out the Google Survey from September 1, 2020 to October 10, 2020. Result: Among the 23 responder hospitals, 8 were accredited by the American Association for Human Research Protection Program (AAHRPP) and 8 were accredited by the HRPP of Ministry of Food and Drug Safety (MFDS). Seven were accredited by Forum for Ethical Review Committees in Asia and the Western Pacific or Korea National Institution for Bioethics Policy. Thirteen of 23 hospitals (56.5%) had 4 levels (less than minimal, low, moderate, high risk), 4 hospitals had 3 levels (less than, slightly over, over than minimal risk), 1 hospital had 5 levels (4 levels plus required data safety monitoring board), and 1 hospital had 2 levels (less than, over than minimal risk) risk classification system. Thirteen of 23 hospitals (56.5%) had difficulty classifying the risk levels of research protocols. Fourteen hospitals (60.9%) responded that different standards among hospitals for risk level determination associated with clinical trials will affect the subject protection. Six hospitals (26.1%) responded that it will not. Three hospitals (13.0%) responded that it will affect the beginning of the clinical trial. To resolve differences in standards between hospitals, 14 hospitals (60.9%) responded that either the Korean Association of IRB or MFDS needs to provide a guideline for risk level determination in clinical trials: 5 hospitals (21.7%) responded education for IRB members and researchers is needed; 3 hospitals (13.0%) responded that difference among institutions needs to be acknowledged; and 1 hospital (4.3%) responded that there needs to be communication among IRB, investigator, and sponsor. Conclusion: After conducting a nationwide survey on how IRB in university hospital determines risk during review of clinical trials, it is reasonable to use 4-level risk classification (less than minimal, low, moderate, high risk); the most utilized method among hospitals. Moreover, personal information and conflict of interest associated with clinical trials have to be considered when reviewing clinical trial protocols.

• Asian-Australasian Journal of Animal Sciences
• /
• 제19권9호
• /
• pp.1291-1297
• /
• 2006

The potential of the spot urine sampling technique as an alternative to performing a total urine collection to predict the microbial nitrogen supply was evaluated in crossbred bulls. In a completely randomized design, 20 growing crossbred bulls were assigned four levels of feed intake (120, 100, 80 and 60% of voluntary dry matter intake) on diets comprised of wheat straw and concentrate mixture (50:50). After three months of experimental feeding, a metabolism trial was conducted for ten days, during which spot urine collections were performed every 6 h post feeding on days 9 and 10. The daily urinary excretion of allantoin (A) and purine derivatives (PD) decreased with the reduction in feed intake while creatinine (C) excretion remained similar in animals fed at different levels. The microbial nitrogen (MN) supply calculated from the PD excreted in total urine (35.08 to 72.08 g/d) was higher at increased levels of feed intake. PD concentration in spot urine samples had poor correlation with feed intake except at 12 h post feeding. A/C ratio and PD/C ratio in spot urine samples remained similar irrespective of sampling time and significantly (p<0.01) correlated with daily urinary PD excretion, digestible organic matter intake and dry matter (DM) intake. However, no significant differences were evident in these ratios among animals fed at levels 120, 100 and 80% of voluntary dry matter intake (VDMI) at different times post feeding. These results suggests that the spot urine sampling technique to predict the microbial protein supply is not suitable for detecting small differences in MN supply and hence, estimation of PD excreted in total urine (mmol/d) is necessary to assess precisely the MN supply in crossbred bulls.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권11호
• /
• pp.4549-4553
• /
• 2014

Background: Infection is a serious cause of mortality in febrile neutropenia of pediatric cancer patients. Recently, monotherapy has replaced the combination therapy in empirical treatment of febrile neutropenia. Since there has been no reported trial comparing the efficacy of meropenem and piperacillin-tazobactam (PIP/TAZ) monotherapies, the present retrospective study was conducted to compare safety and efficacy in febrile neutropenic children with cancer. Materials and Methods: Charts of febrile, neutropenic children hospitalized at our center between March 2008 and April 2011 for hemato-oncological malignancies were reviewed. Patients received PIP/TAZ 360 mg/kg/day or meropenem 60 mg/kg/day intravenously in three divided doses. Duration of fever and neutropenia, absolute neutrophil count, modification, and success rate were compared between the two groups. Resolution of fever without antibiotic change was defined as success and resolution of fever with antibiotic change or death of a patient was defined as failure. Modification was defined as changing the empirical antimicrobial agent during a febrile episode. Results: Two hundred eighty four febrile neutropenic episodes were documented in 136 patients with a median age of 5 years. In 198 episodes meropenem and in 86 episodes PIP/TAZ were used. Duration of fever and neutropenia, neutrophil count, sex, and primary disease were not different between two groups. Success rates and modification rate between two groups showed no significant differences (p>0.05). Overall success rate in the meropenem and PIP/TAZ groups were 92.4% and 91.9% respectively. No serious adverse effects occurred in either of the groups. Conclusions: Meropenem and PIP/TAZ monotherapy are equally safe and effective in the initial treatment of febrile neutropenia in children with cancer.

• 대한한의학회지
• /
• 제33권1호
• /
• pp.12-23
• /
• 2012

Objectives: This study evaluated clinical trials of acupuncture treatment for hypertension and to assess their methodology and results. Methods: Eight Korean databases and four international databases were searched for clinical trials of acupuncture treatment for hypertension up to June 2011. Study quality was assessed using the risk of bias (ROB) tool. Results: Twenty-four trials of acupuncture for hypertension were included. There were 14 randomized and 1 non-randomized controlled trials and 9 before-after studies. The most frequently used acupuncture points were zsnli (ST36), qch (LI11), fngch (GB20), snynjio (SP06), snjin (LI03) and hgu (LI04). In more than half of the studies, needle retention time was 20~30 minutes. Compared to baseline, change of blood pressure after treatment was significant in all studies. However, the results of effect on blood pressure between acupuncture and control were not consistent. Conclusions: There is insufficient evidence to suggest that acupuncture is an effective treatment for hypertension. Further well-designed clinical trials will be required to evaluate the effects and safety of acupuncture treatment for hypertension.

• Journal of Forest and Environmental Science
• /
• 제34권1호
• /
• pp.82-86
• /
• 2018

Loblolly pine (Pinus taeda L.) is widely distributed in the southern part of the United States and it has been used as a major economic species in the region due to its excellent growth and stem straightness. The tree also grows only in the southern part of Korea because it is susceptible to cold. Recently climate changes have had widespread impacts on forest trees. Thus, the use of good quality seeds is prerequisite for assessing assisted migration adaptation trial. In this study, we conducted to investigate its cone and seed characteristics of each family, which is expected to improve seeds productivity for planting valuable timber trees. A total of 14 families were selected from the experimental forest in Boseong, Jeonnam province in 1981. The seed production capacity was estimated to range from 87.2 to 129.4 among families and the average was 111.3. The number of aborted ovules was investigated in the range of 11.4 to 29.5 for the first test and 7.4 to 22.2 for the second test. The average number of empty and filled seeds was 1.4 and 79.2 per cone, respectively. Based on the results, we can conclude that there is a strong correlation between the number of fertile scale and the seed production ability.

• 한방재활의학과학회지
• /
• 제25권3호
• /
• pp.51-57
• /
• 2015

Objectives To evaluate the evidence supporting the effectiveness of Chuna manual therapy for nocturnal crying. Methods We conducted search across the 3 electronic databases (Pubmed, CAJ and Oasis) to find all of randomized controlled clinical trials(RCTs) that used Chuna manual therapy as a treatment for nocturnal crying. The methodological quality of each RCTs was assessed using the Cochrane Risk of Bias tool and nRCTs was assessed using the Cochrane Risk of Bias Assessment tool for Non-randomized Study tool. Results Two RCTs and three nRCTs met our inclusion criteria. The meta-analysis showed positive results for the use of Chuna manual therapy in terms of the efficacy rate when compared to medication treatments alone. Positive results were also obtained, in terms of the efficacy rate, when comparing Chuna manual therapy combined with acupoint application therapy to Chuna manual therapy alone, but was not statistically significant. Conclusions Our systematic review found encouraging but limited evidence of Chuna manual therapy for nocturnal crying. We recommend clinical trials which compare the effectiveness of Chuna manual therapy with usual care to obtain stronger evidence without the demerits of trial design.

• 한국환경농학회지
• /
• 제29권3호
• /
• pp.239-246
• /
• 2010

Aphids are one of the major pests in agricultural crops. A number of synthetic pesticides have been used for control of aphids in agriculture, but increasing public concerns over their adverse effects on the environment have required more environmentally-friendly methods for pest management. In this study, we examined plant oil formulations for the control of green peach aphid (Myzus persicae). Oil formulations were prepared by hydrolyzing the plant oils in ethanolic KOH solution and diluted at the rate of 1:500 for aphid control. The oil formulations showed aphid mortalities ranging from 24.44 to 43.33% in vitro. Significantly increased aphid mortalities were observed by the treatment of oil formulations combined with low-dosed imidacloprid. No significant difference in the aphid mortality was observed between the oil formulations. Mass spectrometry analyses of aphids treated with the low dosedimidacloprid plus the plant oil formulations detected similar concentrations of imidacloprid between the treatments. In field trial bioassays against aphids, significantly decreased aphid population were observed in the pepper plants treated with soybean oil formulation combined with the low-dosed imidacloprid, while aphid population dramatically increased in the pepper plants treated with the low-dosed imidacloprid alone. These results suggested that the plant oil formulations can be used as an environmentally-friendly method for enhancing the insecticidal effectiveness, which may play a role in reducing the use of synthetic pesticide in agriculture.

• 한국축산식품학회지
• /
• 제26권4호
• /
• pp.447-453
• /
• 2006

This study was conducted to investigate the effects of $Megazone^{(R)}$ (a mineral mix) supplementation on growth performance, nutrients digestibility, blood characteristics, meat quality and carcass traits in weaning-to-finishing pigs. A total of 48 crossbred $(Landrace{\times}Yorkshire{\times}Duroc)$ pigs with initial body weight (BW) of $4.46{\pm}0.18kg$ were used in a 21 wks trial. Pigs were blocked by weight and allotted to two dietary treatments in a completly randomized design. There were 6 pens per treatment. Dietary treatments included: 1) Control (CON: basal diet) and 2) MT (basal diet+0.8% $Megazone^{(R)}$). Through the entire experimental period, there were no effects of dietary $Megazone^{(R)}$ supplementation on growth performance nutrients digestibility, blood characteristics and meat quality traits (p>0.05). Market weight and backfat thickness also had no differences between the two treatments (p>0.05). However, carcass weight and carcass ratio in MT treatment were improved significantly compared with CON treatment (p<0.05). In conclusion, supplmentation of $Megazone^{(R)}$ can increase carcass weight and carcass ratio in weaning-to-finishing pigs, however, it has no effects on growth performance, nutrients digestibility, blood characteristics and meat quality traits.